Antimicrobial compositions

Compositions for generating antimicrobial activity comprising a purified enzyme that is able to convert a substrate to release hydrogen peroxide, and a sugar substance that includes a substrate for the enzyme. The compositions do not include sufficient free water to allow the enzyme to convert the substrate. The sugar substance is an unrefined natural sugar substance and the enzyme is an oxidoreductase enzyme. The exemplified sugar substance is pasteurized honey and the exemplified enzyme is glucose oxidase. Use of the compositions to treat microbial infections and wounds is described, as well as methods for their production. The treatment of acne, chaffed lips, infected eczema, fungal nail infections, pressure sores, infected ulcers, Caesarian wounds, infections at line entry points, such as catheters, as well as general wound treatment.

Antimicrobial compositions

Compositions for generating antimicrobial activity comprising a purified enzyme that is able to convert a substrate to release hydrogen peroxide, and a sugar substance that includes a substrate for the enzyme. The compositions do not include sufficient free water to allow the enzyme to convert the substrate. The sugar substance is an unrefined natural sugar substance and the enzyme is an oxidoreductase enzyme. The exemplified sugar substance is pasteurized honey and the exemplified enzyme is glucose oxidase. Use of the compositions to treat microbial infections and wounds is described, as well as methods for their production. The treatment of acne, chaffed lips, infected eczema, fungal nail infections, pressure sores, infected ulcers, Caesarian wounds, infections at line entry points, such as catheters, as well as general wound treatment.

Antimicrobial compositions

Prevention and treatment of microbial infections

Antimicrobial fibers and compositions

A liquid composition for generating antimicrobial activity comprising an enzyme that is able to convert a substrate to release hydrogen peroxide, and a substance that includes a substrate for the enzyme. The substrate is a purified substrate or the substance does not comprise honey. The composition further comprises at least one of non-aqueous solvent, polymer, and antioxidant. The composition has a water activity (aw) of 0.47-0.70 or the composition does not comprise sufficient free water to allow the enzyme to convert the substrate. Also claimed is a method of forming the composition by contacting the enzyme with a substrate in the absence of sufficient free water. The composition may be subject to electrospinning to form a fibre. The composition or fibre may be used as a medicament, preferably in the treatment of a wound, a microbial infection, inflammation, stimulating tissue growth, debriding a wound or deodorising a wound.

Antimicrobial compositions

Antimicrobial compositions

Storage-stable compositions for generating antimicrobial activity are described. The compositions comprise an enzyme that is able to convert a substrate to release hydrogen peroxide, and an unrefined natural substance, such as a honey, that includes a substrate for the enzyme. In certain embodiments, the enzyme is a purified enzyme. In other embodiments, the substrate lacks catalase activity, and the enzyme is additional to any enzyme activity able to convert the substrate to release hydrogen peroxide that may be present in the unrefined natural substance. The storage-stable compositions do not include sufficient free water to allow the enzyme to convert the substrate. Use of the compositions to treat microbial infections and wounds is described, as well as methods for their production.

Antimicrobial compositions and formulations releasing hydrogen peroxide

Compositions for generating antimicrobial activity are described. The compositions comprise: a first phase; a second phase; an enzyme that is able to convert a substrate to release hydrogen peroxide; and a substance that includes a substrate for the enzyme, wherein the first phase and the second phase are immiscible. The compositions may be formulated as colloids, suspensions or emulsions, especially as creams or sprays. Methods of making the compositions are described, as well as their use for the treatment of antimicrobial infections.

Antimicrobial Compositions

Prevention and treatment of microbial infections

Prevention and treatment of microbial infections

Compositions for prevention and treatment of microbial infections, such as microbial infections that comprise a biofilm, or a microbe that is capable of forming a biofilm are described. The compositions comprise an enzyme that is able to convert a substrate to release hydrogen peroxide and a substance that includes a substrate for the enzyme. The enzyme is additional to any enzyme activity able to convert the substrate to release hydrogen peroxide that may be present in the substance. The substance may be an unrefined natural substance or a substance that includes a purified substrate for the enzyme.

Prevention and treatment of microbial infections

Prevention and treatment of microbial infections

Compositions are disclosed for the prevention or treatment of MRSA infection in an individual, preferably a planktonic MRSA infection. The compositions comprise an enzyme that is able to convert a substrate to release hydrogen peroxide and a substance that includes a substrate for the said enzyme. The enzyme is additional to any enzyme activity able to convert the substrate to release hydrogen peroxide that may be present in the substance. The substance may be an unrefined natural substance, preferably honey or a substance that includes a purified substrate for the enzyme. The enzyme is preferably an oxidoreductase, more preferably a glucose oxidase.

Antimicrobial fibers and compositions

Antimicrobial compositions

Antimicrobial fibers and compositions

Fibers for generating antimicrobial activity are described. The fibers comprise an enzyme that is able to convert a substrate to release hydrogen peroxide, and an unrefined natural substance that includes a substrate for the enzyme, wherein the enzyme is additional to any enzyme activity able to convert the substrate to release hydrogen peroxide that may be present in the unrefined natural substance. In the presence of sufficient free water, the enzyme converts the substrate to release hydrogen peroxide, which is effective against a wide range of microbes. Wound dressings and compositions comprising the fibers are also described, as is use of the fibers, wound dressings and compositions, particularly for wound healing.

ANTIMICROBIAL FIBERS AND COMPOSITIONS

ANTIMICROBIAL COMPOSITIONS AND FORMULATIONS RELEASING HYDROGEN PEROXIDE

são descritas composições para gerar atividade antimicrobiana. as composições compreendem: uma primeira fase; uma segunda fase; uma enzima que é capaz de converter um substrato para liberar peróxido de hidrogênio; e uma substância que inclui um substrato para a enzima, em que a primeira fase e a segunda fase são imiscíveis. as composições podem ser formuladas como colóides, suspensões ou emulsões, especialmente como cremes ou pulverizações. são descritos métodos de preparação das composições, bem como o seu uso para o tratamento de infecções antimicrobianas.

prevention and treatment of microbial infections

composições antimicrobianas

ANTIMICROBIAL COMPOSITIONS

ANTIMICROBIAL FIBERS AND COMPOSITIONS

Fibers for generating antimicrobial activity are described. The fibers comprise an enzyme that is able to convert a substrate to release hydrogen peroxide, and an unrefined natural substance that includes a substrate for the enzyme, wherein the enzyme is additional to any enzyme activity able to convert the substrate to release hydrogen peroxide that may be present in the unrefined natural substance. In the presence of sufficient free water, the enzyme converts the substrate to release hydrogen peroxide, which is effective against a wide range of microbes. Wound dressings and compositions comprising the fibers are also described, as is use of the fibers, wound dressings and compositions, particularly for wound healing. 1. A fiber comprising an enzyme that is able to convert a substrate to release hydrogen peroxide , and an unrefined natural substance that includes a substrate for the enzyme , wherein the enzyme is additional to any enzyme activity able to convert the substrate to release hydrogen peroxide that may be present in the unrefined natural substance.2. A fiber according to claim 1 , which is an electrospun fiber.3. A fiber according to or claim 1 , which is a nanofiber.4. A fiber according to any preceding claim claim 1 , which comprises sufficient enzyme and substrate to provide for sustained release of hydrogen peroxide for a period of at least twenty four hours.5. A fiber according to any preceding claim claim 1 , which comprises sufficient enzyme and substrate to provide for sustained release of hydrogen peroxide at a level of less than 2 mmol/litre for a period of at least 24 hours.6. A fiber according to any preceding claim which does not include sufficient free water to allow the enzyme to convert the substrate.7. A fiber according to claim 6 , which comprises sufficient enzyme and substrate to provide for sustained release of hydrogen peroxide for a period of at least twenty four hours following contact with sufficient water to allow the enzyme to ...

ANTIMICROBIAL COMPOSITIONS

Compositions for generating antimicrobial activity are described. The compositions comprise an enzyme that is able to convert a substrate to release hydrogen peroxide, a substrate for the enzyme, and a solute in the form of a sugar or sugar derivative having a solubility of at least 100 g/100 g water at 20° C. and 1 atm. The compositions may not comprise sufficient free water to allow the enzyme to convert the substrate. 1. A composition for generating antimicrobial activity , which comprises:a purified enzyme that is able to convert a substrate to release hydrogen peroxide;a purified substrate for the enzyme; anda solute in the form of a sugar or sugar derivative having a solubility of at least 100 g/100 g water at 20° C. and 1 atm,wherein the composition does not comprise sufficient free water to allow the enzyme to convert the substrate.2. A composition according to claim 1 , wherein the solute has a solubility of at least 300 g/100 g water.3. A composition according to any preceding claim claim 1 , wherein the solute is a monosaccharide.4. A composition according to claim 4 , wherein the monosaccharide is fructose.5. A composition according to any preceding claim claim 4 , wherein the solute is at least 60% by dry weight of the composition.6. A composition according to any preceding claim claim 4 , wherein the substrate is at least 30% by dry weight of the composition.7. A composition according to any preceding claim claim 4 , wherein the combined dry weight of the substrate and the solute is at least 90% claim 4 , preferably at least 95% of the composition claim 4 , or wherein the total amount of sugar or sugar derivative in the composition is at least 90% claim 4 , by dry weight claim 4 , preferably at least 95% claim 4 , by dry weight.8. A composition according to any preceding claim claim 4 , comprising a buffer.9. A composition according to any preceding claim which has a pH of 6 to 8.10. A composition according to any preceding claim claim 4 , which ...

ANTIMICROBIAL COMPOSITIONS

Storage-stable compositions for generating antimicrobial activity are described. The compositions comprise an enzyme that is able to convert a substrate to release hydrogen peroxide, and an unrefined natural substance, such as a honey, that includes a substrate for the enzyme. In certain embodiments, the enzyme is a purified enzyme. In other embodiments, the substrate lacks catalase activity, and the enzyme is additional to any enzyme activity able to convert the substrate to release hydrogen peroxide that may be present in the unrefined natural substance. The storage-stable compositions do not include sufficient free water to allow the enzyme to convert the substrate. Use of the compositions to treat microbial infections and wounds is described, as well as methods for their production. 191-. (canceled)92. A storage-stable composition for generating antimicrobial activity , which comprises:an enzyme that is able to convert a substrate to release hydrogen peroxide; anda substance that lacks catalase activity and that includes a substrate for the enzyme;wherein the enzyme is additional to any enzyme activity able to convert the substrate to release hydrogen peroxide that may be present in the substance, wherein the composition does not include sufficient free water to allow the enzyme to convert the substrate, and wherein the composition does not comprise ozonized honey or ozonated oil.93. A composition according to claim 92 , wherein the substance lacks enzyme activity that is able to convert the substrate to release hydrogen peroxide.94. A composition according to claim 92 , wherein the substance is a sugar substance.95. A composition according to claim 92 , wherein the enzyme is glucose oxidase and the substrate for the enzyme is D-glucose.96. A composition according to claim 92 , which provides for sustained release of hydrogen peroxide at a level of less than 2 mmol/litre for a period of at least twenty four hours claim 92 , following dilution of the composition. ...

ANTIMICROBIAL COMPOSITIONS

Storage-stable compositions for generating antimicrobial activity are described. The compositions comprise an enzyme that is able to convert a substrate to release hydrogen peroxide, and an unrefined natural substance, such as a honey, that includes a substrate for the enzyme. In certain embodiments, the enzyme is a purified enzyme. In other embodiments, the substrate lacks catalase activity, and the enzyme is additional to any enzyme activity able to convert the substrate to release hydrogen peroxide that may be present in the unrefined natural substance. The storage-stable compositions do not include sufficient free water to allow the enzyme to convert the substrate. Use of the compositions to treat microbial infections and wounds is described, as well as methods for their production. 3. A composition according to claim 1 , wherein the unrefined natural substance lacks catalase activity.4. A composition according to or claim 1 , wherein the substance has been treated to remove or inactivate catalase activity.5. A composition according to any preceding claim claim 1 , wherein the substance is an unrefined natural sugar substance.6. A composition according to claim 5 , wherein the sugar substance is a honey.7. A composition according to claim 5 , wherein the sugar substance is a honey that has been treated to remove or inactivate catalase activity.8. A composition according to claim 5 , wherein the sugar substance is a syrup claim 5 , or an inverted syrup.9. A composition according to any preceding claim claim 5 , wherein the substance lacks enzyme activity that is able to convert the substrate to release hydrogen peroxide.10. A composition according to any preceding claim claim 5 , wherein the substance is a pasteurised substance.11. A composition according to claim 6 , wherein the honey is an unpasteurised honery claim 6 , preferably a creamed unpasteurised honey.12. A composition according to any preceding claim claim 6 , wherein the enzyme is an oxidoreductase ...

ANTIMICROBIAL COMPOSITIONS AND FORMULATIONS

Compositions for generating antimicrobial activity are described. The compositions comprise: a first phase; a second phase; an enzyme that is able to convert a substrate to release hydrogen peroxide; and a substance that includes a substrate for the enzyme, wherein the first phase and the second phase are immiscible. The compositions may be formulated as emulsions or creams. Methods of making the compositions are described, as well as their use for the treatment of antimicrobial infections. 1. A composition for generating antimicrobial activity , comprising: a first phase; a second phase; an enzyme that is able to convert a substrate to release hydrogen peroxide; and a substance that includes a substrate for the enzyme , wherein the first phase and the second phase are immiscible , and wherein the composition does not comprise sufficient free water to allow the enzyme to convert the substrate ,wherein the composition comprises i) an inorganic salt and a viscosity-increasing agent and/or wherein ii) the composition comprises water that is additional to any water that may be present in the substance.2. A composition according to wherein the inorganic salt is magnesium sulfate heptahydrate.3. A composition according to claim 1 , wherein the first phase is less polar than the second phase claim 1 , optionally wherein the first phase is a non-polar phase claim 1 , and the second phase is a polar phase.4. A composition according to any preceding claim claim 1 , wherein the first phase is a lipophilic phase and the second phase is an aqueous phase.5. A composition according to any preceding claim claim 1 , wherein the second phase comprises a non-aqueous solvent claim 1 , wherein the non-aqueous solvent is optionally glycerol claim 1 , dimethylsulphoxide claim 1 , propylene glycol or polyethylene glycol.6. A composition according to claim 5 , wherein the second phase comprises glycerol.7. A composition according to any preceding claim claim 5 , wherein the first phase ...

Prevention and treatment of microbial infections

Compositions for prevention and treatment of microbial infectious, such as microbial infections that comprise a biofilm, or a microbe that is capable of forming a biofilm are described. The compositions comprise an enzyme that is able to convert a substrate to release hydrogen peroxide and a substance that includes a substrate for the enzyme. The enzyme is additional to any enzyme activity able to convert the substrate to release hydrogen peroxide that may be present in the substance. The substance may be an unrefined natural substance or a substance that includes a purified substrate for the enzyme.

ANTIMICROBIAL COMPOSITIONS AND FORMULATIONS RELEASING HYDROGEN PEROXIDE

Compositions for generating antimicrobial activity are described. The compositions comprise: a first phase; a second phase; an enzyme that is able to convert a substrate to release hydrogen peroxide; and a substance that includes a substrate for the enzyme, wherein the first phase and the second phase are immiscible. The compositions may be formulated as colloids, suspensions or emulsions, especially as creams or sprays. Methods of making the compositions are described, as well as their use for the treatment of antimicrobial infections. 1. A composition for generating antimicrobial activity , which comprises: a lipophilic phase; an aqueous phase; an enzyme that is able to convert a substrate to release hydrogen peroxide; and a substance that includes a substrate for the enzyme.2. A composition according to claim 1 , which is in the form of colloid or a suspension.3. A composition according to or claim 1 , which is in the form of an emulsion.4. A composition according to any preceding claim claim 1 , wherein the lipophilic phase comprises an oil or a wax.5. A composition according to claim 4 , wherein the oil or wax is selected from:{'i': Vitis Vinifera', 'Carthamus Tinctorius', 'Persea Gratissima', 'Buxus Chinensis', 'Ternifolia', 'Borago Officinalis', 'Mangifera Indica', 'Cannabis Sativa', 'Olea Europaea', 'Oryza Sativa', 'Daucus Carota Sativa', 'Ricinus Communis', 'Carthamus Tinctorius', 'Sesamum Indicum', 'Butyrospermum Parkii', 'Glycine Soja', 'Helianthus Annus', 'Prunus Amygdalus Dulcis', 'Rosa Canina', 'Theobroma Cacao, 'Aleurites Moluccana Seed Oil; Grape () Seed Oil; Almond Oil NF; Hybrid Safflower () Oil; Anhydrous Lanolin USP; Isopropyl Myristate; Apricot Kernel Oil; Isopropyl Palmitate; Avocado () Oil; Jojoba () Oil; Babassu Oil; Lanolin; Beeswax; Macadamia () Nut Oil; Borage () Seed Oil; (Mango) Seed Butter; Brazil Nut Oil; Mineral Oil; C12-15 Alkyl Benzoate; Myristyl Myristate; Seed Oil; Olive () Oil; Canola Oil; (Rice Bran) Oil; Caprylic/Capric ...

ANTIMICROBIAL FIBERS AND COMPOSITIONS

Fibers for generating antimicrobial activity are described. The fibers comprise an enzyme that is able to convert a substrate to release hydrogen peroxide, and a substance that includes a substrate for the enzyme. In the presence of sufficient free water, the enzyme converts the substrate to release hydrogen peroxide, which is effective against a wide range of microbes. Wound dressings and compositions for forming such fibers are also described, as is the use of the fibers, wound dressings and compositions. 1. An electrospinnable composition comprising an enzyme that is able to convert a substrate to release hydrogen peroxide , a substance that includes a substrate for the enzyme , an electrospinnable polymer and a non-aqueous solvent.2. A composition according to claim 1 , wherein the electrospinnable polymer is polycaprolactone.3. A composition according to or claim 1 , wherein the non-aqueous solvent is claim 1 , or comprises claim 1 , an acidic solvent claim 1 , preferably acetic acid.4. A composition according to any preceding claim claim 1 , comprising 5-30% claim 1 , by weight claim 1 , of the electrospinnable polymer.5. A composition according to any preceding claim claim 1 , comprising 10-30% claim 1 , by weight claim 1 , of the electrospinnable polymer.6. A composition according to any preceding claim claim 1 , comprising about 20% claim 1 , by weight claim 1 , of the electrospinnable polymer.7. A composition according to any preceding claim claim 1 , comprising 0.5-50% claim 1 , by weight claim 1 , of the substance.8. A composition according to any preceding claim claim 1 , comprising 5-40% claim 1 , by weight claim 1 , of the substance.9. A composition according to any preceding claim claim 1 , comprising 5-30% claim 1 , by weight of the substance.10. A composition according to any of to claim 1 , comprising 10 to 60% claim 1 , by weight claim 1 , of the substance claim 1 , preferably 20 to 50% claim 1 , by weight claim 1 , of the substance.11. A ...

Antimicrobial compositions

Storage-stable compositions for generating antimicrobial activity are described. The compositions comprise an enzyme that is able to convert a substrate to release hydrogen peroxide, and an unrefined natural substance, such as a honey, that includes a substrate for the enzyme. In certain embodiments, the enzyme is a purified enzyme. In other embodiments, the substrate lacks catalase activity, and the enzyme is additional to any enzyme activity able to convert the substrate to release hydrogen peroxide that may be present in the unrefined natural substance. The storage-stable compositions do not include sufficient free water to allow the enzyme to convert the substrate. Use of the compositions to treat microbial infections and wounds is described, as well as methods for their production.

Antimicrobial compositions

Storage-stable compositions for generating antimicrobial activity are described. The compositions comprise an enzyme that is able to convert a substrate to release hydrogen peroxide, and an unrefined natural substance, such as a honey, that includes a substrate for the enzyme. In certain embodiments, the enzyme is a purified enzyme. In other embodiments, the substrate lacks catalase activity, and the enzyme is additional to any enzyme activity able to convert the substrate to release hydrogen peroxide that may be present in the unrefined natural substance. The storage-stable compositions do not include sufficient free water to allow the enzyme to convert the substrate. Use of the compositions to treat microbial infections and wounds is described, as well as methods for their production.

Antimicrobial compositions

Compositions for generating antimicrobial activity are described. The compositions comprise an enzyme that is able to convert a substrate to release hydrogen peroxide, a substrate for the enzyme, and a solute in the form of a sugar or sugar derivative having a solubility of at least 100g/100g water at 20°C and 1 atm. The compositions may not comprise sufficient free water to allow the enzyme to convert the substrate.

Antimicrobial fibers and compositions

Fibers for generating antimicrobial activity are described. The fibers comprise an enzyme that is able to convert a substrate to release hydrogen peroxide, and a substance that includes a substrate for the enzyme. In the presence of sufficient free water, the enzyme converts the substrate to release hydrogen peroxide, which is effective against a wide range of microbes. Wound dressings and compositions for forming such fibers are also described, as is the use of the fibers, wound dressings and compositions.

Antimicrobial fibers and compositions

Antimicrobial compositions

Antimicrobial fibers and compositions

Fibers for generating antimicrobial activity are described. The fibers comprise an enzyme that is able to convert a substrate to release hydrogen peroxide, and a substance that includes a substrate for the enzyme. In the presence of sufficient free water, the enzyme converts the substrate to release hydrogen peroxide, which is effective against a wide range of microbes. Wound dressings and compositions for forming such fibers are also described, as is the use of the fibers, wound dressings and compositions.

Antimicrobial fibers and compositions

Fibers for generating antimicrobial activity are described. The fibers comprise an enzyme that is able to convert a substrate to release hydrogen peroxide, and a substance that includes a substrate for the enzyme. In the presence of sufficient free water, the enzyme converts the substrate to release hydrogen peroxide, which is effective against a wide range of microbes. Wound dressings and compositions for forming such fibers are also described, as is the use of the fibers, wound dressings and compositions.

Antimicrobial fibers and compositions

Fibers for generating antimicrobial activity are described. The fibers comprise an enzyme that is able to convert a substrate to release hydrogen peroxide, and an unrefined natural substance that includes a substrate for the enzyme, wherein the enzyme is additional to any enzyme activity able to convert the substrate to release hydrogen peroxide that may be present in the unrefined natural substance. In the presence of sufficient free water, the enzyme converts the substrate to release hydrogen peroxide, which is effective against a wide range of microbes. Wound dressings and compositions comprising the fibers are also described, as is use of the fibers, wound dressings and compositions, particularly for wound healing.

Antimicrobial fibers and compositions

Fibers for generating antimicrobial activity are described. The fibers comprise an enzyme that is able to convert a substrate to release hydrogen peroxide, and an unrefined natural substance that includes a substrate for the enzyme, wherein the enzyme is additional to any enzyme activity able to convert the substrate to release hydrogen peroxide that may be present in the unrefined natural substance. In the presence of sufficient free water, the enzyme converts the substrate to release hydrogen peroxide, which is effective against a wide range of microbes. Wound dressings and compositions comprising the fibers are also described, as is use of the fibers, wound dressings and compositions, particularly for wound healing.

抗微生物纖維和組合物

釋放過氧化氫的抗微生物組合物和製劑

Composiciones y formulaciones antimicrobianas.

Se describen composiciones para generar actividad antimicrobiana. Las composiciones comprende: una primera fase; una segunda fase; una enzima que es capaz de convertirse a un sustrato para liberar peróxido de hidrógeno; y una sustancia que incluye un sustrato para la enzima, en donde la primera fase y la segunda fase no son miscibles. Las composiciones pueden formularse como coloides, suspensiones o emulsiones, especialmente como cremas o rocíos. Se describen métodos para hacer las composiciones, así como su uso para el tratamiento de infecciones microbianas.