Systems and methods for preparing autologous fibrin glue

A method of regenerating tissue in a living organism. The method includes the act of contacting an affected area of the living organism with a solid-fibrin web, the solid-fibrin web comprising platelets that release growth factors about one minute after contact to regenerate the tissue in the living organism.

SYSTEMS AND METHODS FOR PREPARING AUTOLOGOUS FIBRIN GLUE

The invention provides a system for preparing an autologous solid-fibrin web suitable for regenerating tissue in a living organism. The system includes a sealed primary container containing a separation medium and a low-density high-viscosity liquid. The separation medium is capable of separating red blood cells from plasma when the container contains blood and is centrifuged, and the primary container has a first pressure. The system further includes a sealed secondary container containing a calcium-coagulation activator. The secondary container has a second pressure that is less than the first pressure. The system also includes a transfer device having a cannula with a first end and a second end. The first and second ends are adapted to puncture the sealed primary and secondary containers in order to provide fluid communication between the first and second containers. 1. A system for preparing an autologous solid-fibrin web , the system comprisinga primary container containing plasma and a high-density, low-viscosity fluid;a secondary container configured to receive the plasma from the primary container; anda transfer device capable of providing fluid communication between the primary and secondary containers, and wherein a portion of the plasma moves to the secondary until the high-density, low viscosity fluid from the primary container enters the transfer device.2. The system of claim 1 , wherein the secondary container is evacuated3. The system of claim 2 , wherein the primary container has a first pressure claim 2 , and wherein the secondary container has a second pressure that is less than the first pressure claim 2 , and wherein the plasma in the primary container moves to the secondary container by pressure differentiation.4. The system of claim 1 , wherein the secondary container includes an ionic coagulation activator.5. The system of claim 4 , wherein the ionic coagulation activator is selected from calcium chloride claim 4 , calcium fluoride claim 4 , ...

Multilayer containers and process for forming multilayer containers

A co-injection process is provided for fabricating improved multi-layer containers, including but not limited to blood collection tubes, evacuated blood collection tubes, culture bottles, centrifuges tubes, and syringe barrels. The container includes a tube (10) having a bottom wall (12) and a side wall (14) with an open end (18). The container can be provided with a stopper having an upper portion (22) and a skirt with an outside portion (30), a well (34) and a cavity (36). The tube and stopper assembly can be used for medical purposes including containing a blood sample within an enclosed interior space (40).

Rubber/plastic stopper composite with mechanical adhesive joints

Multilayer containers and process for forming multilayer containers

A co-injection process is provided for fabricating improved multi-layer containers, including but not limited to blood collection tubes, evacuated blood collection tubes, culture bottles, centrifuges tubes, and syringe barrels. The container includes a tube (10) having a bottom wall (12) and a side wall (14) with an open end (18). The container can be provided with a stopper having an upper portion (22) and a skirt with an outside portion (30), a well (34) and a cavity (36). The tube and stopper assembly can be used for medical purposes including containing a blood sample within an enclosed interior space (40).

Multilayer containers

A multilayer evacuated blood collection tube is provided having a first tube layer, and a second tube layer formed on the first tube layer and a closure, the second tube layer being a nanocomposite barrier layer. Such containers include but are not limited to blood collection tubes, evacuated blood collection tubes, centrifuge tubes, culture bottles, and syringe barrels.

Blood collection assembly including clot-accelerating glass insert

A blood collection assembly includes a tube, preferably plastic, an elastomeric stopper and a siliceous insert immobilized in the tube under the stopper. In a method for taking a blood sample using the assembly, the stopper is punctured and the sample is discharged onto the insert to initiate clotting.

Single evacuated vessel drives blood sampling device which separates out plasma

A device for the separation of a separable component from a liquid sample for use with an evacuated receptable includes a housing having an interior cavity and a separator membrane dividing the cavity into a first portion and a second portion. The separator membrane has a porosity selected for the desired separation thereacross. An inlet structure is provided for fluid communication between the first portion of the interior cavity and the source of the liquid sample. Communication structure is provided for allowing fluid communication between one of the portions of the cavity and the evacuated receptacle. A rigid receptacle is in fluid communication with the other of the portions of the cavity.

A container and related sample collection tube

Blood collection assembly having additive dispensing means

A blood collection assembly includes an evacuated container having an open end with a puncturable stopper therein. A liquid impermeable receptacle in the container contains an additive and is removably immobilized in the stopper. In a method for preparing a blood sample for analysis, the stopper is punctured by a cannula connected to a blood supply. The cannula is then advanced until it contacts and dislodges the receptacle from the stopper causing the additive to be released directly into the container where it mixes with incoming blood.

Blood collection tube assembly

The present invention is a plastic container with a barrier label. In use, the barrier label is wrapped around and adhered to a container. The barrier label preferably is transparent so that the contents of the container are visible to the observer at the same time identifying information may be displayed on the barrier label. The barrier label is useful for providing an effective barrier against gas permeability in containers and for extending shelf-life of containers, especially plastic evacuated blood collection devices.

Methods for preparing autologous fibrin glue

Polymer compositions and their blends

Multilayer containers and process for forming multilayer containers

A co-injection process is provided for fabricating improved multi-layer containers, including but not limited to blood collection tubes, evacuated blood collection tubes, culture bottles, centrifuges tubes, and syringe barrels. The container includes a tube (10) having a bottom wall (12) and a side wall (14) with an open end (18). The container can be provided with a stopper having an upper portion (22) and a skirt with an outside portion (30), a well (34) and a cavity (36). The tube and stopper assembly can be used for medical purposes including containing a blood sample within an enclosed interior space (40).

Blood collection tube assembly

Additive formulation and method of use thereof

An additive formulation comprising heparinase and trehalose, a method for using the formulation and a device containing the formulation. The additive formulation is useful in substantially neutralizing residual heparin from a blood sample when used in a blood collection tube without interfering with the clinical analysis of the blood sample.

Additive formulation and method of use thereof

An additive formulation comprising heparinase and trehalose, a method for using the formulation and a device containing the formulation. The additive formulation is useful in substantially neutralizing residual heparin from a blood sample when used in a blood collection tube without interfering with the clinical analysis of the blood sample.

Device for the membrane separation of the components of a liquid sample

P .?17 A DEVICE FOR THE MEMBRANE SEPARATION OF THE COMPONENTS OF A LIQUID SAMPLE ABSTRACT OF THE DISCLOSURE A device for the separation of a separable component from a liquid sample for use with an evacuated receptable includes a housing having an interior cavity and a separator membrane dividing the cavity into a first portion and a second portion. The separator membrane has a porosity selected for the desired separation thereacross. An inlet structure is provided for fluid communica-tion between the first portion of the interior cavity and the source of the liquid sample. Communication structure is provided for allowing fluid communication between one of the portions of the cavity and the evacuated receptacle. A rigid receptacle is in fluid communication with the other of the portions of the cavity.

Systems and methods of producing membranes

An apparatus and method of forming a solid-fibrin web. The apparatus includes a centrifuge (600) having a housing (604), and actuator (648), a wheel (660), and a flange (664). The housing includes a recessed area (616) and a base (608) supportable on a surface. The wheel is coupled to the actuator and extends into the recessed area and is adapted to contact a first end of a container (620). The flange extends into the recessed area opposite the wheel and defines an adjustable distance between the wheel and the flange. The flange is adapted to contact a second end of the container and the actuator is operable to rotate the container. The container is oriented substantially parallel with respect to the base.

Composite closure for evacuable test tubes

A stopper is provided, particularly for evacuated blood sample tubes, comprised of a combination of thermoplastic and rubber, which combination utilizes plurality of circumferentially spaced joints containing an adhesive. The joints serve to mechanically hold the composite body of rubber and plastic together. The arrangement reduces the quantity of rubber used while retaining its desirable sealing properties, and reducing the quantity of relatively inexpensive thermoplastic and its desirable strength properties. The invention takes advantage of the relatively good joining properties of a rubber-adhesive combination, and avoids the relatively poor joining properties of a thermoplastic adhesive combination.

Method for preparing a solid fibrin sheet

Un método para preparar una lámina de fibrina sólida, incluyendo el método: extraer sangre de un paciente; separar plasma de la sangre; y concomitantemente coagular y centrifugar axialmente el plasma para formar la lámina de fibrina sólida, siendo adecuada la lámina de fibrina sólida para regenerar tejido corporal en un organismo vivo. A method of preparing a solid fibrin sheet, including the method: drawing blood from a patient; separate plasma from blood; and concomitantly coagulate and axially centrifuge the plasma to form the solid fibrin sheet, the solid fibrin sheet being suitable for regenerating body tissue in a living organism.

Multilayer containers

A multilayer evacuated blood collection tube is provided having a first tube layer, and a second tube layer formed on the first tube layer and a closure, the second tube layer being a nanocomposite barrier layer. Such containers include but are not limited to blood collection tubes, evacuated blood collection tubes, centrifuge tubes, culture bottles, and syringe barrels.

A CONTAINER AND A RELATED SAMPLE COLLECTOR TUBE.

Additive formulation and method of use thereof

Verfahren zur herstellung von autologen fibrinklebern

Systeme und verfahren zur herstellung von autologem fibrinkleber

Methods for preparing a solid-fibrin web

The present invention relates to a method of preparing a solid-fibrin web or autologous fibrin glue by contacting plasma from a patient with a calcium-coagulation activator, and concurrently coagulating and axially centrifugating the plasma to form the solid-fibrin web, said web being suitable for regenerating body tissue in a living organism.

Method for preparing a solid-fibrin web

The present invention relates to a method of preparing a solid-fibrin web or autologous fibrin glue by contacting plasma from a patient with a calcium-coagulation activator, and concurrently coagulating and axially centrifugating the plasma to form the solid-fibrin web, said web being suitable for regenerating body tissue in a living organism.