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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 11. Отображено 10.
02-01-2020 дата публикации

SYSTEMS AND METHODS FOR TREATING CANCER

Номер: US20200000808A1
Автор: Inge Landon J., JR. Timothy G., Whitsett
Принадлежит:

Embodiments of the invention provide a method of treating cancer, the method comprising providing a subject having cancer cells, and contacting the cancer cells with a therapeutically effective amount of a G2/M checkpoint inhibitor. Embodiments of the invention also provide a method of treating cancer in a subject, the method comprising the steps of: (a) receiving a sample of the cancer cells from the subject; (b) determining if at least a portion of the sample of the cancer cells is LKB1 deficient; and (c) contacting the cancer cells with a therapeutically effective amount of a G2/M checkpoint inhibitor. Embodiments of the invention also provide a method of treating cancer in a subject, the method comprising contacting the cancer cells with a therapeutically effective amount of a Wee1 inhibitor and a therapeutically effective amount of a second pharmaceutical composition. Embodiments of the invention also provide a method of prognosing or determining the severity of cancer in a subject comprising (a) determining the presence or absence of LKB1 in the cancer cells of the subject; and (b) prognosing the severity of cancer based on the presence of LKB1 deficiency in the cancer cells of the subject. 1. A method of treating adenocarcinoma in a subject , wherein the adenocarcinoma cells are LKB1 deficient , the method comprising the steps of contacting the LKB1 deficient adenocarcinoma cells with a therapeutically effective amount of a Wee1 kinase inhibitor.2. The method of claim 1 , wherein the adenocarcinoma is lung cancer.3. The method of claim 2 , wherein the lung cancer is non-small cell lung cancer.4. The method of claim 1 , wherein the Wee1 kinase inhibitor is AZD1775.5. The method of and further comprising contacting the LKB1 deficient adenocarcinoma cells with a therapeutically effective amount of a second pharmaceutical composition.6. The method of claim 5 , wherein the second pharmaceutical composition comprises at least one of the following: a DNA-damaging ...

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Номер записи: 1
16-05-2019 дата публикации

SYSTEM AND METHOD FOR DETERMINING FILL VOLUME IN A CONTAINER

Номер: US20190145955A1
Автор: Bachur, Foley, Jr. Nicholas R., JR. Timothy G.
Принадлежит: BECTON DICKINSON AND COMPANY

A system and method for detecting a pathogen in a sample is provided, the system capable of measuring the volume of a sample in a container through the use of various measurement technologies, thereby ensuring that a user is aware of volumes not meeting specification and/or allowing correction of results to account for the out-of-specification sample. 125-. (canceled)26. A system for detecting a pathogen in a sample , comprising a plurality of sample containers comprising a growth medium and adapted to receive a biological fluid sample; an incubation and measurement module comprising a plurality of individual openings , each opening adapted to receive one of the plurality of sample containers; a weight variation sensor , separate from or part of said incubation and measurement module , the weight variation sensor adapted to determine a sample volume in said sample containers; and one or more interfaces adapted to perform one or more tasks selected from the group consisting of: (a) notifying a user if said sample containers are not within predetermined sample volume specifications , (b) accepting instructions on subsequent handling of said sample containers that are not within predetermined sample volume specifications , and (c) prompting user to place said sample container into a test rack of said incubation and measurement module if sample volume is within sample volume specification wherein the weight variation sensor: i) determines a prior container weight , wherein the prior container weight is a container weight before the sample is added thereto; ii) stores the prior container weight; iii) determines a sample container weight after the sample is added to the sample container; iv) subtracts the prior container weight from the sample container weight to obtain a weight difference; and iv) calculates a sample volume from the weight difference.27. The system of wherein said weight variation sensor is part of said incubation and measurement module.28. The system of ...

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Номер записи: 2
05-07-2018 дата публикации

Systems and methods for treating cancer

Номер: US20180185371A1
Автор: Landon J. Inge, Timothy G. Whitsett, Jr.
Принадлежит: DIGNITY HEALTH, Translational Genomics Research Institute TGen

Embodiments of the invention provide a method of treating cancer, the method comprising providing a subject having cancer cells, and contacting the cancer cells with a therapeutically effective amount of a G2/M checkpoint inhibitor. Embodiments of the invention also provide a method of treating cancer in a subject, the method comprising the steps of: (a) receiving a sample of the cancer cells from the subject; (b) determining if at least a portion of the sample of the cancer cells is LKB 1 deficient; and (c) contacting the cancer cells with a therapeutically effective amount of a G2/M checkpoint inhibitor.

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Номер записи: 3
19-08-2021 дата публикации

Systems and methods for treating cancer

Номер: US20210251998A1
Автор: Landon J. Inge, Timothy G. Whitsett, Jr.
Принадлежит: DIGNITY HEALTH, Translational Genomics Research Institute TGen

Embodiments of the invention provide a method of treating cancer, the method comprising providing a subject having cancer cells, and contacting the cancer cells with a therapeutically effective amount of a G2/M checkpoint inhibitor. Embodiments of the invention also provide a method of treating cancer in a subject, the method comprising the steps of: (a) receiving a sample of the cancer cells from the subject; (b) determining if at least a portion of the sample of the cancer cells is LKB1 deficient; and (c) contacting the cancer cells with a therapeutically effective amount of a G2/M checkpoint inhibitor. Embodiments of the invention also provide a method of treating cancer in a subject, the method comprising contacting the cancer cells with a therapeutically effective amount of a Wee1 inhibitor and a therapeutically effective amount of a second pharmaceutical composition. Embodiments of the invention also provide a method of prognosing or determining the severity of cancer in a subject comprising (a) determining the presence or absence of LKB1 in the cancer cells of the subject; and (b) prognosing the severity of cancer based on the presence of LKB1 deficiency in the cancer cells of the subject.

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Номер записи: 4
29-09-2016 дата публикации

SYSTEM AND METHOD FOR DETERMINING FILL VOLUME IN A CONTAINER

Номер: US20160282330A1
Автор: Bachur, Foley, Jr. Nicholas R., JR. Timothy G.
Принадлежит: BECTON, DICKINSON AND COMPANY

A system and method for detecting a pathogen in a sample is provided, the system capable of measuring the volume of a sample in a container through the use of various measurement technologies, thereby ensuring that a user is aware of volumes not meeting specification and/or allowing correction of results to account for the out-of-specification sample. 1. A method for the detection of a pathogen in a biological fluid sample comprising the steps of;determining the volume of said sample in a sample container comprising said sample and a growth medium,incubating said sample, andmonitoring one or more parameters in said incubated sample indicative of growth of said pathogen.2. The method of wherein the incubating step comprises;placing said container in an incubation and measurement module.3. The method of wherein the step of determining the volume of said sample comprises;placing said container in a sample volume sensor separate from said incubation and measurement module.4. The method of wherein the step of determining the volume of said sample comprises;placing said container in a sample volume sensor disposed on or within said incubation and measurement module.5. The method of wherein the step of determining the volume of said sample comprises;measuring the height of the sample in the container, andcalculating the sample volume from said sample height measurement.6. The method of wherein said sample height is measured by ultrasonic reflectometry.7. The method of wherein said sample height is measured by a laser displacement sensor.8. The method of wherein said sample height is measured by a through beam optical sensor.9. The method of wherein said sample height is measured by a laser scanning photodiode array.10. The method of wherein said sample height is measured by a refractive index claim 5 , internal reflection apparatus.11. The method of wherein said sample height is measured by a retro-reflective optical detection apparatus.12. The method of wherein said ...

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Номер записи: 5
28-05-2002 дата публикации

Device for monitoring cells

Номер: US6395506B1
Автор: David T. Stitt, Gregory J. Burrell, J. Bruce Pitner, John Jacob Hemperly, Magdalena Wodnicka, Patrick Shawn Beaty, Richard D. Guarino, Timothy G. Foley, Jr.
Принадлежит: Becton Dickinson and Co

The present invention relates to methods for detection and evaluation of metabolic activity of eukaryotic and/or prokaryotic cells based upon their ability to consume dissolved oxygen. The methods utilize a luminescence detection system which makes use of the sensitivity of the luminescent emission of certain compounds to the presence of oxygen, which quenches (diminishes) the compound's luminescent emission in a concentration dependent manner. Respiring eukaryotic and/or prokaryotic cells will affect the oxygen concentration of a liquid medium in which they are immersed. Thus, this invention provides a convenient system to gather information on the presence, identification, quantification and cytotoxic activity of eukaryotic and/or prokaryotic cells by determining their effect on the oxygen concentration of the media in which they are present.

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Номер записи: 6
31-05-2005 дата публикации

Device for monitoring cells

Номер: US6900030B2
Автор: David T. Stitt, Gregory J. Burrell, J. Bruce Pitner, John Jacob Hemperly, Magdalena Wodnicka, Patrick Shawn Beaty, Richard D. Guarino, Timothy G. Foley, Jr.
Принадлежит: Becton Dickinson and Co

The present invention relates to methods for detection and evaluation of metabolic activity of eukaryotic and/or prokaryotic cells based upon their ability to consume dissolved oxygen. The methods utilize a luminescence detection system which makes use of the sensitivity of the luminescent emission of certain compounds to the presence of oxygen, which quenches (diminishes) the compound's luminescent emission in a concentration dependent manner. Respiring eukaryotic and/or prokaryotic cells will affect the oxygen concentration of a liquid medium in which they are immersed. Thus, this invention provides a convenient system to gather information on the presence, identification, quantification and cytotoxic activity of eukaryotic and/or prokaryotic cells by determining their effect on the oxygen concentration of the media in which they are present.

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Номер записи: 7
05-10-2006 дата публикации

An improved system and method for stirring suspended solids in liquid media

Номер: WO2006104962A1
Автор: Alexander W. Clark, Daniel Schwarz, David A. Lentz, Dwight Livingston, Michael R. Walters, Miroslaw Bartkowiak, Nicholas R. Bachur, Jr., Paul R. Hansen, Shawn P. Beaty, Timothy G. Foley, Jr.
Принадлежит: BECTON, DICKINSON AND COMPANY

A system comprising one or more sample vessels is provided, the sample vessels comprising a liquid growth medium and a stirrer element, the stirrer element capable of being influenced by a magnetic force, and an incubation and measurement module comprising one or more openings for holding the one or more sample vessels. The incubation and measurement module further comprises at least two drive magnets associated with each of the sample vessels, and a magnet driver adapted to repeatedly move each of the at least two drive magnets toward and away from the surface of the associated sample vessel.

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Номер записи: 8
12-12-2007 дата публикации

An improved system and method for stirring suspended solids in liquid media

Номер: EP1864141A1
Автор: Alexander W. Clark, Daniel Schwarz, David A. Lentz, Dwight Livingston, Michael R. Walters, Miroslaw Bartkowiak, Nicholas R. Bachur, Jr., Paul R. Hansen, Shawn P. Beaty, Timothy G. Foley, Jr.
Принадлежит: Becton Dickinson and Co

A system comprising one or more sample vessels is provided, the sample vessels comprising a liquid growth medium and a stirrer element, the stirrer element capable of being influenced by a magnetic force, and an incubation and measurement module comprising one or more openings for holding the one or more sample vessels. The incubation and measurement module further comprises at least two drive magnets associated with each of the sample vessels, and a magnet driver adapted to repeatedly move each of the at least two drive magnets toward and away from the surface of the associated sample vessel.

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Номер записи: 9
20-10-2009 дата публикации

System and method for determining fill volume in a container

Номер: US7604985B2
Автор: Nicholas R. Bachur, Jr., Timothy G. Foley, Jr.
Принадлежит: Becton Dickinson and Co

A system and method for detecting a pathogen in a sample is provided, the system capable of measuring the volume of a sample in a container through the use of various measurement technologies, thereby ensuring that a user is aware of volumes not meeting specification and/or allowing correction of results to account for the out-of-specification sample.

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Номер записи: 10