Universal catheter securement device

A universal device for securing a catheter on a patient includes a base which optionally has at least one locating element for positioning or securing a catheter or catheter fitting of various shapes or sizes. The base has an opening and one or more restraining elements positioned on a surface of the base and extending over a portion of the opening. A retention plate includes locating elements for positioning or securing a catheter or catheter fitting of various shapes or sizes on the retention plate. Optionally, the retention plate may be movable. A support plate or similar device attached to the base holds the retention plate between the restraining elements and the support plate. A cover is connected to the base and may optionally have at least one capture element for restraining a catheter or catheter fitting of various shapes or sizes on the base or on the retention plate.

Slide-and-lock stent

The invention relates to an expandable stent comprising circumferentially adjacent modules. The modules comprise longitudinally adjacent slide-and-lock radial elements which permit one-way sliding of the radial elements from a collapsed diameter to an expanded/deployed diameter, but inhibit radial recoil from the expanded diameter.

EXPANDING CAM LOCK FOR SEALING SLAB GELS IN AN ELECTROPHORESIS APPARATUS

An expanding cam lock for use with an electrophoresis system is disclosed herein. The cam lock allows the simultaneous use of multiple slab gel cassettes in first and second buffer core assemblies in an electrophoresis system while maintaining the necessary compressive force to create a liquid-tight seal between the anode and cathode buffer solutions. In one example embodiment, the expanding cam lock includes a base plate with a first surface adapted to engage the first buffer core assembly and a follower plate having second surface adapted to engage the second buffer core assembly, buffer dam or buffer displacement dam. The base plate and the follower plate are slidably coupled together and are designed for insertion between the first buffer core assembly and the second buffer core assembly, buffer dam or buffer displacement dam in the electrophoresis container. A cam is positioned between and moveably coupled with the base plate and the follower plate. The cam is movable from a first position to a second position to urge the first and second surfaces to secure the gel cassette to the first and second buffer core assemblies. Also provided herein is a buffer displacement dam. Also provided herein are kits and assemblies which incorporate the expanding cam and buffer displacement dam described herein. 1109-. (canceled)110. An expanding cam lock for sealing at least one electrophoresis gel cassette in an electrophoresis apparatus , the expanding cam lock comprising:a base plate having a first surface adapted to engage a first buffer core assembly comprising at least one electrophoresis gel cassette;a follower plate having second surface adapted to engage a second buffer core assembly comprising at least one electrophoresis gel cassette;a cam positioned between and moveably coupled with the base plate and the follower plate;wherein, the base plate and the follower plate are slideably coupled together and configured for insertion between the first buffer core assembly ...

Universal Catheter Securement Device

A universal device for securing a catheter on a patient includes a base which optionally has at least one locating element for positioning or securing a catheter or catheter fitting of various shapes or sizes. The base has an opening and one or more restraining elements positioned on a surface of the base and extending over a portion of the opening. A retention plate includes locating elements for positioning or securing a catheter or catheter fitting of various shapes or sizes on the retention plate. Optionally, the retention plate may be movable. A support plate or similar device attached to the base holds the retention plate between the restraining elements and the support plate. A cover is connected to the base and may optionally have at least one capture element for restraining a catheter or catheter fitting of various shapes or sizes on the base or on the retention plate.

Dry powder inhaler

A dry powder inhaler has a dispersion chamber containing beads. A dose of dry powder is released into the chamber, or into an inlet tangentially joining into the chamber. As the patient inhales on a nosepiece or mouthpiece, air moves circularly through the dispersion chamber to drive the beads. The beads roll, bounce, and collide repeatedly with the drug particles on the chamber surfaces or on the beads. The smaller active drug particles are separated from the larger carrier particles and from each other, and a powder aerosol is created and inhaled by the patient. The beads are preferably lightweight, so that they can be rapidly accelerated and moved, even with nominal inspiration. The flow resistance of the inhaler is also reduced via the beads, allowing greater air flow and powder dispersion, without any increased effort by the patient.

Axially nested slide and lock expandable device

The invention relates generally to expandable medical implants for maintaining support of a body lumen and, in particular, to an axially nested, diametrically expandable, slide and lock vascular device for enlarging an occluded portion of a vessel. The axially nested vascular device desirably achieves both competitive crossing profiles while maintaining other key features, such as, for example, radial strength and luminal patency. The collapsed profile can also be made very thin without compromising radial strength. Thus, the vascular device can advantageously be deployed in small and difficult to reach areas or vessels. The axial nesting substantially eliminates radial overlap between mating structural elements thereby desirably allowing for a low, uniform profile.

Slide-and-lock stent

The invention relates to an expandable stent comprising circumferentially adjacent modules. The modules comprise longitudinally adjacent slide-and-lock radial elements which permit one-way sliding of the radial elements from a collapsed diameter to an expanded/deployed diameter, but inhibit radial recoil from the expanded diameter.

Slide-and-lock stent

The invention relates to an expandable stent comprising circumferentially adjacent modules. The modules comprise longitudinally adjacent slide-and-lock radial elements which permit one-way sliding of the radial elements from a collapsed diameter to an expanded/deployed diameter, but inhibit radial recoil from the expanded diameter.

Axially nested slide and lock expandable device

The invention relates generally to expandable medical implants for maintaining support of a body lumen and, in particular, to an axially nested, diametrically expandable, slide and lock vascular device for enlarging an occluded portion of a vessel. The axially nested vascular device desirably achieves both competitive crossing profiles while maintaining other key features, such as, for example, radial strength and luminal patency. The collapsed profile can also be made very thin without compromising radial strength. Thus, the vascular device can advantageously be deployed in small and difficult to reach areas or vessels. The axial nesting substantially eliminates radial overlap between mating structural elements thereby desirably allowing for a low, uniform profile.

Reduced-fat flavor components

A method is provided for producing reduced-fat components that may be used to make reduced and low-fat processed cheese, natural cheese or other reduced and low-fat food products. The reduced-fat flavor components are produced by extraction of fat from full-fat biogenerated cheese flavor components. Alternatively, natural biogenerated cheese flavor components are produced with reduced amounts of fat. Additionally, reduced-fat cheddar cheese can be derived from 1% milk.

Turbine dry powder inhaler

A turbine powered inhaler has a propeller mounted on a turbine shaft within an aerosolizing chamber. An air pathway extends from an inlet, through the turbine to the aerosolizing chamber, and out through a mouth piece. Upon inhalation by a patient, air flowing through the air path rapidly spins up the turbine which directly drives the propeller within the aerosolizing chamber. Air and drug particles are mixed and de-agglomerated in the aerosolizing chamber via the spinning propeller, without the need for a motor and batteries.

Axially nested slide and lock expandable device

The invention relates generally to expandable medical implants for maintaining support of a body lumen and, in particular, to an axially nested, diametrically expandable, slide and lock vascular device for enlarging an occluded portion of a vessel. The axially nested vascular device desirably achieves both competitive crossing profiles while maintaining other key features, such as, for example, radial strength and luminal patency. The collapsed profile can also be made very thin without compromising radial strength. Thus, the vascular device can advantageously be deployed in small and difficult to reach areas or vessels. The axial nesting substantially eliminates radial overlap between mating structural elements thereby desirably allowing for a low, uniform profile.

Axially nested slide and lock expandable device

The invention relates generally to expandable medical implants for maintaining support of a body lumen and, in particular, to an axially nested, diametrically expandable, slide and lock vascular device for enlarging an occluded portion of a vessel. The axially nested vascular device desirably achieves both competitive crossing profiles while maintaining other key features, such as, for example, radial strength and luminal patency. The collapsed profile can also be made very thin without compromising radial strength. Thus, the vascular device can advantageously be deployed in small and difficult to reach areas or vessels. The axial nesting substantially eliminates radial overlap between mating structural elements thereby desirably allowing for a low, uniform profile.

Methods and apparatus for electrophoresis of prior-cast, hydratable separation media

Methods and apparatus that are embodied in Figure 2 are presented that facilitate electrophoresis of prior-cast, hydratable separation media, usefully immobilized pH gradient (IPG) strips: The method exploits the swelling of rehydration to help lodge the media in an enclosing member that permits spaced electrical communication with the enclosed separation media. The electrical communication permits a voltage gradient to be established in the enclosed separation medium sufficient to effect separation of analytes therein. Cassettes, buffer cores, electrophoresis systems and kits are presented for effecting the methods of the invention.

Securement device for catheters

A system for securing a medical device such as a catheter or other medical article having various shapes or sizes in place on a patient includes a securing device. The securing device may optionally include a retainer having one or more receiving areas and one or more retention arms adjacent to the receiving areas. The securing device may also include a retention strap having a latching element that is removably connectable to a retention arm to securely hold a catheter in place. The retainer may optionally be connected to a base which may optionally be connected to an adhesive pad for easy attachment of the securing device to a patient.

Reduced-fat flavor components

A method is provided for producing reduced-fat components that may be used to make reduced and low-fat processed cheese, natural cheese or other reduced and low-fat food products. The reduced-fat flavor components are produced by extraction of fat from full-fat biogenerated cheese flavor components. Alternatively, natural biogenerated cheese flavor components are produced with reduced amounts of fat. Additionally, reduced-fat cheddar cheese can be derived from 1% milk.

Methods and apparatus for low resistance electrophoresis of prior-cast, hydratable separation media

Methods and apparatus are presented that facilitate electrophoresis of prior-cast, hydratable separation media, usefully immbobilized pH gradient (IPG) strips. The method exploits the swelling of prior-cast, hydratable separation media upon rehydration to help lodge the media in an enclosing member that permits spaced electrical communication with the enclosed separation media. The electrical communication permits a voltage gradient to be established in the enclosed separation medium sufficient to effect separation of analytes therein. Cassettes, buffer cores, electrophoresis systems and kits are presented for effecting the methods of the invention.

Slide-and-lock stent

The invention relates to an expandable stent (10) comprising circumferentially adjacent modules (12). The modules (12) comprise longitudinally adjacent slide-and-lock radial elements (14, 16) which permit one-way sliding of the radial elements from a collapsed diameter to an expanded/deployed diameter, but inhibit radial recoil from the expanded diameter.

Methods and apparatus for electrophoresis of prior-cast, hydratable separation media

Methods and apparatus are presented that facilitate electrophoresis of prior-cast, hydratable separation media, usefully immobilized pH gradient (IPG) strips. The method exploits the swelling of rehydration to help lodge the media in an enclosing member that permits spaced electrical communication with the enclosed separation media. The electrical communication permits a voltage gradient to be established in the enclosed separation medium sufficient to effect separation of analytes therein. Cassettes, buffer cores, electrophoresis systems and kits are presented for effecting the methods.

Laminated container

Slide-and-lock stent

The invention relates to an expandable stent (10) comprising circumferentially adjacent modules (12). The modules (12) comprise longitudinally adjacent slide-and-lock radial elements (14, 16) which permit one-way sliding of the radial elements from a collapsed diameter to an expanded/deployed diameter, but inhibit radial recoil from the expanded diameter.

Solution phase electrophoresis device, components, and methods

A device for fluid phase electrophoresis, particularly solution phase isoelectric focusing, components thereof, and methods for use are presented.

Dry powder inhaler

A dry powder inhaler (20) has a dispersion chamber (30) containing beads (40). A dose of dry powder (142) is released into the chamber, or into an inlet (26) tangentially joining into the chamber. As the patient inhales on a nosepiece or mouthpiece (22), air moves circularly through the dispersion chamber to drive the beads. The beads roll, bounce, and collide repeatedly with the drug particles on the chamber surfaces or on the beads. The smaller active drug particles are separated from the larger carrier particles and from each other, and a powder aerosol is created and inhaled by the patient. The beads are preferably lightweight, so that they can be rapidly accelerated and moved, even with nominal inspiration. The flow resistance of the inhaler is also reduced via the beads, allowing greater air flow and powder dispersion, without any increased effort by the patient.

Apparatus and methods for active biological sample preparation

Systems and methods for the electronic sample preparation of biological materials utilize the differential charge-to-mass ratio and/or the differential affinity of sample constituents to separation materials for sample preparation. An integrated system is provided for performing some or all of the processes of: receipt of biological materials, cell selection, sample purification, sample concentration, buffer exchange, complexity reduction and/or diagnosis and analysis. In one embodiment, one or more sample chambers adapted to receive a buffer solution are formed adjacent to a spacer region which may include a trap or other affinity material, electrophoretic motion of the materials to be prepared being effected through operation of electrodes. In another aspect of this invention, a transporter or dipstick serves to collect and permit transport of materials, such as nucleic acids, most preferably DNA and/or RNA. In one embodiment, a membrane or trap is held in a frame which is adapted to mate with a channel formed in the spacer region. In another aspect of this invention, an electrophoretic system for biological sample preparation is operated in a manner so as to utilize the differential charge-to-mass ratio so as to control the migration of materials within the solution. In one aspect, bunching of selected materials is achieved by operation of two electrodes in a manner so as to reduce the spatial dispersion of those materials. In another aspect of this invention, a vertically disposed sample preparation unit includes an upper reservoir including and a collection chamber. A sample is preferably pre-prepared and densified, applied to the conductive polymer, electrophoresed so as to move nucleic acids into the conductive polymer and move undesired material away from the conductive polymer. Integrated systems are described in which cell separation, purification, complexity reduction and diagnosis may be performed together. In the preferred embodiment, cell separation ...

Apparatus and methods for active biological sample preparation

Aparelhos e métodos para o preparo de amostra biológica ativa

Patente de Invenção: <B>"APARELHOS E MéTODOS PARA O PREPARO DE AMOSTRA BIOLóGICA ATIVA<D>". Sistemas e métodos para a preparação de amostra eletrónica de materiais biológicos utiliza a proporção diferencial de carga para massa e/ou a afinidade diferencial dos constituintes da amostra para a separação de materiais para a preparação de amostra. Um sistema integrado é provido para efetuar alguns ou todos os processos de: recebimento dos materiais biológicos, seleção da célula, purificação da amostra, concentração da amostra, troca do solução compensadora, redução de complexidade e/ou diagnose e análise. Em uma modalidade, uma ou mais câmaras de amostra adaptadas para receber uma solução solução compensadora são formadas adjacentes a uma região do espaçador que pode incluir um coletor ou outro material de afinidade, o movimento eletroforético dos materiais a serem preparados sendo efetuado através da operação de eletrodos. Em um aspecto da presente invenção, um transportador ou dipstick serve para coletar e permitir o transporte de materiais, tais como ácido nucleico, mais preferivelmente DNA E/OU RNA. Em uma modalidade, uma membrana, ou coletor, é mantida em uma estrutura que é adaptada para se encaixar a um canal formado na região do espaçador. Em outro aspecto da presente invenção, um sistema eletroforético para preparação de amostra biológica é operado de modo tal a utilizar a proporção diferencial de carga para massa, de modo a controlar a migração de materiais dentro da solução. Em um aspecto, o agrupamento de materiais selecionados é obtido por meio da operação de dois eletrodos de modo tal a reduzir a dispersão espacial desses materiais. Em outro aspecto da presente invenção, uma unidade de preparação de amostra disposta verticalmene inclui um reservatório superior e uma câmara de coleta. Uma amostra é preferivelmente pré-preparada e densificada, aplicada ao polímero condutor, submetida a eletroforese, de modo a mover os ácidos nucleicos para ...

Complexity reduction system for biological sample preparation

A complexity reduction system for a biological sample preparation comprises a printed circuit board containing vias in which a conductive support material is located to capture probes, a chamber adapted to mate with the circuit board, at least one disposal region for the attraction of undesired materials and at least one electrode.

Integrated device including a DNA, RNA or protein trap for biological sample preparation

Method for selective isolation of desired charged biological materials from undesired charged materials

Dry powder inhaler

A dry powder inhaler (20) with a slider (24) for incrementally advancing a blister disk (34), for providing doses of dry powder medicament, with the blister disk (34) rotatably supported by a spindle (48) on a deck plate (42) of the inhaler (20). The deck plate (42) has a powder port (94), an advance slot (44), and a lifter slot (46) extending through the deck plate (42). The slider (24) attached to the deck plate (42) is movable between an open, and closed position. When the slider (24) opens, the lifter (50) moves up the ramp (72) of the slider (24) shearing open a blister (39), the blister (39) contents mix with air, and are then inhaled by a patient. As the slider (24) moves back to the closed position, the lifter (50) withdraws, and an advancing finger (84) turns the blister disk (34) to the next blister (39), positioning the blister (39) for opening, to provide the next dose to the patient. A turbine (230) spins up to a high speed driven by the flow of the patient's inhalation. The turbine (230) is connected to a shaft (246) to turn a propeller (226) located within a mixing chamber (224).

Dry powder inhaler

Laminated assembly for active bioelectronic devices

Montagem laminada para dispositivo bioeletrÈnicos ativos

Patente de Invenção: <B>"MONTAGEM LAMINADA PARA DISPOSITIVOS BIOELETRÈNICOS ATIVOS"<D>. Processos de fabricação e dispositivos para a execução de operações biológicas ativas que utilizam laminadas (30, 11). Na concretização preferida, um primeiro suporte plano de amostra (50, 72, 104, 122) inclui pelo menos um furo atravessante de amostra (56, 74, 90), um eletrodo plano (32, 70, 94, 112, 114) é disposto adjacente ao primeiro suporte plano de amostra (50, 72, 104, 122), e inclui uma região atravessante de eletrodo (38, 76), um segundo suporte plano (40, 78, 96, 102, 124) inclui um furo atravessante de respiro (48, 80, 92, 98), o eletrodo plano (32, 70, 94, 112, 114) estando em uma relação laminada entre o primeiro suporte plano de amostra (50, 72, 104, 122) e o segundo suporte plano (40, 78, 96, 102, 124), adicionalmente caracterizado pelo fato de que o furo atravessante de amostra (56, 74, 90), o furo atravessante do eletrodo (38, 76) e o furo atravessante de respiro (48, 80, 92, 98) estão em uma disposição de superposição. Preferivelmente, alguns ou todos os furos atravessantes, regiões atravessantes e furos atravessantes de respiro são alinhados. Em uma concretização, a dimensão lateral do furo atravessante de respiro é maior do que a dimensão lateral do furo atravessante de eletrodo. Em uma concretização alternativa, a dimensão lateral do furo atravessante de amostra é maior do que a dimensão lateral do furo atravessante de respiro. Na concretização preferida, o suporte de amostra e o suporte plano são formados de material em folha, mais preferivelmente de polimida, tendo uma espessura substancialmente de 1 a substancialmente 5 mils. Os eletrodos são preferivelmente escolhidos a partir de metais nobres, especialmente o ouro. Os furos ou regiões atravessantes são preferivelmente formadas por perfuração a laser, opcionalmente seguida por causticação química. Vias de interconexão apresentam percursos condutivos através dos múltiplos suportes, e s ...