18-09-2014 дата публикации
Номер: US20140275133A1
Принадлежит:
The present invention is directed to compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof that are possible useful for treating aldosterone-mediated diseases. The invention furthermore relates to processes for preparing compounds of the Formula (I), to their possible use for the treatment of the above mentioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical compositions which comprise compounds of the Formula (I). 2. The compound of Formula I claim 1 , according to claim 1 , wherein{'sup': 'a', 'sub': 1', '6', '3, 'Each Ris independently H or C-Calkyl wherein said alkyl is optionally substituted with one to three groups selected from halo, OR, CF, or CN;'}{'sup': 2', '5, 'Ris triazolyl, oxadiazolyl, imidazolyl or oxazolyl, where triazolyl, oxadiazolyl, imidazolyl or oxazolyl is optionally substituted with one to two groups from R;'}{'sup': '4', 'sub': 3', '10, 'Ris aryl or C-Ccycloalkyl, where said aryl or cycloalkyl is optionally substituted with one to four groups selected from halo or OR;'}{'sup': '5', 'sub': 1', '6', '2', '03', '3', '10', '2', '0-3', '2', '0-3', '2', '0-3, 'Each Ris independently OR, C-Calkyl, (CR)—C-Ccycloalkyl, (CR)-aryl, (CR)-heteroaryl, or (CR)-halo, where said alkyl, cycloalkyl, aryl or heteroaryl is optionally substituted with one to three groups selected from aryl, heteroaryl, or heterocyclyl;'}m is 0 or 1; andp is 0, 1 or 2;or a pharmaceutically acceptable salt thereof.4. The compound of claim 3 , having the structural Formula II claim 3 , wherein{'sup': 'b', 'sub': 1', '6, 'Each Ris independently H or C-Calkyl;'}{'sup': '4', 'sub': 3', '10, 'Ris aryl, or C-Ccycloalkyl, where said aryl, or cycloalkyl is optionally substituted with one to four groups selected from halo or OR;'}{'sup': 5', 'c', 'c', 'c, 'sub': 2', '0-3', '3', '10', '2', '0-3', '2', '0-3', '3', '2, 'Each Ris independently (CR)—C-Ccycloalkyl, (CR)-aryl, or (CR)-heteroaryl, where said alkyl, cycloalkyl, aryl or ...
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