PROCEDURE FOR ENANTIOSELEKTIVEN THE HYDROGENATION THE CARBONYLGRUPPE USING RUTHENIUM COMPLEXES WITH BIPHOSPHINELIGANDEN

CHIRALE OF PHOSPHINIGSÄURE BORANE DERIVATIVES, YOUR PRODUCTION AND USE.

WITH BORON KOMPLEXIERTE ORGANIC PHOSPHORUS CONNECTIONS.

PROCESS AND INTERMEDIATES FOR PREPARING PHOSPHINOUS ACID DERIVATIVES

L'invention concerne un produit chimique, constitué par un composé organique du phosphore, de constitution: où Q est un atome de N ou de O, T est un alkylène ou arylène, pouvant porter des substituants, ou bien n'existe pas, tandis que R1 à R7, semblables ou différents, sont des H ou des radicaux hydrocarbonés, aliphatiques, cycloaliphatiques ou/et aryliques, éventuellement substitués, R3 n'existant pas lorsque Q est oxygène. Ce produit est notamment utilisé comme intermédiaire dans la préparation de différents dérivés de l'acide phosphineux. L'invention concerne en outre un procédé pour la préparation de ce produit.

CYCLIC PHOSPHONITE, PREPARATION AND CHEMICAL USE.

CYCLIC [...], THEIR PREPARATION AND THEIR USE FOR OBTAINING BISPHOSPHONATES.

Perfectionnement à la préparation de catalyseurs chiraux à base de complexes du ruthénium et du phosphore.

Procédé de préparation d'un catalyseur chiral, constitué par un complexe organique du ruthénium et du phosphore, qui comprend le chauffage d'un complexe de ruthénium avec une phosphine, au sein d'un liquide organique, inerte vis-à-vis des substances en présence, le complexe chauffé étant à base d'un diène et d'un composé allylique; le produit obtenu à la suite de ce chauffage est soumis à l'action d'un acide dans un solvant organique.

Hydrogenizing process of organic compounds and catalysts with ruthenium for its realization

A method for hydrogenating ethylenically unsatured organic compounds is disclosed. This method is implemented in a homogenous medium containing a hydrogenation catalyser formed by a complex of ruthenium with a phosphine, which comprises two allylic groups as Ru ligands.

VERFAHREN ZUR ENANTIOSELEKTIVEN HYDRIERUNG DER CARBONYLGRUPPE UNTER VERWENDUNG VON RUTHENIUM KOMPLEXEN MIT BIPHOSPHINELIGANDEN

IMPROVEMENT WITH THE PRODUCTION OF CHIRALEN CATALYSTS ON BASIS OF RUTHENIUM AND PHOSPHORUS COMPLEXES.

PROCEDE POUR LA PREPARATION DE DIPHOSPHONITES CYCLIQUES, LES DIPHOSPHONITES OBTENUS ET LEUR APPLICATION

L'invention concerne un procédé pour la préparation de composés organiques renfermant un hétérocycle au phosphore, de type phosphonite, dans lequel l'atome de phosphore est lié d'une part à un atome d'oxygène et, d'autre part, à un atome d'oxygène, de soufre ou d'azote, lesdits composés comportant deux de tels hétérocycles, les deux atomes de phosphore étant reliés par un groupe hydrocarboné, caractérisé en ce que l'on fait agir une tétrahalogéno-diphosphine ou une tétramino-diphosphine sur un diol, alcool-phénol, alcool-thiol, alcool-énol, alcoolacide ou amino-alcool, la réaction étant réalisée en présence d'une base dans le cas d'une tétrahalogénodiphosphine. L'invention concerne également les composés organiques obtenus par la mise en oeuvre dudit procédé. Ces composés sont utiles pour la production d'autres dérivés organiques à 2 atomes de P, en particulier pour celle de diphosphinates, diphosphinamides et oxydes de diphosphines.

MIT BOR KOMPLEXIERTE ORGANISCHE PHOSPHOR-VERBINDUNGEN.

ORGANIC COMPOUNDS OF PHOSPHORUS COMPLEXED BY BORON

Composés organiques du phosphore, constitués par des hétéro- phosphacycloalcanes dont l'atome de phosphore forme un complexe avec un borane. Ils peuvent être préparés par l'action d'un borane sur un hétéro-phosphacycloalcane, au sein d'un solvant, entre -20.degree. et +60.degree.C. Leur transformation en d'autres dérivés, en particulier en phosphinites ou phosphines peut se faire sans perte de la chiralité du complexe initial. Une application particulièrement utile est leur conversion en phosphines optiquement très actives, employées notamment comme catalyseurs de diverses réactions.</ SDOAB> Organic phosphorus compounds, consisting of hetero-phosphacycloalkanes, the phosphorus atom of which forms a complex with a borane. They can be prepared by the action of a borane on a hetero-phosphacycloalkane, in a solvent, between -20.degree. and + 60.degree.C. Their transformation into other derivatives, in particular phosphinites or phosphines can be done without loss of the chirality of the initial complex. A particularly useful application is their conversion into optically very active phosphines, used in particular as catalysts for various reactions. </ SDOAB>

Chirale Phosphinigsäure-Borane-Derivate, ihre Herstellung und Verwendung.

VERFAHREN ZUR HERSTELLUNG VON DERIVATEN PHOSPHINISCHER SAEURE UND ZWISCHENPRODUKTE DAFUER.

NEW CYCLIC PHOSPHONITES, THEIR PREPARATION AND USES

CYCLIC DIPHOSPHONITES, THEIR PREPARATION AND USES

PHOSPHONITES CYCLIQUES, LEUR PREPARATION ET APPLICATIONS

L'invention concerne un procédé pour la préparation de phosphonite cyclique de formule (1): (1) <IMG> où Z désigne O, S, NH ou NH dont l'H est remplacé par un radical aliphatique ou arylique ou/et par un halogène, nitro, nitrile, amido, ester, éther ou lactone, R, R1 et R2, semblables ou différents, sont des H ou des alkyles, alkényles, cycloalkyles ou aryle, non-substitués ou substitués par un ou des substituants halogènes, nitro, nitriles, amido, ester, éther, acétal ou lactone; Y est une liaison simple, une chaîne aliphatique ou un cycle aliphatique ou arylique; Q est un groupe <IMG> , un cycle aliphatique ou arylique, un métallocène ou un groupe contenant un O, S ou N; et la molécule présente une dissymétrie par rapport à un plan perpendiculaire au plan de la formule, passant par R, P et Y; caractérisé en ce que le rapport entre la masse moléculaire M1 de la partie de la molécule située d'un coté dudit plan, et la masse moléculaire M2 de la partie de la molécule située de l'autre côté de ce plan, est d'au moins 3 ou non supérieure à 1/3. L'invention concerne également les phosphonites obtenus ainsi que leur application à la production de phosphinates et d'oxydes de phosphine correspondants.

PREPARATION OF CHIRAL CATALYSTS BASED ON RUTHENIUM AND PHOSPHORUS COMPLEXES

... 2064870 9102588 PCTABS00003 Method for the preparation of a chiral catalyst, comprised of an organic complex of ruthenium and phosphorus, consisting in heating a complex of ruthenium with a phosphine, within an organic liquid, inert in relation to substances in presence, the heated complex being based on a diene and an allylic compound; the product obtained following the heating is subjected to the action of an acid in an organic solvant.

CHIRAL PHOSPHINITE-BORANES AND THEIR PREPARATION AND USE

The present invention relates, by way of novel industrial products, to the phosphinite-borane com-pounds of the general formula (see formula I) in which R1 and R2, which are identical or different, are each a C1-C18-alkyl group, a C5-C18-cycloalkyl group, a C7-C18-aralkyl group or a C6-C14-aryl group, it being possible for each of these groups to carry functional groups, R3 is a C1-C18-alkyl, C5-C18-cycloalkyl, C7-C18-aralkyl, C6-C14-aryl, C1-C18-alkoxy, C7-C18-cyclo-alkoxy, C7-C18-aralkoxy or C6-C14-aryloxy group, and Z is a bridge linking the two phosphorus atoms, said bridge being (i) a hydrocarbon chain having from 1 to 12 catenary C atoms, or (ii) a heterohydrocarbon chain containing from 2 to 12 catenary C atoms and at least one catenary heteroatom selected from O, S, Si, P and N, with the further condition that (i) Z is other than CH2 when R1 - phenyl and R2 = R3 = methyl simul-taneously, and (ii) Z is other than CH2CH2 when R1 = phenyl, R2 = methyl and R3 = methoxy simultaneously. These products are useful in the synthesis of chiral diphosphine compounds.

ORGANIC COMPOUNDS OF PHOSPHORUS COMPLEXED BY BORON

Composés organiques du phosphore, constitués par des hétéro- phosphacycloalcanes dont l'atome de phosphore forme un complexe avec un borane. Ils peuvent être préparés par l'action d'un borane sur un hétéro-phosphacycloalcane, au sein d'un solvant, entre -20.degree. et +60.degree.C. Leur transformation en d'autres dérivés, en particulier en phosphinites ou phosphines peut se faire sans perte de la chiralité du complexe initial. Une application particulièrement utile est leur conversion en phosphines optiquement très actives, employées notamment comme catalyseurs de diverses réactions.

Cyclic diphosphonites, their preparation and uses

Organic compounds containing a phosphorus heterocycle of the phosphonite type, in which the phosphorus atom is connected on the one hand to an oxygen atom and on the other hand to an oxygen, sulphur or nitrogen atom, comprising two of such heterocycles, the two phosphorus atoms being connected by a hydrocarbon group, are prepared by the action of a tetrahalogeno- or tetramino-diphosphines upon diols or alcohols carrying a phenol, thiol, enol, acid or amine function. The new products may be used in the production of other organic derivatives having two P atoms, in particular diphosphinates, diphosphinamides and diphosphine oxides. The compounds may be of the formula:- wherein Z is an O or S atom or an NH or substituted NH group, R<1> and R<2> are the same or different and each is an H atom or an alkyl, alkenyl, cycloalkyl or aryl group, R is a divalent hydrocarbon group, Y is a simple bond, an aliphatic chain or an aliphatic or aryl ring, Q is a group, an aliphatic ring or ...

PROCESS FOR PREPARING PHOSPHINAMIDES; USES AND NEW PRODUCTS

Des phosphinamides sont préparés par l'action d'un halogénure organique sur une oxazaphospholidine. Selon la configuration, désirée pour le stéréoisomère à obtenir, on utilise une oxazaphospholidine issue d'un aminoalcool optiquement actif (+) ou (-). Ces phosphinamides sont utiles à la préparation de phosphinates, en particulier de phosphinates optiquement actifs, de configuration absolue, connue; pour cela le phosphinamide est soumis à l'alcoolyse.

A method of enantioselective hydrogenation of the double bond C=O OXO

An enantioselective method for the catalytic hydrogenation of the secondary alcohol function ketone C=O bond. The method uses a neutral ruthenium complex as the catalyst and a compound with a C=O functionality as the substrate to be hydrogenated, and is characterized in that it includes the hydrogenation of the substrate of a diallyl compound of (diphosphino)ruthenium of formula (I), wherein al is preferably CH2CH=CH2 or CH2C(CH3)=CH2, Q is a hydrocarbon bridge with at least two catenary carbon atoms and possibly 1-4 catenary heteroatoms selected from O, S, N and Si, and each of R<1>-R<4>, which are the same or different, is a C1-18 alkyl, C5-7 cycloalkyl or C6-12 aryl group.

PROCESS FOR THE HYDROGENATION OF ETHYLENICALLY (UNSATURATED ORGANIC COMPOUNDS, AND RUTHENIUM CATALYSTS TO EFFECT IT

... 2099280 9212110 PCTABS00130 La présente invention a trait à un procédé d'hydrogénation de composés organiques éthyléniquement insaturés. Ce procédé est mis en oeuvre dans un milieu homogène contenant un catalyseur d'hydrogénation formé par un complexe de ruthénium avec une phosphine, qui comprend deux groupes allyliques en tant que ligands du Ru.

CHIRAL PHOSPHINITE-BORANES AND THEIR PREPARATION AND USE

The present invention relates, by way of novel industrial products, to the phosphinite-borane compounds of the general formula (Io) in which R1 and R2, which are identical or different, are each a C1-C18-alkyl group, a C5-C18-cycloalkyl group, a C7-C18-aralkyl group or a C6-C14-aryl group, it being possible for each of these groups to carry functional groups, R3 is a C1-C18-alkyl, C5-C18-cycloalkyl, C7C18-aralkyl, C6-C14-aryl, C1-C18-alkoxy, C7-C18-cyclo-alkoxy, C7-C18-aralkoxy or C6-C14-aryloxy group, and Z is a bridge linking the two phosphorus atoms, said bridge being (i) a hydrocarbon chain having from 1 to 12 catenary C atoms, or (ii) a heterohydrocarbon chain containing from 1 to 12 catenary C atoms and at least one catenary heteroatom selected from 0, S, Si, P and N, with the further condition that (i) Z is other than CH2 when R1 = phenyl and R2 = R3 = methyl simultaneously, and (ii) Z is other than CH2CH2 when R1 = phenyl, R2 = methyl and R3 = methoxy simultaneously. These products ...

chiral Phosphinite-boranes, their preparation and applications

Synthèse et applications de phosphinite-boranes pour la préparation de diphosphines. Nouveaux composés organiques renfermant deux atomes de phosphores complexés chacun à un groupe borane, et liés entre eux par une chaîne carbonée porteur ou non d'hétéroatome O,S,P,Si... Applications des nouveaux produits à la production d'autres dérivés organiques à deux atomes de phosphore ou plus, en particulier diphosphines.

PROCESS FOR ENANTIOSELECTIVE HYDROGENATION OF THE OXO C=O DOUBLE BOND

... 2139361 9401390 PCTABS00030 An enantioselective method for the catalytic hydrogenation of the secondary alcohol function ketone C=O bond. The method uses a neutral ruthenium complex as the catalyst and a compound with a C=O functionality as the substrate to be hydrogenated, and is characterized in that it includes the hydrogenation of the substrate of a diallyl compound of (diphosphino)ruthenium of formula (I), wherein al is preferably CH2CH=CH2 or CH2C(CH3)=CH2, Q is a hydrocarbon bridge with at least two catenary carbon atoms and possibly 1-4 catenary heteroatoms selected from O, S, N and Si, and each of R1-R4, which are the same or different, is a C1-18 alkyl, C5-7 cycloalkyl or C6-12 aryl group.

New cyclic phosphonites, their preparation and uses

Cyclic phosphonites, in which one of the oxygen atoms of the ring can be replaced by an atom of sulphur or nitrogen, the molecule of which has an asymmetry due to at least two carbon atoms, one or more nitrogen and/or oxygen atoms or several of these elements together, may be prepared by the reaction of dihalogeno-phosophines with compounds having two active H atoms, in the presence of a hydracid acceptor. …The phosphonites may be used in the production of the corresponding phosphinates and phosphine oxides. The phosphonite may be of the formula:… …… wherein Z is an O or S atom or an NH or substituted NH group, R, R<1> and R<2> are the same or different and each is an H atom or an alkyl, alkenyl, cycloalkyl or aryl group, Y is a simple bond, an aliphatic chain or an aliphatic or aryl ring, Q is a… …… group, an aliphatic or aryl ring, a metallocene or a group containing an O, S or N atom, and wherein the molecule has an asymmetry with respect to a plane, perpendicular to ...

VERFAHREN ZUR HYDRIERUNG VON OLEFINISCHEN UNGESÄTTIGTEN VERBINDUNGEN UD RUTHENIUM-KATALYSATOREN ZU IHRER DURCHFÜHRUNG.

Cyclische Phosphonite, Verfahren zu deren Herstellung und ihre Verwendung

CYCLISCHE DIPHOSPHONITE, VERFAHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG

Chirale Phosphinigsäure-Borane-Derivate, ihre Herstellung und Verwendung.

LINOLEIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITION OR FOOD COMPOSITION COMPRISING SAID LINOLEIC ACID DERIVATIVES, AND THEIR USES

Disclosed is a linoleic acid derivative of Formula (I) below including a hydrophobic part CHlinked to a polar head part “A”: 2. The linoleic acid derivative according to claim 1 , having a molecular weight ranging from about 300 to about 600 g/mol.3. The linoleic acid derivative according to claim 1 , wherein in A claim 1 , Rand Rare a saturated or unsaturated claim 1 , straight or branched alkyl group containing 1 to 2 carbon atoms claim 1 , or a pharmaceutically/food quality acceptable salt thereof.7. The linoleic acid derivative according to claim 1 , wherein in A claim 1 , Ris H claim 1 , Ris —COCHand Ris H claim 1 , or a pharmaceutically/food quality acceptable salt thereof.8. The linoleic acid derivative according to claim 1 , wherein in A claim 1 , Ris H claim 1 , Ris CH claim 1 , and Ris H claim 1 , or a pharmaceutically/food quality acceptable salt thereof.10. A pharmaceutical composition or food composition comprising claim 1 , respectively claim 1 ,{'claim-ref': {'@idref': 'CLM-00009', 'claim 9'}, 'at least one pharmaceutically acceptable carrier and at least one linoleic acid derivative according to , or'}{'claim-ref': {'@idref': 'CLM-00009', 'claim 9'}, 'at least one food ingredient and/or at least one food additive and at least one linoleic acid derivative according to .'}11. A method for treatment of a disorder modulated by the GPR120 receptor and/or the CD36 receptor claim 1 , comprising administering to a subject in need thereof a therapeutically effective amount of said linoleic acid derivative of .12. The method according to claim 11 , wherein the disorder modulated by the GPR120 receptor and/or the CD36 receptor is selected from the group consisting of diabetes claim 11 , hyperglycemia claim 11 , impaired glucose tolerance claim 11 , gestational diabetes claim 11 , insulin resistance claim 11 , hyperinsulinemia claim 11 , retinopathy claim 11 , neuropathy claim 11 , nephropathy claim 11 , diabetic kidney disease claim 11 , acute kidney injury ...

CYCLISCHE PHOSPHONITE, VERFAHREN ZU DEREN HERSTELLUNG UND IHRE VERWENDUNG

Cyclische Diphosphonite, Verfahren zu deren Herstellung und Verfahren zur Herstellung von Diphosphinat- und Diphosphinoxid-Derivaten

VERBESSERUNG BEI DER HERSTELLUNG VON CHIRALEN KATALYSATOREN AUF BASIS VON RUTHENIUM- UND PHOSPHORKOMPLEXEN.

P-chirogenic organophosphorus compounds

Novel P-chirogenic organophosphorus compounds of general formula (I), a process for the synthesis of the compounds of formula (I), and intermediate products of general formulae (II), (III) and (IV), as shown below, are involved in the synthesis of compounds (I). Metal complexes including compounds (I) as ligands are also described. The novel compounds and complexes are useful in asymmetric catalysis by transition metal complexes or organocatalysis, especially for asymmetric hydrogenation or allylation. Compounds of general formula (I) may be useful as agrochemical and therapeutic substances, or as reagents or intermediates for fine chemistry.

Versatile and stereospecific synthesis of ,-unsaturated amino acids by Wittig reaction

The ,-unsaturated -amino acids of general formula (I). Also, a versatile process for the stereospecific synthesis of said compounds of formula (I), involving a Wittig reaction. Further, intermediate products of general formulae (II) and (III), as shown below, which are involved in the synthesis of compounds (I). Compounds of general formula (I) may be useful as therapeutic substances, or as reagents or intermediates for fine chemistry.

MIT BOR KOMPLEXIERTE ORGANISCHE PHOSPHOR-VERBINDUNGEN.

VERFAHREN ZUR HYDRIERUNG VON OLEFINISCHEN UNGESÄTTIGTEN VERBINDUNGEN UD RUTHENIUM-KATALYSATOREN ZU IHRER DURCHFÜHRUNG.

PROCESS FOR PREPARING PHOSPHINAMIDES, APPLICATIONS AND PRODUCTS

VERBESSERUNG BEI DER HERSTELLUNG VON CHIRALEN KATALYSATOREN AUF BASIS VON RUTHENIUM- UND PHOSPHORKOMPLEXEN.

VERFAHREN ZUR ENANTIOSELEKTIVEN HYDRIERUNG DER CARBONYLGRUPPE UNTER VERWENDUNG VON RUTHENIUM KOMPLEXEN MIT BIPHOSPHINELIGANDEN

P-CHIROGENIC ORGANOPHOSPHORUS COMPOUNDS

Novel P-chirogenic organophosphorus compounds of general formula (I), a process for the synthesis of the compounds of formula (I), and intermediate products of general formulae (II), (III) and (IV), as shown below, are involved in the synthesis of compounds (I). 2. Process according to claim 1 , wherein the electrophile is selected from the group comprising boronate reagents claim 1 , aldehydes claim 1 , ketones claim 1 , acyl chlorides claim 1 , halosilanes claim 1 , haloalkanes claim 1 , halophosphines or phosphinites claim 1 , Michael acceptors such as α claim 1 ,β-insaturated ester claim 1 , α claim 1 ,β-insaturated ketones claim 1 , α claim 1 ,β-insaturated phosphine derivatives.3. Process according to claim 1 , wherein the oxidative reagent is selected from the group comprising transition metal salts claim 1 , transition metal complexes claim 1 , wherein the metal is selected from the group comprising iron claim 1 , copper.4. Process according to claim 1 , wherein compound (VII) is chiral.12. A metallic complex catalyst including at least one compound of general formula (I) according to .13. A metallic complex catalyst including at least one compound of general (II) according to .14. A metallic complex catalyst including at least one compound of general formula (III) according to .15. A metallic complex catalyst including at least one compound of general formula (IV) according to . The present invention relates to novel P-chirogenic organophosphorus compounds of general formula (I). The present invention also provides a process for the synthesis of said compounds of formula (I). The present invention also relates to intermediate products of general formulae (II), (III) and (IV), as shown below, which are involved in the synthesis of compounds (I).Compounds of general formula (I) may useful as agrochemical and therapeutic substances, or as reagents or intermediates for fine chemistry.Further, the invention relates to metal complexes comprising compounds (I) as ...

P-chirogenic organophosphorus compounds

P-chirogenic organophosphorus compounds of general formula (I), a process for the synthesis of the compounds of formula (I), and intermediate products of general formulae (II), (III) and (IV), as shown below, are involved in the synthesis of compounds (I). Metal complexes comprising compounds (I) as ligands are also described. The compounds and complexes are useful in asymmetric catalysis by transition metal complexes or organocatalysis, especially for asymmetric hydrogenation or allylation. Compounds of general formula (I) may be useful as agrochemical and therapeutic substances, or as reagents or intermediates for fine chemistry.

Versatile and stereospecific synthesis of gamma,delta -unsaturated amino acids by wittig reaction

The present invention relates to gamma, delta-unsaturated a-amino acids of general formula (I). The present invention also provides a versatile process for the stereospecific synthesis of said compounds of formula (I), involving a Wittig reaction. The present invention also relates to intermediate products of general formulae (II) and (III), as shown below, which are involved in the synthesis of compounds (I).

P-chirogenic organophosphorus compounds

The present invention relates to novel P-chirogenic organophosphorus compounds of the general formula (I). The present invention also provides a process for synthesis of the compounds of the formula (I). The present invention also relates to intermediates of general formulae (II), (III) and (IV), as shown below, which are involved in the synthesis of the compounds (I). Further, the invention relates to metal complexes comprising the compounds (I) as ligands. The novel compounds and the complexes of the present invention are useful in asymmetric catalysis by transition metal complexes or organocatalysis, especially for asymmetric hydrogenation or allylation. Compounds of the general formula (I) may be used as agrochemical and therapeutic substances, or as reagents or intermediates for fine chemistry.

P-CHIROGENIC ORGANOPHOSPHORUS COMPOUNDS

Novel P-chirogenic organophosphorus compounds of general formula (I), a process for the synthesis of the compounds of formula (I), and intermediate products of general formulae (II), (III) and (IV), as shown below, are involved in the synthesis of compounds (I). 2. The process according to claim 1 , wherein the electrophile is selected from the group consisting of boronate reagents claim 1 , aldehydes claim 1 , ketones claim 1 , acyl chlorides claim 1 , halosilanes claim 1 , haloalkanes claim 1 , and Michael acceptors such as α claim 1 ,β-insaturated ester claim 1 , α claim 1 ,β-insaturated ketones claim 1 , and α claim 1 ,β-insaturated phosphine derivatives.3. The process according to claim 1 , wherein the oxidative reagent is selected from the group consisting of transition metal salts and transition metal complexes claim 1 , wherein the metal is selected from the group comprising iron claim 1 , copper.4. The process according to claim 1 , wherein compound (VII) is chiral. The present invention relates to novel P-chirogenic organophosphorus compounds of general formula (I). The present invention also provides a process for the synthesis of said compounds of formula (I). The present invention also relates to intermediate products of general formulae (II), (III) and (IV), as shown below, which are involved in the synthesis of compounds (I).Compounds of general formula (I) may useful as agrochemical and therapeutic substances, or as reagents or intermediates for fine chemistry.Further, the invention relates to metal complexes comprising compounds (I) as ligands. The novel compounds and complexes of the present invention are useful in asymmetric catalysis by transition metal complexes or organocatalysis, especially for asymmetric hydrogenation or allylation.During the past decades, asymmetric organocatalysis and organometallic catalysis made a breakthrough and became methodologies of choice for the synthesis of chiral substances on laboratory as well as on industrial ...

OLEIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITION OR FOOD COMPOSITION COMPRISING SAID OLEIC ACID DERIVATIVES, AND THEIR USES

Disclosed is an oleic acid derivative including a hydrophobic part C17H33 linked to a particular polar head part “A”, especially for use as a medicament, for instance, for the treatment of a disorder caused by the GPR120 receptor and/or the CD36 receptor, including administering to a subject in need thereof a therapeutically effective amount of the oleic acid derivative or of the pharmaceutical composition. Also disclosed is the use of the oleic acid derivative as a food composition. 2. The oleic acid derivatives according to claim 1 , having a molecular weight ranging from about 300 to about 600 g/mol.3. The oleic acid derivatives according to claim 1 , wherein in A claim 1 , Rand Rare independently selected from the group composed of methyl claim 1 , or a saturated or unsaturated claim 1 , straight or branched alkyl group containing 4 to 6 carbon atoms.4. The oleic acid derivatives according to claim 1 , wherein in A1 claim 1 , Rand Rare linked together so that —R-R— is —(CH)or Rand Rare a saturated straight alkyl group containing 4 carbon atoms claim 1 , or a pharmaceutically/food quality acceptable salts thereof.7. The oleic acid derivatives according to claim 1 , wherein in A claim 1 , Ris H claim 1 , Ris —COCHand Ris H or Ris —COCH claim 1 , Ris H and Ris H claim 1 , or a pharmaceutically/food quality acceptable salts thereof.8. The oleic acid derivatives according to claim 1 , wherein in A claim 1 , Ris H claim 1 , Ris CHand Ris H claim 1 , or a pharmaceutically/food quality acceptable salts thereof.10. A pharmaceutical composition or food composition comprising claim 1 , respectively claim 1 ,{'claim-ref': {'@idref': 'CLM-00009', 'claim 9'}, 'at least one pharmaceutically acceptable carrier and at least one oleic acid derivative as defined in .'}{'claim-ref': {'@idref': 'CLM-00009', 'claim 9'}, 'at least one food ingredient and/or at least one food additive and at least one oleic acid derivative such as defined in .'}12. The oleic acid derivatives according ...

VERSATILE AND STEREOSPECIFIC SYNTHESIS OF GAMMA,DELTA -UNSATURATED AMINO ACIDS BY WITTIG REACTION

The γ,δ-unsaturated α-amino acids of general formula (I). Also, a versatile process for the stereospecific synthesis of said compounds of formula (I), involving a Wittig reaction. Further, intermediate products of general formulae (II) and (III), as shown below, which are involved in the synthesis of compounds (I). 4. The process according to claim 1 , wherein R2 is a hydrogen atom claim 1 , R3 is a Boc group claim 1 , R4 is phenyl and R5 is allyl.5. The process according to claim 1 , wherein the weak base is KPO claim 1 ,CsCOor KCO.6. The process according to claim 1 , wherein the solvent suitable for phase transition conditions is selected from the group consisting of chlorobenzene claim 1 , dichloromethane claim 1 , chloroform claim 1 , dichlorobenzene claim 1 , dichloroethane claim 1 , and dioxane.7. The process according to claim 1 , wherein R1 is selected from the group consisting of hydrogen atom claim 1 , allyl group and benzyl group.8. The process according to claim 1 , wherein R2 is a hydrogen atom or Boc and R3 is Boc.9. The process according to claim 1 , wherein the phosphine P(R4)is selected from the group consisting of tricyclohexylphosphine claim 1 , triphenylphosphine claim 1 , trifurylphosphine claim 1 , tri(4-methoxyphenyl)phosphine claim 1 , tri(4-trifluoromethylphenyl)phosphine claim 1 , tri(4-fluorophenylphosphine) and tri(4-chlorophenyl)phosphine.10. The process according to claim 1 , wherein RaCORb is selected from the group consisting of benzaldehyde claim 1 , 4-trifluoromethylbenzaldehyde claim 1 , 4-nitrobenzaldehyde claim 1 , 4-cyanobenzaldehyde claim 1 , 4-methoxybenzaldehyde claim 1 , 3 claim 1 ,4-dimethoxybenzaldehyde claim 1 , 2-furaldehyde claim 1 , 3-phenylpropanal claim 1 , paraformaldehyde claim 1 , phenylacetaldehyde claim 1 , 4-(4 claim 1 ,4 claim 1 ,5 claim 1 ,5-tetramethyl-1 claim 1 ,3 claim 1 ,2-dioxaborolan-2-yl)benzaldehyde claim 1 , aldehyde derived from calix-[4]-arene claim 1 , ferrocene-carboxaldehyde claim 1 , m- ...

C-BULKY P-CHIROGENIC ORGANOPHOSPHORUS COMPOUNDS

In the field of organic phosphorus chemistry, especially the chemistry of bulky organophosphorus compounds, a process for the synthesis of compound of formula (I). This process is especially useful to obtain chiral bulky phosphorus compounds. The present invention also relates to compounds of formula (VII), (VIII), (IX) and (X) and their processes of manufacturing starting from a compound of formula (I). 113-. (canceled)15. The process according to claim 14 , wherein the amine is a mono or a diamine.16. The process according to claim 14 , further comprising heating. The present invention relates to the field of organic phosphorus chemistry, especially the chemistry of bulky organophosphorus compounds. The present invention provides a process for the synthesis of compound of formula (I). This process is especially useful to obtain chiral bulky phosphorus compounds. The present invention also relates to compound of formula (VII), (VIII), (IX) and (X) and their processes of manufacturing starting from a compound of formula (I).The organic phosphorus compounds are currently used in agrochemistry, pharmacy, catalysis, materials, or as flame retardants, extracting agents for hydrometallurgy, or still as chemical reagents. In addition, the properties of organic phosphorus compounds can depend on their chirality.Depending on their substitution, the phosphorus compounds can bear the chirality on the P-center.In recent years the electronically bulky phosphorus ligands (bulky phosphines) bearing substituents such as t-butyl or adamantyl gave a lot of interest in catalysis because they allow the activation of weakly actived substrates. That is explained by the steric hindrance of the ligand, allowing on one hand a weakly coordination of the metal in the catalyst, which makes it more reactive in respect of a substrate, and on the other hand favoring the reductive elimination of the product of the coordination sphere.In the field of chirality, in recent years many chiral ligands ...

NOVEL CYCLIC PHOSPHONITES, THEIR PREPARATION AND APPLICATIONS

Enantioselective carbonyl group hydrogenation method using ruthenium/diphosphine ligand complexes

An enantioselective method for the catalytic hydrogenation of the secondary alcohol function ketone C=O bond. The method uses a neutral ruthenium complex as the catalyst and a compound with a C=O functionality as the substrate to be hydrogenated, and is characterized in that it includes the hydrogenation of the substrate of a diallyl compound of (diphosphino)ruthenium of formula (I), wherein al is preferably CH2CH=CH2 or CH2C(CH3)=CH2, Q is a hydrocarbon bridge with at least two catenary carbon atoms and possibly 1-4 catenary heteroatoms selected from O, S, N and Si, and each of R1-R4, which are the same or different, is a C¿1-18? alkyl, C5-7 cycloalkyl or C6-12 aryl group.

Process for enantioselective hydrogenation of the oxo C═O double bond

The present invention concerns a process for enantioselective catalytic hydrogenation of the ketone C═O double bond to a secondary alcohol function, said process using a neutral ruthenium complex as the catalyst and a compound containing a C═O group as the substrate to be hydrogenated, characterised in that it comprises hydrogenation of the substrate using a diallyl (diphosphino) ruthenium compound with formula ##STR1## where al preferably represents CH 2 CH═CH 2 or CH 2 C(CH 3 )═CH 2 , Q represents a hydrocarbon bridge containing at least two catenary carbon atoms and which can contain one to four catenary heteroatoms selected from O, S, N and Si, R 1 to R 4 may be identical or different and each represents a C 1 -C 18 alkyl, C 5 -C 7 cycloalkyl or C 6 -C 12 aryl group.

Method for hydrogenating ethylenically unsaturated organic compounds, and ruthenium catalysers therefor

A method for hydrogenating ethylenically unsatured organic compounds is disclosed. This method is implemented in a homogenous medium containing a hydrogenation catalyser formed by a complex of ruthenium with a phosphine, which comprises two allylic groups as Ru ligands.

Process for the hydrogenation of ethylenically unsaturated organic compounds and ruthenium catalysts for carrying out said process

The present invention relates to a process for the hydrogenation of ethylenically unsaturated organic compounds. This process is carried out in a homogeneous medium containing a hydrogenation catalyst formed by a complex of ruthenium with a phosphine, which comprises two allylic groups as ligands on the Ru.

P-CHIROGENIC ORGANOPHOSPHORUS COMPOUNDS

AIRCRAFT TURBOPROPOWER UNIT COMPRISING A CIRCUIT FOR RECOVERING AND CONVERTING THERMAL ENERGY

L'invention concerne un groupe turbopropulseur d'aéronef comprenant un circuit (30) de récupération et de conversion d'énergie thermique en énergie mécanique. Le circuit comprend un réservoir (32) stockant un fluide de travail, un évaporateur (38), un détendeur (40) et un condenseur (44). Le fluide est chauffé avant d'entrer dans l'évaporateur par échange thermique avec une ou plusieurs sources chaudes secondaires (36). Le détendeur comprend une turbine (40a) couplée à un arbre de sortie (40b) et qui récupère une partie de l'énergie thermique de détente pour la transformer en énergie mécanique de rotation de l'arbre. L'énergie mécanique récupérée permet ainsi de réduire la consommation en carburant du groupe turbopropulseur. The invention relates to an aircraft turboprop engine comprising a circuit (30) for recovering and converting thermal energy into mechanical energy. The circuit includes a reservoir (32) storing a working fluid, an evaporator (38), an expander (40) and a condenser (44). The fluid is heated before entering the evaporator by heat exchange with one or more secondary hot springs (36). The expander comprises a turbine (40a) coupled to an output shaft (40b) and which recovers a portion of the thermal expansion energy to transform it into mechanical rotational energy of the shaft. The recovered mechanical energy thus makes it possible to reduce the fuel consumption of the turboprop unit.

VERSATILE AND STEREOSPECIFIC SYNTHESIS OF AMINO ACIDS GAMMA, DELTA-UNSATURATED BY THE REACTION OF WITTIG

La présente invention concerne des acides alpha-aminés gamma,delta-insaturés de formule générale (I). La présente invention propose également un procédé versatile pour la synthèse stéréospécifique des composés de formule (I), faisant appel à la réaction de Wittig. La présente invention concerne aussi les produits intermédiaires de formules générales (II) et (III), telles que présentées ci-dessous, qui sont impliqués dans la synthèse des composés (I). Les composés de formule générale (I) peuvent être utilisés comme substances thérapeutiques, ou comme réactifs ou intermédiaires de synthèse pour la chimie fine. The present invention relates to alpha-amino gamma, delta-unsaturated acids of general formula (I). The present invention also provides a versatile method for the stereospecific synthesis of the compounds of formula (I), using the Wittig reaction. The present invention also relates to the intermediates of general formulas (II) and (III), as presented below, which are involved in the synthesis of compounds (I). The compounds of general formula (I) can be used as therapeutic substances, or as reagents or synthesis intermediates for fine chemistry.

Process for the preparation of phosphinamides, applications and new products

Phosphinamides are prepared by the action of an organic halide on an oxazaphospholidine. Depending on the desired configuration of the stereoisomer to be obtained, an oxazaphospholidine originating from a (+) or (-) optically active aminoalcohol is employed. These phosphinamides are useful for the preparation of phosphinates, in particular of optically active phosphinates of known absolute configuration; the phosphinamide is subjected to alcoholysis for this purpose.

PROCESS FOR HYDROGENATION OF ORGANIC COMPOUNDS AND RUTHENIUM CATALYSTS FOR THEIR PRODUCTION.

BIFUNCTIONAL COMPOUNDS WITH THIOPHOSPHINE FUNCTION, USEFUL AS EXTRACTANTS OF URANIUM (VI), METHODS OF SYNTHESIS AND USES THEREOF

L'invention se rapporte à des composés bifonctionnels qui présentent une fonction thiophosphine et qui sont capables d'extraire très efficacement l'uranium(VI) d'une solution aqueuse d'acide phosphorique et ce, avec une forte sélectivité vis-à-vis du fer. Ces composés répondent à la formule générale (I) : dans laquelle R1 et R2, identiques ou différents, représentent chacun un groupe alkyle linéaire ou ramifié en C2 à C16 ; R3 représente un groupe alkyle linéaire ou ramifié en C1 à C15 ; Z représente O ou S ; et R4 représente H, un groupe alkyle linéaire ou ramifié en C1 à C16, un groupe aromatique ou hétéroaromatique monocyclique. L'invention se rapporte également à des procédés permettant de synthétiser ces composés, à leurs utilisations comme extractants de l'uranium(VI) et, notamment, pour extraire l'uranium(VI) d'une solution aqueuse d'acide phosphorique telle qu'une solution issue de l'attaque d'un phosphate naturel par l'acide sulfurique, ainsi qu'à un procédé permettant de récupérer l'uranium(VI) présent dans une solution aqueuse d'acide phosphorique issue de l'attaque d'un phosphate naturel par l'acide sulfurique.

METHOD FOR INSTALLING A SYSTEM FOR RECORDING ENGINE DATA IN AN AIRCRAFT

L'invention concerne un procédé d'installation d'un système d'enregistrement (150) dans un aéronef (100) comportant une baie avionique (104) et deux moteurs (108a-b), le procédé d'installation comportant : - une étape d'installation d'un enregistreur de données (112) dans la baie avionique (104), pour chaque moteur (108a-b), - une étape de sélection d'un câble électrique (114a-b) à deux fils présent dans l'aéronef (100), s'étendant entre ledit moteur (108a-b) et la baie avionique (104) et non relié à un circuit électrique en fonctionnement habituel de l'aéronef (100), - une étape d'installation d'un premier convertisseur (116a-b) au voisinage dudit moteur (108a-b) et d'un deuxième convertisseur (118a-b) dans la baie avionique (104), - une étape de mise en place d'une pluralité de capteurs (120a-b) et d'un concentrateur de données (110a-b) dans ledit moteur (108a-b) et de connexion de chaque capteur (120a-b) audit concentrateur de données (110a-b), - une étape de connexion du premier convertisseur (116a-b) entre le concentrateur de données (110a-b) et le câble électrique (114a-b), et - une étape de connexion du deuxième convertisseur (118a-b) entre ledit câble électrique (114a-b) et l'enregistreur de données (112). Un tel procédé permet une mise en œuvre rapide pour recueillir rapidement des données moteur.

METHOD FOR INSTALLING AN ENGINE DATA RECORDING SYSTEM IN AN AIRCRAFT

L'invention concerne un procédé d'installation d'un système d'enregistrement (150) dans un aéronef (100) comportant une baie avionique (104) et deux moteurs (108a-b), le procédé d'installation comportant : - une étape d'installation d'un enregistreur de données (112) dans la baie avionique (104), pour chaque moteur (108a-b), - une étape de sélection d'un câble électrique (114a-b) à deux fils présent dans l'aéronef (100), s'étendant entre ledit moteur (108a-b) et la baie avionique (104) et non relié à un circuit électrique en fonctionnement habituel de l'aéronef (100), - une étape d'installation d'un premier convertisseur (116a-b) au voisinage dudit moteur (108a-b) et d'un deuxième convertisseur (118a-b) dans la baie avionique (104), - une étape de mise en place d'une pluralité de capteurs (120a-b) et d'un concentrateur de données (110a-b) dans ledit moteur (108a-b) et de connexion de chaque capteur (120a-b) audit concentrateur de données (110a-b), - une étape de connexion du premier convertisseur (116a-b) entre le concentrateur de données (110a-b) et le câble électrique (114a-b), et - une étape de connexion du deuxième convertisseur (118a-b) entre ledit câble électrique (114a-b) et l'enregistreur de données (112). Un tel procédé permet une mise en œuvre rapide pour recueillir rapidement des données moteur. The invention relates to a method of installing a recording system (150) in an aircraft (100) comprising an avionics bay (104) and two engines (108a-b), the installation method comprising: - a step of installing a data recorder (112) in the avionics bay (104), for each engine (108a-b), - a step of selecting an electric cable (114a-b) with two wires present in the aircraft (100), extending between said engine (108a-b) and the avionics bay (104) and not connected to an electrical circuit in normal operation of the aircraft (100), - a step of installation d '' a first converter (116a-b) in ...

CYCLIC DIPHOSPHONITES, THEIR PREPARATION AND APPLICATIONS

VERSATILE AND STEREOSPECIFIC SYNTHESIS OF AMINO ACIDS GAMMA, DELTA-UNSATURATED BY THE REACTION OF WITTIG

PHOSPHINITE-BORANES CHIRAUX, THEIR PREPARATION AND APPLICATIONS.

Phosphine amide(s) from organic halide(s) and oxaza-phospholine(s) - intermediates for optically active phosphinate(s), useful as ligands for transition metal catalysts

Prepn. of phosphinamides comprises reaction of an organic halide with a oxaza-phospholidine in the absence of air and moisture and in darkness. Phosphinamides of formula R1R2PO-NR7-CR5R6-CR3R4-X (I) are new (where R1, R3, R6 are 1-4C alkyl, opt. substd. phenyl or benzyl; R4, R5 are H and R2, R7 are 1-4C alkyl). The phosphinamides are intermediates for the prepn. of organic phosphorus cpds., such as phosphinates. The phospinamides allow good yields of optically active cpds., having high optical purity, to be obtd. The phosphinates, esp. the optically active cps. are useful as ligands for transition metals. These organo-phosphorus metal cpds. are catalysts used in asymmetric synthesis of organic cpds. used in the agriculture, pharmaceutical, perfume, food industries, etc.

Enantioselective hydrogenation process for the C = O OXO double bond.

Improvement to the preparation of chiral catalysts based on ruthenium and phosphorus complexes.

Procédé de préparation d'un catalyseur chiral, constitué par un complexe organique du ruthénium et du phosphore, qui comprend le chauffage d'un complexe de ruthénium avec une phosphine, au sein d'un liquide organique, inerte vis-à-vis des substances en présence, le complexe chauffé étant à base d'un diène et d'un composé allylique; le produit obtenu à la suite de ce chauffage est soumis à l'action d'un acide dans un solvant organique. Process for the preparation of a chiral catalyst, consisting of an organic complex of ruthenium and phosphorus, which comprises heating a complex of ruthenium with a phosphine, within an organic liquid, inert towards the substances present, the heated complex being based on a diene and an allylic compound; the product obtained following this heating is subjected to the action of an acid in an organic solvent.

P-CHIROGENIC ORGANOPHOSPHORUS COMPOUNDS

La présente invention concerne des nouveaux composés organophosphorés P-chirogéniques de formule générale (I). La présente invention concerne également les produits intermédiaires de formule générale (II), (III) et (IV), telles que représentées ci-dessous , qui sont impliqués dans la synthèse des composés (I) L'invention concerne également les complexes métalliques comprenant les composés (I) en tant ligands. Les nouveaux composés et complexes de la présente invention sont utiles en catalyse asymétrique par des complexes de métaux de transition, en particulier en particuliers pour des réactions asymétriques d'hydrogénation ou d'allylation. Les composés de formule générale (I) peuvent être utilisés en agrochimie ou en tant que substances thérapeutiques ou encore comme réactifs ou intermédiaires pour la chimie fine. The present invention relates to novel P-chirogenic organophosphorus compounds of the general formula (I). The present invention also relates to the intermediates of general formula (II), (III) and (IV), as represented below, which are involved in the synthesis of compounds (I). The invention also relates to metal complexes comprising the compounds (I) as ligands. The novel compounds and complexes of the present invention are useful in asymmetric catalysis by transition metal complexes, particularly in particular for asymmetric hydrogenation or allylation reactions. The compounds of general formula (I) can be used in agrochemistry or as therapeutic substances or as reagents or intermediates for fine chemistry.

Enantioselective hydrogenation of the carbonyl bond using ruthenium complexes with biphosphine ligands

An enantioselective method for the catalytic hydrogenation of the secondary alcohol function ketone C=O bond. The method uses a neutral ruthenium complex as the catalyst and a compound with a C=O functionality as the substrate to be hydrogenated, and is characterized in that it includes the hydrogenation of the substrate of a diallyl compound of (diphosphino)ruthenium of formula (I), wherein al is preferably CH2CH=CH2 or CH2C(CH3)=CH2, Q is a hydrocarbon bridge with at least two catenary carbon atoms and possibly 1-4 catenary heteroatoms selected from O, S, N and Si, and each of R1-R4, which are the same or different, is a C¿1-18? alkyl, C5-7 cycloalkyl or C6-12 aryl group.

ORGANIC PHOSPHORUS COMPOUNDS COMPLEXED BY BORON, THEIR PREPARATION AND APPLICATIONS

METHOD FOR PRODUCING DERIVATIVES OF PHOSPHINIC ACID AND INTERMEDIATE PRODUCTS THEREFOR.

Process for preparation of derivatives of phosphinous acid

New chemical product, constituted by an organic phosphorus compound of the structure ##STR1## where Q is an N or O atom, T is an alkylene or arylene, possibly carrying substituents, or not existing, while R 1 to R 7 , the same or different, are H or aliphatic, cycloaliphatic and/or arylic hydrocarbon radicals, possibly substituted, R 3 not existing when Q is oxygen. This product is used as an intermediate in the preparation of different derivatives of phosphinous acid.

METHOD FOR INSTALLING A DATA TRANSFER SYSTEM BETWEEN AN AIRCRAFT AND THE GROUND

L'invention concerne un procédé d'installation d'un système de transfert (150) dans un aéronef (100) comportant une baie avionique (104) avec un système de transmission sans fil (112), deux moteurs (108a-b), chacun équipé d'un ordinateur (110a-b), le procédé d'installation comportant : pour chaque moteur (108a-b), - une étape de sélection d'un câble électrique (114a-b) à deux fils présent dans l'aéronef (100), s'étendant entre ledit moteur (108a-b) et la baie avionique (104) et non relié à un circuit électrique en fonctionnement habituel de l'aéronef (100), - une étape d'installation d'un premier convertisseur (116a-b) au voisinage dudit moteur (108a-b), et d'un deuxième convertisseur (118a-b) dans la baie avionique (104), - une étape de connexion du premier convertisseur (116a-b) entre l'ordinateur (110a-b) dudit moteur (108a-b) et le câble électrique (114a-b), et - une étape de connexion du deuxième convertisseur (118a-b) entre ledit câble électrique (114a-b) et le système de transmission sans fil (112). Un tel procédé d'installation d'un système de transfert (150) permet de créer simplement un réseau pour transférer les données des moteurs vers le sol. The invention relates to a method for installing a transfer system (150) in an aircraft (100) comprising an avionics bay (104) with a wireless transmission system (112), two engines (108a-b), each equipped with a computer (110a-b), the installation method comprising: for each motor (108a-b), - a step of selecting a two-wire electrical cable (114a-b) present in the aircraft (100), extending between said engine (108a-b) and the avionics bay (104) and not connected to an electrical circuit in normal operation of the aircraft (100), - a step of installing a first converter (116a-b) in the vicinity of said engine (108a-b), and a second converter (118a-b) in the avionics bay (104), - a step of connecting the first converter (116a-b) between the computer (110a-b) ...

ORGANIC COMPOUNDS OF PHOSPHORUS COMPLEXED BY BORON, THEIR PREPARATION AND APPLICATIONS

Nouveaux composés organiques du phosphore, constitués par des hétéro-phospha-cycloalcanes dont l'atome de phosphore forme un complexe avec un borane. Ils peuvent être préparés par l'action d'un borane sur un hétéro-phospha-cycloalcane, au sein d'un solvant, entre - 20 degre(s)C et + 60 degre(s)C. Leur transformation en d'autres dérivés, en particulier en phosphinites ou phosphines peut se faire sans aucune modification de la chiralité du complexe initial. Une application particulièrement utile est leur conversion en phosphines optiquement très actives, employées notamment comme catalyseurs de diverses réactions. New organic phosphorus compounds, consisting of hetero-phospha-cycloalkanes, the phosphorus atom of which forms a complex with a borane. They can be prepared by the action of a borane on a hetero-phospha-cycloalkane, in a solvent, between - 20 degree (s) C and + 60 degree (s) C. Their transformation into other derivatives, in particular phosphinites or phosphines can be done without any modification of the chirality of the initial complex. A particularly useful application is their conversion into optically very active phosphines, used in particular as catalysts for various reactions.

Process for preparing phosphinamides, applications and products

Enantioselective hydrogenation of the carbonyl bond using ruthenium complexes with biphosphine ligands.

PCT No. PCT/FR93/00663 Sec. 371 Date Mar. 5, 1995 Sec. 102(e) Date Mar. 9, 1995 PCT Filed Jun. 30, 1993 PCT Pub. No. WO94/01390 PCT Pub. Date Jan. 20, 1994The present invention concerns a process for enantioselective catalytic hydrogenation of the ketone C=O double bond to a secondary alcohol function, said process using a neutral ruthenium complex as the catalyst and a compound containing a C=O group as the substrate to be hydrogenated, characterised in that it comprises hydrogenation of the substrate using a diallyl (diphosphino) ruthenium compound with formula <IMAGE> (I) where al preferably represents CH2CH=CH2 or CH2C(CH3)=CH2, Q represents a hydrocarbon bridge containing at least two catenary carbon atoms and which can contain one to four catenary heteroatoms selected from O, S, N and Si, R1 to R4 may be identical or different and each represents a C1-C18 alkyl, C5-C7 cycloalkyl or C6-C12 aryl group.

OXIDATION OF EPOXY ALCOHOLS TO EPOXY CARBOXYLIC ACIDS

IMPROVEMENT IN THE PREPARATION OF CHIRAL CATALYSTS BASED ON RUTHENIUM AND PHOSPHORUS COMPLEXES.

Verfahren zur hydrierung von olefinischen ungesättigten verbindungen ud ruthenium- katalysatoren zu ihrer durchführung.

Fosfoniti cicliche, loro preparazione e applicazioni.

Difosfoniti cicliche loro preparazione e applicazioni.

Verbesserung bei der herstellung von chiralen katalysatoren auf basis von ruthenium- und phosphorkomplexen.

Chirale phosphinigsäure-borane-derivate, ihre herstellung und verwendung.

Oxydation d'alcools en aldehydes ou en cetones

Linoleic acid derivatives, pharmaceutical composition or food composition comprising said linoleic acid derivatives, and their uses

Disclosed is a linoleic acid derivative of Formula (I) below including a hydrophobic part C17H31 linked to a polar head part “A”:wherein the polar head part A is selected from A1 to A4 below:or a pharmaceutically/food quality acceptable salt thereof.

Linoleic acid derivatives, pharmaceutical composition or food composition comprising said linoleic acid derivatives, and their uses

This invention relates to linoleic acid derivative of Formula (I) below comprising a hydrophobic part C 17 H 31 linked to a polar head part "A": (I) wherein said polar head part A is selected from A 1 to A 4 below: (ll) wherein R 1 and R 2 are independently selected from the group composed of H or a saturated or unsaturated, straight or branched alkyl group containing 1 to 8 carbon atoms, or R 1 and R 2 are linked together to form a divalent radical of formula -R 1 -R 2 -, wherein -R 1 -R 2- -is preferably -CH 2 -CH 2 or –(CH 2 ) 3 -; R 3 is independently selected from the group composed of: wherein R 4 is independently selected from the group composed of H or a saturated or unsaturated, straight or branched alkyl group containing 1 to 4 carbon atoms, or an aromatic group (such as Ph, Tol, Xyl) or-CO 2 R 13 in which R 13 is a saturated alkyl group containing 1 to 4 carbon atoms, and R 14 , R 15 , R 16 is independently selected from H or CH 3 , preferably R 14 = R 15 = R 16 =CH 3 or R 14 = H or CH 3 and R 15 = R 16 = H; R 5 , R 6 and R 7 are independently selected from the group composed of H or a saturated or unsaturated, straight or branched alkyl group containing 1 to 4 carbon atoms, or -CO 2 R 8 in which R 8 is a saturated or unsaturated, straight or branched alkyl group containing 1 to 4 carbon atoms with the proviso that when R 7 = H or CH 3 , R 5 and R 6 are different from each other, especially when they correspond to CH 3 or to H; R 9 to R 11 are independently selected from the group composed of H or a saturated or unsaturated, straight or branched alkyl group containing 1 to 4 carbon atoms provided that when R 10 and R 11 = H, R 9 is different from an ethyl-group or H, or a pharmaceutically / food quality acceptable salt there of.

Verfahren zur enantioselektiven hydrierung der carbonylgruppe unter verwendung von ruthenium komplexen mit biphosphineliganden

Nouveaux derives dioxaniques pouvant etre optiquement actifs, leur procede de preparation et applications