25-02-2016 дата публикации
Номер: US20160052878A1
Принадлежит:
Catalysts of protein-disulfide isomerization of formula: 2. The compound of claim 1 , wherein the calculated logP of (CH)NRis greater than or equal to 0.3. The compound of claim 1 , wherein each Rand each Rare hydrogens.4. The compound of claim 1 , wherein Ris —COR.5. The compound of claim 4 , wherein Ris an alkyl group having 1-20 carbon atoms or an alkenyl group having 3-20 carbon atoms.6. The compound of claim 4 , wherein Ris an alkyl group having 1-6 carbon atoms.7. The compound of claim 4 , wherein Ris an aromatic group having 6-12 carbon atoms.8. The compound of claim 4 , wherein Ris a cyclopentyl claim 4 , cyclohexyl claim 4 , cyclooctyl claim 4 , cyclononyl claim 4 , cyclodecyl claim 4 , cyclopentenyl claim 4 , cyclohexenyl claim 4 , cyclooctenyl claim 4 , cyclononenyl or cyclodecenyl group.9. The compound of claim 4 , wherein Ris a phenyl claim 4 , benzyl claim 4 , biphenyl claim 4 , naphthyl claim 4 , indanyl or indenyl group.10. The compound of claim 4 , wherein Ris an alkyl-substituted phenyl group.11. The compound of claim 1 , wherein R claim 1 , each Rand each of Rare hydrogens.12. The compound of claim 1 , wherein each Rand each of Rare hydrogens and Ris —COR claim 1 , where Ris an unsubstituted straight-chain or branched alkyl group having 3-6 carbon atoms.13. The compound of claim 1 , wherein each Rand each of Rare hydrogens and Ris —COR claim 1 , where Ris a phenyl claim 1 , benzyl claim 1 , phenethyl claim 1 , or an alkyl-substituted phenyl group.14. The compound of claim 1 , wherein each Rand each of Rare hydrogens and Ris —COR claim 1 , where Ris an unsubstituted cycloalkyl group having 5-8 carbon atoms.15. The compound of claim 1 , wherein each Ris —COR.16. The compound of claim 1 , wherein each Ris —COR claim 1 , each Ris hydrogen and Ris —COR.17. A refolding buffer comprising one or more compounds of .18. A method for forming a disulfide bond in a polypepetide or protein containing at least two cysteines which comprises contacting the ...
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