30-01-2014 дата публикации
Номер: US20140031317A1
The present invention is directed to a novel 2-substituted benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor. 2. A compound as in claim 1 , wherein{'sup': '1', 'sub': 2', '2-4', '2', '2-4', '2', '2', '2', '3', '2, 'Ris selected from the group consisting of hydrogen, lower alkyl, (lower alkyl)-CN, —(CH)—(Calkenyl), —(CH)—(Calkynyl), fluorinated lower alkyl, —(CH)-heteroaryl, —(CH)-aryl, —(CH)-(fluorinated lower alkyl), -(lower alkyl)-C(O)—O-(lower alkyl), -(lower alkyl)-O-(lower alkyl), and —(lower alkyl)-O—Si(CH)(t-butyl);'}{'sup': 2', '3', 'A', 'B', 'A', 'A, 'Rand Rare each independently selected from the group consisting of halogen, hydroxy, carboxy, lower alkyl, halogen substituted lower alkyl, cyano, nitro, amino, lower alkylamino, di(lower alkyl)amino, —C(O)-(lower alkyl), —C(O)-(lower alkoxy), —C(O)—NRR, —N(R)—C(O)-(lower alkyl) and —N(R)—C(O)-(halogen substituted lower alkyl);'}{'sup': A', 'B, 'wherein each Rand Ris independently selected from hydrogen methyl or ethyl;'}{'sup': '4', 'sub': 2-4', '2-4, 'Ris selected from the group consisting of alkenyl, alkynyl, aryl, —(Calkyl)-aryl, heteroaryl and —(Calkyl)-heteroaryl;'}{'sup': E', 'F', 'E', 'E', 'F, 'wherein the alkenyl or alkynyl is optionally substituted with one substituent selected from the group consisting of halogen, hydroxy, carboxy, cyano, nitro, NRR, NR—C(O)-lower alkyl and phenyl; wherein Rand Rare each independently selected from hydrogen or lower alkyl; and wherein the phenyl is optionally substituted with one to two substituents independently selected from the group consisting of halogen, lower alkyl, lower alkoxy, hydroxy, carboxy, cyano, nitro, amino, (lower alkyl)amino and di(lower alkyl) amino;'}{'sup': C', 'D', 'B', 'C', 'C', 'D, 'wherein the aryl or heteroaryl, whether alone or as part of a substituent group is optionally substituted with one to two substituents selected from ...
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