23-12-2021 дата публикации
Номер: US20210395211A1
Принадлежит:
Embodiments relate to a continuous process for the production of hydroxyethylpiperazine that includes feeding neat piperazine, recycled piperazine, and ethylene oxide to a reactor to form crude hydroxyethylpiperazine, in which the reactor is a continuous stirred tank reactor or a plug flow reactor. The process further includes continuously feeding the crude hydroxyethylpiperazine from the reactor to a distillation system that includes at least one distillation column, the distillation system produces at least a recycled piperazine stream and a hydroxyethylpiperazine stream, the recycled piperazine stream includes the recycled piperazine that is fed to the reactor to form the crude hydroxyethylpiperazine, and the hydroxyethylpiperazine stream includes at least 60 wt % of hydroxyethylpiperazine based on a total weight of the hydroxyethylpiperazine stream. 1. A continuous process for the production of hydroxyethylpiperazine , the process comprising:feeding neat piperazine, recycled piperazine, and ethylene oxide to a reactor to form crude hydroxyethylpiperazine, the reactor being a continuous stirred tank reactor or a plug flow reactor; andcontinuously feeding the crude hydroxyethylpiperazine from the reactor to a distillation system that includes at least one distillation column, the distillation system producing at least a recycled piperazine stream and a hydroxyethylpiperazine stream, the recycled piperazine stream including the recycled piperazine that is fed to the reactor to form the crude hydroxyethylpiperazine and the hydroxyethylpiperazine stream including at least 60 wt % of hydroxyethylpiperazine based on a total weight of the hydroxyethylpiperazine stream.2. The process as claimed in claim 1 , wherein a molar ratio of ethylene oxide to neat piperazine added to the reactor is greater than 1.01.3. The process as claimed in claim 1 , wherein a molar ratio of ethylene oxide to total piperazine claim 1 , including neat piperazine and recycled piperazine claim 1 ...
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