17-01-2019 дата публикации
Номер: US20190016701A1
This disclosure relates to polycyclic heteroaromatic compounds useful as TRPA1 modulators, as well as compositions and methods of treating pain that include the compounds. 186.-. (canceled)88. The compound of claim 87 , or a pharmaceutically acceptable salt thereof claim 87 , or an isotopic variant thereof claim 87 , wherein:{'sup': 'f', 'sub': 1', '3', '1', '3, 'each Ris independently selected from the group consisting of hydrogen, C-Calkyl, C-Cfluoroalkyl, and halo.'}89. The compound of claim 88 , or a pharmaceutically acceptable salt thereof claim 88 , or an isotopic variant thereof claim 88 , wherein:{'sup': 'f', 'sub': 1', '3, 'each Ris independently selected from the group consisting of hydrogen and C-Calkyl.'}90. The compound of claim 87 , or a pharmaceutically acceptable salt thereof claim 87 , or an isotopic variant thereof claim 87 , wherein:{'sup': 'd', 'X is CR; and'}{'sup': 'd', 'sub': 1', '4, 'Ris selected from the group consisting of hydrogen, halo, and C-Calkyl.'}92. The compound of claim 91 , or a pharmaceutically acceptable salt thereof claim 91 , or an isotopic variant thereof claim 91 , wherein:{'sup': 'a', 'sub': 1', '4', '1', '4', '1', '4', '1', '4', '1', '6, 'each Ris independently selected from the group consisting of cyano, C-Calkyl, C-Calkoxy, C-Chaloalkyl, C-Chaloalkoxy, halo, C-Camido, and hydroxyl.'}95. The compound of claim 94 , or a pharmaceutically acceptable salt thereof claim 94 , or an isotopic variant thereof claim 94 , wherein:{'sup': 'b', 'sub': 1', '4', '1', '4', '1', '4', '1', '4', '1', '6', '1', '6, 'each Ris independently selected from the group consisting of cyano, C-Calkyl, C-Calkoxy, C-Chaloalkyl, C-Chaloalkoxy, halo, C-Calkylamino, amino, C-Camido, and hydroxyl.'}104. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 87 , or a pharmaceutically acceptable salt thereof claim 87 , and at least one pharmaceutically acceptable carrier claim 87 , excipient claim 87 , or diluent. ...
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