17-09-2015 дата публикации
Номер: US20150257718A1
Disclosed herein are methods, systems and therapeutics concerning radiotherapy of microscopic disease based on realtime imaging. The system comprises an intra-corporeal component and an extra-corporeal component. The intra-corporeal component comprises a detector/imaging subunit and a treatment subunit, where both subunits are placed in a cavity of a patient. The extra-corporeal component comprises a detector that is placed outside any cavity of the patient. Through this system, a treatment can be applied to a target tissue in a patient concurrently or within a short period time to signal detections. 1. A tomographic imaging system for realtime imaging of sub-millimeter-sized tumor clusters in a patient , comprising: i) a first detector in a cavity within the body of a patient, wherein the first detector has an imaging hemisphere;', 'ii) a radiation source capable of emitting a therapeutic radiation, where said radiation source is also in the cavity within the body of the patient;, 'an intra-corporeal component comprisinga contrast agent, which modulates the intensity of the therapeutic radiation, andan extra-corporeal component comprising a second detector outside any cavity of the body of the patient, wherein the second detector is configured to always face the imaging hemisphere of said first detector;wherein the first detector can be rotated with respect to the body of said patient.2. The system of claim 1 , wherein the contrast agent is selected from the group consisting of an iodinated agent claim 1 , a high-Z material liquid claim 1 , and a combination thereof.3. The system of claim 1 , wherein the first detector is a gamma detector.4. The system of claim 1 , wherein the second detector is a gamma detector.5. The system of claim 1 , wherein the radiation source is a miniature x-ray source.6. The system of claim 5 , wherein the radiation source further comprises an inlet and an outlet for an x-ray source coolant.7. The system of claim 1 , further comprises:an ...
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