DEVICE AND METHOD FOR PREVENTING STENOSIS AT AN ANASTOMOSIS SITE

The present invention relates to treating or preventing stenosis at an anastomosis site. In one embodiment, the present invention is a stent is curved along the longitudinal axis for placement in and adjacent to the graft orifice. In a further embodiment, the stent is drug coated to allow delivery of antivasculoproliferative drugs directly to the vicinity of the graft orifice. In a further embodiment, the stent is expandable by use of an external wire. In another embodiment, the present invention is a kit comprising the specially configured stent together with a sleeve comprising a biocompatible matrix material and a pharmaceutical agent, wherein the sleeve is applied to the external surface of the vessel or graft, resulting in extravascular delivery of a pharmaceutical agent. Methods for treating or preventing stenosis at an anastomosis site by applying the extravascular sleeve and the intravascular stent are also provided. 1. A stent , comprising:a structure defining an essentially tubular body having a tubular wall with a longitudinal axis and a circumferential diameter, the structure being expandable from a contracted configuration to an expanded configuration, wherein the stent is curved along the longitudinal axis for placement at an anastomosis site.2. The stent of claim 1 , wherein the degree of curvature in the stent is approximately 5 degrees.3. The stent of claim 1 , wherein the degree of curvature in the stent is approximately 10 degrees.4. The stent of claim 1 , wherein the degree of curvature in the stent is approximately 15 degrees.5. The stent of claim 1 , wherein the degree of curvature in the stent is approximately 20 degrees.6. The stent of claim 1 , wherein the degree of curvature in the stent is approximately 25 degrees.7. The stent of claim 1 , wherein the degree of curvature in the stent is approximately 30 degrees.8. The stent of claim 1 , wherein the degree of curvature in the stent is approximately 35 degrees.9. The stent of claim 1 , ...

ORIFICE INTRODUCER DEVICE

An orifice introducer device for introducing, e.g., a surgical device, into, e.g., an orifice of a body, includes a tubular member having a distal end and a proximal end. The distal end is adjustable between a first position for insertion into an orifice and a second position once inserted into the orifice. Alternatively, the orifice introducer device includes a distal portion having a proximal end configured to be detachably secured to the distal end of the tubular member. The distal portion is selectively detachable when the orifice introducer device is positioned in the orifice. 116-. (canceled)17. An orifice introducer device , comprising:a tubular member having a distal end and a proximal end;the distal end being adjustable between a first position for insertion into an orifice and a second position once inserted into the orifice.18. The orifice introducer device of claim 17 , wherein the tubular member includes at least one slit claim 17 , seam claim 17 , or perforation longitudinally extending from the distal end.19. The orifice introducer device of claim 18 , wherein said at least one slit claim 18 , seam claim 18 , or perforation is radially opposed to any other slit claim 18 , seam claim 18 , or perforation which also extends longitudinally from the distal end.20. The orifice introducer device of claim 19 , wherein the diameter of the distal end of said tubular member is adjusted to the second position relative to the first position by manipulation of the at least one slit claim 19 , seam claim 19 , or perforation.21. The orifice introducer device of claim 20 , wherein the at least one slit claim 20 , seam claim 20 , or perforation defines a longitudinally extending V-shaped opening upon said tubular member claim 20 , wherein said V-shaped opening defines a distal end which is wider than a proximal end thereof.22. The orifice introducer device of claim 21 , wherein claim 21 , in the first position claim 21 , the distal end of the tubular member has a ...

DEVICE AND METHOD FOR PREVENTING STENOSIS AT AN ANASTOMOSIS SITE

The present invention relates to treating or preventing stenosis at an anastomosis site. In one embodiment, the present invention is a stent is curved along the longitudinal axis for placement in and adjacent to the graft orifice. In a further embodiment, the stent is drug coated to allow delivery of antivasculoproliferative drugs directly to the vicinity of the graft orifice. In a further embodiment, the stent is expandable by use of an external wire. In another embodiment, the present invention is a kit comprising the specially configured stent together with a sleeve comprising a biocompatible matrix material and a pharmaceutical agent, wherein the sleeve is applied to the external surface of the vessel or graft, resulting in extravascular delivery of a pharmaceutical agent. Methods for treating or preventing stenosis at an anastomosis site by applying the extravascular sleeve and the intravascular stent are also provided. 1109-. (canceled)110. A method for preventing stenosis of a vein , a graft , an artery , a vessel , and an anastomotic orifice at an anastomosis site having an extravascular surface , comprising the steps of:a. Providing a stent comprising a structure defining an essentially tubular body having a tubular wall with a longitudinal axis and a circumferential diameter, the structure being expandable from a contracted configuration to an expanded configuration, wherein the stent is beveled at the edge and curved along the longitudinal axis for placement in the anastomosis site;b. Providing a sleeve comprising a biocompatible matrix material imbibed with a therapeutic agent;c. Applying the sleeve to the extravascular surface of the anastomosis site; andd. Inserting the stent into the vein and the anastomotic orifice of the anastomosis site.111. The method of claim 110 , wherein the therapeutic agent is rapamycin.112. The method of claim 110 , wherein the therapeutic agent is an analogue of rapamycin.113. The method of claim 110 , wherein the ...

DEVICE AND METHOD FOR PREVENTING STENOSIS AT AN ANASTOMOSIS SITE

The present invention relates to treating or preventing stenosis at an anastomosis site. In one embodiment, the present invention is a stent is curved along the longitudinal axis for placement in and adjacent to the graft orifice. In a further embodiment, the stent is drug coated to allow delivery of antivasculoproliferative drugs directly to the vicinity of the graft orifice. In a further embodiment, the stent is expandable by use of an external wire. In another embodiment, the present invention is a kit comprising the specially configured stent together with a sleeve comprising a biocompatible matrix material and a pharmaceutical agent, wherein the sleeve is applied to the external surface of the vessel or graft, resulting in extravascular delivery of a pharmaceutical agent. Methods for treating or preventing stenosis at an anastomosis site by applying the extravascular sleeve and the intravascular stent are also provided. 1. A method for preventing or treating stenosis in a vascular structure having an anastomosis comprising deploying a drug free stent within the lumen of a vascular structure and applying locally and externally to the vascular structure , a biocompatible matrix material that carries an anti-vasculoproliferative drug and is free of biological cells , wherein the anastomosis is a part of an artery , vein or graft.2. The method of wherein the anastomosis results from the formation of an arterio-venous fistula claim 1 , or an arterio-venous graft or an arterial-arterial graft.3. The method of wherein the matrix material carries about 75 micrograms per cmof the anti-vasculoproliferative drug.4. The method of wherein the anti-vasculoproliferative drug carried by the matrix material is rapamycin or an analogue of rapamycin.5. The method of wherein the analogue of rapamycin is everolimus or zotarolimus.6. The method of wherein the anti-vasculoproliferative drug carried by the matrix material is the only active ingredient carried by the matrix material.7. ...

Endovascular prosthesis and method of making

The present invention provides a prosthesis formed from a plurality of tubular layers members deployed in vivo using endovascular techniques and material. The layers define a lumen through a diseased portion of a vascular system. Each layer may be constructed using overlapping tubular members to provide a custom prosthesis. Subsequent prosthesis layers overlapping in the central portion of the lumen strengthen the prosthesis walls and may incorporate biocompatible materials having desirable properties.

Endovascular prosthesis accommodating torsional and longitudinal displacements and methods of use

A prosthesis is provided comprising a plurality of telescoping tubular members that are deployed and assembled in vivo to define a lumen through a diseased portion of a vascular system. The individual tubular members are capable of accommodating torsional and longitudinal displacements caused by relative motion of the healthy portions on either side of the diseased portion of vessel.

Electro-mechanical surgical device

Infusion catheter having an atraumatic tip

The present invention is directed to apparatus and methods for treating a vascular occlusion by providing an infusion catheter (10) having an atraumatic tip (12) and at least one delivery port (14) configured to infuse fluid into the occlusion. The fluid that is infused dilutes the occlusion and reduces adhesion of the occlusion to an intima of the vessel wall, thereby causing the occlusion to dislodge. Emboli generated in the process are directed into an emboli removal catheter (60) for removal.

Electro-mechanical surgical device with data memory unit

An electro-mechanical surgical device includes: a housing; an elongated shaf t extending from the housing, a distal end of the elongated shaft being detachably coupleable to a surgical instrument; at least two axially rotatab le drive shafts disposed within the elongated shaft, a distal end of each of th e drive shafts being configured to couple with the surgical instrument; a steering cable arrangement, the steering cable arrangement being configured to steer the distal end of the elongated shaft; and a motor system disposed within the housing, the motor system being configured to drive the drive shafts and the steering cable arrangement. A control system may be provided for controlling the motor system. A remote control unit may also be provided for controlling the motor system via the control system. Sensors, such as optical of Hall-effect devices, may be provided for determining the position of the elements of the surgical instrument based on the detected rotation of the drive shafts. A memory unit stores a plurality of operating programs or algorithms, each corresponding to a type of surgical instrument attachable t o the electro-mechanical surgical device. The control system reads or selects from the plurality of operating programs or algorithms, the operating progra m or algorithm corresponding to the type of surgical instrument attached to th e electro-mechanical surgical device.

Apparatus and methods for treating stroke and controlling cerebral flow characteristics

Apparatus and methods for treatment of stroke are provided. In a preferred embodiment, the present invention disposes at least one catheter (41) having a distal occlusive member (42) in either the common carotid artery (CCA) or both the vertebral artery (VA) and the CCA on the hemisphere of the cerebral occlusion. Blood flow in the opposing carotid and/or vertebral arteries may be inhibited. Retrograde or antegrade flow may be provided through either catheter (41) independently to effectively control cerebral flow characteristics. Under such controlled flow conditions, a thrombectomy device (200) may be used to treat the occlusion, and any emboli generated are directed into the catheter(s).

Orifice introducer device

An orifice introducer device for introducing, e.g., a surgical device, into, e.g., an orifice of a body, includes a tubular member having a distal end and a proximal end. The distal end is adjustable between a first position for insertion into an orifice and a second position once inserted into the orifice. Alternatively, the orifice introducer device includes a distal portion having a proximal end configured to be detachably secured to the distal end of the tubular member. The distal portion is selectively detachable when the orifice introducer device is positioned in the orifice.

Orifice introducer device

Endovascular prosthesis and method of making

The present invention provides a prosthesis (10) formed from a plurality of tubular layers members (14, 16, 18) deployed in vivo using endovascular techniques, and material. The layers (14, 16, 18) define a lumen through a diseased portion of a vascular system (36). Each layer may be constructed using overlapping tubular members to provide a custom prosthesis. Subsequent prosthesis layers overlapping in the central portion of the lumen strengthen the prosthesis walls, and may incorporate biocompatible materials having desirable properties.

Electro-mechanical surgical device

A surgical device, comprising: an elongated shaft (20) having a first coupling (26); and a surgical instrument (250,2250) including at least one movable element (256,2256,264,2264), the elongated shaft including at least one rotatable drive shaft (30,32) configured to effect movement of the at least one movable element; characterised in that the surgical instrument has a second coupling, the second coupling being complimentary to and configured to couple with the first coupling; wherein the elongated shaft is configured to be inserted into a body via a first orifice and the surgical instrument is configured to be inserted into the body via one of the first orifice and a second orifice; and wherein the elongated shaft is configured to be-coupled with the surgical instrument via the first coupling and the second coupling after the elongated shaft is inserted into the body via the first orifice and after the surgical instrument is inserted into the body via the one of the first orifice and the second orifice.

Pressure generator for intravascular dilator

A pressure generator for intravascular dilators includes a ram and a syringe holder. A screw drive having a large mechanical advantage is coupled for advancing the ram at a controlled rate. A coupler at one end of the ram is adapted to engage one end of a syringe plunger whereby dilation liquid will be discharged at a controlled pressure from the syringe as the ram is advanced. The pressure generator may be provided with a pistol grip and the ram may be calibrated for direct pressure readout.

Apparatus and methods for treating stroke and controlling cerebral flow characteristics

Apparatus and methods for tretment of stroke are provided. In the preferred embodiment, the present invention disposes at least one catheter (2) having a distal occlusive member (4) in the common carotif artery of the hemisphere of the cerebral occlusion. Retrograde flow may be provided through the catheter (2) to effectively control cerebral flow characteristics. Under such controlled flow conditions, a thrombectomy device (12) may be used to treat the occlusion, and any emboli generated are directed into the catheter (2).

Separable sheath and method of use

A separable insertion sheath is for inserting a medical device into a patient. The insertion sheath includes releasably connectable ends. A medical device loaded into the insertion sheath is deployed by using an elongate member connected to the insertion sheath to shift the proximal and distal sections away from each other to expose the medical device.

Apparatus and methods for treating stroke and controlling cerebral flow characteristics

Apparatus and methods for treatment of stroke are provided. In a preferred embodiment, the present invention disposes at least one catheter (41) having a distal occlusive member (42) in either the common carotid artery (CCA) or bo th the vertebral artery (VA) and the CCA on the hemisphere of the cerebral occlusion. Blood flow in the opposing carotid and/or vertebral arteries may be inhibited. Retrograde or antegrade flow may be provided through either catheter (41) independently to effectively control cerebral flow characteristics. Under such controlled flow conditions, a thrombectomy devic e (200) may be used to treat the occlusion, and any emboli generated are directed into the catheter(s).

Apparatus with infusion catheter with atraumatic tip

Infusion catheter having an atraumatic tip

The present invention is directed to apparatus and methods for treating a vascular occlusion by providing an infusion catheter (10) having an atraumat ic tip (12) and at least one delivery port (14) configured to infuse fluid into the occlusion. The fluid that is infused dilutes the occlusion and reduces adhesion of the occlusion to an intima of the vessel wall, thereby causing t he occlusion to dislodge. Emboli generated in the process are directed into an emboli removal catheter (60) for removal.

Apparatus and methods for treating stroke and controlling cerebral flow characteristics

Apparatus and methods for treatment of stroke are provided. In a preferred embodiment, the present invention disposes at least one catheter having a distal occlusive member in either the common carotid artery (CCA) or both the vertebral artery (VA) and the CCA on the hemisphere of the cerebral occlusion. Blood flow in the opposing carotid and/or vertebral arteries may be inhibited. Retrograde or antegrade flow may be provided through either catheter independently to effectively control cerebral flow characteristics. Under such controlled flow conditions, a thrombectomy device may be used to treat the occlusion, and any emboli generated are directed into the catheter(s).

Orifice introducer device

An orifice introducer device for introducing, e.g., a surgical device, into, e.g., an orifice of a body, includes a tubular member having a distal end and a proximal end. The distal end is adjustable between a first position for insertion into an orifice and a second position once inserted into the orifice. Alternatively, the orifice introducer device includes a distal portion having a proximal end configured to be detachably secured to the distal end of the tubular member. The distal portion is selectively detachable when the orifice introducer device is positioned in the orifice.

Apparatus and methods for treating stroke and controlling cerebral flow characteristics

Apparatus and methods for treatment of stroke are provided. In a preferred embodiment, the present invention disposes at least one catheter having a distal occlusive member in either the common carotid artery (CCA) or both the vertebral artery (VA) and the CCA on the hemisphere of the cerebral occlusion. Blood flow in the opposing carotid and/or vertebral arteries may be inhibited. Retrograde or antegrade flow may be provided through either catheter independently to effectively control cerebral flow characteristics. Under such controlled flow conditions, a thrombectomy device may be used to treat the occlusion, and any emboli generated are directed into the catheter(s).

Electro-mechanical surgical device with data memory unit

An electro-mechanical surgical device, comprising: at least one rotatable drive shaft; a motor arrangement configured to rotate the at least one rotatable drive shaft from a proximal end thereof; a first gear arrangement disposed at a distal end of the rotatable drive shaft; and at least one element driven by the gear arrangement; wherein the gear arrangement is configured to convert a high speed rotation of the rotatable drive shaft to drive the at least one driven element at a high torque.

Orifice introducer device

An orifice introducer device for introducing, e.g., a surgical device, into, e.g., an orifice of a body, includes a tubular member having a distal end and a proximal end. The distal end is adjustable between a first position for insertion into an orifice and a second position once inserted into the orifice. Alternatively, the orifice introducer device includes a distal portion having a proximal end configured to be detachably secured to the distal end of the tubular member. The distal portion is selectively detachable when the orifice introducer device is positioned in the orifice.

Electro-mechanical surgical device with data memory unit

An electro-mechanical surgical device, comprising: at least one rotatable drive shaft; a motor arrangement configured to rotate the at least one rotatable drive shaft from a proximal end thereof; a first gear arrangement disposed at a distal end of the rotatable drive shaft; and at least one element driven by the gear arrangement; wherein the gear arrangement is configured to convert a high speed rotation of the rotatable drive shaft to drive the at least one driven element at a high torque.

Einführungsvorrichtung in einer öffnung

Separable sheath and method of using

A separable or splittable insertion sheath is for inserting a medical device into a patient. The insertion sheath includes releasably connectable ends or is configured to split into proximal and distal sections upon application of a predetermined level of pulling or twisting force to opposite ends of the insertion sheath. A medical device loaded into the insertion sheath is deployed by pulling the proximal and distal sections away from each other to expose the medical device.

Apparat mit infusionskatheter mit atraumatischer spitze

Orifice introducer device

An orifice introducer device for introducing, for example a surgical device, into, for example an orifice of a body, includes a tubular member having a distal end and a proximal end. The distal end is adjustable between a first position for insertion into an orifice and a second position once inserted into the orifice. Alternatively, the orifice introducer device includes a distal portion having a proximal end configured to be detachably secured to the distal end of the tubular member. The distal portion is selectively detachable when the orifice introducer device is positioned in the orifice.