27-04-2017 дата публикации
Номер: US20170115243A1
Принадлежит:
Systems and methods for controlling the temperature of small volumes such as yoctoliter volumes, are described. The systems include one or more plasmonic nanostructures attached at or near a nanopore. Upon excitation of the plasmonic nanostructures, such as for example by exposure to laser light, the nanoparticles are rapidly heated thereby causing a change in the ionic conductance along the nanopore. The temperature change is determined from the ionic conductance. These temperature changes can be used to control rapid thermodynamic changes in molecular analytes as they interact with the nanopore. 115-. (canceled)16. A method for analyzing polymers comprising:providing plasmonic nanostructures;providing a surface containing a nanopore;affixing the plasmonic nanostructures proximate the nanopore;disposing a polymer to be analyzed in the nanopore;emitting light of sufficient intensity and wavelength to excite the plasmonic nanostructures and induce a change in temperature within the nanopore;analyzing the polymer disposed in the nanopore by use of the change in temperature within the nanopore.17. The method of wherein the analyzing includes assessing at least one of (i) physical changes to polymers claim 16 , (ii) chemical changes to polymers claim 16 , (iii) thermodynamic properties of polymers claim 16 , and (iv) kinetic properties of polymers.18. The method of wherein during the emitting of the light claim 16 , the light is absorbed at or near the surface plasmon resonance and increases the temperature of the nanostructures.19. The method of wherein the analyzing includes estimating at least one of (i) absorbance of emitted light by nanostructures claim 16 , (ii) excitation of surface plasmons in nanostructures due to absorption of light claim 16 , (iii) change in temperature of nanostructures due to excitation of surface plasmons by light claim 16 , and (iv) estimation of the change in temperature in the vicinity of the nanostructure claim 16 , including at the ...
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