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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Применить Всего найдено 4. Отображено 4.
06-06-2023 дата публикации

Refining method of bisoprolol

Номер: CN116217417A
Автор: ZHU HUA, LU TIEGANG, ZHANG QINFEN, LIU GUO, LI XIAOXUN, HU TONGJUN, DU YAXIN, SHE HONGQIANG, WANG YING
Принадлежит:

The invention relates to a bisoprolol free alkali refining method which comprises the following steps: dissolving bisoprolol free alkali in an organic solvent, firstly adding a certain amount of acid to completely salify an impurity A, then adding alkali to selectively dissociate bisoprolol, then extracting and separating by using the organic solvent to obtain an organic phase, drying the organic phase, and concentrating under reduced pressure to obtain a bisoprolol free alkali refined product. According to the technical scheme provided by the invention, the operation process is simple, the cost is low, the amount of the impurity A can be controlled to be lower than 0.06%, the refining yield is also high, and the method can be used for industrial production.

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Номер записи: 1
04-04-2023 дата публикации

Preparation method of ticagrelor key intermediate

Номер: CN115894430A
Автор: LIU LINWEI, ZHU HUA, CHEN FENG, LI XIAOXUN, HU TONGJUN, WANG YING
Принадлежит:

The invention discloses a preparation method of a ticagrelor key intermediate I. The preparation method comprises the following steps: reacting a compound II with ethylene carbonate in an organic solvent under an alkaline condition to obtain a compound IV, and hydrolyzing in the organic solvent under the alkaline condition to obtain a compound I. The synthesis route has the advantages of cheap and easily available synthesis raw materials, mild reaction conditions, high yield, low cost, safety, environmental protection, and suitableness for industrial large-scale production.

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Номер записи: 2
22-08-2023 дата публикации

Preparation method of high-purity aminohexenoic acid

Номер: CN116621720A
Автор: LU TIEGANG, ZHANG YONG, ZHU HUA, XIONG FEI, WANG ZUOLIANG, HU TONGJUN, SHE HONGQIANG, ZOU JIE, ZHOU YAJIE, XU JIAYU, WU XUEYIN, WANG YING
Принадлежит:

The invention belongs to the field of pharmaceutical chemistry preparation, and particularly relates to a preparation method of high-purity vigabenic acid, which comprises the following steps: hydrolyzing a compound I under an alkaline condition, and further performing Boc protection, hydrochloric acid neutralization, dissociation, Boc protection removal, alkali addition and seed crystal preparation to obtain the high-purity vigabenic acid. And the method can be used for industrial production.

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Номер записи: 3
30-06-2023 дата публикации

Separation method, detection method, composition of rotigotine or pharmaceutical salt thereof, pharmaceutical preparation and application

Номер: CN116359381A
Автор: ZHOU MEIGUI, XU JIAYU, XIONG SHU, HU TONGJUN, XIE YA, WANG YING
Принадлежит:

The invention discloses a separation method and a detection method of a substance A in rotigotine or a composition thereof, a pharmaceutical salt of rotigotine or the composition thereof, a composition containing the rotigotine or the pharmaceutical salt thereof, a pharmaceutical preparation and application. The separation and detection method comprises the following steps: the rotigotine or the composition thereof and the rotigotine pharmaceutical salt or the composition thereof are taken and separated by adopting a high performance liquid chromatography, a mobile phase in the high performance liquid chromatography comprises a water phase and an organic phase, and the pH value of the water phase is 6.0-8.0; the separation and detection method has the advantages of being good in separation degree, symmetrical in peak shape, high in sensitivity and accurate in quantification of the substance A, overcomes the defect of quality control of the rotigotine, and can be used for quality inspection ...

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Номер записи: 4