INJECTOR AND METHOD OF ASSEMBLY

An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state. 1. An injector comprising:a container including a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product;a volume of a drug product disposed in the sterile reservoir, the drug product comprising a PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9)-specific antibody;a fluid delivery system comprising a container needle having a point, the point not disposed through the seal assembly in a storage state, and disposed through the seal assembly and into the sterile reservoir in a delivery state; andan actuator that is adapted to move the container needle from the storage state to the delivery state.2. The injector of claim 1 , wherein the wall of the container comprises a rigid wall.3. The injector of claim 1 , wherein the wall of the container comprises a flexible wall.4. The injector of claim 1 , wherein the seal assembly consists of a flexible unitary wall having an interior surface that defines the interior surface of the seal assembly.5. The injector of claim 4 , wherein the flexible unitary wall defines a septum disposed across an opening of the container and fixedly attached to the wall of the container.6. The injector of claim 4 , wherein the wall of ...

Insertion device

An insertion device, generally used with an infusion set, including a needle being adapted for puncturing at one end and including at the opposite end a hub. The hub includes a handle part and a guard part that are capable of securing the needle through the use of locks. Locking structures are used to secure the insertion device in a position where the needle is covered in a locked position, avoiding unintended contact with the needle.

INSERTION DEVICE

An insertion device, generally used with an infusion set, including a needle being adapted for puncturing at one end and including at the opposite end a hub. The hub includes a handle part and a guard part that are capable of securing the needle through the use of locks. Locking structures are used to secure the insertion device in a position where the needle is covered in a locked position, avoiding unintended contact with the needle.

Insertion device

An insertion device, generally used with an infusion set, including a needle being adapted for puncturing at one end and including at the opposite end a hub. The hub includes a handle part and a guard part that are capable of securing the needle through the use of locks. Locking structures are used to secure the insertion device in a position where the needle is covered in a locked position, avoiding unintended contact with the needle.

Infusion medium delivery device and method with compressible or curved reservoir or conduit

A delivery device includes a durable housing portion and a separable disposable portion that selectively engage and disengage from each other. The disposable housing portion secures to the patient-user and may be disposed of after it has been in use for a prescribed period. Components that normally come into contact with a patient-user or with infusion media are supported by the disposable housing portion for disposal after the prescribed use, while the durable housing portion supports other components such as electronics for controlling delivery of infusion media from the reservoir and a drive device and drive linkage.

Insertion device

An insertion device, generally used with an infusion set, including a needle being adapted for puncturing at one end and including at the opposite end a hub. The hub includes a handle part and a guard part that are capable of securing the needle through the use of locks. Locking structures are used to secure the insertion device in a position where the needle is covered in a locked position, avoiding unintended contact with the needle.

METHOD OF ASSEMBLING AND FILLING A DRUG DELIVERY DEVICE

An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product, including a granulocyte colony-stimulating factor (G-CSF). The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state. 1. A method of assembling an injector , the method comprising:providing a container having a wall defining an interior surface and a seal assembly having an interior surface, the wall and seal assembly defining a reservoir;providing a fluid delivery system physically separate from the container, the fluid delivery system comprising a container needle having a point;sterilizing the container including the reservoir and fluid delivery system while the container and the fluid delivery system are separate from each other;filling the sterile reservoir of the container with a volume of a drug product under sterile conditions, the drug product comprising a granulocyte colony-stimulating factor (G-CSF);attaching the fluid delivery system to the filled container under clean room conditions such that the point of the container needle is disposed adjacent to the seal assembly to define a storage state;attaching the container needle to an actuator, the actuator adapted to move the container needle from the storage state to a delivery state wherein the container needle is disposed through the seal assembly, into the sterile reservoir, and in fluid communication with the drug product for delivery to a patient.2. The method of claim 1 , further ...

Insertion device

An insertion device, generally used with an infusion set, including a needle being adapted for puncturing at one end and including at the opposite end a hub. The hub includes a handle part and a guard part that are capable of securing the needle through the use of locks. Locking structures are used to secure the insertion device in a position where the needle is covered in a locked position, avoiding unintended contact with the needle.

INSERTION DEVICE

An insertion device, generally used with an infusion set, including a needle being adapted for puncturing at one end and including at the opposite end a hub. The hub includes a handle part and a guard part that are capable of securing the needle through the use of locks. Locking structures are used to secure the insertion device in a position where the needle is covered in a locked position, avoiding unintended contact with the needle.

Drug Delivery Device

A drug delivery device includes a housing having an interior space, a needle having retracted and deployed states, an injector to move the needle between retracted and deployed states, and a reservoir disposed within the interior space, the reservoir configured to receive a volume of a drug and to be in fluid communication with the needle. The drug delivery device also includes a controller coupled to the injector and the reservoir, and configured to actuate the injector to move the needle from the retracted state to the deployed state only once, and to actuate the reservoir to deliver the volume of the drug to the patient as a single bolus after a preselected time period has elapsed, the controller disposed within the interior space and configured prior to being disposed within the interior space. The delivery device is wearable, disposable, and single-use.

INSERTION DEVICE

An insertion device, generally used with an infusion set, including a needle being adapted for puncturing at one end and including at the opposite end a hub. The hub includes a handle part and a guard part that are capable of securing the needle through the use of locks. Locking structures are used to secure the insertion device in a position where the needle is covered in a locked position, avoiding unintended contact with the needle. 1. An insertion set , comprising:a cannula housing of an infusion set including a cannula adapted to be inserted into the skin of a patient; and a hub removably attachable to a base of the cannula housing of the infusion set, including a handle part and a guard part;', 'a needle attached to the hub, wherein the guard part is adapted to cover the needle; and', 'a collapse part attached to the handle part, wherein the collapse part is connected to a push block, wherein the collapse part is configured to flex into the push block, and wherein the push block is configured to push the needle so as to bend the needle up and into a needle recess of the guard part., 'an insertion device including2. The insertion set of claim 1 , wherein the handle part is disposed between the collapse part and the guard part.3. The insertion set of claim 1 , wherein the collapse part has two opposing collapsible walls that are biased to improve collapse of both walls when pressure is applied to the collapse part.4. The insertion set of claim 1 , wherein the insertion device further includes locks adapted to secure the needle in the guard part when the needle is covered by the guard part.5. The insertion set of claim 4 , wherein the locks are catches positioned inside the hub on opposite sides that lock when pushed together.6. The insertion set of claim 5 , wherein the collapse part has two opposing collapsible walls claim 5 , and the catches lock together when said collapsible walls are collapsed.7. The insertion set of claim 5 , wherein the catches lock the ...

Infusion medium delivery device and method with compressible or curved reservoir or conduit

A delivery device includes a durable housing portion and a separable disposable portion that selectively engage and disengage from each other. The disposable housing portion secures to the patient-user and may be disposed of after it has been in use for a prescribed period. Components that normally come into contact with a patient-user or with infusion media are supported by the disposable housing portion for disposal after the prescribed use, while the durable housing portion supports other components such as electronics for controlling delivery of infusion media from the reservoir and a drive device and drive linkage.

INJECTOR AND METHOD OF ASSEMBLY

An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product, including a granulocyte colony-stimulating factor (G-CSF). The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state. 1. An injector comprising:a container including a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product;a drug product disposed in the sterile reservoir, the drug product comprising a granulocyte colony-stimulating factor (G-CSF);a fluid delivery system comprising a container needle having a point, the point not disposed through the seal assembly in a storage state, and disposed through the seal assembly and into the sterile reservoir in a delivery state; andan actuator that is adapted to move the container needle from the storage state to the delivery state.2. The injector of claim 1 , wherein the wall of the container comprises a rigid wall.3. The injector of claim 1 , wherein the wall of the container comprises a flexible wall.4. The injector of claim 1 , wherein the seal assembly consists of a flexible unitary wall having an interior surface that defines the interior surface of the seal assembly.5. The injector of claim 4 , wherein the flexible unitary wall defines a septum disposed across an opening of the container and fixedly attached to the wall of the container.6. The injector of claim 4 , ...

Infusion medium delivery device and method with drive device for driving plunger in reservoir

A delivery device includes a durable housing portion and a separable disposable portion that selectively engage and disengage from each other. The disposable housing portion secures to the patient-user and may be disposed of after it has been in use for a prescribed period. Components that normally come into contact with a patient-user or with infusion medium are supported by the disposable housing portion, while the durable housing portion supports other components such as electronics and a drive device. A reservoir is supported by the disposable housing portion and has a moveable plunger that operatively couples to the drive device, when the disposable and durable housing portions are engaged.

Insertion device

An insertion device, generally used with an infusion set, including a needle being adapted for puncturing at one end and including at the opposite end a hub. The hub includes a handle part and a guard part that are capable of securing the needle through the use of locks. Locking structures are used to secure the insertion device in a position where the needle is covered in a locked position, avoiding unintended contact with the needle.

Injector and method of assembly

The invention discloses an injector (100) which may include a container (102) having a wall (110) with an interior surface (112) and a seal assembly (140) with an interior surface (142), the interior surfaces (110) of the wall (110) and the seal assembly (140) defining a closed sterile reservoir (150) filled with a drug product. The injector (100) may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle (180) having a point (182) disposed only partially through the seal assembly (140) in a storage state, and disposed through the interior surface (142) of the seal assembly (140) into the sterile reservoir (150) in a delivery state. Further, the injection may include an actuator (106) that is adapted to move the container needle from the storage state to the delivery state.

INSERTION DEVICE

An insertion device, generally used with an infusion set, including a needle being adapted for puncturing at one end and including at the opposite end a hub. The hub includes a handle part and a guard part that are capable of securing the needle through the use of locks. Locking structures are used to secure the insertion device in a position where the needle is covered in a locked position, avoiding unintended contact with the needle.

Infusion medium delivery device and method with drive device for driving plunger in reservoir

A delivery device includes first and second housing portions that selectively engage and disengage. A reservoir on one housing portion operatively engages a drive device and/or a needle inserting device on the other housing portion. Upon proper engagement of the housing portions, the reservoir operatively couples to the drive device and/or the needle inserting device. A first magnet on the first housing portion and a second magnet (or a magnetically-attractive material) on the second housing portion are positioned to magnetically interact with each other, upon operative engagement of the housing portions. A third magnet on the second housing portion may be opposed to the first magnet to help align the housing portions for connection. A magnet-responsive device may be on one or both housing portions to detect alignment and/or connection of the housing portions.

Insertion device

An insertion device, generally used with an infusion set, including a needle being adapted for puncturing at one end and including at the opposite end a hub. The hub includes a handle part and a guard part that are capable of securing the needle through the use of locks. Locking structures are used to secure the insertion device in a position where the needle is covered in a locked position, avoiding unintended contact with the needle.

Infusion medium delivery device and method with drive device for driving plunger in reservoir

A delivery device includes a durable housing portion and a separable disposable portion that selectively engage and disengage from each other. The disposable housing portion secures to the patient-user and may be disposed of after it has been in use for a prescribed period. Components that normally come into contact with a patient-user or with infusion medium are supported by the disposable housing portion, while the durable housing portion supports other components such as electronics and a drive device. A reservoir is supported by the disposable housing portion and has a moveable plunger that operatively couples to the drive device, when the disposable and durable housing portions are engaged.

MULTI-POSITION INFUSION SET DEVICE AND PROCESS

An infusion set for subcutaneous delivery of an infusant. The infusion set may include a base removably attachable to an infusion site and a connector temporarily lockable to the base. The connector can engage the base in a plurality of orientations. The connector locks into the base after at least partial rotation of the connector about the base. The connector may include flexible arms which unlock the connector from the base. The base includes a cannula for insertion through the infusion site. The connector includes a tubing for passing the infusant. The infusant is subcutaneously passable from the tubing through the cannula when the connector is attached to the base. The infusion set may also include a hub removably attachable to the base that includes a needle that extends through the base and the cannula and a guard removably attachable to the base opposite the hub for surrounding the needle.

Infusion medium delivery device and method with drive device for driving plunger in reservoir

A delivery device includes a durable housing portion and a separable disposable portion that selectively engage and disengage from each other. The disposable housing portion secures to the patient-user and may be disposed of after it has been in use for a prescribed period. Components that normally come into contact with a patient-user or with infusion medium are supported by the disposable housing portion, while the durable housing portion supports other components such as electronics and a drive device. A reservoir is supported by the disposable housing portion and has a moveable plunger that operatively couples to the drive device, when the disposable and durable housing portions are engaged.

Multi-position infusion set device and process

An infusion set for subcutaneous delivery of an infusant. The infusion set may include a base removably attachable to an infusion site and a connector temporarily lockable to the base. The connector can engage the base in a plurality of orientations. The connector locks into the base after at least partial rotation of the connector about the base. The connector may include flexible arms which unlock the connector from the base. The base includes a cannula for insertion through the infusion site. The connector includes a tubing for passing the infusant. The infusant is subcutaneously passable from the tubing through the cannula when the connector is attached to the base. The infusion set may also include a hub removably attachable to the base that includes a needle that extends through the base and the cannula and a guard removably attachable to the base opposite the hub for surrounding the needle.

INFUSION MEDIUM DELIVERY DEVICE AND METHOD WITH DRIVE DEVICE FOR DRIVING PLUNGER IN RESERVOIR

A delivery device includes first and second housing portions that selectively engage and disengage. A reservoir on one housing portion operatively engages a drive device and/or a needle inserting device on the other housing portion. Upon proper engagement of the housing portions, the reservoir operatively couples to the drive device and/or the needle inserting device. A first magnet on the first housing portion and a second magnet (or a magnetically-attractive material) on the second housing portion are positioned to magnetically interact with each other, upon operative engagement of the housing portions. A third magnet on the second housing portion may be opposed to the first magnet to help align the housing portions for connection. A magnet-responsive device may be on one or both housing portions to detect alignment and/or connection of the housing portions.

Insertion device

An insertion device, generally used with an infusion set, including a needle being adapted for puncturing at one end and including at the opposite end a hub. The hub includes a handle part and a guard part that are capable of securing the needle through the use of locks. Locking structures are used to secure the insertion device in a position where the needle is covered in a locked position, avoiding unintended contact with the needle.

Infusion medium delivery device and method with drive device for driving plunger in reservoir

A delivery device includes a durable housing portion and a separable disposable portion that selectively engage and disengage from each other. The disposable housing portion secures to the patient-user and may be disposed of after it has been in use for a prescribed period. Components that normally come into contact with a patient-user or with infusion medium are supported by the disposable housing portion, while the durable housing portion supports other components such as electronics and a drive device. A reservoir is supported by the disposable housing portion and has a moveable plunger that operatively couples to the drive device, when the disposable and durable housing portions are engaged.

Infusion medium delivery device and method with compressible or curved reservoir or conduit

A delivery device includes a durable housing portion and a separable disposable portion that selectively engage and disengage from each other. The disposable housing portion secures to the patient-user and may be disposed of after it has been in use for a prescribed period. Components that normally come into contact with a patient-user or with infusion media are supported by the disposable housing portion for disposal after the prescribed use, while the durable housing portion supports other components such as electronics for controlling delivery of infusion media from the reservoir and a drive device and drive linkage.

INSERTION DEVICE

An insertion device, generally used with an infusion set, including a needle being adapted for puncturing at one end and including at the opposite end a hub. The hub includes a handle part and a guard part that are capable of securing the needle through the use of locks. Locking structures are used to secure the insertion device in a position where the needle is covered in a locked position, avoiding unintended contact with the needle.

Infusion medium delivery device and method with drive device for driving plunger in reservoir

A delivery device includes first and second housing portions that selectively engage and disengage. A reservoir on one housing portion operatively engages a drive device and/or a needle inserting device on the other housing portion. Upon proper engagement of the housing portions, the reservoir operatively couples to the drive device and/or the needle inserting device. A first magnet on the first housing portion and a second magnet (or a magnetically-attractive material) on the second housing portion are positioned to magnetically interact with each other, upon operative engagement of the housing portions. A third magnet on the second housing portion may be opposed to the first magnet to help align the housing portions for connection. A magnet-responsive device may be on one or both housing portions to detect alignment and/or connection of the housing portions.

Drug delivery device

A drug delivery device includes a housing having an interior space, a needle having retracted and deployed states, an injector to move the needle between retracted and deployed states, and a reservoir disposed within the interior space, the reservoir configured to receive a volume of a drug and to be in fluid communication with the needle. The drug delivery device also includes a controller coupled to the injector and the reservoir, and configured to actuate the injector to move the needle from the retracted state to the deployed state only once, and to actuate the reservoir to deliver the volume of the drug to the patient as a single bolus after a preselected time period has elapsed, the controller disposed within the interior space and configured prior to being disposed within the interior space. The delivery device is wearable, disposable, and single-use.

INSERTION DEVICE

An insertion device, generally used with an infusion set, including a needle being adapted for puncturing at one end and including at the opposite end a hub. The hub includes a handle part and a guard part that are capable of securing the needle through the use of locks. Locking structures are used to secure the insertion device in a position where the needle is covered in a locked position, avoiding unintended contact with the needle.

METHOD OF ASSEMBLING AND FILLING A DRUG DELIVERY DEVICE

An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state. 1. A method of assembling an injector , the method comprising:providing a container having a wall defining an interior surface and a seal assembly having an interior surface, the wall and seal assembly defining a reservoir;providing a fluid delivery system physically separate from the container, the fluid delivery system comprising a container needle having a point;sterilizing the container including the reservoir and fluid delivery system while the container and the fluid delivery system are separate from each other;filling the sterile reservoir of the container with a volume of a drug product under sterile conditions;attaching the fluid delivery system to the filled container under clean room conditions such that the point of the container needle is disposed adjacent to the seal assembly to define a storage state;attaching the container needle to an actuator, the actuator adapted to move the container needle from the storage state to a delivery state wherein the container needle is disposed through the seal assembly, into the sterile reservoir, and in fluid communication with the drug product for delivery to a patient.2. The method of claim 1 , wherein filling the sterile reservoir with a volume of a drug product comprises filling the sterile reservoir with a volume of a PCSK9 (Proprotein ...

Insertion device

An insertion device, generally used with an infusion set, including a needle being adapted for puncturing at one end and including at the opposite end a hub. The hub includes a handle part and a guard part that are capable of securing the needle through the use of locks. Locking structures are used to secure the insertion device in a position where the needle is covered in a locked position, avoiding unintended contact with the needle.

Infusion medium delivery device and method with drive device for driving plunger in reservoir

Method for processing prolamin-containing feed for a ruminant animal to potentiate milk production or conception

Composition and method for processing prolamin-containing feed source into a low-vitreous gelatinous feedstuff. The feedstuff is fed to ruminant animals for the purpose of potentiating either milk production and/or conception. The feed source can be corn and the ruminant animal can be a bovine, and might be a cow. The method includes processing, by extrusion, a prolamin-containing feed source having a starch-protein matrix within which the included protein is composed of at least 3% percent prolamin. This processing produces a hydrophilic gelatinous feedstuff that has starch and protein content. The hydrophilic low-vitreous gelatinous feedstuff is fed to a ruminant animal. A rumen-retained portion of the fed feedstuff is retained within the rumen of the animal for at least a twenty-four hour period, and during the first twenty-four hours of that period, at least seventy-five percent of the starch content of the rumen-retained portion of the fed feedstuff is digested.

INSERTION DEVICE

An insertion device, generally used with an infusion set, including a needle being adapted for puncturing at one end and including at the opposite end a hub. The hub includes a handle part and a guard part that are capable of securing the needle through the use of locks. Locking structures are used to secure the insertion device in a position where the needle is covered in a locked position, avoiding unintended contact with the needle. 1. A method for covering an insertion needle , comprising: a hub removably attachable to a base of a cannula housing of an infusion set, said hub including a handle part and a guard part, wherein said handle part has a vertical portion and a horizontal portion; and', "a needle attached to the hub, wherein, for the entirety of its travel, the guard part is configured to slide along an outer surface of the handle part according to a direction pulled to cover the needle, said direction being parallel to the needle's longitudinal axis and perpendicular to the handle part's horizontal portion;"], 'inserting a cannula into the skin of a patient with an insertion device, wherein the insertion device includesremoving the insertion device from the cannula housing; andsliding the guard part along the handle part in said direction parallel to the needle's longitudinal axis and perpendicular to the handle part's horizontal portion so as to cover the needle with the guard part.2. The method of claim 1 , wherein the insertion device further includes locks configured to secure the needle in the guard part when the needle is covered by the guard part.3. The method of claim 2 , wherein the locks are configured to interlock the guard part to the handle part when the guard part is slid over the needle.4. The method of claim 3 , wherein the locks are detents on outer sides of the handle part and catches on inner sides of the guard part that correspond to the detents.5. The method of claim 4 , wherein the detents snap into the catches when the guard part ...

Method for processing feed grain for dairy animals

Method of producing a feedstuff for a dairy animal that potentiates milk production. The method includes a multi-stage process having one stage in which a feed grain for dairy animals is heat-treated for a period of time at a temperature above 90 degrees Celsius. The grain is processed for another period of time that includes disrupting the prolamin/protein bonds which produces a hydrophilic, vitreous feedstuff having a starch and protein matrix composed at least partially by prolamin. The feed grain is heat-treated for a first period of time, of which at least 200 seconds is maintained above 90 degrees Celsius, and thereafter the feed grain is processed in a second stage by applying sufficient processing to disrupt the prolamin/protein bonds and thereby producing a hydrophilic, vitreous, feedstuff comprising a starch and protein matrix composed of at least three percent prolamin.

VIAL ADAPTER AND SYSTEM

A vial adapter includes a base having first and second opposing sides, a spike depending from the first side of the base, the spike having a spike passageway, and a connector disposed on the second side of the base, the connector having a connector passageway that is in fluid communication with the spike passageway. The vial adapter may be combined with a vial. 19-. (canceled)10. A vial adapter comprising:a base having first and second opposing sides;a tubular skirt depending from the first side of the base, the tubular skirt bounding a space to receive a vial therein;a spike depending from the first side of the base into the space, the spike having a longitudinal axis and a spike passageway,the tubular skirt having at least one slot formed therein, the at least one slot having a first section that extends parallel to the longitudinal axis of the spike and a second section extending in an arc about the longitudinal axis and connected to the first section; anda connector disposed on the second side of the base, the connector having a connector passageway that is in fluid communication with the spike passageway.11. The vial adapter according to claim 10 , comprising a biasing mechanism disposed about the spike and depending into the space.12. The vial adapter according to claim 11 , wherein the spike comprises an elongated aperture having first and second ends axially spaced from each other.13. The vial adapter according to claim 10 , wherein the first and second sections of the at least one slot connect at right angles to each other.14. The vial adapter according to claim 13 , wherein the second section of the at least one slot has a first open end connected to the first section and a second closed end claim 13 , the width of the second section being uniform between the first and second ends.15. The vial adapter according to claim 13 , wherein the second section of the at least one slot has a first open end connected to the first section and a second closed end claim ...

INJECTOR AND METHOD OF ASSEMBLY

An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state. 1. An injector comprising:a container including a wall with an interior surface and a septum with an interior surface, the interior surfaces of the wall and the septum defining a reservoir;a stopper movably disposed in the container;a fluid delivery system comprising a container needle having a point, the needle having a storage state and a delivery state; anda clean barrier positioned exterior to the septum such that the septum and the clean barrier define an enclosed clean space disposed between the septum and the clean barrier, the point of the container needle being disposed in the enclosed clean space in the storage state and disposed through the septum in the delivery state.2. The injector of claim 1 , wherein the clean barrier is free from contact with the septum.3. The injector of claim 1 , wherein the clean barrier is immovable relative to the wall of the container.4. The injector of claim 1 , wherein the clean barrier is coupled with the container needle such that the point of the container needle penetrates the clean barrier in the storage state.5. The injector of claim 1 , comprising an actuator configured to move the container needle from the storage state to the delivery state.6. The injector of claim 5 , comprising a mechanical input device coupled to the actuator.7. The injector ...

METHOD OF ASSEMBLING AND FILLING A DRUG DELIVERY DEVICE

An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state. 1. A method of assembling an injector , the method comprising:providing a container having a wall defining an interior surface and a seal assembly having an interior surface, the wall and seal assembly defining a reservoir;providing a fluid delivery system physically separate from the container, the fluid delivery system comprising a container needle having a point;providing an injection member physically separate from the container needle and configured to be connected in fluid communication with the container needle during use of the injector;sterilizing the container including the reservoir and fluid delivery system while the container and the fluid delivery system are separate from each other;filling the sterile reservoir of the container with a volume of a drug product under sterile conditions in a first assembly space, the drug product comprising a granulocyte colony-stimulating factor (G-CSF);after sterilizing the container and filling the sterile reservoir, attaching the fluid delivery system to the container in a second assembly space such that the point of the container needle is disposed adjacent to or within the seal assembly to define a storage state, wherein the first assembly space has a higher level of freedom from contamination than the second assembly space;arranging the ...

INJECTOR AND METHOD OF ASSEMBLY

An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state. 1. An injector comprising:a container including a wall having an interior surface and defining a bore;a seal assembly comprising a first stopper moveable along the bore, the interior surface of the container and an interior surface of the seal assembly defining a closed sterile reservoir filled with a drug product;a fluid delivery system comprising a container needle having a point disposed at least partially through the first stopper in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state; andan actuator that is adapted to move the container needle from the storage state to the delivery state.2. The injector of claim 1 , wherein the wall of the container comprises a rigid wall.3. The injector of claim 1 , wherein the wall of the container comprises a flexible wall.4. The injector of claim 1 , wherein the wall of the container includes a closed end opposite the first stopper and an open end in which the first stopper is disposed.5. The injector of claim 1 , wherein the first stopper includes an interior surface that defines the interior surface of the seal assembly.6. The injector of claim 1 , wherein the seal assembly comprises a flexible wall having an interior surface that defines the interior surface of the seal ...

Method for processing feed grain for dairy animals

Method of producing a feedstuff for a dairy animal that potentiates milk production. The method includes a multi-stage process having one stage in which a feed grain for dairy animals is heat-treated for a period of time at a temperature above 90 degrees Celsius. The grain is processed for another period of time that includes disrupting the prolamin/protein bonds which produces a hydrophilic, vitreous feedstuff having a starch and protein matrix composed at least partially by prolamin. The feed grain is heat-treated for a first period of time, of which at least 200 seconds is maintained above 90 degrees Celsius, and thereafter the feed grain is processed in a second stage by applying sufficient processing to disrupt the prolamin/protein bonds and thereby producing a hydrophilic, vitreous, feedstuff comprising a starch and protein matrix composed of at least three percent prolamin.

METHOD OF ASSEMBLING AND FILLING A DRUG DELIVERY DEVICE

An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state. 1. A method of assembling an injector , the method comprising:providing a container having a wall defining an interior surface and a seal assembly, the wall and seal assembly defining a reservoir;providing a fluid delivery system physically separate from the container, the fluid delivery system comprising a container needle having a point;sterilizing the container including the reservoir and fluid delivery system while the container and the fluid delivery system are separate from each other;filling the reservoir of the container with a volume of a drug product under sterile conditions;after filling the reservoir of the container, attaching the fluid delivery system to the filled container under clean room conditions such that the point of the container needle is disposed adjacent to the seal assembly to define a storage state; andattaching the container needle to an actuator, the actuator adapted to move the container needle from the storage state to a delivery state wherein the container needle is disposed through the seal assembly, into the reservoir, and in fluid communication with the drug product for delivery to a patient.2. The method of claim 1 , wherein filling the reservoir with a volume of a drug product comprises filling the reservoir with a volume of a PCSK9 (Proprotein Convertase ...

Injector and method of assembly

An injector (100) may include a container (102) having a wall (110) with an interior surface (112) and a seal assembly (140) with an in¬ terior surface (142), the interior surfaces (110) of the wall (110) and the seal assembly (140) defining a closed sterile reservoir (150) filled with a drug product. The injector (100) may also include a fluid de¬ livery system comprising a clean, unsheathed, rigid container needle (180) having a point (182) disposed only partially through the seal as¬ sembly (140) in a storage state, and disposed through the interior sur¬ face (142) of the seal assembly (140) into the sterile reservoir (150) in a delivery state. Further, the injection may include an actuator (106) that is adapted to move the container needle from the storage state to the delivery state.

Injector and method of assembly

An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

Injector and method of assembly

An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

Injector and method of assembly

An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

Injector and method of assembly

An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

Injector and method of assembly

An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

Injector and method of assembly

An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

Injector and method of assembly

An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

Injector and mounting method

An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

Formed resilient orthopaedic device

An orthopaedic support includes a sheet of foam material that has been compression molded in specific areas. These areas have a thickness and density that is different from other areas of the support and serve to better fit the support to the body. The support may include compression molded grooves or cavities to accommodate straps, struts, gel-filled pads, inflatable bladders, pumps, and other accessories. The support may also include compression molded grooves that reduce bunching when the support is bent, and may include molded edges to minimize skin irritation during activity. The brace may also be a back brace or an ankle brace having compression molded components. A method of compression molding an orthopaedic support includes compression molding at least one sheet of resilient foam material in selected areas to reduce the thickness and increase the density of the material in those areas. Various embodiments of the present invention may include compression-molded bladders having walls which are compression-molded about the bladder perimeter.

Injector and method of assembly

An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

Infusion medium delivery device and method with drive device for driving plunger in reservoir

A delivery device includes first and second housing portions that selectively engage and disengage. A reservoir on one housing portion operatively engages a drive device and/or a needle inserting device on the other housing portion. Upon proper engagement of the housing portions, the reservoir operatively couples to the drive device and/or the needle inserting device. A first magnet on the first housing portion and a second magnet (or a magnetically-attractive material) on the second housing portion are positioned to magnetically interact with each other, upon operative engagement of the housing portions. A third magnet on the second housing portion may be opposed to the first magnet to help align the housing portions for connection. A magnet-responsive device may be on one or both housing portions to detect alignment and/or connection of the housing portions.

Insertion device

Injector and method of assembly

Injector and method of assembly

An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

Infusion medium delivery device with drive device for driving plunger in reservoir

Infusion medium delivery device for delivering an infusion medium to a user, with first and second housing portions, the device having a specific drive structure including a nut member and a rotatable lead shaft supported by the second housing portion.

Multi-position infusion set device and process

An infusion set (10) for subcutaneous delivery of an infusant. The infusion set (10) may include a base (14) removably attachable to an infusion site and a connector (12) temporarily lockable to the base (14). The connector (12) can engage the base (14) in a plurality of orientations. The connector (12) locks into the base (14) after at least partial rotation of the connector (12) about the base (14). The connector (12) may include flexible arms (16) which unlock the connector (12) from the base (14). The base (14) includes a cannula for insertion through the infusion site. The connector (12) includes a tubing for passing the infusant. The infusant is subcutaneously passable from the tubing through the cannula when the connector (12) is attached to the base (14).

Infusion medium delivery device and method with drive device for driving plunger in reservoir

A delivery device includes a durable housing portion and a separable disposable portion that selectively engage and disengage from each other. The disposable housing portion secures to the patient-user and may be disposed of after it has been in use for a prescribed period. Components that normally come into contact with a patient-user or with infusion medium are supported by the disposable housing portion, while the durable housing portion supports other components such as electronics and a drive device. A reservoir is supported by the disposable housing portion and has a moveable plunger that operatively couples to the drive device, when the disposable and durable housing portions are engaged.

Injector and method of assembly

86340813 Abstract An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state. Date Recue/Date Received 2020-05-01

Infusion medium delivery device and method with drive device for driving plunger in reservoir

A delivery device includes first and second housing portions that selectively engage and disengage. A reservoir on one housing portion operatively engages a drive device and/or a needle inserting device on the other housing portion. Upon proper engagement of the housing portions, the reservoir operatively couples to the drive device and/or the needle inserting device. A first magnet on the first housing portion and a second magnet (or a magnetically-attractive material) on the second housing portion are positioned to magnetically interact with each other, upon operative engagement of the housing portions. A third magnet on the second housing portion may be opposed to the first magnet to help align the housing portions for connection. A magnet-responsive device may be on one or both housing portions to detect alignment and/or connection of the housing portions.

Needle guard

A needle guard (17) for an insertion device (18) generally used with an infusion set. The needle of the insertion device is commonly adapted for puncturing at one end and including at the opposite end a hub. The needle guard includes an opening (7) adapted to receive the insertion device and a locking mechanism adapted to secure the insertion device in the needle guard. By pushing the needle hub into the needle guard for disposal, barbs on the needle hub will mate with undercuts (10,11) on the inside of the needle guard and secure the needle hub in a position where the needle is covered, preventing unintended contact with the needle.

Injector and method of assembly

Method for processing feed grain for dairy animals

Method of producing a feedstuff for a dairy animal that potentiates milk production. The method includes a multi-stage process having one stage in which a feed grain for dairy animals is heat-treated for a period of time at a temperature above 90 degrees Celsius. The grain is processed for another period of time that includes disrupting the prolamin/protein bonds which produces a hydrophilic, vitreous feedstuff having a starch and protein matrix composed at least partially by prolamin. The feed grain is heat-treated for a first period of time, of which at least 200 seconds is maintained above 90 degrees Celsius, and thereafter the feed grain is processed in a second stage by applying sufficient processing to disrupt the prolamin/protein bonds and thereby producing a hydrophilic, vitreous, feedstuff comprising a starch and protein matrix composed of at least three percent prolamin.

Injector and method of assembly

Multi-position infusion set device and process

An infusion set (10) for subcutaneous delivery of an infusant. The infusion set (10) may include a base (14) removably attachable to an infusion site and a connector (12) temporarily lockable to the base (14). The connector (12) can engage the base (14) in a plurality of orientations. The connector (12) locks into the base (14) after at least partial rotation of the connector (12) about the base (14). The connector (12) may include flexible arms (16) which unlock the connector (12) from the base (14). The base (14) includes a cannula for insertion through the infusion site. The connector (12) includes a tubing for passing the infusant. The infusant is subcutaneously passable from the tubing through the cannula when the connector (12) is attached to the base (14).

Injector and method of assembly

Inyector y metodo de ensamble.

La presente invención se refiere a un inyector que puede incluir un contenedor que tiene una pared con una superficie interior y un ensamble de sello con una superficie interior, las superficies interiores de la pared y el ensamble de sello definen un reservorio estéril cerrado lleno con un producto de fármaco. El inyector también puede incluir un sistema de suministro de fluido que comprende una aguja de contenedor rígido, sin protector, limpio que tiene un punto dispuesto solamente parcialmente a través del ensamble de sello en un estado de almacenamiento, y dispuesta a través de la superficie interior del ensamble de sello en el reservorio estéril en un estado de suministro. Además, la inyección puede incluir un accionador que está adaptado para mover la aguja del contenedor a partir del estado de almacenamiento al estado de suministro.

Injector and method of assembly

An injector (100) may include a container (102) having a wall (110) with an interior surface (112) and a seal assembly (140) with an interior surface (142), the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir (150) filled with a drug product. The injector (100) may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle (180) having a point (182) disposed only partially through the seal assembly (140) in a storage state, and disposed through the interior surface (142) of the seal assembly (140) into the sterile reservoir (150) in a delivery state. Further, the injector may include an actuator (106) that is adapted to move the container needle from the storage state to the delivery state. Figure 1 100 130 74 *-128 170 160 172 -- 112 102 150, 11 110 124 142 18 120 182 122- 126 144 144180 106 104 i'- 200 FIG. 2 192 19419 FIG. 1 100 a 174 128 170 - '-160 172 102 15011 110 124,- 142 12114 1 -Il82 120 122 40 IT-126 144 180 106 104 200 190:: -9 192 194 FIG. 3

Injector and method of assembly

An injector ( 100 ) may include a container ( 102 ) having a wall ( 110 ) with an interior surface ( 112 ) and a seal assembly ( 140 ) with an interior surface ( 142 ), the interior surfaces ( 110 ) of the wall ( 110 ) and the seal assembly ( 140 ) defining a closed sterile reservoir ( 150 ) filled with a drug product. The injector ( 100 ) may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle ( 180 ) having a point ( 182 ) disposed only partially through the seal assembly ( 140 ) in a storage state, and disposed through the interior surface ( 142 ) of the seal assembly ( 140 ) into the sterile reservoir ( 150 ) in a delivery state. Further, the injection may include an actuator ( 106 ) that is adapted to move the container needle from the storage state to the delivery state.

Method for processing prolamin-containing feed for a ruminant animal to potentiate milk production or conception

Composition and method for processing prolamin-containing feed source into a low-vitreous gelatinous feedstuff. The feedstuff is fed to ruminant animals for the purpose of potentiating either milk production and/or conception. The feed source can be corn and the ruminant animal can be a bovine, and might be a cow. The method includes processing, by extrusion, a prolamin-containing feed source having a starch-protein matrix within which the included protein is composed of at least 3% percent prolamin. This processing produces a hydrophilic gelatinous feedstuff that has starch and protein content. The hydrophilic low-vitreous gelatinous feedstuff is fed to a ruminant animal. A rumen-retained portion of the fed feedstuff is retained within the rumen of the animal for at least a twenty-four hour period, and during the first twenty-four hours of that period, at least seventy-five percent of the starch content of the rumen-retained portion of the fed feedstuff is digested.