COMPOSITIONS AND METHODS FOR NON-INVASIVE IMAGING

The present invention relates to a novel composition useful in targeted diagnostic and/or therapy of a target site, such as cancerous tissue. The composition and methods disclosed herein find particular use in diagnosing and imaging cancerous tissue. The present invention provides a new diagnostic tool for the utilization of positron emission tomography (PET) imaging technique. 146-. (canceled)49. A composition comprising:(a) liposomes in a pharmaceutically acceptable medium, said liposomes each having an interior space and a membrane separating said interior space from said medium, said membrane comprising one or more lipids; and{'claim-ref': {'@idref': 'CLM-00047', 'claim 47'}, '(b) a compound of entrapped in at least one liposome of the liposomes of (a).'}50. A composition comprising:(a) liposomes in a pharmaceutically acceptable medium, said liposomes each having an interior space and a membrane separating said interior space from said medium, said membrane comprising one or more lipids; and{'claim-ref': {'@idref': 'CLM-00048', 'claim 48'}, '(b) a compound of entrapped in at least one liposome of the liposomes of (a).'}52. The composition claim 48 , wherein M is d) and the composition comprises at least 0.1 μCi of a radioisotope of copper.53. The composition claim 49 , wherein claim 49 , following storage at a temperature of from 4° C. to 40° C. or a room temperature of about 25° C. or is 37° C. for 90 days claim 49 , or 4 months claim 49 , or 5 months claim 49 , or 6 months claim 49 , less than 15% of the compound has degraded.55. The method of claim 54 , wherein prior to becoming encapsulated by the at least one liposome claim 54 , the compound of Formula III is uncharged claim 54 , and subsequent to becoming encapsulated by at least one liposome claim 54 , the compound of Formula III is charged.56. A method of imaging a tissue in a patient claim 54 , the method comprising:{'claim-ref': {'@idref': 'CLM-00048', 'claim 48'}, '(a) injecting the patient with a ...