FUSED TRICYCLIC DUAL INHIBITORS OF CDK 4/6 AND FLT3

Compounds of Formula I are useful inhibitors of CDK 4, CDK6, and FLT3. Such compounds are useful in treating cancer and various other disease conditions. Compounds of Formula I have the following structure: 2. The compound of or the pharmaceutically acceptable salt thereof claim 1 , the hydrate thereof claim 1 , or the mixture thereof claim 1 , wherein Ris a C-Ccycloalkyl group that is unsubstituted or is substituted with 1-3 substituents independently selected from unsubstituted —(C-Calkyl) claim 1 , —OH claim 1 , halo claim 1 , —O—(C-Calkyl) claim 1 , —COH claim 1 , —C(═O)—O—(C-Calkyl) claim 1 , —C(═O)—NR′R″ claim 1 , —NR′R″ claim 1 , or a substituted —(C-Calkyl) claim 1 , wherein the substituted —(C-Calkyl) is substituted with 1-3 substituents independently selected from halo claim 1 , —OH claim 1 , —OCH claim 1 , —S(═O)—CH claim 1 , or —C(═O)—CH.3. The compound of or the pharmaceutically acceptable salt thereof claim 2 , the hydrate thereof claim 2 , or the mixture thereof claim 2 , wherein Ris a cyclohexyl group substituted with a —(C-Calkyl) group.5. The compound of or the pharmaceutically acceptable salt thereof claim 1 , the hydrate thereof claim 1 , or the mixture thereof claim 1 , wherein Ris a group of Formula IA or IB.6. The compound of or the pharmaceutically acceptable salt thereof claim 5 , the hydrate thereof claim 5 , or the mixture thereof claim 5 , wherein Ris a group of Formula IA.7. The compound of claim 1 , wherein:{'sup': '2', 'sub': 5', '7', '1', '6, 'Ris a C-Ccycloalkyl group that is unsubstituted or is substituted with 1-3 —(C-Calkyl) groups;'}{'sup': '3a', 'sub': 1', '3', '1', '3, 'Ris selected from —H, —(C-Calkyl), or —O—(C-Calkyl);'}{'sup': '3b', 'Ris —H;'}{'sup': '3c', 'Ris —H;'}{'sup': '4', 'Ris —H;'}{'sup': '5', 'Ris —H;'}{'sup': '6', 'sub': 1', '6', '1', '6', '1', '6', '1', '6', '2', '1', '6', '1', '6, 'Ris selected from —H, —(C-Calkyl), —C(═O)—(C-Calkyl), or —C(═O)—C(═O)—OH, wherein the alkyl group of the —(C-Calkyl) and —C(═O)—(C- ...

Method and apparatus for allocating erasure coded data to disk storage

Allocation process that allows erasure coded data to be stored on any of a plurality of disk drives, in a pool of drives, so that the allocation is not tied to a fixed group of drives. Still further, the encoded data can be generated by any of multiple different erasure coding algorithms, where again storage of the encoded data is not restricted to a single group of drives based on the erasure algorithm being utilized to encode the data. In another embodiment, the encoded data can be “stacked” (aligned) on select drives to reduce the number of head seeks required to access the data. As a result of these improvements, the system can dynamically determine which one of multiple erasure coding algorithms to utilize for a given incoming data block, without being tied to one particular algorithm and one particular group of storage devices as in the prior art.

DIAGNOSTIC INSTRUMENT AND FLOW PROCESS

A diagnostic instrument having a cellular analysis system capable of running standardized immune monitoring panels. The system could include an automated and integrated specimen sampling method through a continuous flow process. The instrument could include a probe washer station, scheduler, cassette autoloader, bar coding system, and/or containment area common interface. An improved optimization test is proposed for instrument and flow cytometer quality assurance. The proposed method analyzes population separation for measuring instrument performance and/or sample quality. Such a method may also use population separation for measuring sample and/or run quality. 120.-. (canceled)21. A system for analyzing a cellular sample in a specimen tube , the system comprising:a well;a mixing station including a rocker that displaces the specimen tube in a rocking motion;a probe displaceable above the rocker and above the well;a flow cytometer coupled to the well; anda processor to control the mixing station, the probe, and the flow cytometer, the rocker to orient the specimen tube upright;', 'the probe to transfer the cellular sample from the upright specimen tube to the well;', 'and', 'the flow cytometer to aspirate from the well and to analyze the cellular sample., 'wherein the processor directs22. The system of wherein the specimen tube is held in a tube cassette claim 21 , wherein the mixing station further includes a cassette holder to support the tube cassette claim 21 , and wherein the rocker is coupled to the cassette holder and displaces the specimen tube by displacing the cassette holder.23. The system of further comprising an autoloader coupled to the mixing station claim 22 , the autoloader including a cassette queue to hold the tube cassette claim 22 , wherein the autoloader delivers the tube cassette to the cassette holder of the mixing station.24. The system of wherein the specimen tube includes a cap and the processor directs the probe to pierce the cap to ...

REMOTE DIAGNOSTIC IMAGING

Systems and methods for performing remote diagnostic imaging. One system includes a stand-alone imaging station including a housing that includes a first housing module and a second housing module, a diagnostic imaging device, and a door. The first housing module and the second housing module are separate and configured to be assembled together. The diagnostic imaging device is contained within the housing and includes a radiation source and a radiation detector. The door is coupled to the housing and is configured to allow a patient to enter the housing. The door includes a lock configured to maintain the door in a locked state at least while the diagnostic imaging device captures the diagnostic image. 1. A stand-alone imaging station comprising:a housing including a first housing module and a second housing module, the first housing module and the second housing module being separate and configured to be assembled together;a diagnostic imaging device contained within the housing, the diagnostic imaging device including a radiation source and a radiation detector; anda door coupled to the housing and configured to allow a patient to enter the housing, the door including a lock configured to maintain the door in a locked state at least while the diagnostic imaging device captures the diagnostic image.2. The stand-alone imaging station of claim 1 , wherein the first housing module includes a wall having a lead lining.3. The stand-alone imaging station of claim 1 , wherein the lock is a remotely-controlled lock.4. The stand-alone imaging station of claim 1 , further comprising a controller included in the stand-alone imaging station including a processing unit claim 1 , the processing unit configured to receive a control signal from a remote device through a network to operate the diagnostic imaging device.5. The stand-alone imaging station of claim 1 , further comprising a device coupled to the housing claim 1 , the device configured to receive payment information ...

Desoldering apparatus and method

Disclosed is a solder punch tool and method of using the same. The solder punch tool includes an extensible rod, such as a graphite rod, extensible from a first end of the solder punch tool, and a metal punch on an opposite end of the solder punch tool. Optionally, an A/C power cord and a light may each be removably attachable to the solder punch tool. In use, a user may melt solder clogging a hole in a printed circuit board, push a portion of the extensible rod through the hole and the molten solder, break off a portion of the extensible rod extending through the hole in the printed circuit board, and push such broken portion of the extensible rod through the hole using the metal punch so as to clear the hole to receive a replacement component.

Piperidinone Derivatives as MDM2 Inhibitors for the Treatment of Cancer

The present invention provides MDM2 inhibitor compounds of Formula I, 130-. (canceled)31. A pharmaceutical composition comprising a compound of 2-(3R ,5R ,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid , or a pharmaceutically acceptable salt thereof.32. The pharmaceutical composition of claim 31 , further comprising microcrystalline cellulose.33. The pharmaceutical composition of claim 31 , further comprising lactose.34. The pharmaceutical composition of claim 31 , further comprising carboxymethylcellulose.35. The pharmaceutical composition of claim 31 , further comprising magnesium stearate.36. The pharmaceutical composition of claim 31 , in a dosage form formulated for topical administration.37. The pharmaceutical composition of claim 36 , wherein the dosage form is an ointment.38. The pharmaceutical composition of claim 36 , wherein the dosage form is spray.39. The pharmaceutical composition of claim 36 , wherein the dosage form is inhalants.40. The pharmaceutical composition of is in a dosage form for oral administration.41. The pharmaceutical composition of claim 40 , wherein the dosage form is tablets.42. The pharmaceutical composition of claim 40 , wherein the dosage form is capsules.43. The pharmaceutical composition of claim 31 , further comprising a pharmaceutically active agent selected from the group consisting of dronabinol claim 31 , granisetron claim 31 , metoclopramide claim 31 , ondansetron claim 31 , and prochlorperazine claim 31 , and a pharmaceutically acceptable salt thereof.44. A method of treating nausea in a subject in need thereof claim 43 , the method comprising administering to the subject an effective amount of the pharmaceutical composition of .451. A method of treating cancer in a subject in need thereof claim 43 , the method comprising administering to the subject an effective amount of the pharmaceutical composition of claim claim 43 , wherein the ...

FUSED TRICYCLIC DUAL INHIBITORS OF CDK 4/6 AND FLT3

Compounds of Formula I are useful inhibitors of CDK 4, CDK6, and FLT3. Such compounds are useful in treating cancer and various other disease conditions. Compounds of Formula I have the following structure: 2. The method of claim 1 , wherein Ris a C-Ccycloalkyl group that is unsubstituted or is substituted with 1-3 substituents independently selected from unsubstituted —(C-Calkyl) claim 1 , —OH claim 1 , halo claim 1 , —O—(C-Calkyl) claim 1 , —COH claim 1 , —C(═O)—O—(C-Calkyl) claim 1 , —C(═O)—NR′R″ claim 1 , —NR′R″ claim 1 , or a substituted —(C-Calkyl) claim 1 , wherein the substituted —(C-Calkyl) is substituted with 1-3 substituents independently selected from halo claim 1 , —OH claim 1 , —OCH claim 1 , —S(═O)—CH claim 1 , or —C(═O)—CH.3. The method of claim 2 , wherein Ris a cyclohexyl group substituted with a —(C-Calkyl) group.5. The method of claim 1 , wherein Ris a group of Formula IA or IB.6. The method of claim 5 , wherein Ris a group of Formula IA.7. The method of claim 1 , wherein:{'sup': '2', 'sub': 5', '7', '1', '6, 'Ris a C-Ccycloalkyl group that is unsubstituted or is substituted with 1-3-(C-Calkyl) groups;'}{'sup': '3a', 'sub': 1', '3', '1', '3, 'Ris selected from —H, —(C-Calkyl), or —O—(C-Calkyl);'}{'sup': '3b', 'Ris —H;'}{'sup': '3c', 'Ris —H;'}{'sup': '4', 'Ris —H;'}{'sup': '5', 'Ris —H;'}{'sup': '6', 'sub': 1', '6', '1', '6', '1', '6', '1', '6', '2', '1', '6', '1', '6, 'Ris selected from —(C-Calkyl), —C(═O)—(C-Calkyl), or —C(═O)—C(═O)—OH, wherein the alkyl group of the —(C-Calkyl) and —C(═O)—(C-Calkyl) groups is unsubstituted or is substituted with 1-3 substituents independently selected from —OH, F, —S(═O)—(C-Calkyl), or —O—(C-Calkyl);'}{'sup': '7a', 'Ris —H;'}{'sup': 7b', '1, 'Ris —H; or is absent if Ris a group of Formula IB or Formula ID;'}{'sup': 7c', '1, 'Ris —H; or is absent if Ris a group of Formula IA or Formula IC;'}{'sup': '8a', 'Ris —H;'}{'sup': '8b', 'Ris —H;'}{'sup': '8c', 'sub': 1', '6, 'Ris selected from —H, —OH, or unsubstituted ...

HEALTH TESTING AND DIAGNOSTICS PLATFORM

Systems and methods for providing a universal platform for at-home health testing and diagnostics are provided herein. In particular, a health testing and diagnostic platform is provided to connect medical providers with patients and to generate a unique, private testing environment. In some embodiments, the testing environment may facilitate administration of a medical test to a patient with the guidance of a proctor. In some embodiments, the patient may be provided with step-by-step instructions for test administration by the proctor within a testing environment. The platform may display unique, dynamic testing interfaces to the patient and proctor to ensure proper testing protocols and accurate test result verification. 120-. (canceled)21. A computer-implemented system for a proctored examination platform , the computer-implemented system comprising:an electronic storage medium comprising computer-executable instructions; [ first image data from a first imaging device of a user device, the first imaging device comprising a forward facing camera of the user device, and the first imaging data comprising at least an image of a user, and', 'second image data from a second imaging device of the user, the second imaging device comprising a rearward facing camera of the user device, and the second imaging data comprising an image of a test kit for a medical diagnostic test; and, 'during a medical diagnostic testing procedure, receive, the first image data to verify an identity of the user during the medical diagnostic testing procedure, and', 'the second image data to verify that the test kit is not replaced by a different test kit during the diagnostic testing procedure; and, 'during or after the medical diagnostic testing procedure, dynamically verify that the medical diagnostic testing procedure is administered without abnormalities by analyzing, 'based on a determination that the identity of the user cannot be verified during the diagnostic testing procedure or that ...

Piperidinone Derivatives as MDM2 Inhibitors for the Treatment of Cancer

The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Piperidinone Derivatives as MDM2 Inhibitors for the Treatment of Cancer

The present invention provides MDM2 inhibitor compounds of Formula I, 2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein Ris —C(H)RR claim 1 , —NRR claim 1 , phenyl or pyridine claim 1 , wherein the phenyl or the pyridyl substituted with one or more Ras allowed by valence.12. The compound of claim 11 , or a pharmaceutically acceptable salt thereof claim 11 , wherein Re is H or methyl or ethyl.14. The compound of claim 13 , or a pharmaceutically acceptable salt thereof claim 13 , wherein Re is H or methyl or ethyl.19. A compound claim 13 , or a pharmaceutically acceptable salt thereof claim 13 , selected from:2-((3R,5R,6S)-1-((S)-1-tert-butoxy-1-oxobutan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-2-oxopiperidin-3-yl)acetic acid;2-((3S,5R,6S)-1-((S)-1-tert-butoxy-1-oxobutan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-2-oxopiperidin-3-yl)acetic acid;2-((3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-ethoxy-1-oxobutan-2-yl)-2-oxopiperidin-3-yl)acetic acid;2-((3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-ethoxy-4-methyl-1-oxopentan-2-yl)-2-oxopiperidin-3-yl)acetic acid;2-((3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-ethoxy-1-oxopentan-2-yl)-2-oxopiperidin-3-yl)acetic acid;2-((3S,5S,6R)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-((R)-1-ethoxy-1-oxopentan-2-yl)-2-oxopiperidin-3-yl)acetic acid;2-((3R,5R,6S)-1-((S)-2-tert-Butoxy-1-cyclopropyl-2-oxoethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-2-oxopiperidin-3-yl)acetic acid;2-((3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-hydroxybutan-2-yl)-2-oxopiperidin-3-yl)acetic acid;2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-cyclopropyl-2-hydroxyethyl)-2-oxopiperidin-3-yl)acetic acid;2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(cyclopropylmethoxy)butan-2-yl)-2-oxopiperidin-3-yl)acetic acid;2-((3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-methoxybutan-2-yl)-2-oxopiperidin-3-yl)acetic acid;2-((3R,5R,6S)-5-( ...

Remote diagnostic testing and treatment

Augmented-reality (AR)-enabled first aid kit are described herein. As one example, an AR-enabled first aid kit can include a container, a plurality of first aid items located within the container, wherein each of the plurality of first aid items comprises equipment necessary to perform a first aid, and a machine-readable code located on an external surface of the container. The machine-readable code may be configured to be imaged by a camera of a portable user computing device to enable causing the portable user computing device to display a user-selectable graphic on the display of the portable user computing device that, when selected by a user, causes a software application stored on the portable user computing device to access a provider webpage that enables initiation of the augmented reality presentation that includes display of AR content relating to the plurality of first aid items.

Remote diagnostic testing and treatment

Systems and methods for facilitating self-administered medical diagnostic tests and receiving treatment based on the results of such tests. In some examples, a user may take a medical diagnostic test under the supervision of a proctor over a video conference connection. The proctor or the system can verify the results of the test. The system can facilitate treatment based on the results of the test by, for example, facilitating the generation, fulfillment, and delivery of medication.

REMOTE DIAGNOSTIC TESTING AND TREATMENT

A medical diagnostic kit are described. In one example, a medical diagnostic kit includes a container, and a plurality of medical diagnostic test kits located within the container. Each of the plurality of medical diagnostic test kits can include equipment necessary to perform a particular self-administered medical diagnostic test. The plurality of medical diagnostic test kits can include at least a first medical diagnostic kit adapted to facilitate user completion of a first medical diagnostic test and a second medical diagnostic kit adapted to facilitate user completion of a second medical diagnostic test different from the first medical diagnostic test. The container can include a machine-readable code located on an external surface of the container. 1. A medical diagnostic kit , comprising:a container; anda plurality of medical diagnostic test kits located within the container;wherein each of the plurality of medical diagnostic test kits comprises equipment necessary to perform a particular self-administered medical diagnostic test,wherein the plurality of medical diagnostic test kits comprise at least a first medical diagnostic kit adapted to facilitate user completion of a first medical diagnostic test and a second medical diagnostic kit adapted to facilitate user completion of a second medical diagnostic test different from the first medical diagnostic test,wherein the container comprises a machine-readable code located on an external surface of the container.2. The medical diagnostic kit of claim 1 , wherein at least one of the plurality of medical diagnostic test kits comprises one of: a Covid-19 test kit claim 1 , a UTI test kit claim 1 , a drug test kit claim 1 , a syphilis test kit claim 1 , a streptococcal pharyngitis test kit claim 1 , an influenza test kit claim 1 , and a sexually transmitted disease (STD) test kit.3. The medical diagnostic kit of claim 1 , wherein the machine-readable code configured to be imaged by a camera of a portable user ...

Remote diagnostic testing and treatment

Systems and methods for facilitating self-administered medical diagnostic tests and receiving treatment based on the results of such tests. In some examples, a user may take a medical diagnostic test under the supervision of a proctor over a video conference connection. The proctor or the system can verify the results of the test. The system can enable treatment based on the results of the test by, for example, facilitating the generation, fulfillment, and delivery of medication.

DIAGNOSTIC COLLECTOR FOR HADOOP

Systems and methods for identifying a faulty node in a Hadoop cluster using an interface to the Hadoop cluster are described. A method may include receiving, at an interface to a Hadoop cluster, an input requesting diagnostic information for one or more nodes in the Hadoop cluster. The input may also specify the one or more nodes in the Hadoop cluster for which diagnostic information is requested. The method may further include initiating a diagnostic analysis of the one or more nodes, and displaying, at the interface, the diagnostic information for the one or more nodes. The diagnostic information may identify a node exhibiting a fault and be displayed while the diagnostic analysis is in progress. 1. A method for identifying a faulty node in a Hadoop cluster using an interface to the Hadoop cluster , comprising:receiving, at an interface to a Hadoop cluster, an input requesting diagnostic information for one or more nodes in the Hadoop cluster, wherein the input also specifies the one or more nodes in the Hadoop cluster for which diagnostic information is requested;initiating, by the interface, a diagnostic analysis of the one or more nodes; anddisplaying, at the interface, the diagnostic information for the one or more nodes,wherein the diagnostic information identifies a node exhibiting a fault, and wherein the diagnostic information is displayed while the diagnostic analysis is in progress.2. The method of claim 1 , wherein the diagnostic information displayed at the interface comprises at least one of individual diagnostic information for at least one of the one or more nodes and an indication of the completion percentage of the diagnostic analysis of the one or more nodes.3. The method of claim 1 , wherein the one or more nodes comprise a cluster of nodes.4. The method of claim 1 , further comprising receiving an input canceling the diagnostic analysis claim 1 , wherein the diagnostic analysis ceases when the input cancelling the diagnostic analysis is ...

REMOTE DIAGNOSTIC IMAGING

Systems and methods for performing remote diagnostic imaging. One system includes a stand-alone imaging station including a first housing module and a diagnostic imaging device. The diagnostic imaging device is contained within the first housing module and includes a radiation source and a radiation detector. The imaging station also includes a door and a device. The door is coupled to the first housing module and configured to allow a patient to enter the first housing module. The device is configured to receive payment information for a diagnostic imaging procedure performed using the diagnostic imaging device. The device may be magnetic stripe reader, a bill pay unit, a user identification card dispenser, or a scanner. 1. A stand-alone imaging station comprising:a first housing module;a diagnostic imaging device contained within the first housing module, the diagnostic imaging device including a radiation source and a radiation detector;a door coupled to the first housing module and configured to allow a patient to enter the first housing module; anda device configured to receive payment information for a diagnostic imaging procedure performed using the diagnostic imaging device.2. The stand-alone imaging station of claim 1 , wherein the device configured to receive the payment information includes one selected from a group consisting of a magnetic stripe reader claim 1 , a bill pay unit claim 1 , a user identification card dispenser claim 1 , and a scanner.3. The stand-alone imaging station of claim 1 , wherein the first housing module includes a wall having a lead lining.4. The stand-alone imaging station of claim 1 , wherein the door includes a lock configured to maintain the door in a locked state at least while the diagnostic imaging device captures a diagnostic image claim 1 , and wherein the lock is a remotely-controlled lock.5. The stand-alone imaging station of claim 4 , further comprising a controller included in the stand-alone imaging station ...

MOTORCYCLE LOCKING SYSTEM

A system for locking the wheel of a motorcycle and hence the motorcycle itself utilizes a locking housing with a back wall, dual sidewalls, and a bottom floor which partially circumscribe a slotted space for receiving the Wheel of a motorcycle. The bottom floor has lateral sections extending outside the sidewalls. A locking base is provided which has rail members extending along the side of the base, the rail members being configured to slidably receive the lateral sections of the bottom floor. Bolts secure the locking housing to the locking base when the system is assembled to receive the front wheel of a motorcycle. An elongated cycle lock is provided to extend through holes in the sidewalls and the motorcycle wheel positioned within the slotted space, to secure the wheel and thus the motorcycle within the locking housing. 1. A system for locking the wheel of a motorcycle , the system comprising:a locking housing having a back wall and dual sidewalls extending outwardly from the back wall, a bottom floor located below the sidewalls and having lateral sections extending outside the sidewalls, and a slotted space partially circumscribed by the back wall, sidewalls, and bottom floor for receiving the wheel of a motorcycle, said space having a front opening;a locking base having rail members extending along the sides of the base, the rail members being configured to slidably receive the lateral sections of the bottom floor, whereby in a connected position, the locking housing is atop the locking base and the lateral sections are located within the rail members, and in a detached position the lateral sections are slid out of the rail members, separating the locking housing and the locking base;attachment means to secure the locking housing to the locking base in the connected position; andlocking means to secure the motorcycle wheel within the space.2. The system as in wherein the attachment means comprises holes in the locking base aligned with holes in the bottom ...

Methods and Systems for Automatically Scoring Diagnoses associated with Clinical Images

Methods and systems for automatically scoring diagnoses associated with clinical images. One system includes a server including an electronic processor and an interface for communicating with at least one data source. The electronic processor is configured to receive a diagnosis associated with an image of a patient from the at least one data source over the interface. The diagnosis is for an anatomical structure represented in the image. The electronic processor is also configured to receive a pathology result for the patient for the anatomical structure generated after the diagnosis from the at least one pathology result source over the interface. The electronic processor is also configured to automatically generate a score based on a comparison of the diagnosis and the pathology result. The electronic processor is also configured to display the score within a graphical user interface.

FUSED TRICYCLIC DUAL INHIBITORS OF CDK 4/6 AND FLT3

Compounds of Formula I are useful inhibitors of CDK 4, CDK6, and FLT3. Such compounds are useful in treating cancer and various other disease conditions. Compounds of Formula I have the following structure: 143-. (canceled)52. The method of claim 51 , wherein the compound is in a hydrochloride salt form.53. The method of claim 51 , wherein the cancer is selected from acute myeloid leukemia claim 51 , acute lymphoblastic leukemia claim 51 , myelodysplastic syndrome claim 51 , multiple myeloma claim 51 , chronic myeloid leukemia claim 51 , acute lymphocytic leukemia claim 51 , chronic lymphocytic leukemia claim 51 , non-Hodgkin lymphoma claim 51 , another lymphoma claim 51 , another myeloma claim 51 , or another leukemia.54. The method of claim 53 , wherein the cancer is acute myeloid leukemia.55. The method of claim 53 , wherein the cancer is Rb-positive.56. The method of claim 48 , wherein the cancer is selected from acute myeloid leukemia claim 48 , acute lymphoblastic leukemia claim 48 , myelodysplastic syndrome claim 48 , multiple myeloma claim 48 , chronic myeloid leukemia claim 48 , acute lymphocytic leukemia claim 48 , chronic lymphocytic leukemia claim 48 , non-Hodgkin lymphoma claim 48 , another lymphoma claim 48 , another myeloma claim 48 , or another leukemia.57. A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of .58. A pharmaceutical composition of claim 57 , wherein the compound is present as a hydrochloride salt. This application is a continuation of, and claims priority to, U.S. patent application Ser. No. 14/088,796, which is a divisional of, and claims priority to, U.S. patent application Ser. No. 13/425,817, filed on Mar. 21, 2012, which claims the benefit of, and priority to, U.S. Provisional Application No. 61/466,841, filed on Mar. 23, 2011, both of which are hereby incorporated by reference in their entireties and for all purposes as if fully set forth herein.The present invention relates to ...

SYSTEMS, DEVICES, AND METHODS FOR DIAGNOSTIC AID KIT APPARATUS

An at-home medical diagnostic test kit container including a plurality of at-home medical diagnostic test kits is provided herein. In particular, the medical diagnostic test kit container may include a machine-readable code (e.g., QR code) configured to facilitate an augmented reality experience associated with the at-home medical diagnostic test kit container. In some embodiments, a testing and diagnostic platform may facilitate tracking of inventory within the at-home medical diagnostic test kit container and/or may facilitate coordination of prescription medication order fulfillment and delivery upon indication of a medical condition that could benefit from taking prescription medication. 1. A computing system for electronic procurement authorization of prescription medication via a courier , the computing system comprising an electronic storage medium storing instructions configured to cause a processor to:receive, by a computer system, through an electronic communication network a prescription medication procurement request for a user, wherein the prescription medication procurement request is based on a result of a proctored examination test and a physician issued prescription for the prescription medication,wherein the proctored examination test is proctored through an online video conference connection between a proctor and the user, wherein the user inputs verification information comprising a name of the user, a date of birth of the user, and a location of the user, and wherein the proctored examination test results in a verification of the proctored examination test result, the verification based on the computer system dynamically verifying that the proctored examination test was administered by the user without abnormalities by analyzing monitored video frame data associated with the online video conference connection for abnormalities,wherein the physician issued prescription is based on a physician reviewing the result for result of the proctored ...

System and apparatus for control of sputter deposition process

A method and apparatus for sputter deposition in which both a pulsed DC power supply and an RF power supply apply power to the target in the sputter deposition equipment. The pulsed DC power supply provides an on cycle where power is applied to the target, and an off cycle, in which a reverse polarity is applied to the target. The application of the reverse polarity has the effect of removing any charge that may have built up on the surface of the target. This reduces the likelihood of arcing occurring on the surface of the target, which can degrade the quality of the film being deposited on the substrate. By applying RF power simultaneously with the pulsed DC power to the target, the ionization efficiency on the target surface is increased. This results in a greater amount of material being removed from the target surface more quickly.

Method of arranging the components of a battery pack

METHOD AND APPARATUS FOR PRODUCING AN ENERGY BEAM

System and apparatus for control of sputter deposition process

A method and apparatus for sputter deposition in which both a pulsed DC power supply and an RF power supply apply power to the target in the sputter deposition equipment. The pulsed DC power supply provides an on cycle where power is applied to the target, and an off cycle, in which a reverse polarity is applied to the target. The application of the reverse polarity has the effect of removing any charge that may have built up on the surface of the target. This reduces the likelihood of arcing occurring on the surface of the target, which can degrade the quality of the film being deposited on the substrate. By applying RF power simultaneously with the pulsed DC power to the target, the ionization efficiency on the target surface is increased. This results in a greater amount of material being removed from the target surface more quickly.

Piperidinone derivatives as MDM2 inhibitors for the treatment of cancer

Medication compliance system and associated methods

A system for monitoring medication compliance in a patient includes an electronic pill that includes a drug-transporting device and an antenna positioned on a surface of the drug-transporting device. A detector is positionable external a gastrointestinal tract of a patient for detecting a presence of the antenna in the patient gastrointestinal tract.

Liquid fuel cooking stove

CONDENSED TRICYCLIC DUAL INHIBITORS OF CDK 4/6 AND FLT3

Ac/dc power tools with brushless motors

A power tool comprising: a housing; a brushless motor (202) including a rotor and a stator having at least three stator windings corresponding to at least three phases of the motor, the rotor being moveable by the stator when the stator windings are appropriately energized within the corresponding phases, the motor being configured to operate within an operating voltage range; a power supply interface (128-5) arranged to receive at least one of AC power from an AC power supply having a first nominal voltage or DC power from a DC power supply having a second nominal voltage; and a motor control circuit (204) comprising: a rectifier circuit (220) configured to convert the AC power to a rectified voltage signal, a power switch circuit (226) having a plurality of power switches configured to supply electric power from at least one of the DC power or the rectified voltage signal to the motor (202), and a controller (230) configured to control a switching operation of the plurality of power switches to regulate the supply of electric power from at least one of the rectified voltage signal or the DC power to the motor (202) at a level corresponding to the operating voltage range of the motor (202).

Tire siping machine

Inverted TIJ

A fluid ejection die includes a substrate including an array of nozzles.

Isolator and assembly configuration

Multiple isolators are configured with respect to an assembly (101), such as a sensor assembly in an inertial navigation system or other system where cross-axis acceleration or rotation coupling is undesirable. The system utilizes a set of isolators (203, 209, 215, and 221; 305, 307, 311, 313, 317, 319, 323, 325; or 403, 405; 407, 411, 413, and 415) that are substantially matched to each other, but may have uncorrelated axial stiffness and radial stiffness. The system configuration does not introduce cross-axis coupling, such as cross-axis translational coupling and cross-axis rotational coupling.

Ac/dc power tools with brushless motors

A power tool comprising: a housing; a brushless motor (202) including a rotor and a stator having a plurality of stator windings corresponding to at least three phases of the motor, the rotor being moveable by the stator; a power switch circuit (226) comprising a plurality of high-side power switches and a plurality of low-side power switches configured as a multi-phase inverter circuit for driving the phases of the motor (202), the power switch circuit outputting at least three phase voltage signals to the motor (202); a power supply interface (128-5) configured to receive alternating-current (AC) power from an AC power supply having a root-mean-square (RMS) voltage value; a rectifier (220) coupled to the first set of nodes of the power supply interface to convert the AC power to a rectified DC voltage, and comprising a capacitor (224); and a controller (230) outputting a plurality of drive signals to the power switch circuit to control a supply of power to the motor.

Medication compliance system and associated methods

A system for monitoring medication compliance in a patient includes an electronic pill that includes a drug-transporting device and an antenna positioned on a surface of the drug-transporting device. A detector is positionable external a gastrointestinal tract of a patient for detecting a presence of the antenna in the patient gastrointestinal tract.

Piperidinone derivatives as MDM2 inhibitors for the treatment of cancer

The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Method and apparatus for service processor updates

A service processor computing arrangement is associated with a cellular multiprocessing cell. The arrangement includes a scan machine coupled to communicate with processing hardware of the cell and a service processor coupled to an external communications interface of the scan machine. The scan machine includes remote scan software that performs at least one of monitoring and configuration of the processing hardware, and a first remote install program that receives update data via the external communications interface and applies the update data to the remote scan software. The service processor includes a server control program that performs at least one of monitoring and configuring the cell via the remote scan machine, and a second remote install program that applies the update data to the scan machine via the first remote install program.

DEHYDRATED tricyclic DUALINHIBITORER OF CDK 4/6 AND FLT3

Electronic pill for monitoring medication compliance

A system for monitoring medication compliance in a patient includes an electronic pill that includes a drug-transporting device and an antenna positioned on a surface of the drug-transporting device. A detector is positionable external a gastrointestinal tract of a patient for detecting a presence of the antenna in the patient gastrointestinal tract.

Battery pack for cordless devices

A battery pack including a housing, a terminal block, a printed circuit board electrically connected to the terminal block, at least one battery cell, and a spark gap device on the printed circuit board to provide electrostatic discharge protection and disposed between the printed circuit board and the terminal block.

Remote diagnostic imaging

Systems and methods for performing remote diagnostic imaging. One system includes a stand-alone imaging station including a housing that includes a first housing module and a second housing module, a diagnostic imaging device, and a door. The first housing module and the second housing module are separate and configured to be assembled together. The diagnostic imaging device is contained within the housing and includes a radiation source and a radiation detector. The door is coupled to the housing and is configured to allow a patient to enter the housing. The door includes a lock configured to maintain the door in a locked state at least while the diagnostic imaging device captures the diagnostic image.

Bulk updates and tape synchronization

Described are techniques for processing a request to store data. The request to store data in accordance with a single instance storage technique is received. A schedule for storing the data in accordance with information included in the request is determined. Data for processing is requested in accordance with the single instance storage technique in accordance with the schedule.

Fused tricyclic dual inhibitors of CDK 4/6 and FLT3

Compounds of Formula (I) are useful inhibitors of CDK 4, CDK6, and FLT3. Such compounds are useful in treating cancer and various other disease conditions. Compounds of Formula (I) have the following structure: where R

Processing of photoplethysmography signals

Disclosed herein are methods and devices of processing photoplethysmography signal information. The methods for processing will allow numerous medical observations and diagnoses from a simple, non-invasive probe.

Fused tricyclic dual inhibitors of cdk 4/6 and flt3.

Se describen compuesto de la Fórmula I que son inhibidores útiles de .CDK4, CDK6, y FLT3. Tales compuestos son útiles en el tratamiento del cáncer y varias otras condiciones de enfermedad. Los compuestos de la Fórmula I tienen la siguiente estructura: (ver Fórmula) donde R1 en un grupo de la Fórmula IA, Fórmula IB, Fórmula IC, o Fórmula ID (ver Fórmulas) y las definiciones de las otras variables se proporcionan en la presente.

Internet Content Delivery Management System

A delivery management engine that monitors and controls system Internet content delivery, primarily advertisement, is presented. The system uses automated scripts to track delivery of content and includes a discrepancy reconciliation engine that reconciles delivery counts between multiple server systems. The system includes user encoded business rules that enable automatic adjustments to advertisement campaigns to ensure that a contracted number of deliveries is met. The system avoids both over-delivery and under-delivery of content against a target and therefore optimizes the use of valuable advertising space.

Techniques for performing a restoration operation using device scanning

Described are techniques for performing restoration processing for a data segment. A list of tokens is received. The list represents a first data state of said data segment. Each of the tokens correspond to a data portion of said data segment. Data portions of the data segment are scanned. A token is determined for each data portion. The token represents the data currently stored in said data segment at said each data portion. For each data portion of said data segment, it is determined whether a first token from said list associated with said each data portion is different from a second token associated with said each data portion. The second token is determined as part of said scanning and corresponds to data currently stored at said each data portion. Each data portion of the data segment determined to have a first token that is different from a second token representing data currently stored at said each data portion is restored.

PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR CANCER TREATMENT

La presente invención proporciona compuestos de inhibidor MDM2 de la Fórmula I,en donde las variables se definen arriba, cuyos compuestos son útiles como agentes terapéuticos, particularmente para el tratamiento de cánceres. La presente invención también se refiere a composiciones farmacéuticas que contienen un inhibidor MDM2 .

Systems, devices, and methods for diagnostic aid kit apparatus

An at-home medical diagnostic test kit container including a plurality of at-home medical diagnostic test kits is provided herein. In particular, the medical diagnostic test kit container may include a machine-readable code (e.g., QR code) configured to facilitate an augmented reality experience associated with the at-home medical diagnostic test kit container. In some embodiments, a testing and diagnostic platform may facilitate tracking of inventory within the at-home medical diagnostic test kit container and/or may facilitate coordination of prescription medication order fulfillment and delivery upon indication of a medical condition that could benefit from taking prescription medication.

Systems, devices, and methods for diagnostic aid kit apparatus

An at-home medical diagnostic test kit container including a plurality of at-home medical diagnostic test kits is provided herein. In particular, the medical diagnostic test kit container may include a machine-readable code (e.g., QR code) configured to facilitate an augmented reality experience associated with the at-home medical diagnostic test kit container. In some embodiments, a testing and diagnostic platform may facilitate tracking of inventory within the at-home medical diagnostic test kit container and/or may facilitate coordination of prescription medication order fulfillment and delivery upon indication of a medical condition that could benefit from taking prescription medication.

Systems, devices, and methods for diagnostic aid kit apparatus

An at-home medical diagnostic test kit container including a plurality of at-home medical diagnostic test kits is provided herein. In particular, the medical diagnostic test kit container may include a machine-readable code (e.g., QR code) configured to facilitate an augmented reality experience associated with the at-home medical diagnostic test kit container. In some embodiments, a testing and diagnostic platform may facilitate tracking of inventory within the at-home medical diagnostic test kit container and/or may facilitate coordination of prescription medication order fulfillment and delivery upon indication of a medical condition that could benefit from taking prescription medication.

Health testing and diagnostics platform

Systems and methods for providing a universal platform for at-home health testing and diagnostics are provided herein. In particular, a health testing and diagnostic platform is provided to connect medical providers with patients and to generate a unique, private testing environment. In some embodiments, the testing environment may facilitate administration of a medical test to a patient with the guidance of a proctor. In some embodiments, the patient may be provided with step-by-step instructions for test administration by the proctor within a testing environment. The platform may display unique, dynamic testing interfaces to the patient and proctor to ensure proper testing protocols and accurate test result verification.

Systems, methods, and devices for non-human readable diagnostic tests

Systems and methods for ensuring medical diagnostic test integrity are disclosed. In particular, systems and methods herein can be used to ensure compliance with testing procedures. Some embodiments provide systems and methods for verifying test results. According to some embodiments, test results can be non-human-readable results that can be interpreted by a computing system.

Systems, devices, and methods for diagnostic aid kit apparatus

An at-home medical diagnostic test kit container including a plurality of at-home medical diagnostic test kits is provided herein. In particular, the medical diagnostic test kit container may include a machine-readable code (e.g., QR code) configured to facilitate an augmented reality experience associated with the at-home medical diagnostic test kit container. In some embodiments, a testing and diagnostic platform may facilitate tracking of inventory within the at-home medical diagnostic test kit container and/or may facilitate coordination of prescription medication order fulfillment and delivery upon indication of a medical condition that could benefit from taking prescription medication.

Health testing and diagnostics platform

Systems and methods for providing a universal platform for at-home health testing and diagnostics are provided herein. In particular, a health testing and diagnostic platform is provided to connect medical providers with patients and to generate a unique, private testing environment. In some embodiments, the testing environment may facilitate administration of a medical test to a patient with the guidance of a proctor. In some embodiments, the patient may be provided with step-by-step instructions for test administration by the proctor within a testing environment. The platform may display unique, dynamic testing interfaces to the patient and proctor to ensure proper testing protocols and accurate test result verification.

Systems, methods, and devices for non-human readable diagnostic tests

Systems and methods for ensuring medical diagnostic test integrity are disclosed. In particular, systems and methods herein can be used to ensure compliance with testing procedures. Some embodiments provide systems and methods for verifying test results. According to some embodiments, test results can be non-human-readable results that can be interpreted by a computing system.

Systems, methods, and devices for non-human readable diagnostic tests

Systems and methods for ensuring medical diagnostic test integrity are disclosed. In particular, systems and methods herein can be used to ensure compliance with testing procedures. Some embodiments provide systems and methods for verifying test results. According to some embodiments, test results can be non-human-readable results that can be interpreted by a computing system.

Hand gun holsters

Remote diagnostic testing and treatment

A medical diagnostic kit are described. In one example, a medical diagnostic kit includes a container, and a plurality of medical diagnostic test kits located within the container. Each of the plurality of medical diagnostic test kits can include equipment necessary to perform a particular self-administered medical diagnostic test. The plurality of medical diagnostic test kits can include at least a first medical diagnostic kit adapted to facilitate user completion of a first medical diagnostic test and a second medical diagnostic kit adapted to facilitate user completion of a second medical diagnostic test different from the first medical diagnostic test. The container can include a machine-readable code located on an external surface of the container.

Health testing and diagnostics platform

Systems and methods for providing a universal platform for at-home health testing and diagnostics are provided herein. In particular, a health testing and diagnostic platform is provided to connect medical providers with patients and to generate a unique, private testing environment. In some embodiments, the testing environment may facilitate administration of a medical test to a patient with the guidance of a proctor. In some embodiments, the patient may be provided with step-by-step instructions for test administration by the proctor within a testing environment. The platform may display unique, dynamic testing interfaces to the patient and proctor to ensure proper testing protocols and accurate test result verification.

Remote diagnostic testing and treatment

Systems and methods for facilitating self-administered medical diagnostic tests and receiving treatment based on the results of such tests. In some examples, a user may take a medical diagnostic test under the supervision of a proctor over a video conference connection. The proctor or the system can verify the results of the test. The system can enable treatment based on the results of the test by, for example, facilitating the generation, fulfillment, and delivery of medication.

Health testing and diagnostics platform

Systems and methods for providing a universal platform for at-home health testing and diagnostics are provided herein. In particular, a health testing and diagnostic platform is provided to connect medical providers with patients and to generate a unique, private testing environment. In some embodiments, the testing environment may facilitate administration of a medical test to a patient with the guidance of a proctor. In some embodiments, the patient may be provided with step-by-step instructions for test administration by the proctor within a testing environment. The platform may display unique, dynamic testing interfaces to the patient and proctor to ensure proper testing protocols and accurate test result verification.

Health testing and diagnostics platform

Systems and methods for providing a universal platform for at-home health testing and diagnostics are provided herein. In particular, a health testing and diagnostic platform is provided to connect medical providers with patients and to generate a unique, private testing environment. In some embodiments, the testing environment may facilitate administration of a medical test to a patient with the guidance of a proctor. In some embodiments, the patient may be provided with step-by-step instructions for test administration by the proctor within a testing environment. The platform may display unique, dynamic testing interfaces to the patient and proctor to ensure proper testing protocols and accurate test result verification.

Systems, methods, and devices for remotely deployed diagnostic testing

This disclosure relates to remote medical testing. Embodiments of this disclosure relate to systems, methods, and devices for providing remote medical testing services in developing regions or remote locations. Some embodiments include cost-shifting to enable users of remote medical testing services to shift data costs to a third party. Some embodiments include data transfer protocols for transmitting testing data to a remote server. Some embodiments include remotely-deployable testing apparatuses.

Systems and methods for at-home testing, treatment, and monitoring

According to some aspects, a method for at-home diagnostic testing and treatment can include receiving, from a first data source, forecast information, the forecast information indicating a projected infection trend; receiving, from a second data source, a risk profile; receiving, from a third data source, a selection of one or more individuals; converting the selection of one or more individuals to a format compatible with a fourth data source; requesting, from the fourth data source, health information associated with at least one of the one or more individuals; receiving, from the fourth data source, health information of at least one of the one or more individuals; determining, for each of the one or more individuals, a risk score, wherein the risk score is based at least in part on the health information and the forecast information; and determining that a risk score of an individual meets the risk profile.

Remote diagnostic testing and treatment

Methods and systems for a proctored examination platform that can facilitate self-administration of a medical diagnostic test are described herein. The methods and systems can establish video conference sessions between users and proctors, dynamically verify positive medical diagnostic indicators by analyzing monitored video frame data associated with the video conference sessions, provide user prompts for determining whether users desire to order prescription drugs for treatment responsive to the positive result for the medical diagnostic test, and generate physician prompts for generating a prescription for ordering the prescription drugs for treatment responsive to the positive result for the medical diagnostic test.

Health testing and diagnostics platform

Systems and methods for providing a universal platform for at-home health testing and diagnostics are provided herein. In particular, a health testing and diagnostic platform is provided to connect medical providers with patients and to generate a unique, private testing environment. In some embodiments, the testing environment may facilitate administration of a medical test to a patient with the guidance of a proctor. In some embodiments, the patient may be provided with step-by-step instructions for test administration by the proctor within a testing environment. The platform may display unique, dynamic testing interfaces to the patient and proctor to ensure proper testing protocols and accurate test result verification.

Systems, devices, and methods for diagnostic aid kit apparatus

An at-home medical diagnostic test kit container including a plurality of at-home medical diagnostic test kits is provided herein. In particular, the medical diagnostic test kit container may include a machine-readable code (e.g., QR code) configured to facilitate an augmented reality experience associated with the at-home medical diagnostic test kit container. In some embodiments, a testing and diagnostic platform may facilitate tracking of inventory within the at-home medical diagnostic test kit container and/or may facilitate coordination of prescription medication order fulfillment and delivery upon indication of a medical condition that could benefit from taking prescription medication.

Remote diagnostic testing and treatment

A medical diagnostic kit are described. In one example, a medical diagnostic kit includes a container, and a plurality of medical diagnostic test kits located within the container. Each of the plurality of medical diagnostic test kits can include equipment necessary to perform a particular self-administered medical diagnostic test. The plurality of medical diagnostic test kits can include at least a first medical diagnostic kit adapted to facilitate user completion of a first medical diagnostic test and a second medical diagnostic kit adapted to facilitate user completion of a second medical diagnostic test different from the first medical diagnostic test. The container can include a machine-readable code located on an external surface of the container.

Remote diagnostic testing and treatment

Methods and systems for a proctored examination platform that can facilitate self-administration of a medical diagnostic test are described herein. The methods and systems can establish video conference sessions between users and proctors, dynamically verify positive medical diagnostic indicators by analyzing monitored video frame data associated with the video conference sessions, provide user prompts for determining whether users desire to order prescription drugs for treatment responsive to the positive result for the medical diagnostic test, and generate physician prompts for generating a prescription for ordering the prescription drugs for treatment responsive to the positive result for the medical diagnostic test.

Safety medical swabs

A medical swab for medical diagnostic testing in provided herein. In particular, the medical swab may include a crumple zone configured to crumple, elastically deform, plastically deform, bend, flex, collapse, and/or give when an axial force and/or a radial force is applied to the medical swab. In some embodiments, a stem of the medical swab may retract into or extend from one or more bases. In some embodiments, the medical swab can include a telescoping mechanism configured to control retraction and/or extension of the stem. In some embodiments, the medical swab can include a color changing tip and/or a color changing stem.

Systems, methods, and devices for non-human readable diagnostic tests

Systems and methods for ensuring medical diagnostic test integrity are disclosed. In particular, systems and methods herein can be used to ensure compliance with testing procedures. Some embodiments provide systems and methods for verifying test results. According to some embodiments, test results can be non-human-readable results that can be interpreted by a computing system.

Remote diagnostic testing and treatment

A medical diagnostic kit are described. In one example, a medical diagnostic kit includes a container, and a plurality of medical diagnostic test kits located within the container. Each of the plurality of medical diagnostic test kits can include equipment necessary to perform a particular self-administered medical diagnostic test. The plurality of medical diagnostic test kits can include at least a first medical diagnostic kit adapted to facilitate user completion of a first medical diagnostic test and a second medical diagnostic kit adapted to facilitate user completion of a second medical diagnostic test different from the first medical diagnostic test. The container can include a machine-readable code located on an external surface of the container.

Systems, methods, and devices for remotely deployed diagnostic testing

This disclosure relates to remote medical testing. Embodiments of this disclosure relate to systems, methods, and devices for providing remote medical testing services in developing regions or remote locations. Some embodiments include cost-shifting to enable users of remote medical testing services to shift data costs to a third party. Some embodiments include data transfer protocols for transmitting testing data to a remote server. Some embodiments include remotely-deployable testing apparatuses.

Systems, methods, and devices for diagnostic testing and secure and verified exchange of electronic medical records

A method can include receiving, from a user device of a user, a request for a remote diagnostic test session. A method can include initiate the remote diagnostic test session, the remote diagnostic test session comprising a video conference session. A method can include receive monitored video frame data from the user device, the monitored video frame data comprising video of the user performing a step of a remote diagnostic test procedure. A method can include detect in the monitored video frame data a diagnostic test tool. A method can include determine a bounding box including at least a portion of the diagnostic test tool. A method can include track a movement of the diagnostic test tool. A method can include determine an insertion depth of the diagnostic test tool. A method can include determine completion of a test action by the user.

Remote diagnostic testing and treatment

A medical diagnostic kit are described. In one example, a medical diagnostic kit includes a container, and a plurality of medical diagnostic test kits located within the container. Each of the plurality of medical diagnostic test kits can include equipment necessary to perform a particular self-administered medical diagnostic test. The plurality of medical diagnostic test kits can include at least a first medical diagnostic kit adapted to facilitate user completion of a first medical diagnostic test and a second medical diagnostic kit adapted to facilitate user completion of a second medical diagnostic test different from the first medical diagnostic test. The container can include a machine-readable code located on an external surface of the container.

Remote diagnostic testing and treatment

A medical diagnostic kit are described. In one example, a medical diagnostic kit includes a container, and a plurality of medical diagnostic test kits located within the container. Each of the plurality of medical diagnostic test kits can include equipment necessary to perform a particular self-administered medical diagnostic test. The plurality of medical diagnostic test kits can include at least a first medical diagnostic kit adapted to facilitate user completion of a first medical diagnostic test and a second medical diagnostic kit adapted to facilitate user completion of a second medical diagnostic test different from the first medical diagnostic test. The container can include a machine-readable code located on an external surface of the container.

Remote diagnostic testing and treatment

A medical diagnostic kit are described. In one example, a medical diagnostic kit includes a container, and a plurality of medical diagnostic test kits located within the container. Each of the plurality of medical diagnostic test kits can include equipment necessary to perform a particular self-administered medical diagnostic test. The plurality of medical diagnostic test kits can include at least a first medical diagnostic kit adapted to facilitate user completion of a first medical diagnostic test and a second medical diagnostic kit adapted to facilitate user completion of a second medical diagnostic test different from the first medical diagnostic test. The container can include a machine-readable code located on an external surface of the container.

Remote diagnostic testing and treatment

A medical diagnostic kit are described. In one example, a medical diagnostic kit includes a container, and a plurality of medical diagnostic test kits located within the container. Each of the plurality of medical diagnostic test kits can include equipment necessary to perform a particular self-administered medical diagnostic test. The plurality of medical diagnostic test kits can include at least a first medical diagnostic kit adapted to facilitate user completion of a first medical diagnostic test and a second medical diagnostic kit adapted to facilitate user completion of a second medical diagnostic test different from the first medical diagnostic test. The container can include a machine-readable code located on an external surface of the container.

Remote diagnostic testing and treatment

A medical diagnostic kit are described. In one example, a medical diagnostic kit includes a container, and a plurality of medical diagnostic test kits located within the container. Each of the plurality of medical diagnostic test kits can include equipment necessary to perform a particular self-administered medical diagnostic test. The plurality of medical diagnostic test kits can include at least a first medical diagnostic kit adapted to facilitate user completion of a first medical diagnostic test and a second medical diagnostic kit adapted to facilitate user completion of a second medical diagnostic test different from the first medical diagnostic test. The container can include a machine-readable code located on an external surface of the container.

Health testing and diagnostics platform

Systems and methods for providing a universal platform for at-home health testing and diagnostics are provided herein. In particular, a health testing and diagnostic platform is provided to connect medical providers with patients and to generate a unique, private testing environment. In some embodiments, the testing environment may facilitate administration of a medical test to a patient with the guidance of a proctor. In some embodiments, the patient may be provided with step-by-step instructions for test administration by the proctor within a testing environment. The platform may display unique, dynamic testing interfaces to the patient and proctor to ensure proper testing protocols and accurate test result verification.

Health testing and diagnostics platform

Systems and methods for providing a universal platform for at-home health testing and diagnostics are provided herein. In particular, a health testing and diagnostic platform is provided to connect medical providers with patients and to generate a unique, private testing environment. In some embodiments, the testing environment may facilitate administration of a medical test to a patient with the guidance of a proctor. In some embodiments, the patient may be provided with step-by-step instructions for test administration by the proctor within a testing environment. The platform may display unique, dynamic testing interfaces to the patient and proctor to ensure proper testing protocols and accurate test result verification.

Health testing and diagnostics platform

Systems and methods for providing a universal platform for at-home health testing and diagnostics are provided herein. In particular, a health testing and diagnostic platform is provided to connect medical providers with patients and to generate a unique, private testing environment. In some embodiments, the testing environment may facilitate administration of a medical test to a patient with the guidance of a proctor. In some embodiments, the patient may be provided with step-by-step instructions for test administration by the proctor within a testing environment. The platform may display unique, dynamic testing interfaces to the patient and proctor to ensure proper testing protocols and accurate test result verification.

System and method for laser cavity length control

Systems, methods, and devices for diagnostic testing and secure and verified exchange of electronic medical records

A method can include receiving, from a user device of a user, a request for a remote diagnostic test session. A method can include initiate the remote diagnostic test session, the remote diagnostic test session comprising a video conference session. A method can include receive monitored video frame data from the user device, the monitored video frame data comprising video of the user performing a step of a remote diagnostic test procedure. A method can include detect in the monitored video frame data a diagnostic test tool. A method can include determine a bounding box including at least a portion of the diagnostic test tool. A method can include track a movement of the diagnostic test tool. A method can include determine an insertion depth of the diagnostic test tool. A method can include determine completion of a test action by the user.

System and method for laser cavity length control

A system and method for controlling the cavity length of a ring laser gyroscope to properly tune the resonant wavelengths of the ring laser gyroscope during moments when experiencing sudden shocks or high g force accelerations. The system controls the position of a movable mirror in the laser cavity of the gyroscope to control the length of the laser cavity. The system measures the acceleration experienced by the laser cavity, wherein the position of the movable mirror is adjusted to counteract the effects of the acceleration on the movable mirror in a real-time response to the measured acceleration. By adjusting the position of the movable mirror, the resonant wavelengths propagating in the ring laser gyroscope will be maintained at their desired intensity and continue to lase even after experiencing this acceleration. The system may further include a control servo-loop for providing additional cavity length control in order to maintain the desired intensity of the wavelengths propagating within the gyroscope.

System and method for laser cavity length control

A system and method for controlling the cavity length of a ring laser gyroscope to properly tune the resonant wavelengths of the ring laser gyroscope during moments when experiencing sudden shocks or high g force accelerations. The system controls the position of a movable mirror in the laser cavity of the gyroscope to control the length of the laser cavity. The system measures the acceleration experienced by the laser cavity, wherein the position of the movable mirror is adjusted to counteract the effects of the acceleration on the movable mirror in a real-time response to the measured acceleration. By adjusting the position of the movable mirror, the resonant wavelengths propagating in the ring laser gyroscope will be maintained at their desired intensity and continue to lase even after experiencing this acceleration. The system may further include a control servo-loop for providing additional cavity length control in order to maintain the desired intensity of the wavelengths propagating within the gyroscope.

Systems, devices, and methods for diagnostic aid kit apparatus

An at-home medical diagnostic test kit container including a plurality of at-home medical diagnostic test kits is provided herein. In particular, the medical diagnostic test kit container may include a machine-readable code (e.g., QR code) configured to facilitate an augmented reality experience associated with the at-home medical diagnostic test kit container. In some embodiments, a testing and diagnostic platform may facilitate tracking of inventory within the at-home medical diagnostic test kit container and/or may facilitate coordination of prescription medication order fulfillment and delivery upon indication of a medical condition that could benefit from taking prescription medication.

Systems, devices, and methods for diagnostic aid kit apparatus

An at-home medical diagnostic test kit container including a plurality of at-home medical diagnostic test kits is provided herein. In particular, the medical diagnostic test kit container may include a machine-readable code (e.g., QR code) configured to facilitate an augmented reality experience associated with the at-home medical diagnostic test kit container. In some embodiments, a testing and diagnostic platform may facilitate tracking of inventory within the at-home medical diagnostic test kit container and/or may facilitate coordination of prescription medication order fulfillment and delivery upon indication of a medical condition that could benefit from taking prescription medication.

Systeme, Vorrichtungen und Verfahren für diagnostische Hilfsmittelvorrichtungen

Es wird ein Behälter für medizinische Diagnosetestkits für zu Hause, der eine Vielzahl von medizinischen Diagnosetestkits für zu Hause enthält, bereitgestellt. Insbesondere kann der Behälter für medizinische Diagnosetestkits einen maschinenlesbaren Code (z. B. QR-Code) enthalten, der so konfiguriert ist, dass er ein Augmented-Reality-Erlebnis in Verbindung mit dem Behälter für medizinische Diagnosetestkits für zu Hause ermöglicht. In einigen Ausführungsformen kann eine Test- und Diagnoseplattform die Verfolgung des Bestands innerhalb des Behälters für medizinische Diagnosetestkits für zu Hause erleichtern und/oder die Koordination der Bestellung und Lieferung von verschreibungspflichtigen Medikamenten bei Anzeichen einer Krankheit, die der Einnahme verschreibungspflichtiger Medikamente bedarf, erleichtern.

Systems, devices, and methods for diagnostic aid kit apparatus

An at-home medical diagnostic test kit container including a plurality of at-home medical diagnostic test kits is provided herein. In particular, the medical diagnostic test kit container may include a machine-readable code (e.g., QR code) configured to facilitate an augmented reality experience associated with the at-home medical diagnostic test kit container. In some embodiments, a testing and diagnostic platform may facilitate tracking of inventory within the at-home medical diagnostic test kit container and/or may facilitate coordination of prescription medication order fulfillment and delivery upon indication of a medical condition that could benefit from taking prescription medication.

Safety medical swabs

A medical swab for medical diagnostic testing in provided herein. In particular, the medical swab may include a crumple zone configured to crumple, elastically deform, plastically deform, bend, flex, collapse, and/or give when an axial force and/or a radial force is applied to the medical swab. In some embodiments, a stem of the medical swab may retract into or extend from one or more bases. In some embodiments, the medical swab can include a telescoping mechanism configured to control retraction and/or extension of the stem. In some embodiments, the medical swab can include a color changing tip and/or a color changing stem.

Tire siping machine

Remote diagnostic testing and treatment

A medical diagnostic kit are described. In one example, a medical diagnostic kit includes a container, and a plurality of medical diagnostic test kits located within the container. Each of the plurality of medical diagnostic test kits can include equipment necessary to perform a particular self-administered medical diagnostic test. The plurality of medical diagnostic test kits can include at least a first medical diagnostic kit adapted to facilitate user completion of a first medical diagnostic test and a second medical diagnostic kit adapted to facilitate user completion of a second medical diagnostic test different from the first medical diagnostic test. The container can include a machine-readable code located on an external surface of the container.

Bread-board.

Systems, devices, and methods for diagnostic aid kit apparatus

An at-home medical diagnostic test kit container including a plurality of at-home medical diagnostic test kits is provided herein. In particular, the medical diagnostic test kit container may include a machine-readable code (e.g., QR code) configured to facilitate an augmented reality experience associated with the at-home medical diagnostic test kit container. In some embodiments, a testing and diagnostic platform may facilitate tracking of inventory within the at-home medical diagnostic test kit container and/or may facilitate coordination of prescription medication order fulfillment and delivery upon indication of a medical condition that could benefit from taking prescription medication.

Systems and methods for at-home testing, treatment, and monitoring

According to some aspects, a method for at-home diagnostic testing and treatment can include receiving, from a first data source, forecast information, the forecast information indicating a projected infection trend; receiving, from a second data source, a risk profile; receiving, from a third data source, a selection of one or more individuals; converting the selection of one or more individuals to a format compatible with a fourth data source; requesting, from the fourth data source, health information associated with at least one of the one or more individuals; receiving, from the fourth data source, health information of at least one of the one or more individuals; determining, for each of the one or more individuals, a risk score, wherein the risk score is based at least in part on the health information and the forecast information; and determining that a risk score of an individual meets the risk profile.