Chiral PCN pincerlike metal compound derived from diphenyl prolinol and synthesis method thereof

The invention discloses a chiral PCN pincerlike metal compound derived from diphenyl prolinol and a synthesis method thereof. The chiral PCN pincerlike metal compound has a structural formula as follow: in the formula, M is metallic Pd (II) or Ni (II) ions, R1 and R2 are hydrogen, and alkyl of C1-C6 or phenyl substituted by alkyl, and X is halogen. In the invention, a series of chiral PCN pincerlike metal compounds derived from diphenyl prolinol can be synthesized by adopting one-pot phosphorylation/metallization reaction; and the synthesis method of the chiral PCN pincerlike palladium compound comprises the following steps of: performing phosphorylation reaction of m-hydroxyl imidazoline benzene compounds, and then directly adding metal salts in a reaction solution to further react without separating instable PCN ligands. The invention successfully realizes the C2-bit C-H bond activation of the ligand, simplifies the synthesis steps, ensures that the operation is simple, convenient and ...

Chiral and non-chiral diimidazolinylbenzene compounds and synthesis method

Chirality and non-chirality PCN pincerlike palladium compound, synthesizing method and uses

The invention provides an achiral or chiral PCN forcipated palladium compound, a synthesis method and the application thereof in catalyzing Suzuki reaction. The general formulas of the achiral and the chiral PCN forcipated palladium compounds are respectively shown as Formula 1 and Formula 2; wherein R is alkyl or hydrogen; R1, R2 and R' are alkyls or aryls. The invention adopts one-pot phosphonation or palladation reaction, which synthesizes a series of achiral and chiral PCN forcipated palladium compounds with m-hydroxybenzene compounds containing nitrogen heterocyclic rings. The method eliminates the necessity of separating unstable PCN ligands, thereby simplifying the synthesis procedure and operation and improving the product yield, so the invention provides a new approach to synthesize achiral and chiral PCN forcipated palladium compounds. The achiral PCN forcipated palladium compound can be used for catalyzing Suzuki coupled reaction of aryl halides and phenyloboric acid to produce ...

Chirality and non-chirality PCN pincerlike palladium compound, synthesizing method and uses

The invention provides an achiral or chiral PCN forcipated palladium compound and synthesis and application thereof in catalyzing Suzuki reaction. The general formula of the achiral and the chiral PCN forcipated palladium compounds are respectively shown as Formula 1 and Formula 2, wherein R is an alkyl or a hydrogen; R1, R2 and R' are alkyls or aryls. The invention adopts one-pot phosphonation/palladation reaction, which synthesizes a series of achiral and chiral PCN forcipated palladium compounds with m-hydroxybenzene compounds containing nitrogen heterocyclic rings. The method eliminates the necessity of separating unstable PCN ligands, thereby simplifying the synthesis procedure and operation and improving the product yield, so the invention provides a new approach to synthesize achiral and chiral PCN forcipated palladium compounds. The achiral PCN forcipated palladium compound can be used for catalyzing Suzuki coupled reaction of aryl halides and phenyloboric acid to produce biaryl ...

A Cyclo palladium diferrocenyl imine amino phosphine compound and an application thereof

Piperazine ketone-nitrogen heterocyclic compound and synthesis method

The invention discloses a piperazine ketone-nitrogen heterocyclic compound and a synthesis method. The general formula 1 and the general formula 2 are disclosed in the specification, wherein R1 is Ts, Cbz or Boc, and R2 is H, phenyl or R2-R2 which is (CH2)4. The synthesis method comprises the following steps of: using iminodiacetonitrile as a starting material, and protecting imino group nitrogen and hydrogen; in an ice bath, introducing hydrogen chloride gas into a product in aether for reacting for at least 10 hours until the solution is saturated; pumping and filtering under the protection of nitrogen, adding aether and washing to obtain imidoate hydrochloride; then refluxing and reacting the product with a derivative thereof or propane diamine for 24-27 hours in dichloromethane; washing by using a saturated sodium bicarbonate solution, and extracting by using the dichloromethane; and drying, concentrating and carrying out chromatographic separation to obtain the compound. The compound ...

Forcipated diimidazoline palladium compound and its application in Suzuki reaction

The present invention discloses one kind of forcipated diimidazoline palladium compound in the structure as shown and its application in Suzuki reaction. The forcipated diimidazoline palladium compound is synthesized through heating and refluxing diimidazoline benzene and palladium acetate in glacial acetic acid, the subsequent evaporating to dry, adding acetone/water solution of lithium chloride,stirring at room temperature to extract, drying, concentrating and thin-layer chromatographic separation. The compound is used in catalyzing coupling Suzuki reaction to synthesize biaryl compound.

Piperazine ketone-nitrogen heterocyclic compound and synthesis method

The invention discloses a piperazine ketone-nitrogen heterocyclic compound and a synthesis method. The general formula 1 and the general formula 2 are disclosed in the specification, wherein R1 is Ts, Cbz or Boc, and R2 is H, phenyl or R2-R2 which is (CH2)4. The synthesis method comprises the following steps of: using iminodiacetonitrile as a starting material, and protecting imino group nitrogenand hydrogen; in an ice bath, introducing hydrogen chloride gas into a product in aether for reacting for at least 10 hours until the solution is saturated; pumping and filtering under the protectionof nitrogen, adding aether and washing to obtain imidoate hydrochloride; then refluxing and reacting the product with a derivative thereof or propane diamine for 24-27 hours in dichloromethane; washing by using a saturated sodium bicarbonate solution, and extracting by using the dichloromethane; and drying, concentrating and carrying out chromatographic separation to obtain the compound. The compound ...