SYSTEMS AND REAGENTS FOR DETECTION OF FREE MONOCLONAL IMMUNOGLOBULIN LIGHT CHAINS IN BIOLOGICAL SAMPLES

Compositions and methods for determining the presence of free monoclonal immunoglobulin light chains in biological samples with improved resolution and sensitivity are described. The methods detect subjects who have or are at risk of neoplastic monoclonal gammopathies and identify residual/minimal residual disease in subjects who have received therapy for neoplastic monoclonal gammopathies. The methods include immunofixation electrophoresis modified by applying undiluted or concentrated biological samples, washing/blotting of gels to enhance removal of residual proteins, and staining for free light chains with antisera specific to free light chains. Kits including compositions required for the methods are also provided.

Protein-Coupled Red Blood Cell Compositions and Methods of Their Use

Methods and compositions for using N-hydroxysuccinimide and N-hydroxysulfosuccinimide to covalently couple protein(s) to the surface of red blood cells universally, rapidly and conveniently are provided. In one embodiment, the compositions promote immune tolerance in a subject. One embodiment provides autologous or allogenic red blood cells having whole protein(s) of interests conjugated to proteins on or within the plasma membrane of the red blood cells, wherein the conjugated proteins display at least one antigen to which immune tolerance is desired. The proteins are conjugated to the RBCs using carbodiimide chemistry. In a preferred embodiment, the whole proteins are conjugated using EDC in combination with NHS or sulfo-NHS.

WIND TURBINE BLADE

A wind turbine blade comprising a leeward shell portion and a windward shell portion, each of the shell portions extending in a chordwise direction between a leading edge and a trailing edge of the wind turbine blade; a leading reinforcement arrangement comprising at least a leading leeward reinforcement structure engaging the leeward shell portion and a leading windward reinforcement structure engaging the windward shell portion; and a trailing reinforcement arrangement comprising at least a trailing leeward reinforcement structure engaging the leeward shell portion and a trailing windward reinforcement structure engaging the windward shell portion. The trailing windward reinforcement structure has a first stiffness in the lengthwise direction and the trailing leeward reinforcement structure has a second stiffness in the lengthwise direction, wherein the first stiffness is greater than the second stiffness at a chordwise plane of the wind turbine blade.

WIDE-RANGE INDUCTOR-BASED DELAY-CELL AND AREA EFFICIENT TERMINATION SWITCH CONTROL

A quadrature clock generator that takes advantage of the inherently low delay of a shunt-series inductively peaked clock buffer to generate quadrature clocks with the high jitter performance using just one additional stage in Q path compared to I path. The generator includes a delay cell that uses shunt-series peaking and uses a resistive DAC in series with the shunt inductor to provide a large delay range with good jitter characteristics. The resistive DAC can be placed near a real or a virtual ground to minimize capacitive loading on the signal path. This delay cell can provide greater than 2× delay tuning range and is suitable for clocks at high frequencies. This delay cell can also be used as a ring oscillator with large frequency tuning range. A low voltage differential signaling termination switch control that uses feed forward mechanism to control termination impedance of device in a receiver.

Equipotential bonding of wind turbine rotor blade

A wind turbine rotor blade having a blade shell with a generally chordwise layup of fibre plies and a generally spanwise spar cap. A lightning conductor extends over the spar cap, and the spar cap includes conductive material. An equipotential bonding element electrically bonds the lightning conductor to the spar cap. The equipotential bonding element extends between an outboard edge of one stack of the fibre plies and an inboard edge of an adjacent stack of the fibre plies, which overlap to define an overlapping edge region.

A WIND TURBINE BLADE

A wind turbine blade having a length of at least 100 meters comprising: a root end (and a tip end, the blade extending in a spanwise direction from the root end to the tip end, the root end having a substantially circular profile with a root end diameter, and a profile of the blade transitioning into a lift generating profile moving in the spanwise direction from the root end towards the tip end; a leading edge and a trailing edge, the blade extending in a chordwise direction along a chord from the leading edge to the trailing edge; an inboard region extending in the spanwise direction from the root end to a distal end, the inboard region having a length defined between the root end and the distal end; wherein in the inboard region, the chord of the blade is within 5% of the root end diameter and the inboard region has a length of at least 10% span of the blade.

EQUIPOTENTIAL BONDING OF WIND TURBINE ROTOR BLADE

A wind turbine rotor blade having a blade shell with a generally chordwise layup of fibre plies and a generally spanwise spar cap. A lightning conductor extends over the spar cap, and the spar cap includes conductive material. An equipotential bonding element electrically bonds the lightning conductor to the spar cap. The equipotential bonding element extends between an outboard edge of one stack of the fibre plies and an inboard edge of an adjacent stack of the fibre plies, which overlap to define an overlapping edge region.

A wind turbine blade

The present disclosure provides a blade for a wind turbine, where the blade extends in a lengthwise direction between a root end and a tip end of the blade. The blade comprises a leeward shell portion and a windward shell portion, each of the shell portions defining respective inner and outer surfaces extending in a chordwise direction between a leading edge of the blade and a trailing edge of the blade. The blade further comprises a first windward reinforcement structure, a first leeward reinforcement structure, a second windward reinforcement structure, and a second leeward reinforcement structure, the reinforcement structures being arranged internally within the blade and extending in the lengthwise direction of the blade. The second windward and second leeward reinforcement structures are arranged closer to the trailing edge than the first windward reinforcement structure and the first leeward reinforcement structure, respectively, and the second windward reinforcement structure is longer than the second leeward reinforcement structure in the lengthwise direction.

A wind turbine blade

A wind turbine blade having a length of at least 100 meters comprising: a root end (and a tip end, the blade extending in a spanwise direction from the root end to the tip end, the root end having a substantially circular profile with a root end diameter, and a profile of the blade transitioning into a lift generating profile moving in the spanwise direction from the root end towards the tip end; a leading edge and a trailing edge, the blade extending in a chordwise direction along a chord from the leading edge to the trailing edge; an inboard region extending in the spanwise direction from the root end to a distal end, the inboard region having a length defined between the root end and the distal end; wherein in the inboard region, the chord of the blade is within 5% of the root end diameter and the inboard region has a length of at least 10% span of the blade.

Equipotential bonding of wind turbine rotor blade

A blade for a wind turbine

The present disclosure provides a blade for a wind turbine, where the blade extends in a lengthwise direction between a root end and a tip end of the blade. The blade comprises a leeward shell portion and a windward shell portion, each extending in a chordwise direction between a leading edge of the blade and a trailing edge of the blade. A first windward reinforcement structure and a first leeward reinforcement structure are arranged internally within the blade and engage the windward and the leeward shell portion, respectively. The first windward and first leeward reinforcement structures extend in the lengthwise direction of the blade and have a thickness in the thickness direction of the blade. The respective thicknesses of the first leeward reinforcement structure and the first windward reinforcement structure decrease towards the tip end in the lengthwise direction in a first section of the blade; and at at least one position along the length of the blade, the decrease of the thickness of the first leeward reinforcement structure is staggered with respect to the decrease of the thickness of the first windward reinforcement structure.

A wind turbine blade

The present disclosure provides a blade for a wind turbine, where the blade extends in a lengthwise direction between a root end and a tip end of the blade. The blade comprises a leeward shell portion and a windward shell portion, each of the shell portions defining respective inner and outer surfaces extending in a chordwise direction between a leading edge of the blade and a trailing edge of the blade. The blade further comprises a first windward reinforcement structure, a first leeward reinforcement structure, a second windward reinforcement structure, and a second leeward reinforcement structure, the reinforcement structures being arranged internally within the blade and extending in the lengthwise direction of the blade. The second windward and second leeward reinforcement structures are arranged closer to the trailing edge than the first windward reinforcement structure and the first leeward reinforcement structure, respectively, and the second windward reinforcement structure is longer than the second leeward reinforcement structure in the lengthwise direction.

Unión equipotencial de pala de rotor de turbina eólica

Una pala de rotor de turbina eólica que tiene una carcasa de pala con una disposición de capas de fibra generalmente en sentido de cuerda y una tapa de larguero generalmente en sentido de envergadura. Un pararrayos se extiende sobre la tapa del larguero, y la tapa del larguero incluye material conductor. Un elemento de conexión equipotencial une eléctricamente el pararrayos con el casquillo del larguero. El elemento de conexión equipotencial se extiende entre un borde exterior de una pila de capas de fibra y un borde interior de una pila adyacente de capas de fibra, que se superponen para definir una región de borde superpuesta. (Traducción automática con Google Translate, sin valor legal)

A wind turbine blade

A wind turbine blade comprising a leeward shell portion and a windward shell portion, each of the shell portions extending in a chordwise direction between a leading edge and a trailing edge of the wind turbine blade; a leading reinforcement arrangement comprising at least a leading leeward reinforcement structure engaging the leeward shell portion and a leading windward reinforcement structure engaging the windward shell portion; and a trailing reinforcement arrangement comprising at least a trailing leeward reinforcement structure engaging the leeward shell portion and a trailing windward reinforcement structure engaging the windward shell portion. The trailing windward reinforcement structure has a first stiffness in the lengthwise direction and the trailing leeward reinforcement structure has a second stiffness in the lengthwise direction, wherein the first stiffness is greater than the second stiffness at a chordwise plane of the wind turbine blade.

Wind turbine blade

According to the present invention there is provided a wind turbine blade comprising a blade shell that extends longitudinally in a spanwise direction from a root end to a tip end, and transversely in a chordwise direction between a leading edge and a trailing edge. The blade shell is formed from first and second opposing half shells of composite laminate construction. Each half shell comprises an inner skin on an inside of the blade shell and an outer skin on an outside of the blade shell. The blade further comprises a first spar cap located between the inner and outer skins of the first half shell and a second spar cap located between the inner and outer skins of the second half shell. The first and second spar caps are mutually opposed. The first spar cap comprises a plurality of side-by-side stacks of longitudinally-extending strips of reinforcing material, the stacks including at least one web-supporting stack and at least one non-web-supporting stack. The blade further comprises a shear web connected between the first and second spar caps. The shear web comprises a longitudinally-extending web panel and first and second mounting flanges, the first and second mounting flanges extending transversely to the web panel along respective longitudinal edges of the web panel. The first mounting flange is adhesively bonded to the inside of the first half shell in the region of the web-supporting stack(s) of the first spar cap and the second mounting flange is adhesively bonded to the inside of the second half shell in the region of the second spar cap. At a first spanwise location along the blade, the number of strips in a web-supporting stack of the first spar cap is different to the number of strips in a non-web-supporting stack of the first spar cap.

Family of wind turbine blades

According to the present invention there is provided a family of wind turbine blades of substantially equal length and of substantially the same external shape. Each blade comprises a blade shell that extends longitudinally in a spanwise direction from a root end to a tip end and transversely in a chordwise direction between a leading edge and a trailing edge. The blade shell is formed from first and second opposing half shells. Each blade further comprises a first spar cap associated with the first half shell and a second spar cap associated with the second half shell. The first and second spar caps are mutually opposed. The first spar cap comprises a plurality of side-by-side stacks of longitudinally- extending strips of reinforcing material, the stacks including at least one web-supporting stack and at least one non-web-supporting stack. Each blade further comprises a shear web connected between the first and second spar caps. The family of wind turbine blades comprises a first blade designed for a first wind turbine operating in a first wind class or having a first rated power, and a second blade designed for a second wind turbine operating in a second wind class or having a second rated power. The second wind class or second rated power is different to the first wind class or first rated power. At a first spanwise location along the blade, the number of strips in a non-web-supporting stack of the first spar cap of the first blade is different to the number of strips in a corresponding non-web-supporting stack of the first spar cap of the second blade.

[UNK]

This invention relates to preparation of food supplement comprising of herbal extract of Fenugreek, Turmeric, Ginger and Guggul for the treatment of arthritis and related symptoms. The said preparation comprises of Trigonella foenum-graecum, Curcuma longa. Zingiber officinale and Commiphora mukul.

A blade for a wind turbine

The present disclosure provides a blade for a wind turbine, where the blade extends in a lengthwise direction between a root end and a tip end of the blade. The blade comprises a leeward shell portion and a windward shell portion, each extending in a chordwise direction between a leading edge of the blade and a trailing edge of the blade. A first windward reinforcement structure and a first leeward reinforcement structure are arranged internally within the blade and engage the windward and the leeward shell portion, respectively. The first windward and first leeward reinforcement structures extend in the lengthwise direction of the blade and have a thickness in the thickness direction of the blade. The respective thicknesses of the first leeward reinforcement structure and the first windward reinforcement structure decrease towards the tip end in the lengthwise direction in a first section of the blade; and at at least one position along the length of the blade, the decrease of the thickness of the first leeward reinforcement structure is staggered with respect to the decrease of the thickness of the first windward reinforcement structure.

Electrostatic discharge robustness for a single rail transmitting driver

An ESD protection circuit in an interface circuit has a first diode coupled between a power source of an integrated circuit device and an input/output pad of the integrated circuit device, a second diode coupled between a first terminal of a first resistive element and the input/output pad, with a second terminal of the first resistive element being coupled to the power source, a second resistive element that couples the second diode to the first diode and to the input/output pad; a first clamping circuit coupled between the power source and a ground reference of the integrated circuit device, and a second clamping circuit coupled between the first terminal of the first resistive element and the ground reference. The power source supplies a driver circuit coupled to the input/output pad.

A wind turbine blade

The present disclosure provides a blade for a wind turbine, where the blade extends in a lengthwise direction between a root end and a tip end of the blade. The blade comprises a leeward shell portion and a windward shell portion, each of the shell portions defining respective inner and outer surfaces extending in a chordwise direction between a leading edge of the blade and a trailing edge of the blade. The blade further comprises a first windward reinforcement structure, a first leeward reinforcement structure, a second windward reinforcement structure, and a second leeward reinforcement structure, the reinforcement structures being arranged internally within the blade and extending in the lengthwise direction of the blade. The second windward and second leeward reinforcement structures are arranged closer to the trailing edge than the first windward reinforcement structure and the first leeward reinforcement structure, respectively, and the second windward reinforcement structure is longer than the second leeward reinforcement structure in the lengthwise direction.

Qos‑aware optical fog‑assisted cyber‑physical system in 5g ready heterogeneous network and method for the same

The present disclosure relates to a QOS-aware optical fog-assisted cyber-physical system in 5G ready heterogeneous network and method for the same. NFV, ONV, and SDN is used to create a computational OpticalFog node in the middle- ware of cloud and edge that provides an ecosystem to facilitate an ultra-fast infrastructure in the 5G network. The system exploit the computational potential of optical resources to create an OpticalFog node to be integrated into the 5G network infrastructure for CPS-based applications, presents an technique for optimum placement that provide service assurance to various CPS-based applications, and enables CPS-based applications, which are able to run on top of the OpticalFog and 5G infrastructure. iFogSim toolkit is used to implement the proposed OpticalFog-based deployment for the surveillance cameras. The results show the significant advantages of the proposed system for CPS-based applications in the 5G network. 28 o 001 0 Q) 0. U-U LU ~0 I4- CCL 0