22-01-2015 дата публикации
Номер: US20150025120A1
Принадлежит:
A compound represented by the following formula: 9. A pharmaceutical composition comprising the compound according to any one of to , or a pharmaceutically acceptable salt thereof , and a pharmaceutically acceptable carrier.10. A method for inhibiting PDHK in a mammal comprising administering a pharmaceutically effective amount of the compound according to any one of to , or a pharmaceutically acceptable salt thereof , to the mammal.11. A method for inhibiting PDHK1 in a mammal comprising administering a pharmaceutically effective amount of the compound according to any one of to , or a pharmaceutically acceptable salt thereof , to the mammal.12. A method for inhibiting PDHK2 in a mammal comprising administering a pharmaceutically effective amount of the compound according to any one of to , or a pharmaceutically acceptable salt thereof , to the mammal.13. A method for decreasing the blood glucose level in a mammal comprising administering a pharmaceutically effective amount of the compound according to any one of to , or a pharmaceutically acceptable salt thereof , to the mammal.14. A method for decreasing lactate level in a mammal comprising administering a pharmaceutically effective amount of the compound according to any one of to , or a pharmaceutically acceptable salt thereof , to the mammal.15. A method for the prophylaxis or treatment of diabetes , insulin resistance syndrome , metabolic syndrome , hyperglycemia , hyperlactacidemia , diabetic complications , cardiac failure , cardiomyopathy , myocardial ischemia , myocardial infarction , angina pectoris , dyslipidemia , atherosclerosis , peripheral arterial disease , intermittent claudication , chronic obstructive pulmonary disease , brain ischemia , cerebral apoplexy , mitochondrial disease , mitochondrial encephalomyopathy , cancer or pulmonary hypertension in a mammal , comprising administering a pharmaceutically effective amount of the compound according to any one of to , or a pharmaceutically ...
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