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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Применить Всего найдено 8. Отображено 8.
27-08-2009 дата публикации

New Crystalline Atorvastatin Hemicalcium Salt Polymorph Form

Номер: US20090215855A1
Автор: Jozsef Barkoczy, Norbert Nemeth, Gyorgy Ruzsics, Judit Cselenyak
Принадлежит:

The present invention relates to a new crystalline polymorph B-52 form of atorvastatin hemicalcium salt [A[(3R,5R)-7-[3-phenyl-4-[(phenyl carbamoyl]-2-(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrole-1-yl]-3,5-dihydroxy-heptanoic acid calcium salt (2:1)], medicinal preparations containing the new polymorph form, process for the preparation thereof and the use of the new polymorph form for the preparation of medicinal products.

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Номер записи: 1
24-10-2013 дата публикации

METHOD FOR PREPARING ROSUVASTATIN SALTS

Номер: US20130281694A1
Автор: Marta Porcs-Makkay, Ferenc Lorant Bartha, Gyorgy Krasznai, Balazs Volk, Gyorgy Ruzsics, Laszlo Pongo, Gyula Lukacs, Tibor Szabo, Jozsef Barkoczy, Jozsef Debreczeni, Adrienn Keszthelyi, Angela Pandur, Eniko Molnar, Matyas Milen, Maria Tothne Lauritz
Принадлежит: EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENY-TARSASAG

The present invention is related to methods for the preparation of pharmaceutically acceptable salts of (+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-(3R,5S,6E)-dihydroxy-hept-6-enoic acid, intermediates thereof and methods for producing said intermediates.

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Номер записи: 2
15-09-2015 дата публикации

Method for the preparation of high-purity pharmaceutical intermediates

Номер: US0009133132B2
Автор: Gyorgyi Kovanyine Lax, Gyula Simig, Balazs Volk, Ferenc Lorant Bartha, Gyorgy Krasznai, Gyorgy Ruzsics, Eva Sipos, Kalman Nagy, Gyorgy Morovjan, Jozsef Barkoczy, Adrienn Keszthelyi, Janos Imre, Gabor Bagyinszki, KOVANYINE LAX GYORGYI, SIMIG GYULA, VOLK BALAZS, BARTHA FERENC LORANT, KRASZNAI GYORGY, RUZSICS GYORGY, SIPOS EVA, NAGY KALMAN, MOROVJAN GYORGY, BARKOCZY JOZSEF, KESZTHELYI ADRIENN, IMRE JANOS, BAGYINSZKI GABOR
Принадлежит: EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG, KOVANYINE LAX GYORGYI, SIMIG GYULA, VOLK BALAZS, BARTHA FERENC LORANT, KRASZNAI GYORGY, RUZSICS GYORGY, SIPOS EVA, NAGY KALMAN, MOROVJAN GYORGY, BARKOCZY JOZSEF, KESZTHELYI ADRIENN, IMRE JANOS, BAGYINSZKI GABOR

The present invention is related to intermediates useful in the preparation of pharmaceutically acceptable salts of (+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-(3R,5S)-dihydroxy-hept-6-enoic acid and polymorphs of said intermediates, methods for preparation thereof and use thereof.

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Номер записи: 3
22-05-2014 дата публикации

PROCESS FOR THE PREPARATION OF A RIVAROXABAN AND INTERMEDIATES FORMED IN SAID PROCESS

Номер: US20140142303A1
Автор: Eva Sipos, Gyorgyi Kovanyine Lax, Balazs Havasi, Balazs Volk, Gyorgy Krasznai, Gyorgy Ruzsics, Jozsef Barkoczy, Maria Tothne Lauritz, Gyula Lukacs, Andras Boza, Laszlo Jozsef Hegedus, Maria Julia Taborine Toth, Eva Pecsi, SIPOS EVA, KOVANYINE LAX GYORGYI, HAVASI BALAZS, VOLK BALAZS, KRASZNAI GYORGY, RUZSICS GYORGY, BARKOCZY JOZSEF, TOTHNE LAURITZ MARIA, LUKACS GYULA, BOZA ANDRAS, HEGEDUS LASZLO JOZSEF, TABORINE TOTH MARIA JULIA, PECSI EVA
Принадлежит: EGIS Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag

The invention relates to a process for the preparation of 5-chloro-N-({(5-S)-2-oxo3-[4-(3-oxo-morj)holine-4-yl)-phenyl]-1,3-oxazolidine-5-yl}-methyl) thiophen-2-carboxamide having the INN rivaroxaban. The process is characterized by the reactions according to claim 1. The invention also relates to intermediates formed in the above process.

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Номер записи: 4
16-02-2016 дата публикации

Pharmaceutical intermediates and process for the preparation thereof

Номер: US0009260421B2
Автор: Imre Kiraly, Tibor Szabo, Gyula Simig, Balazs Volk, Laszlo Szlavik, Jozsef Barkoczy, Gyorgy Ruzsics, Gyula Lukacs, Laszlo Pongo, Andras Boza, Maria Tothne Lauritz, Maria Kovacs
Принадлежит: EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG

The present invention relates to a process for the preparation of dabigatran etexilate of the formula or pharmaceutically accepted salts thereof.

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Номер записи: 5
31-01-2017 дата публикации

Process for the preparation of a rivaroxaban and intermediates formed in said process

Номер: US0009556163B2
Автор: Eva Sipos, Gyorgyi Kovanyine Lax, Balazs Havasi, Balazs Volk, Gyorgy Krasznai, Gyorgy Ruzsics, Jozsef Barkoczy, Maria Tothne Lauritz, Gyula Lukacs, Andras Boza, Laszlo Jozsef Hegedus, Maria Julia Taborine Toth, Eva Pecsi, SIPOS EVA, KOVANYINE LAX GYORGYI, HAVASI BALAZS, VOLK BALAZS, KRASZNAI GYORGY, RUZSICS GYORGY, BARKOCZY JOZSEF, TOTHNE LAURITZ MARIA, LUKACS GYULA, BOZA ANDRAS, HEGEDUS LASZLO JOZSEF, TABORINE TOTH MARIA JULIA, PECSI EVA, Sipos Eva, Kovanyine Lax Gyorgyi, Havasi Balazs, Volk Balazs, Krasznai Gyorgy, Ruzsics Gyorgy, Barkoczy Jozsef, Tothne Lauritz Maria, Lukacs Gyula, Boza Andras, Hegedus Laszlo Jozsef, Taborine Toth Maria Julia, Pecsi Eva
Принадлежит: EGIS Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag, SIPOS EVA, KOVANYINE LAX GYORGYI, HAVASI BALAZS, VOLK BALAZS, KRASZNAI GYORGY, RUZSICS GYORGY, BARKOCZY JOZSEF, TOTHNE LAURITZ MARIA, LUKACS GYULA, BOZA ANDRAS, HEGEDUS LASZLO JOZSEF, TABORINE TOTH MARIA JULIA, PECSI EVA, EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG, Sipos Eva, Kovanyine Lax Gyorgyi, Havasi Balazs, Volk Balazs, Krasznai Gyorgy, Ruzsics Gyorgy, Barkoczy Jozsef, Tothne Lauritz Maria, Lukacs Gyula, Boza Andras, Hegedus Laszlo Jozsef, Taborine Toth Maria Julia, Pecsi Eva

The invention relates to a process for the preparation of 5-chloro-N-({(5-S)-2-oxo3-[4-(3-oxo-morj)holine-4-yl)-phenyl]-1,3-oxazolidine-5-yl}-methyl) thiophen-2-carboxamide having the INN rivaroxaban. The invention also relates to intermediates formed in the above process.

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Номер записи: 6
05-06-2014 дата публикации

PHARMACEUTICAL INTERMEDIATES AND PROCESS FOR THE PREPARATION THEREOF

Номер: US20140155614A1
Автор: Imre Kiraly, Tibor Szabo, Gyula Simig, Balazs Volk, Laszlo Szlavik, Jozsef Barkoczy, Gyorgy Ruzsics, Gyula Lukacs, Laszlo Pongo, Andras Boza, Maria Tothne Lauritz, Maria Kovacs, KIRALY IMRE, SZABO TIBOR, SIMIG GYULA, VOLK BALAZS, SZLAVIK LASZLO, BARKOCZY JOZSEF, RUZSICS GYORGY, LUKACS GYULA, PONGO LASZLO, BOZA ANDRAS, TOTHNE LAURITZ MARIA, KOVACS MARIA
Принадлежит: EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG

The present invention relates to a process for the preparation of dabigatran etexilate of the formula or pharmaceutically accepted salts thereof.

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Номер записи: 7
26-05-2015 дата публикации

Method for preparing rosuvastatin salts

Номер: US0009040696B2
Автор: Marta Porcs-Makkay, Ferenc Lorant Bartha, Gyorgy Krasznai, Balazs Volk, Gyorgy Ruzsics, Laszlo Pongo, Gyula Lukacs, Tibor Szabo, Jozsef Barkoczy, Jozsef Debreczeni, Adrienn Keszthelyi, Angela Pandur, Eniko Molnar, Matyas Milen, Maria Tothne Lauritz, PORCS-MAKKAY MARTA, BARTHA FERENC LORANT, KRASZNAI GYORGY, VOLK BALAZS, RUZSICS GYORGY, PONGO LASZLO, LUKACS GYULA, SZABO TIBOR, BARKOCZY JOZSEF, DEBRECZENI JOZSEF, KESZTHELYI ADRIENN, PANDUR ANGELA, MOLNAR ENIKO, MILEN MATYAS, TOTHNE LAURITZ MARIA
Принадлежит: EGIS Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag, PORCS-MAKKAY MARTA, BARTHA FERENC LORANT, KRASZNAI GYORGY, VOLK BALAZS, RUZSICS GYORGY, PONGO LASZLO, LUKACS GYULA, SZABO TIBOR, BARKOCZY JOZSEF, DEBRECZENI JOZSEF, KESZTHELYI ADRIENN, PANDUR ANGELA, MOLNAR ENIKO, MILEN MATYAS, TOTHNE LAURITZ MARIA, EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG

The present invention is related to methods for the preparation of pharmaceutically acceptable salts of (+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-(3R,5S,6E)-dihydroxy-hept-6-enoic acid, intermediates thereof and methods for producing said intermediates.

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Номер записи: 8