Techniques for neuromodulation

The subject matter of the present disclosure generally relates to techniques for neuromodulation of lymphatic tissue that include applying one or more energy pulses to a neuron of a subject, e.g., via an electrode positioned to deliver sufficient energy to the neuron, to modulate immune function. For example, an adaptive immune reflex of a subject may be modulated via neuromodulation.

Monitoring system and current transformers for partial discharge detection

A high frequency current transformer (HFCT) sensor for detecting partial discharges produced by a component is disclosed. The HFCT sensor includes at least one electrically conductive pattern formed on a substrate, where the substrate comprises multiple segmented regions connected by intermediate regions for folding along multiple fold lines between the segmented regions to form the HFCT sensor. A system for monitoring at least one component of an aircraft wiring system is also disclosed. The monitoring system includes at least one of the HFCT sensors for detecting partial discharges produced by the aircraft wiring system component. The monitoring system further includes a data acquisition system configured to monitoring signals from the HFCT sensor(s).

Method and system for enhancing pace pulses

A method for enhancing pace pulses is presented. The method includes providing a set of digital electrocardiogram data comprising a plurality of pulses, wherein each pulse is of a generally constant width. Furthermore, the method includes differentiating the plurality of pulses to generate a plurality of pairs of differentiated pulses, wherein each pair of differentiated pulses is separated by the generally constant width of the corresponding pulse. In addition, the method includes enhancing the plurality of pairs of differentiated pulses. Systems and computer-readable medium that afford functionality of the type defined by this method are also provided by the present technique.

Neuromodulation energy application techniques

Embodiments of the present disclosure relate to techniques for facilitating personalized neuromodulation treatment protocols. In one embodiment, a predetermined treatment position of an energy application device is used to guide future treatments for the patient. In one embodiment, a position of the energy application device relative to the predetermined treatment position is determined. In one embodiment, a total dose of ultrasound energy applied to the region of interest is determined.

METHOD AND SYSTEM FOR RADIO DETECTION AND RANGING INTRUSION DETECTION SYSTEM

A RADAR system including a set of RADAR apparatuses is disclosed. Each apparatus includes a processor, a pulse unit in signal communication with the processor, a waveform signal generator in signal communication with the pulse unit, and a set of radar antennas in signal communication with the waveform signal generator. The waveform signal generator is capable of generating a waveform signal in response to pulses provided by the pulse unit. The set of antennas is capable of transmitting a burst of microwave energy in response to each waveform signal and to receive a plurality of reflected bursts associated with the transmitted bursts. An acquisition unit is configured to develop and amplify a finite window integral associated with each reflected burst, the acquisition unit in signal communication with the set of antennas and a pre-processor configured to digitize and store information relating to each finite window integral for subsequent processing.

SYSTEMS AND METHODS OF ALIGNMENT CONTROL FOR NEUROMODULATION DELIVERY SYSTEM

The present discussion relates to structures and devices to facilitate application of an ultrasound therapy beam to a target anatomic region in a replicable manner. In certain aspects, an alignment controller may be used to analyze images generated by an ultrasound transducer. The alignment controller may then send a communication to indicate the energy application device is positioned to provide therapy to the target region, or if the device needs to be repositioned. The alignment control of the energy application device provides guided repeatable targeting of the target anatomic region, even when in non-clinical settings.

System and methods for physiological monitoring

Embodiments of devices, methods, and non-transitory computer readable media for monitoring a subject are presented. The monitoring device includes at least one sensor configured to monitor one or more physiological parameters of a subject and a processing unit operatively coupled to the sensor. The sensor comprises a plurality of radiation sources and detectors disposed on a flexible substrate in a designated physical arrangement. The processing unit is configured to dynamically configure an operational geometry of the sensor by controlling the intensity of one or more of the radiation sources and the gain of one or more of the detectors so as to satisfy at least one quality metric associated with one or more physiological parameters of the subject.

Method and apparatus for calibrating a remote system which employs coherent signals

A method for calibrating a remote system having a plurality of N elements, N being a positive integer number. An input signal to each of the N elements is processed according to beamforming bits to determine the output of a corresponding element. The output of the plurality of N elements is a composite signal. The method includes the steps of: (a) transmitting a calibration signal to input the plurality of N elements of the remote system; (b) selecting a first set of beamforming bits for each of the plurality of N elements based upon entries of a predetermined invertible matrix; (c) processing the calibration signal at the remote system according to the beamforming bits for each of the N plurality of elements; (d) detecting a reference signal from the remote system and the composite signal transmitted from the N plurality of elements based on the first set of beamforming bits; (e) repeating steps (b)-(d) for successive sets of beamforming bits to generate a set of signals; and (f) processing ...

Neuromodulation energy application techniques

Embodiments of the present disclosure relate to techniques for facilitating personalized neuromodulation treatment protocols. In one embodiment, a predetermined treatment position of an energy application device is used to guide future treatments for the patient. In one embodiment, a position of the energy application device relative to the predetermined treatment position is determined. In one embodiment, a total dose of ultrasound energy applied to the region of interest is determined.

SYSTEM AND METHOD FOR DETERMINING A STATE OF A DOOR

A system for determining a state of a door having a locking mechanism for locking the door includes a locking mechanism and a door sensor. The locking mechanism sensor is disposed for sensing a condition of the locking mechanism and generating a signal indicative thereof. The door sensor disposed for sensing a condition of the door and generating a signal indicative thereof. The system further includes a processor for determining a state of the door, in response to the signals from the locking mechanism sensor and the door sensor. The state of the door is a secured state when the door sensor senses the condition of the door as closed and the locking mechanism sensor senses the condition of the locking mechanism as locked. A method for determining a state of a door having a locking mechanism for locking the door includes sensing a condition of the locking mechanism and sensing a condition of the door. The method further includes, determining a state of the door as a secured state when the ...

DELIVERY OF THERAPEUTIC NEUROMODULATION

Embodiments of the present disclosure relate to techniques for neuromodulation delivery. Based on image data acquired from the subject, control parameters controlling energy application of neuromodulating energy may be dynamically changed during the course of the delivery to maintain desired characteristics of the neuromodulating energy. For example, the beam of the neuromodulating energy may be dynamically adjusted to account for movement of an organ during breathing. In another embodiment, a desired region of interest is identified within the subject based on a trained neural network and the acquired image data.

ULTRASONIC BEAM PATH DETERMINATION AND TARGETING

The present discussion relates to the delivery of ultrasonic therapy energy to a target region in conjunction with a clear path determination that may assess one or more of: (1) presence of non-soft tissue regions within the therapy beam path (e.g., bone or bone-like structures, gas-filled cavities, and so forth), (2) partial “lift-off” of the probe head; or (3) sufficiency of acoustic coupling. Upon determination or confirmation of at least a partial clear path with respect to some or all of these factors, the therapy beam may be delivered to the target region.

Detection of physiological changes in impedance monitoring

Implementations are disclosed for monitoring a state or change in state of a physiological parameter based on measured impedance data. In certain implementations, no images are reconstructed from the impedance data. In certain implementations, a metric (e.g., distinguishability, likelihood ratios, and so forth) may be computed and compared to reference metrics or thresholds, such as for changes over time or in comparison to a standard to determine the presence or absence of a physiological state of interest or of a change in such state.

IMPLANTABLE SENSOR ASSEMBLY SYSTEMS AND METHODS

A system includes an implantable sensor assembly. The implantable sensor assembly includes a housing. The housing includes a substrate layer comprising an interior surface and an exterior surface, and a cap layer, wherein the substrate layer and the cap layer are coupled to form an enclosed cavity that at least partially encloses the interior surface of the substrate layer within the cavity and wherein both the substrate layer and the cap layer are formed from an insulating material. The implantable sensor assembly also includes one or more electronic components disposed within the cavity of the housing and one or more probes disposed on the exterior surface of the substrate layer and electrically coupled to the one or more electronic components by one or more electrical connections extending through the housing. 1. A system , comprising: [ a substrate layer comprising an interior surface and an exterior surface; and', 'a cap layer, wherein the substrate layer and the cap layer are coupled to form an enclosed cavity that at least partially encloses the interior surface of the substrate layer within the cavity and wherein both the substrate layer and the cap layer are formed from an electrically insulating material;, 'a housing comprising, 'one or more electronic components disposed within the cavity of the housing; and', 'one or more probes disposed on the exterior surface of the substrate layer and electrically coupled to the one or more electronic components by one or more electrical connections extending through the housing., 'an implantable sensor assembly comprising2. The system of claim 1 , wherein the one or more electronic components are disposed directly on the interior surface of the substrate layer.3. The system of claim 1 , wherein the at least some of the one or more electronic components are disposed directly on an interior surface of the cap layer.4. The system of claim 1 , comprising a side-feed through connection disposed on the interior surface of ...

NEUROMODULATION ENERGY APPLICATION TECHNIQUES

Embodiments of the present disclosure relate to techniques for facilitating personalized neuromodulation treatment protocols. In one embodiment, a predetermined treatment position of an energy application device is used to guide future treatments for the patient. In one embodiment, a position of the energy application device relative to the predetermined treatment position is determined. In one embodiment, a total dose of ultrasound energy applied to the region of interest is determined.

SYSTEMS AND METHODS FOR MONITORING SENSORS

An impedance analyzer is provided. The analyzer includes a signal excitation generator comprising a digital to analog converter, where a transfer function of the digital to analog converter from digital to analog is programmable. The impedance analyzer further includes a receiver comprising a low noise amplifier (LNA) and an analog to digital converter (ADC), where the LNA is a current to voltage converter; where the programmable digital to analog transfer function is implemented by a direct digital synthesizer (DDS) and a voltage mode digital to analog converter, or a digital phase locked loop (PLL), or both. Further, a multivariable sensor node having an impedance analyzer is provided. Furthermore, a multivariable sensor network having a plurality of multivariable sensor nodes is provided. 1. An impedance analyzer comprising:a signal excitation generator comprising a digital to analog converter, wherein a transfer function of the digital to analog converter from digital to analog is programmable;a receiver comprising a low noise amplifier (LNA) and an analog to digital converter (ADC), wherein the LNA is a current to voltage converter;wherein the programmable digital to analog transfer function is implemented by a direct digital synthesizer (DDS) and a voltage mode digital to analog converter, or a digital phase locked loop (PLL), or both.2. The impedance analyzer of claim 1 , comprising a current to voltage converter (CVC) trans-impedance amplifier integrated with the ADC.3. The impedance analyzer of claim 1 , wherein the ADC comprises a low-power successive approximation register (SAR) analog to digital converter.4. The impedance analyzer of claim 1 , comprising a mixer configured to down convert a radio frequency signal to a baseband signal.5. The impedance analyzer of claim 4 , where the mixer is a low power mixer.6. The impedance analyzer of claim 1 , where a number of bits in the ADC is reduced to reduce the total power consumption of the device.7. The ...

Field-portable impedance reader and methods of making the same

A field-portable impedance reader is provided. The impedance reader comprises a reader antenna, an impedance compensator, a calibrator, and a synchronous sampler. The impedance reader further comprises a digital processor that receives and processes signals from the synchronous sampler. Further, a wireless system comprising the impedance reader of the invention is provided.

MULTI-BEAM NEUROMODULATION TECHNIQUES

The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue that include applying energy (e.g., ultrasound energy) into the tissue at multiple regions of interest, concurrently or consecutively. The neuromodulation may result in tissue displacement, which may be observed through changes in one or more molecules of interest.

SYSTEMS AND METHODS FOR IMPROVED PHYSIOLOGICAL MONITORING

A system and method for monitoring a subject are presented. The system includes a sensing device including at least one magnetic source to generate a magnetic field and an array of magnetic sensors disposed within the magnetic field. The sensor array obtains a plurality of magnetic field measurements at a plurality of locations along a vessel carrying a fluid including one or more magnetic particles. Further, the system includes a processing subsystem communicatively coupled to the sensing device, where the processing subsystem determines variations in the measurements caused by magnetization-relaxation of the magnetic particles based on a coupled model that defines behavior of the fluid in the varying magnetic field based on principles of magnetization-relaxation, bulk motion of the magnetic particles towards a determined gradient of the magnetic field, magnetostatics, and conservation of momentum. The processing subsystem estimates values of one or more desired parameters based on the determined variations. 1. A system for monitoring a subject , comprising: at least one magnetic source to generate a magnetic field;', 'an array of magnetic sensors disposed within the magnetic field to obtain a plurality of measurements corresponding to the magnetic field at a plurality of locations along a vessel comprising a fluid, wherein the fluid comprises one or more magnetic particles;, 'a sensing device, comprising determines variations in the plurality of measurements caused by magnetization-relaxation of the magnetic particles in the fluid flowing through the vessel based on a coupled model, wherein the coupled model defines a behavior of the fluid in the varying magnetic field based on principles of magnetization-relaxation, bulk motion of the magnetic particles in the fluid towards a determined gradient of the magnetic field, magnetostatics, and conservation of momentum; and', 'estimates values of one or more desired parameters based on the determined variations., 'a ...

Standoff detection systems and methods

Embodiments of the invention include a system and a method for determining whether a person is carrying concealed contraband, such as an improvised explosives device or other weapon. The system includes a people tracking video subsystem, a people tracking decisioning subsystem, a concealed contraband detection aiming subsystem, and a concealed contraband detection decisioning subsystem.

System and method for determining physiological parameters based on electrical impedance measurements

A system and method for determining physiological parameters based on electrical impedance measurements is provided. One method includes obtaining electrical measurement signals acquired from a plurality of transducers coupled to a surface of an object and spatially pre-conditioning the obtained electrical measurement signals. The method also includes performing multiple-input-multiple-output (MIMO) analog to information conversion (AIC) of the spatially pre-conditioned electrical measurement signals to correlate the spatially pre-conditioned electrical measurement signals to separate the electrical measurement signals.

DETECTION OF PHYSIOLOGICAL CHANGES IN IMPEDANCE MONITORING

Implementations are disclosed for monitoring a state or change in state of a physiological parameter based on measured impedance data. In certain implementations, no images are reconstructed from the impedance data. In certain implementations, a metric (e.g., distinguishability, likelihood ratios, and so forth) may be computed and compared to reference metrics or thresholds, such as for changes over time or in comparison to a standard to determine the presence or absence of a physiological state of interest or of a change in such state.

System and method for transducer placement in soft-field tomography

A system and method for transducer placement in soft-field tomography are provided. One system includes a plurality of transducers configured for positioning at a surface of an object in a non-soft-field tomography configuration. The system also includes an interface and a processor communicating with the plurality of transducers via the interface. The processor is configured to perform soft-field sensing using soft-field data acquired by the plurality of transducers.

NONINVASIVE TISSUE DISPLACEMENT CONTROL AND MONITORING FOR NEUROMODULATION

The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into an internal tissue to cause tissue displacement and identifying that the tissue displacement has occurred. In one embodiment, the presence of tissue displacement is associated with a desired therapeutic or physiological outcome, such as a change in a molecule of interest.

System and method for determining a hydration level of a tissue region

In accordance with one aspect of the present technique, a method is disclosed. The method includes applying a mechanical perturbation to a tissue region using a displacement device. The method further includes calculating a compression impedance of the tissue region in response to applying the mechanical perturbation. The method further includes retracting the displacement device and calculating a retraction impedance of the tissue region in response to retracting the displacement device. The method also includes determining a hydration level of the tissue region based on at least one of the compression impedance and the retraction impedances.

NEUROMODULATION TECHNIQUES FOR PERTURBATION OF PHYSIOLOGICAL SYSTEMS

Embodiments of the present disclosure relate to techniques for inducing physiological perturbations in a subject via neuromodulation, e.g., peripheral neuromodulation of a region of interest of an organ. The nature and degree of the perturbations may be related to the subject's clinical condition. Accordingly, an assessment of one or more characteristics of the perturbations may be used to determine a clinical condition of the subject.

Pulse oximetry devices and systems and methods of making the same

An array of emitters includes a device substrate having first and second sides, a thermally and electrically conductive layer disposed on the first side of the device substrate, and an interconnect layer disposed on a first plurality of portions of the second side of the device substrate. The array of the emitters further includes a plurality of emitters disposed in a second plurality of portions of the device substrate, where the plurality of emitters is electrically coupled to the thermally and electrically conductive layer. Also, the array of the emitters includes a plurality of wirebond contacts configured to electrically couple a portion of the interconnect layer to a corresponding emitter of the plurality of emitters, and a plurality of encapsulations, where one or more encapsulations of the plurality of encapsulations are disposed on at least a portion of a corresponding wirebond contact of the plurality of wirebond contacts.

TECHNIQUES FOR NEUROMODULATION

The subject matter of the present disclosure generally relates to techniques for neuromodulation of lymphatic tissue that include applying one or more energy pulses to a neuron of a subject, e.g., via an electrode positioned to deliver sufficient energy to the neuron, to modulate immune function. For example, an adaptive immune reflex of a subject may be modulated via neuromodulation

Method and system for radio detection and ranging intrusion detection system

A RADAR system including a set of RADAR apparatuses is disclosed. Each apparatus includes a processor, a pulse unit in signal communication with the processor, a waveform signal generator in signal communication with the pulse unit, and a set of radar antennas in signal communication with the waveform signal generator. The waveform signal generator is capable of generating a waveform signal in response to pulses provided by the pulse unit. The set of antennas is capable of transmitting a burst of microwave energy in response to each waveform signal and to receive a plurality of reflected bursts associated with the transmitted bursts. An acquisition unit is configured to develop and amplify a finite window integral associated with each reflected burst, the acquisition unit in signal communication with the set of antennas and a pre-processor configured to digitize and store information relating to each finite window integral for subsequent processing.

Method and system for detecting pace pulses

The present technique provides for the detection of pace pulses in electrocardiogram data. The technique provides for processing one or more sets of electrocardiogram data via a non-linear algorithm. Furthermore, the technique provides for detecting one or more pace pulses in the one or more sets of electrocardiogram data via a non-linear detection algorithm. Systems and computer programs that afford functionality of the type defined by this method are also provided by the present technique.

RADAR BASED SYSTEMS AND METHODS FOR DETECTING A FALLEN PERSON

Methods, systems and non-transitory computer readable mediums that store instructions executable by one or more processors to perform a method for detecting a fallen person are presented. The present technique includes identifying a reference plane and a reference line in a designated space monitored using one or more range-controlled radars. These radars are coupled to one or more antennas configured to define fields of the range-controlled radars to one or more portions of the designated space, where at least one portion corresponds to the reference plane. The range-controlled radars detect presence of one or more parameters corresponding to a subject disposed in the designated space. The parameters, for example, include one or more physiological parameters and one or more motion parameters. The range-controlled radars then identify the subject as the fallen person if the one or more physiological parameters corresponding to the subject are detected proximate the reference plane. 1. A method for detecting a fallen person , comprising:identifying a reference plane and a reference line in a designated space;monitoring the designated space using one or more range-controlled radars coupled to one or more antennas are configured to define corresponding fields of the one or more range-controlled radars to one or more portions of the designated space, wherein at least one of the one or more portions corresponds to the reference plane;detecting presence of one or more parameters corresponding to a subject disposed in the designated space using the one or more range-controlled radars, wherein the one or more parameters comprise one or more physiological parameters and one or more motion parameters; andidentifying the subject as the fallen person if the one or more physiological parameters corresponding to the subject are detected proximate the reference plane.2. The method of claim 1 , further comprising generating an audio output claim 1 , a visual output claim 1 , an ...

SYSTEM AND METHOD FOR DETERMINING A HYDRATION LEVEL OF A TISSUE REGION

In accordance with one aspect of the present technique, a method is disclosed. The method includes applying a mechanical perturbation to a tissue region using a displacement device. The method further includes calculating a compression impedance of the tissue region in response to applying the mechanical perturbation. The method further includes retracting the displacement device and calculating a retraction impedance of the tissue region in response to retracting the displacement device. The method also includes determining a hydration level of the tissue region based on at least one of the compression impedance and the retraction impedances. 1. A method comprising:applying a mechanical perturbation to a tissue region using a displacement device;calculating a compression impedance (CI) of the tissue region in response to applying the mechanical perturbation;retracting the displacement device;calculating a retraction impedance (RI) of the tissue region in response to retracting the displacement device; anddetermining a hydration level of the tissue region based on at least one of the CI and the RI.2. The method of claim 1 , wherein the hydration level includes at least one of an edema stage and a dehydration stage of the tissue region.3. The method of claim 1 , further comprising applying the mechanical perturbation to the tissue region based on at least one of a pre-determined force and a pre-determined displacement of the tissue region.4. The method of claim 1 , further comprising:calculating a rate of change of CI and a rate of change of RI; anddetermining the hydration level of the tissue region based on at least one of the rate of change CI and the rate of change of RI.5. The method of claim 4 , further comprising:determining whether the rate of change of CI is within a stabilization threshold range;calculating a CI change in response to determining that the rate of change of CI is within the stabilization threshold range; anddetermining the hydration level of ...

TECHNIQUES FOR NEUROMODULATION

The subject matter of the present disclosure generally relates to techniques for neuromodulation of lymphatic tissue that include applying one or more energy pulses to a neuron of a subject, e.g., via an electrode positioned to deliver sufficient energy to the neuron, to modulate immune function. For example, an adaptive immune reflex of a subject may be modulated via neuromodulation

MONITORING SYSTEM AND CURRENT TRANSFORMERS FOR PARTIAL DISCHARGE DETECTION

A high frequency current transformer (HFCT) sensor for detecting partial discharges produced by a component is disclosed. The HFCT sensor includes at least one electrically conductive pattern formed on a substrate, where the substrate comprises multiple segmented regions connected by intermediate regions for folding along multiple fold lines between the segmented regions to form the HFCT sensor. A system for monitoring at least one component of an aircraft wiring system is also disclosed. The monitoring system includes at least one of the HFCT sensors for detecting partial discharges produced by the aircraft wiring system component. The monitoring system further includes a data acquisition system configured to monitoring signals from the HFCT sensor(s).

Systems and methods for electrical impedance imaging

A method and system for performing electrical impedance imaging of a subject of interest using a plurality of electrodes is provided. The method includes applying one or more determined current patterns to one or more electrodes of the plurality of electrodes. Further, the method includes determining a resultant voltage at at least one electrode of the one or more electrodes in response to the one or more determined current patterns. Moreover, the method includes estimating a change in a contact impedance for the at least one electrode of the one or more electrodes. Additionally, the method includes calculating a compensated voltage for the at least one electrode based on an estimated change in a corresponding contact impedance of the at least one electrode.

SYSTEMS AND METHODS FOR MONITORING SENSORS

A method for multivariable measurements using a single-chip impedance analyzer includes providing a sensor, exposing the sensor to an environmental parameter, determining a complex impedance of the sensor over a measured spectral frequency range of the sensor, and monitoring at least three spectral parameters of the sensor. 1. A method for multivariable measurements using a single-chip impedance analyzer , the method comprisingproviding a sensor;exposing the sensor to an environmental parameter;determining a complex impedance of the sensor over a measured spectral frequency range of the sensor; andmonitoring at least three spectral parameters of the sensor.2. The method of claim 1 , further comprising down converting a radio frequency signal to a baseband signal.3. The method of claim 1 , further comprising reducing a number of bits for analog to digital conversion to reduce the total power consumption.4. The method of claim 1 , further comprising filtering out undesirable signals and noise sources.5. The method of claim 1 , further comprising:regulating an excitation amplitude of the sensor, anddetecting a phase of a sensor signal.6. A method claim 1 , comprising:generating an excitation signal for a plurality of sensors, comprising digital to analog conversion, wherein a transfer function for the digital to analog conversion is programmable;monitoring a plurality of responses from the sensors; andtransmitting sensor data.7. The method of claim 6 , further comprising wirelessly transmitting the sensor data.8. The method of claim 6 , comprising transmitting data from one or more sensors of the plurality of sensors to a sensor network.9. The method of claim 6 , further comprising harvesting energy from an ambient environment claim 6 , wherein the energy comprises a thermal energy claim 6 , a radio frequency energy claim 6 , a light energy claim 6 , a vibration energy claim 6 , a motion energy claim 6 , or a combination thereof.10. The method of claim 6 , further ...

SYSTEM AND METHOD FOR DETERMINING PHYSIOLOGICAL PARAMETERS BASED ON ELECTRICAL IMPEDANCE MEASUREMENTS

A system and method for determining physiological parameters based on electrical impedance measurements is provided. One method includes obtaining electrical measurement signals acquired from a plurality of transducers coupled to a surface of an object and constructing a system matrix to define one or more relationships between the impedance measurement signals. The method also includes decomposing the system matrix to separate the electrical measurement signals.

Method and system for wireless respiration rate monitoring using space and frequency diversities

A system and method include a plurality of sensors proximate a subject, wherein each sensor includes a plurality of antennas, and wherein each sensor operates on a plurality of frequency channels. The method includes receiving, at a respiration module, a signal associated with each antenna for each of the plurality of frequency channels; and calculating a respiration rate of the subject based on the received signal associated with each antenna for each of the plurality of frequency channels. Numerous other aspects are provided.

Systems and methods for monitoring sensors

An impedance analyzer is provided. The analyzer includes a signal excitation generator comprising a digital to analog converter, where a transfer function of the digital to analog converter from digital to analog is programmable. The impedance analyzer further includes a receiver comprising a low noise amplifier (LNA) and an analog to digital converter (ADC), where the LNA is a current to voltage converter; where the programmable digital to analog transfer function is implemented by a direct digital synthesizer (DDS) and a voltage mode digital to analog converter, or a digital phase locked loop (PLL), or both. Further, a multivariable sensor node having an impedance analyzer is provided. Furthermore, a multivariable sensor network having a plurality of multivariable sensor nodes is provided.

SYSTEMS AND METHODS FOR SHIELDED AND ADJUSTABLE MEDICAL MONITORING DEVICES

A system for monitoring medical conditions includes a conformable medical monitoring device that includes a first substrate layer, which includes an electronics module, many signal traces, and at least one electrode, such that one or more of the many signal traces electrically couple the at least one electrode to the electronics module. The conformable medical monitoring device includes a second substrate layer positioned over the electronics module, the first substrate layer, or any combination thereof to insulate the electronics module, the first substrate layer, or any combination thereof. The conformable medical monitoring device also includes a third substrate layer positioned over the second substrate layer, such that the third substrate layer reduces electromagnetic interference caused by a voltage pulse and includes an adjustable system coupled to the first substrate layer and that changes a position of the at least one electrode relative to the electronics module. 1. A system for monitoring medical conditions , the system comprising: a first substrate layer comprising an electronics module, a plurality of signal traces and at least one electrode, wherein one or more of the plurality of signal traces electrically couple the at least one electrode to the electronics module;', 'a second substrate layer positioned over the electronics module, the first substrate layer, or any combination thereof, wherein the second substrate layer is configured to insulate the electronics module, the first substrate layer, or any combination thereof;', 'a third substrate layer positioned over the second substrate layer, wherein the third substrate layer is configured to reduce electromagnetic interference caused by a voltage pulse; and', 'an adjustable system coupled to the first substrate layer, wherein the adjustable system is configured to change a position of the at least one electrode relative to the electronics module., 'a conformable medical monitoring device, ...

ARRAYS OF EMITTERS FOR PULSE OXIMETRY DEVICES AND METHODS OF MAKING THE SAME

An array of emitters includes a device substrate having first and second sides, a thermally and electrically conductive layer disposed on the first side of the device substrate, and an interconnect layer disposed on a first plurality of portions of the second side of the device substrate. The array of the emitters further includes a plurality of emitters disposed in a second plurality of portions of the device substrate, where the plurality of emitters is electrically coupled to the thermally and electrically conductive layer. Also, the array of the emitters includes a plurality of wirebond contacts configured to electrically couple a portion of the interconnect layer to a corresponding emitter of the plurality of emitters, and a plurality of encapsulations, where one or more encapsulations of the plurality of encapsulations are disposed on at least a portion of a corresponding wirebond contact of the plurality of wirebond contacts. 1. An array of emitters , comprisinga device substrate having a first side and a second side;a thermally and electrically conductive layer disposed on the first side of the device substrate;an interconnect layer disposed on a first plurality of portions of the second side of the device substrate;a plurality of emitters disposed in a second plurality of portions of the device substrate, wherein the plurality of emitters is electrically coupled to the thermally and electrically conductive layer;a plurality of wirebond contacts configured to electrically couple a portion of the interconnect layer to a corresponding emitter of the plurality of emitters; anda plurality of encapsulations, wherein one or more encapsulations of the plurality of encapsulations are disposed on at least a portion of a corresponding wirebond contact of the plurality of wirebond contacts and a corresponding emitter of the plurality of emitters.2. The array of emitters of claim 1 , wherein the plurality of encapsulations comprises epoxy.3. The array of emitters of ...

MULTI-BEAM NEUROMODULATION TECHNIQUES

The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue that include applying energy (e.g., ultrasound energy) into the tissue at multiple regions of interest, concurrently or consecutively. The neuromodulation may result in tissue displacement, which may be observed through changes in one or more molecules of interest. 1. An ultrasound system , comprising:at least one ultrasound transducer comprising a plurality of elements; and receive image data of tissue of the subject from the ultrasound transducer;', 'divide the image data of the tissue into a plurality of segments representative of the tissue;', 'focus the ultrasound transducer on a plurality of regions of interest, each region of interest being located within a different segment of the plurality of segments; and', 'control the ultrasound transducer to apply ultrasound energy distributed between the plurality of regions of interest to cause tissue displacement of each region of interest., 'a controller configured to control a dose of ultrasound energy applied to the subject, wherein the controller is configured to2. The system of claim 1 , wherein the tissue comprises a first organ and a second organ different than the first organ claim 1 , and wherein a first region of interest of the plurality of regions of interest is in the first organ and a second region of interest of the plurality of regions of interest is in the second organ.3. The system of claim 2 , wherein at least 75% of the dose is applied to the first organ.4. The system of claim 2 , wherein the first organ is a pancreas claim 2 , spleen claim 2 , or liver.5. The system of claim 1 , wherein the tissue comprises an organ claim 1 , and wherein the plurality of regions of interest are in the organ.6. The system of claim 1 , wherein the controller is configured to control applying the dose such that no individual segment of the plurality of segments receives more than a selected threshold of ...

METHOD AND SYSTEM FOR WIRELESS RESPIRATION RATE MONITORING USING SPACE AND FREQUENCY DIVERSITIES

A system and method include a plurality of sensors proximate a subject, wherein each sensor includes a plurality of antennas, and wherein each sensor operates on a plurality of frequency channels. The method includes receiving, at a respiration module, a signal associated with each antenna for each of the plurality of frequency channels; and calculating a respiration rate of the subject based on the received signal associated with each antenna for each of the plurality of frequency channels. Numerous other aspects are provided.

Systems and methods for monitoring sensors

A method for multivariable measurements using a single-chip impedance analyzer includes providing a sensor, exposing the sensor to an environmental parameter, determining a complex impedance of the sensor over a measured spectral frequency range of the sensor, and monitoring at least three spectral parameters of the sensor.

DELIVERY OF THERAPEUTIC NEUROMODULATION

Embodiments of the present disclosure relate to techniques for neuromodulation delivery. Based on image data acquired from the subject, control parameters controlling energy application of neuromodulating energy may be dynamically changed during the course of the delivery to maintain desired characteristics of the neuromodulating energy. For example, the beam of the neuromodulating energy may be dynamically adjusted to account for movement of an organ during breathing. In another embodiment, a desired region of interest is identified within the subject based on a trained neural network and the acquired image data. 1. A neuromodulation delivery system , comprising:an energy application device configured to deliver neuromodulating energy to a region of interest in a subject; and receive image data of an internal tissue of the subject;', 'identify the region of interest within the image data;', 'control application of the neuromodulating energy via the energy application device to the identified region of interest to deliver a dose of the neuromodulating energy thereto;', 'receive updated image data of the internal tissue of the subject before delivering the dose is complete;', 'identify a change in a location of the region of interest in relation to the energy application device based on the updated image data; and', 'adjust application of the neuromodulating energy via the energy application device based on the changed location of the region of interest to continue the delivering of the dose of the neuromodulating energy to treat the subject., 'a controller configured to2. The system of claim 1 , wherein the energy application device comprises an ultrasound transducer and wherein the controller is configured to control the energy application device to steer and/or focus an ultrasound beam formed by the ultrasound transducer to the identified region of interest.3. The system of claim 1 , wherein the energy application device comprises a motor configured to change a ...

SYSTEM AND METHOD FOR TRANSDUCER PLACEMENT IN SOFT-FIELD TOMOGRAPHY

A system and method for transducer placement in soft-field tomography are provided. One system includes a plurality of transducers configured for positioning at a surface of an object in a non-soft-field tomography configuration. The system also includes an interface and a processor communicating with the plurality of transducers via the interface. The processor is configured to perform soft-field sensing using soft-field data acquired by the plurality of transducers. 1. A soft-field tomography sensing system comprising:a plurality of transducers configured for positioning at a surface of an object in a non-soft-field tomography configuration;an interface; anda processor communicating with the plurality of transducers via the interface, the processor configured to perform soft-field sensing using soft-field data acquired by the plurality of transducers.2. The soft-field tomography sensing system of claim 1 , wherein the plurality of transducers comprises an electrocardiography (ECG) transducer set.3. The soft-field tomography sensing system of claim 1 , wherein the plurality of transducers comprises an electroencephalography (EEG) transducer set.4. The soft-field tomography sensing system of claim 1 , wherein the plurality of transducers comprises a non-soft-field sensing transducer set and at least one additional transducer.5. The soft-field tomography sensing system of claim 1 , wherein the plurality of transducers comprises a non-soft-field sensing transducer set and a soft-field sensing transducer set.6. The soft-field tomography sensing system of claim 1 , wherein the soft-field data is acquired at all of the plurality of transducers.7. The soft-field tomography sensing system of claim 1 , wherein the soft-field data is acquired at a subset of the plurality of transducers.8. The soft-field tomography sensing system of claim 1 , further comprising a connector configured to interface with at least one type of non-soft-field sensing transducer set and at least one ...

NEUROMODULATION ENERGY APPLICATION TECHNIQUES

Embodiments of the present disclosure relate to techniques for facilitating personalized neuromodulation treatment protocols. In one embodiment, a predetermined treatment position of an energy application device is used to guide future treatments for the patient. In one embodiment, a position of the energy application device relative to the predetermined treatment position is determined. In one embodiment, a total dose of ultrasound energy applied to the region of interest is determined.

Systems and methods for shielded and adjustable medical monitoring devices

A system for monitoring medical conditions includes a conformable medical monitoring device that includes a first substrate layer, which includes an electronics module, many signal traces, and at least one electrode, such that one or more of the many signal traces electrically couple the at least one electrode to the electronics module. The conformable medical monitoring device includes a second substrate layer positioned over the electronics module, the first substrate layer, or any combination thereof to insulate the electronics module, the first substrate layer, or any combination thereof. The conformable medical monitoring device also includes a third substrate layer positioned over the second substrate layer, such that the third substrate layer reduces electromagnetic interference caused by a voltage pulse and includes an adjustable system coupled to the first substrate layer and that changes a position of the at least one electrode relative to the electronics module.

PATIENT-SPECIFIC NEUROMODULATION ALIGNMENT STRUCTURES

The present discussion relates to structures and devices to facilitate application of an ultrasound therapy beam to a target anatomic region in a replicable manner. In certain aspects, adjustable positioning structures are described that allow a general probe positioning structure to be configured for a specific patient in a manner that allows the device to be used repeatedly to target the anatomic region, even when in non-clinical settings. In other aspects, a probe positioning structure is fabricated that is specific to a respective patient anatomy, such that use of the probe positioning structure provides repeatable targeting of the target anatomic region, even when in non-clinical settings.

Radar based systems and methods for monitoring a subject

Methods and systems for monitoring a subject in a resting state using one or more range-controlled radars are presented. The radars non-invasively detect one or more motion and/or physiological parameters corresponding to the subject. The motion parameters comprise one or more activity levels and the physiological parameters comprise one or more of heartbeat and respiration. Further, one or more patterns in the motion parameters detected over a designated motion period of time are determined. Additionally, one or more patterns in the physiological parameters detected over the designated physiological period of time are also determined. The systems then assess a health condition of the subject based on the determined patterns of the motion parameters and/or the determined patterns of the physiological parameters.

IN SITU ASSEMBLY OF A BI-DIRECTIONAL NEURAL INTERFACE

The subject matter of the present disclosure generally relates to a method and system for providing a bi-directional neural interface having an electrode configured to be positioned on a nerve; a substrate holding the electrode; a biocompatible insulator configured to electrically isolate the electrode when the electrode is positioned on the nerve, wherein the biocompatible insulator is formed in place about the electrode; and a pulse generator configured to deliver energy pulses to the electrode. 1. A method of assembling a neural interface , comprising:positioning an electrode proximate to a nerve such that the electrode is positioned partially proximate to or about an outer circumference of the nerve;applying an injectable biocompatible adhesive between the electrode and the nerve; andapplying an injectable biocompatible insulator around the biocompatible adhesive, the nerve, and the electrode to provide in situ assembly of a neural interface around the nerve.2. The method of claim 1 , wherein the biocompatible adhesive is applied before the positioning of the electrode.3. The method of claim 1 , wherein the biocompatible adhesive is applied after the positioning of the electrode.4. The method of claim 1 , wherein applying the biocompatible adhesive comprises forming a gap between the nerve and the electrode that is at least partially filled by the biocompatible adhesive.5. The method of claim 1 , further comprising: positioning a second electrode proximate to the nerve and spaced apart from the first electrode and wherein applying the biocompatible adhesive comprises applying the biocompatible adhesive between the nerve and the second electrode.6. The method of claim 5 , wherein applying the biocompatible insulator around the biocompatible adhesive claim 5 , the nerve claim 5 , and the electrode comprises applying the biocompatible insulator around the second electrode.7. The method of claim 1 , wherein one or both of injectable biocompatible insulator or the ...

ACCELERATING CUTANEOUS HEALING UTILIZING NON-INVASIVE FOCUSED ULTRASOUND

The present approaches are generally directed to facilitating healing of wounds, including chronic wounds typically associated with slow heal times or which are persistent. In one embodiment, a method of promoting wound healing comprises positioning an ultrasound transducer at a stimulation site on a subject having a wound. Pulsed focused ultrasound (pFUS) is non-invasively applies using the transducer to cause modulation of a target anatomic site containing resident or circulating immune cells. Modulation of the target anatomic site of the subject causes migration of one or more of monocytes, macrophages, or neutrophils to a wound bed of the wound.

NEUROMODULATION ENERGY APPLICATION TECHNIQUES

Embodiments of the present disclosure relate to techniques for accurate positioning of an energy application device for neuromodulation treatment protocols. In one embodiment, a neuromodulation positioning patch is applied to a patient's skin. The energy application device is configured to couple to a frame of the neuromodulation positioning patch to position a transducer of the energy application device within an opening at a treatment position within the opening. In one embodiment, the frame is also configured to couple to a removable dock for an imaging probe that, when coupled to the removable dock and, in turn, the frame of the neuromodulation positioning patch, is configured to acquire image data through the opening to identify or verify a treatment position. 1. A neuromodulation energy application system , comprising: ["a conformable substrate comprising an application surface configured to be applied to a subject's skin, the application surface comprising an adhesive portion, wherein the conformable substrate forms a first opening that permits viewing of a portion of the subject's skin through the first opening when the conformable substrate is applied;", 'a resilient frame disposed on the conformable substrate to frame the first opening and protruding from a top surface of the conformable substrate, the top surface opposing the adhesive surface;', 'a dock configured to removably mate with the resilient frame, wherein the dock forms a shaped passage that terminates in a second opening, wherein the second opening sits within the first opening when the dock is mated with the resilient frame; and, 'a neuromodulation positioning patch comprisingan ultrasound therapy probe configured to fit within or couple to the frame to apply neuromodulating energy through the portion of the subject's skin to a region of interest of an internal tissue.2. The system of claim 1 , wherein the shaped passage is configured to accommodate an ultrasound imaging probe claim 1 , the ...

Radio detection and ranging intrusion detection system

A radar system having a processor, a waveform generator, a plurality of antenna interfaces, a set of first antennas configured to transmit a waveform, and a set of second antennas configured to receive a reflected waveform is disclosed. The waveform generator and antenna interfaces are in control and signal communication with the processor, each of the first antennas are in signal communication with one of each antenna interface, and each of the second antennas are in signal communication with one of each antenna interface. The waveform generator is in control and signal communication with each antenna interface, and is configurable to generate a waveform conforming to at least two ISM bands. Each first antenna is configured to transmit a circularly polarized electromagnetic waveform, and each second antenna is configured to receive a reflected circularly polarized electromagnetic waveform complementary to the first antennas.

Multi-beam neuromodulation techniques

The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue that include applying energy (e.g., ultrasound energy) into the tissue at multiple regions of interest, concurrently or consecutively. The neuromodulation may result in tissue displacement, which may be observed through changes in one or more molecules of interest.

RADAR BASED SYSTEMS AND METHODS FOR MONITORING A SUBJECT

Methods and systems for monitoring a subject in a resting state using one or more range-controlled radars are presented. The radars non-invasively detect one or more motion and/or physiological parameters corresponding to the subject. The motion parameters comprise one or more activity levels and the physiological parameters comprise one or more of heartbeat and respiration. Further, one or more patterns in the motion parameters detected over a designated motion period of time are determined Additionally, one or more patterns in the physiological parameters detected over the designated physiological period of time are also determined The systems then assess a health condition of the subject based on the determined patterns of the motion parameters and/or the determined patterns of the physiological parameters. 1. A method for monitoring a subject , comprising:monitoring a subject in a resting state using one or more range-controlled radars;non-invasively detecting one or more motion parameters, one or more physiological parameters, or combinations thereof, corresponding to the subject, wherein the motion parameters comprise one or more activity levels and the physiological parameters comprise one or more of heartbeat and respiration;determining one or more patterns in the motion parameters detected over a designated motion period of time;determining one or more patterns in the physiological parameters detected over the designated phyiological period of time; andassessing a health condition of the subject based on the determined patterns of the motion parameters, the determined patterns of the physiological parameters, or combinations thereof.2. The method of claim 1 , wherein non-invasively detecting one or more physiological parameters comprsies:receiving one or more signals using the one or more range-controlled radars;processing the received signals to extract components corresponding to one or more frequency bands, wherein each frequency band corresponds to a ...

SYSTEMS AND METHODS FOR ELECTRICAL IMPEDANCE IMAGING

A method and system for performing electrical impedance imaging of a subject of interest using a plurality of electrodes is provided. The method includes applying one or more determined current patterns to one or more electrodes of the plurality of electrodes. Further, the method includes determining a resultant voltage at at least one electrode of the one or more electrodes in response to the one or more determined current patterns. Moreover, the method includes estimating a change in a contact impedance for the at least one electrode of the one or more electrodes. Additionally, the method includes calculating a compensated voltage for the at least one electrode based on an estimated change in a corresponding contact impedance of the at least one electrode. 1. A method for impedance imaging of a subject of interest using a plurality of electrodes , comprising:applying one or more determined current patterns to one or more electrodes of the plurality of electrodes;determining a resultant voltage at at least one electrode of the one or more electrodes in response to the one or more determined current patterns;estimating a change in a contact impedance for the at least one electrode of the one or more electrodes; andcalculating a compensated voltage for the at least one electrode based on an estimated change in a corresponding contact impedance of an electrode of the one or more electrodes.2. The method for electrical impedance imaging of claim 1 , comprising estimating a change in a contact impedance between each pair of electrodes of the plurality of electrodes.3. The method for electrical impedance imaging of claim 1 , comprising estimating a change in a contact impedance for at least one electrode of the one or more electrodes at two or more instants in time.4. The method for electrical impedance imaging of claim 1 , wherein calculating the compensated voltage for the at least one electrode comprises subtracting a portion of a voltage from the determined resultant ...

Neuromodulation energy application techniques

Techniques for accurate positioning of an energy application device for neuromodulation treatment protocols are provided. A neuromodulation positioning patch is applied to a patient's skin. The energy application device is coupled to a frame of the neuromodulation positioning patch to position a transducer of the energy application device within an opening at a treatment position within the opening. The frame is also coupled to a removable dock for an imaging probe. When the frame is coupled to the removable dock the frame of the neuromodulation positioning patch, acquires image data through the opening to identify or verify the treatment position.

ELECTRICAL IMPEDANCE IMAGING SYSTEMS

An electrical channel having inbuilt current limiting is provided. The electrical channel includes an electrode current source. The electrode current source includes a voltage-to-current converter, a negative impedance converter, and at least one passive current limiting component. Further, the voltage-to-current converter is configured to receive an input voltage and output a corresponding output current. Moreover, the negative impedance converter is operatively coupled to the voltage-to-current converter, where the negative impedance converter is configured to cancel an output impedance of the voltage-to-current converter, a parasitic impedance, or both. Also, the passive current limiting component is configured to limit the output current to a load below a threshold value. 1. An electrical channel having inbuilt current limiting , comprising: a voltage-to-current converter configured to receive an input voltage and output a corresponding output current;', 'a negative impedance converter operatively coupled to the voltage-to-current converter, wherein the negative impedance converter is configured to cancel an output impedance of the voltage-to-current converter, a parasitic impedance, or both; and', 'at least one passive current limiting component configured to limit the output current to a load below a threshold value., 'an electrode current source, comprising2. The electrical channel of claim 1 , wherein the at least one passive current limiting component is an integrated passive current limiting component.3. The electrical channel of claim 2 , wherein the integrated passive current limiting component is integrated with a circuit topology of the voltage-to-current converter claim 2 , the negative impedance converter claim 2 , or both.4. The electrical channel of claim 1 , wherein the passive current limiting component is disposed between the voltage-to-current converter and the negative impedance converter claim 1 , in series with the load claim 1 , or both.5. ...

SYSTEM AND METHODS FOR PHYSIOLOGICAL MONITORING

Embodiments of devices, methods, and non-transitory computer readable media for monitoring a subject are presented. The monitoring device includes at least one sensor configured to monitor one or more physiological parameters of a subject and a processing unit operatively coupled to the sensor. The sensor comprises a plurality of radiation sources and detectors disposed on a flexible substrate in a designated physical arrangement. The processing unit is configured to dynamically configure an operational geometry of the sensor by controlling the intensity of one or more of the radiation sources and the gain of one or more of the detectors so as to satisfy at least one quality metric associated with one or more physiological parameters of the subject. 1. A monitoring device , comprising:at least one sensor configured to monitor one or more physiological parameters of a subject, wherein the sensor comprises a plurality of radiation sources and detectors disposed on a flexible substrate in a designated physical arrangement;a processing unit operatively coupled to the sensor, herein the processing unit is configured to dynamically configure an operational geometry of the sensor by controlling the intensity of one or more of the radiation sources and the gain of one or more of the detectors so as to satisfy at least one quality metric associated with one or more physiological parameters of the subject.2. The monitoring device of claim 1 , wherein the operational geometry of the sensor comprises a subset of one or more radiation sources and detectors selected from the plurality of radiation sources and detectors disposed on the flexible substrate claim 1 , which when operational claim 1 , provide desired location and intensity characteristics.3. The monitoring device of claim 1 , wherein the monitoring device comprises a multi-wavelength photoplethysmograph.4. The monitoring device of claim 1 , wherein the monitoring device comprises a multi-source multi-detector arrayed ...

PATIENT-SPECIFIC NEUROMODULATION ALIGNMENT STRUCTURES

The present discussion relates to structures and devices to facilitate application of an ultrasound therapy beam to a target anatomic region in a replicable manner. In certain aspects, adjustable positioning structures are described that allow a general probe positioning structure to be configured for a specific patient in a manner that allows the device to be used repeatedly to target the anatomic region, even when in non-clinical settings. In other aspects, a probe positioning structure is fabricated that is specific to a respective patient anatomy, such that use of the probe positioning structure provides repeatable targeting of the target anatomic region, even when in non-clinical settings.

METHODS FOR DETERMINING PHYSIOLOGICAL PARAMETERS BASED ON ELECTRICAL IMPEDANCE MEASUREMENTS

A system and method for determining physiological parameters based on electrical impedance measurements is provided. One method includes obtaining electrical measurement signals acquired from a plurality of transducers coupled to a surface of an object and spatially pre-conditioning the obtained electrical measurement signals. The method also includes performing multiple-input-multiple-output (MIMO) processing of the spatially pre-conditioned electrical measurement signals to correlate the spatially pre-conditioned electrical measurement signals to separate the electrical measurement signals. 2. The method of claim 1 , wherein the measurement response signals are electrical measurement response signals.3. The method of claim 1 , wherein classifying the sub-space of undesired non-physiological signals as ambulatory motion information includes identifying at least one of a type of motion or a position.4. The method of claim 3 , wherein the ambulatory motion information includes an identification of at least one of breathing claim 3 , bending claim 3 , twisting claim 3 , or reaching motion5. The method of wherein the ambulatory motion information includes an identification of at least one of a supine position claim 4 , seated position claim 4 , or standing.6. The method of claim 1 , further comprising using an output of the MIMO processor and multi-lead transducer signals to determine an ambulatory motion index.7. The method of claim 2 , wherein spatially pre-conditioning the obtained electrical measurement response signals comprises using a common mode averaging of all of the electrical measurement response signals.8. The method of claim 2 , wherein the electrical measurement response signals are obtained from electrodes in an electrocardiography (ECG) electrode placement configuration.9. The method of claim 2 , wherein the excitations comprises one of an electrical claim 2 , magnetic claim 2 , or radio-frequency excitation.10. The method of claim 9 , wherein ...

SYSTEM AND METHOD FOR DETERMINING PHYSIOLOGICAL PARAMETERS BASED ON ELECTRICAL IMPEDANCE MEASUREMENTS

A system and method for determining physiological parameters based on electrical impedance measurements is provided. One method includes obtaining electrical measurement signals acquired from a plurality of transducers coupled to a surface of an object and spatially pre-conditioning the obtained electrical measurement signals. The method also includes performing multiple-input-multiple-output (MIMO) analog to information conversion (AIC) of the spatially pre-conditioned electrical measurement signals to correlate the spatially pre-conditioned electrical measurement signals to separate the electrical measurement signals.

SYSTEM AND METHOD FOR ENHANCED ELECTRICAL IMPEDANCE TOMOGRAPHY

A method includes applying a plurality of currents to a plurality of electrodes disposed on a surface surrounding an anatomical region in a subject. Further, the method includes measuring a plurality of voltages generated in response to the plurality of currents. The method also includes selecting a coarse-scale basis corresponding to a response function associated with the plurality of electrodes. Moreover, the method includes determining simultaneously an internal admittivity corresponding to the anatomical region and a contact impedance corresponding to the plurality of electrodes based on the plurality of voltages and the coarse-scale basis. The method also includes reconstructing the diagnostic image based on the internal admittivity. 1. A method , comprising:applying a plurality of currents to a plurality of electrodes disposed on a surface surrounding an anatomical region in a subject;measuring a plurality of voltages generated in response to the plurality of currents;selecting a coarse-scale basis corresponding to a response function associated with the plurality of electrodes;determining simultaneously an internal admittivity corresponding to the anatomical region and a contact impedance corresponding to the plurality of electrodes based on the plurality of voltages and the coarse-scale basis; andreconstructing a diagnostic image based on the internal admittivity.2. The method of claim 1 , wherein determining the internal admittivity comprises modelling the plurality of voltages using a linear measurement model.3. The method of claim 2 , wherein the determining the internal admittivity comprises determining a least squares solution corresponding to the linear measurement model or a regularized least squares solution corresponding to the linear measurement model.4. The method of claim 3 , wherein determining the regularized least squares solution comprises determining a regularization parameter.5. The method of claim 4 , wherein determining the ...

NEUROMODULATION TECHNIQUES FOR PERTURBATION OF PHYSIOLOGICAL SYSTEMS

Embodiments of the present disclosure relate to techniques for inducing physiological perturbations in a subject via neuromodulation, e.g., peripheral neuromodulation of a region of interest of an organ. The nature and degree of the perturbations may be related to the subject's clinical condition. Accordingly, an assessment of one or more characteristics of the perturbations may be used to determine a clinical condition of the subject.

STANDOFF DETECTION SYSTEMS AND METHODS

Embodiments of the invention include a system and a method for determining whether a person is carrying concealed contraband, such as an improvised explosives device or other weapon. The system includes a people tracking video subsystem, a people tracking decisioning subsystem, a concealed contraband detection aiming subsystem, and a concealed contraband detection decisioning subsystem.

FIELD-PORTABLE IMPEDANCE READER AND METHODS OF MAKING THE SAME

A field-portable impedance reader is provided. The impedance reader comprises a reader antenna, an impedance compensator, a calibrator, and a synchronous sampler. The impedance reader further comprises a digital processor that receives and processes signals from the synchronous sampler. Further, a wireless system comprising the impedance reader of the invention is provided. 1. A field-portable impedance reader , comprising:a reader antenna;an impedance compensator;a calibrator;a synchronous sampler; anda digital processor that receives and processes signals from the synchronous sampler.2. The field-portable impedance reader of claim 1 , wherein the synchronous sampler comprises a master oscillator claim 1 , or a coherent clock generator claim 1 , or both.3. The field-portable impedance reader of claim 2 , wherein the synchronous sampler comprises a digital direct synthesizer in communication with the master oscillator and the coherent clock generator.4. The field-portable impedance reader of claim 3 , wherein the digital direct synthesizer is in communication with the reader antenna.5. The field-portable impedance reader of claim 1 , wherein the digital processor comprises one or more analog to digital converters.6. The field-portable impedance reader of claim 5 , wherein the digital processor comprises a reference analog to digital converter claim 5 , and a sample analog to digital converter.7. The field-portable impedance reader of claim 1 , wherein the impedance reader monitors in real-time.8. The field-portable impedance reader of claim 1 , wherein the impedance reader is inductively coupled to a resonant sensor.9. The field-portable impedance reader of claim 8 , wherein the impedance reader reads real and imaginary impedance spectra of a sensor.10. The field-portable impedance reader of claim 8 , wherein the impedance reader reads real and imaginary impedance spectra of a sensor and simultaneously calculates at least two parameters of the sensor impedance ...

Radar based systems and methods for detecting a fallen person

Methods, systems and non-transitory computer readable mediums that store instructions executable by one or more processors to perform a method for detecting a fallen person are presented. The present technique includes identifying a reference plane and a reference line in a designated space monitored using one or more range-controlled radars. These radars are coupled to one or more antennas configured to define fields of the range-controlled radars to one or more portions of the designated space, where at least one portion corresponds to the reference plane. The range-controlled radars detect presence of one or more parameters corresponding to a subject disposed in the designated space. The parameters, for example, include one or more physiological parameters and one or more motion parameters. The range-controlled radars then identify the subject as the fallen person if the one or more physiological parameters corresponding to the subject are detected proximate the reference plane.

Patient-specific neuromodulation alignment structures

The present discussion relates to structures and devices to facilitate application of an ultrasound therapy beam to a target anatomic region in a replicable manner. In certain aspects, adjustable positioning structures are described that allow a general probe positioning structure to be configured for a specific patient in a manner that allows the device to be used repeatedly to target the anatomic region, even when in non-clinical settings. In other aspects, a probe positioning structure is fabricated that is specific to a respective patient anatomy, such that use of the probe positioning structure provides repeatable targeting of the target anatomic region, even when in non-clinical settings.

Noninvasive tissue displacement control and monitoring for neuromodulation

The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into an internal tissue to cause tissue displacement and identifying that the tissue displacement has occurred. In one embodiment, the presence of tissue displacement is associated with a desired therapeutic or physiological outcome, such as a change in a molecule of interest.

Delivery of therapeutic neuromodulation

Embodiments of the present disclosure relate to techniques for neuromodulation delivery. Based on image data acquired from the subject, control parameters controlling energy application of neuromodulating energy may be dynamically changed during the course of the delivery to maintain desired characteristics of the neuromodulating energy. For example, the beam of the neuromodulating energy may be dynamically adjusted to account for movement of an organ during breathing. In another embodiment, a desired region of interest is identified within the subject based on a trained neural network and the acquired image data.

PULSE OXIMETRY DEVICES AND SYSTEMS AND METHODS OF MAKING THE SAME

An array of emitters includes a device substrate having first and second sides, a thermally and electrically conductive layer disposed on the first side of the device substrate, and an interconnect layer disposed on a first plurality of portions of the second side of the device substrate. The array of the emitters further includes a plurality of emitters disposed in a second plurality of portions of the device substrate, where the plurality of emitters is electrically coupled to the thermally and electrically conductive layer. Also, the array of the emitters includes a plurality of wirebond contacts configured to electrically couple a portion of the interconnect layer to a corresponding emitter of the plurality of emitters, and a plurality of encapsulations, where one or more encapsulations of the plurality of encapsulations are disposed on at least a portion of a corresponding wirebond contact of the plurality of wirebond contacts. 1. A pulse oximetry system , comprising: a device substrate having a first side and a second side;', 'a thermally and electrically conductive layer disposed on the first side of the device substrate;', 'an interconnect layer disposed on the second side of the device substrate;', 'a plurality of arrays of emitters disposed on the second side of the device substrate, wherein the plurality of arrays of the emitters is electrically coupled to the thermally and electrically conductive layer;', 'a plurality of detectors disposed on the second side of the device substrate and configured to detect emission signals from one or more emitters of the plurality of arrays of the emitters;', 'a plurality of wirebond contacts configured to electrically couple a portion of the interconnect layer to a corresponding emitter of the plurality of arrays of the emitters; and, 'a pulse oximetry device comprisinga processor configured to process the detected emission signals.2. The pulse oximetry system of claim 1 , wherein one or more emitters of the plurality ...

Physiology Monitoring and Alerting System and Process

A system for monitoring physiology, having: a RADAR transmitter and a RADAR receiver; a state estimation module configured to process a returned RADAR signal to detect a presence of motion and set a motion state upon said presence of motion, said state estimation module configured to detect a presence of one or more physiological parameters including heartbeat and respiration, and said state estimation module configured to assign a still state or a concern state based on said presence of physiological parameters; a rate estimation module configured to estimate one or more estimated physiological rates including an estimated respiration rate and an estimated heart rate; and an alerting module configured to provide an alert if an alert value exceeds an alert value threshold, wherein the alert value is derived from at least one of the motion state, concern state, still state and the estimated physiological rates.

Systems and methods for improved physiological monitoring

A system and method for monitoring a subject are presented. The system includes a sensing device including at least one magnetic source to generate a magnetic field and an array of magnetic sensors disposed within the magnetic field. The sensor array obtains a plurality of magnetic field measurements at a plurality of locations along a vessel carrying a fluid including one or more magnetic particles. Further, the system includes a processing subsystem communicatively coupled to the sensing device, where the processing subsystem determines variations in the measurements caused by magnetization-relaxation of the magnetic particles based on a coupled model that defines behavior of the fluid in the varying magnetic field based on principles of magnetization-relaxation, bulk motion of the magnetic particles towards a determined gradient of the magnetic field, magnetostatics, and conservation of momentum. The processing subsystem estimates values of one or more desired parameters based on the determined variations.

System and method for enhanced electrical impedance tomography

A method includes applying a plurality of currents to a plurality of electrodes disposed on a surface surrounding an anatomical region in a subject. Further, the method includes measuring a plurality of voltages generated in response to the plurality of currents. The method also includes selecting a coarse-scale basis corresponding to a response function associated with the plurality of electrodes. Moreover, the method includes determining simultaneously an internal admittivity corresponding to the anatomical region and a contact impedance corresponding to the plurality of electrodes based on the plurality of voltages and the coarse-scale basis. The method also includes reconstructing the diagnostic image based on the internal admittivity.

System and method for determining a state of a door

A system for determining a state of a door having a locking mechanism for locking the door includes a locking mechanism and a door sensor. The locking mechanism sensor is disposed for sensing a condition of the locking mechanism and generating a signal indicative thereof. The door sensor disposed for sensing a condition of the door and generating a signal indicative thereof. The system further includes a processor for determining a state of the door, in response to the signals from the locking mechanism sensor and the door sensor. The state of the door is a secured state when the door sensor senses the condition of the door as closed and the locking mechanism sensor senses the condition of the locking mechanism as locked. A method for determining a state of a door having a locking mechanism for locking the door includes sensing a condition of the locking mechanism and sensing a condition of the door. The method further includes, determining a state of the door as a secured state when the condition of the locking mechanism is sensed as locked and the condition of the door is sensed as closed.

NEUROMODULATION ENERGY APPLICATION TECHNIQUES

Embodiments of the present disclosure relate to techniques for facilitating personalized neuromodulation treatment protocols. In one embodiment, a predetermined treatment position of an energy application device is used to guide future treatments for the patient. In one embodiment, a position of the energy application device relative to the predetermined treatment position is determined. In one embodiment, a total dose of ultrasound energy applied to the region of interest is determined.

Methods for determining physiological parameters based on electrical impedance measurements

A system and method for determining physiological parameters based on electrical impedance measurements is provided. One method includes obtaining electrical measurement signals acquired from a plurality of transducers coupled to a surface of an object and spatially pre-conditioning the obtained electrical measurement signals. The method also includes performing multiple-input-multiple-output (MIMO) processing of the spatially pre-conditioned electrical measurement signals to correlate the spatially pre-conditioned electrical measurement signals to separate the electrical measurement signals.

SYSTEMS AND METHODS FOR SOFT-FIELD TOMOGRAPHY

One system includes a pattern generator that generates one or more excitation patterns suitable for probing a hydration level of a tissue of a subject at one or more depths from a surface of the subject into an interrogation region. Each of the excitation patterns has a spatial sensitivity at one of the one or more predetermined depths. A data analysis module receives one or more measured responses of the subject at a plurality of electrodes to excitation applied by the plurality of electrodes based on the one or more excitation patterns and determines one or more hydration changes at the one or more depths within the subject based on the measured responses. Each of the measured responses corresponds to the one of the one or more predetermined depths for which the applied excitation pattern has spatial sensitivity. 1. A soft-field tomography system , comprising:a plurality of electrodes configured to be positioned on a surface of an interrogation region of a subject;a pattern generator configured to determine one or more excitation patterns for probing a tissue of the subject at one or more predetermined depths from the surface of the subject into the interrogation region, wherein each of the one or more excitation patterns has a spatial sensitivity at one of the one or more predetermined depths;a plurality of excitation sources coupled to the plurality of electrodes and configured to apply each of the one or more excitation patterns to the plurality of electrodes to excite the plurality of electrodes substantially simultaneously with each of the excitation patterns; anda plurality of receivers coupled to the plurality of electrodes and configured to measure one or more responses of the subject at the plurality of electrodes to the excitation applied by the plurality of electrodes, wherein each of the one or more responses corresponds to one of the one or more predetermined depths for which the applied excitation pattern has spatial sensitivity.2. The system of ...

SYSTEM AND METHOD FOR GATHERING DIAGNOSTIC INFORMATION IN A PROCESSING PATH OF A COAL GASIFICATION SYSTEM

A system and method for gathering diagnostic information relating to an operating condition of a gas stream or processing path of a coal gasification system is disclosed. The information is gathered by deploying one or more specially constructed modules or seeds that proceed through the gas stream of the coal gasification system as part of the mass flow of the gas stream. The seed may be physically recoverable in which an outer material of the seed ablates when exposed to a predetermined temperature of the gas stream. The seed may be physically non-recoverable in which electronic circuitry transmits a signal to a receiver relating to the temperature of the gas stream.

System and method for determining physiological parameters based on electrical impedance measurements

A system and method for determining physiological parameters based on electrical impedance measurements is provided. One method includes obtaining electrical measurement signals acquired from a plurality of transducers coupled to a surface of an object and constructing a system matrix to define one or more relationships between the impedance measurement signals. The method also includes decomposing the system matrix to separate the electrical measurement signals.

LUNG FUNCTION MONITORING

A signal of a current-voltage sensor array in one embodiment is processed for output of data in a form for use by a care provider. The current-voltage sensor array in one embodiment is a non-invasive current-voltage sensor array adapted to surround a thorax of a patient. The output of data in one embodiment is provided in a lung function visualization output form that depicts functioning of a patient's lungs. 1. An apparatus comprising:circuitry operative to obtain a signal of a current-voltage sensor array, the current-voltage sensor array adapted to surround a thorax of a patient;wherein the apparatus is operative to output data in one or more lung function visualization output form based on the signal of a current-voltage sensor array, the one or more lung function visualization output form selected from the group consisting of a flow volume loop lung function visualization form and a respiratory index lung function visualization output form.2. The apparatus of claim 1 , wherein the apparatus is operative to output data in one or more lung function visualization output form based on the signal of a current-voltage sensor array and based on a processing of a signal of spirometer.3. The apparatus of claim 1 , wherein the apparatus is operative to output data in one or more lung function visualization output form that outputs information of a localized region of a thorax.4. The apparatus of claim 1 , wherein current-voltage sensor array is a multiple source current-voltage sensor array.5. The apparatus of claim 1 , wherein the one or more lung function visualization output form includes a flow volume loop lung function visualization output form.6. The apparatus of claim 1 , wherein the one or more lung function visualization output form includes a respiratory index lung function visualization output form.7. The apparatus of claim 6 , wherein the respiratory index lung function visualization output form is an RSBI lung function visualization output form.8. The ...

Multi-beam neuromodulation techniques

The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue that include applying energy (e.g., ultrasound energy) into the tissue at multiple regions of interest, concurrently or consecutively. The neuromodulation may result in tissue displacement, which may be observed through changes in one or more molecules of interest.

Radio detection and ranging intrusion detection system

A radar system having a processor, a waveform generator, a plurality of antenna interfaces, a set of first antennas configured to transmit a waveform, and a set of second antennas configured to receive a reflected waveform is disclosed. The waveform generator and antenna interfaces are in control and signal communication with the processor, each of the first antennas are in signal communication with one of each antenna interface, and each of the second antennas are in signal communication with one of each antenna interface. The waveform generator is in control and signal communication with each antenna interface, and is configurable to generate a waveform conforming to at least two ISM bands. Each first antenna is configured to transmit a circularly polarized electromagnetic waveform, and each second antenna is configured to receive a reflected circularly polarized electromagnetic waveform complementary to the first antennas.

Systems and methods for improved physiological monitoring

A system and method for monitoring a subject are presented. The system includes a sensing device including at least one magnetic source to generate a magnetic field and an array of magnetic sensors disposed within the magnetic field. The sensor array obtains a plurality of magnetic field measurements at a plurality of locations along a vessel carrying a fluid including one or more magnetic particles. Further, the system includes a processing subsystem communicatively coupled to the sensing device, where the processing subsystem determines variations in the measurements caused by magnetization-relaxation of the magnetic particles based on a coupled model that defines behavior of the fluid in the varying magnetic field based on principles of magnetization-relaxation, bulk motion of the magnetic particles towards a determined gradient of the magnetic field, magnetostatics, and conservation of momentum. The processing subsystem estimates values of one or more desired parameters based on the determined variations.

Delivery of therapeutic neuromodulation

Embodiments of the present disclosure relate to techniques for neuromodulation delivery. Based on image data acquired from the subject, control parameters controlling energy application of neuromodulating energy may be dynamically changed during the course of the delivery to maintain desired characteristics of the neuromodulating energy. For example, the beam of the neuromodulating energy may be dynamically adjusted to account for movement of an organ during breathing. In another embodiment, a desired region of interest is identified within the subject based on a trained neural network and the acquired image data.

Method for estimating the precise orientation of a phase-controlled antenna mounted on a satellite and a remote receiver

Combined neuromodulation techniques

Combined neuromodulation techniques are disclosed to treat metabolic disorders. The combined neuromodulation techniques may include dual-site neuromodulation or single-site neuromodulation. In embodiments, the neuromodulation may be administered as a combined therapy with a pharmaceutical treatment. In one embodiment, the techniques may include applying ultrasound energy to a region of interest of a subject having a metabolic disorder to cause an autonomic signaling response in the subject.

Techniques for neuromodulation

The subject matter of the present disclosure generally relates to techniques for neuromodulation of lymphatic tissue that include applying one or more energy pulses to a neuron of a subject, e.g., via an electrode positioned to deliver sufficient energy to the neuron, to modulate immune function. For example, an adaptive immune reflex of a subject may be modulated via neuromodulation.

Combined neuromodulation techniques

Combined neuromodulation techniques are disclosed to treat metabolic disorders. The combined neuromodulation techniques may include dual-site neuromodulation or single-site neuromodulation. In embodiments, the neuromodulation may be administered as a combined therapy with a pharmaceutical treatment. In one embodiment, the techniques may include applying ultrasound energy to a region of interest of a subject having a metabolic disorder to cause an autonomic signaling response in the subject.

Neuromodulation techniques for perturbation of physiological systems

Embodiments of the present disclosure relate to techniques for inducing physiological perturbations in a subject via neuromodulation, e.g., peripheral neuromodulation of a region of interest of an organ. The nature and degree of the perturbations may be related to the subject's clinical condition. Accordingly, an assessment of one or more characteristics of the perturbations may be used to determine a clinical condition of the subject.

Neuromodulation techniques for perturbation of physiological systems

Neuromodulation techniques for perturbation of physiological systems

Embodiments of the present disclosure relate to techniques for inducing physiological perturbations in a subject via neuromodulation, e.g., peripheral neuromodulation of a region of interest of an organ. The nature and degree of the perturbations may be related to the subject's clinical condition. Accordingly, an assessment of one or more characteristics of the perturbations may be used to determine a clinical condition of the subject.

Multi-beam neuromodulation techniques

Delivery of therapeutic neuromodulation

Patient-specific neuromodulation alignment structures

The present discussion relates to structures and devices to facilitate application of an ultrasound therapy beam (206) to a target anatomic region in a replicable manner. In certain aspects, adjustable positioning structures are described that allow a general probe positioning structure (100, 200) to be configured for a specific patient in a manner that allows the device to be used repeatedly to target the anatomic region, even when in non-clinical settings. In other aspects, a probe positioning structure (100, 200) is fabricated that is specific to a respective patient anatomy, such that use of the probe positioning structure (100, 200) provides repeatable targeting of the target anatomic region, even when in non-clinical settings.

Non-invasive focused ultrasound neuromodulation to treat physiological conditions

The subject matter of the present disclosure generally relates to techniques for applying focused ultrasound energy to a region of interest in a subject to induce neuromodulation of the celiac plexus to treat inflammatory bowel disease. The region of interest ay include at least a portion of a peripheral ganglion of the celiac plexus.

System and method for determining a hydration level of a tissue region

In accordance with one aspect of the present technique, a method is disclosed. The method includes applying a mechanical perturbation to a tissue region using a displacement device. The method further includes calculating a compression impedance of the tissue region in response to applying the mechanical perturbation. The method further includes retracting the displacement device and calculating a retraction impedance of the tissue region in response to retracting the displacement device. The method also includes determining a hydration level of the tissue region based on at least one of the compression impedance and the retraction impedances.

Implantable sensor assembly systems and methods

A system includes an implantable sensor assembly. The implantable sensor assembly includes a housing. The housing includes a substrate layer comprising an interior surface and an exterior surface, and a cap layer, wherein the substrate layer and the cap layer are coupled to form an enclosed cavity that at least partially encloses the interior surface of the substrate layer within the cavity and wherein both the substrate layer and the cap layer are formed from an insulating material. The implantable sensor assembly also includes one or more electronic components disposed within the cavity of the housing and one or more probes disposed on the exterior surface of the substrate layer and electrically coupled to the one or more electronic components by one or more electrical connections extending through the housing.

Neuromodulation energy application techniques

Embodiments of the present disclosure relate to techniques for facilitating personalized neuromodulation treatment protocols. In one embodiment, a predetermined treatment position of an energy application device is used to guide future treatments for the patient. In one embodiment, a position of the energy application device relative to the predetermined treatment position is determined. In one embodiment, a total dose of ultrasound energy applied to the region of interest is determined.

Neuromodulation energy application techniques

Embodiments of the present disclosure relate to techniques for facilitating personalized neuromodulation treatment protocols. In one embodiment, a predetermined treatment position of an energy application device is used to guide future treatments for the patient. In one embodiment, a position of the energy application device relative to the predetermined treatment position is determined. In one embodiment, a total dose of ultrasound energy applied to the region of interest is determined.

Noninvasive tissue displacement control and monitoring for neuromodulation

Patient-specific neuromodulation alignment structures

The present discussion relates to structures and devices to facilitate application of an ultrasound therapy beam (206) to a target anatomic region in a replicable manner. In certain aspects, adjustable positioning structures are described that allow a general probe positioning structure (100, 200) to be configured for a specific patient in a manner that allows the device to be used repeatedly to target the anatomic region, even when in non-clinical settings. In other aspects, a probe positioning structure (100, 200) is fabricated that is specific to a respective patient anatomy, such that use of the probe positioning structure (100, 200) provides repeatable targeting of the target anatomic region, even when in non-clinical settings.

Ultrasonic beam path determination and targeting

The present discussion relates to the delivery of ultrasonic therapy energy to a target region in conjunction with a clear path determination that may assess one or more of: (1) presence of non-soft tissue regions within the therapy beam path (e.g., bone or bone-like structures, gas-filled cavities, and so forth), (2) partial "lift-off" of the probe head; or (3) sufficiency of acoustic coupling. Upon determination or confirmation of at least a partial clear path with respect to some or all of these factors, the therapy beam may be delivered to the target region.

Field-portable impedance reader and method for quantitating parameters in an environment

Überwachungssystem und Stromtransformatoren für den Teilentladungs-Nachweis

Ein Hochfrequenz-Stromtransformator(HFCT)-Sensor (10) zum Nachweisen von Teilentladungen, die durch eine Komponente (20) erzeugt werden, wird offenbart. Der HFCT-Sensor schließt mindestens ein auf einem Substrat (14) gebildetes elektrisches Leitungsmuster (12) ein, wobei das Substrat eine Vielzahl segmentierter Regionen (27) umfasst, die durch Zwischenregionen (28) verbunden sind, zum Falten entlang einer Vielzahl von Faltlinien (16) zwischen den segmentierten Regionen, um den HFCT-Sensor zu bilden. Ein System (100) zum Überwachen mindestens einer Komponente (20) eines Flugzeug-Verdrahtungssystems (130) wird auch offenbart. Das Überwachungssystem schließt mindestens einen HFCT-Sensor zum Nachweisen von Teilentladungen ein, die durch die Komponente des Flugzeug-Verdrahtungssystems erzeugt werden. Das Überwachungssystem schließt weiter ein Datenerfassungssystem (40) ein, das zum Überwachen von Signalen von dem (den) HFCT-Sensor(en) (10) konfiguriert ist.

Non-invasive focused ultrasound neuromodulation to treat physiological conditions

Accelerating cutaneous healing utilizing non-invasive focused ultrasound

The present approaches are generally directed to facilitating healing of wounds, including chronic wounds typically associated with slow heal times or which are persistent. In one embodiment, a method of promoting wound healing comprises positioning an ultrasound transducer at a stimulation site on a subject having a wound. Pulsed focused ultrasound (pFUS) is non-invasively applies using the transducer to cause modulation of a target anatomic site containing resident or circulating immune cells. Modulation of the target anatomic site of the subject causes migration of one or more of monocytes, macrophages, or neutrophils to a wound bed of the wound.

Standoff detection systems and methods

Embodiments of the invention include a system and a method for determining whether a person is carrying concealed contraband, such as an improvised explosives device or other weapon. The system includes a people tracking video subsystem, a people tracking decisioning subsystem, a concealed contraband detection aiming subsystem, and a concealed contraband detection decisioning subsystem.

Neuromodulation energy application techniques

Embodiments of the present disclosure relate to techniques for facilitating personalized neuromodulation treatment protocols. In one embodiment, a predetermined treatment position of an energy application device is used to guide future treatments for the patient. In one embodiment, a position of the energy application device relative to the predetermined treatment position is determined. In one embodiment, a total dose of ultrasound energy applied to the region of interest is determined.

Neuromodulation energy application techniques

Embodiments of the present disclosure relate to techniques for accurate positioning of an energy application device for neuromodulation treatment protocols. In one embodiment, a neuromodulation positioning patch is applied to a patient's skin. The energy application device is configured to couple to a frame of the neuromodulation positioning patch to position a transducer of the energy application device within an opening at a treatment position within the opening. In one embodiment, the frame is also configured to couple to a removable dock for an imaging probe that, when coupled to the removable dock and, in turn, the frame of the neuromodulation positioning patch, is configured to acquire image data through the opening to identify or verify a treatment position.

Systems and methods of alignment control for neuromodulation delivery system

The present discussion relates to structures and devices to facilitate application of an ultrasound therapy beam (106) to a target anatomic region in a replicable manner. In certain aspects, an alignment controller (30) may be used to analyze images generated by an ultrasound transducer. The alignment controller (30) may then send a communication to indicate the energy application device is positioned to provide therapy to the target region, or if the device needs to be repositioned. The alignment control of the energy application device provides guided repeatable targeting of the target anatomic region, even when in non-clinical settings.

Noninvasive tissue displacement control and monitoring for neuromodulation

The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into an internal tissue to cause tissue displacement and identifying that the tissue displacement has occurred. In one embodiment, the presence of tissue displacement is associated with a desired therapeutic or physiological outcome, such as a change in a molecule of interest.

Field-portable impedance reader

Field-portable impedance reader and method for quantitating parameters in an environment

A field-portable impedance reader is provided. The impedance reader comprises a reader antenna, an impedance compensator, a calibrator, and a synchronous sampler. The impedance reader further comprises a digital processor that receives and processes signals from the synchronous sampler. Further, a wireless system comprising the impedance reader of the invention is provided.

Neuromodulation energy application techniques

Standoff detection systems and methods

Embodiments of the invention include a system and a method for determining whether a person is carrying concealed contraband, such as an improvised explosives device or other weapon. The system includes a people tracking video subsystem, a people tracking decisioning subsystem, a concealed contraband detection aiming subsystem, and a concealed contraband detection decisioning subsystem.

Neuromodulation energy application techniques

Embodiments of the present disclosure relate to techniques for accurate positioning of an energy application device for neuromodulation treatment protocols. In one embodiment, a neuromodulation positioning patch is applied to a patient's skin. The energy application device is configured to couple to a frame of the neuromodulation positioning patch to position a transducer of the energy application device within an opening at a treatment position within the opening. In one embodiment, the frame is also configured to couple to a removable dock for an imaging probe that, when coupled to the removable dock and, in turn, the frame of the neuromodulation positioning patch, is configured to acquire image data through the opening to identify or verify a treatment position.

Neuromodulation energy application techniques

Neuromodulation energy application techniques

Neuromodulation energy application techniques

Embodiments of the present disclosure relate to techniques for accurate positioning of an energy application device for neuromodulation treatment protocols. In one embodiment, a neuromodulation positioning patch is applied to a patient's skin. The energy application device is configured to couple to a frame of the neuromodulation positioning patch to position a transducer of the energy application device within an opening at a treatment position within the opening. In one embodiment, the frame is also configured to couple to a removable dock for an imaging probe that, when coupled to the removable dock and, in turn, the frame of the neuromodulation positioning patch, is configured to acquire image data through the opening to identify or verify a treatment position.

Neuromodulation energy application techniques

Embodiments of the present disclosure relate to techniques for accurate positioning of an energy application device for neuromodulation treatment protocols. In one embodiment, a neuromodulation positioning patch is applied to a patient's skin. The energy application device is configured to couple to a frame of the neuromodulation positioning patch to position a transducer of the energy application device within an opening at a treatment position within the opening. In one embodiment, the frame is also configured to couple to a removable dock for an imaging probe that, when coupled to the removable dock and, in turn, the frame of the neuromodulation positioning patch, is configured to acquire image data through the opening to identify or verify a treatment position.

Neuromodulation energy application techniques

Embodiments of the present disclosure relate to techniques for facilitating personalized neuromodulation treatment protocols. In one embodiment, a predetermined treatment position of an energy application device is used to guide future treatments for the patient. In one embodiment, a position of the energy application device relative to the predetermined treatment position is determined. In one embodiment, a total dose of ultrasound energy applied to the region of interest is determined.

Procedimiento para estimar la orientacion precisa de un conjunto de antenas en fase montado sobre un satelite y direccionamiento de un receptor remto.

LA POSICION TRI-AXIAL EXACTA DE UN SISTEMA ESPACIAL DE ANTENAS EN FASE TRANSPORTADAS, SE ESTIMA BASANDOSE EN LA SUPOSICION DE QUE LA GEOMETRIA DEL SISTEMA, CONSISTENTE DE UN NUMERO DE ELEMENTOS RADIANTES Y DE SUS ESPACIAMIENTOS RELATIVOS EN TRES DIMENSIONES ES CONOCIDO, Y DE QUE LA POSICION DEL SISTEMA Y EL CONOCIMIENTO BURDO DE LA POSTURA DEL SISTEMA ESTAN DISPONIBLES A PRIORI. PRIMERO SE HACE UNA ESTIMACION (21 1 , 21 SU B,2 ... 21 M ) QUE DEFINE LA CONTRIBUCION RECTA-TRANVERSAL DE CADA ELEMENTO A LAS SEÑALES RECIBIDAS EN CADA UNO DE DOS O MAS LUGARES REMOTOS DE CALIBRACION, EN DONDE SE DEFINE UNA CONFIGURACION DE ANTENA "RECTA-TRANSVERSAL" COMO LA CONDICION EN LA CUAL TODOS ELEMENTOS SE PONEN A IRRADIAR CON LA MISMA AMPLITUD Y CON LA MISMA FASE. SE UTILIZA ENTONCES, UNA ESTRATEGIA DE OPTIMIZACION (22, 23) PARA DETERMINAR CUAL DE LAS POSTURAS DEL SISTEMA, QUE ESTAN CERCA DE LA POSTURA QUE SE CONOCE DE FORMA BURDA, ES MAS CONSISTENTE CON EL CONJUNTO COMPLETO DE VALORES DE GANANCIA RECTA-TRANSVERSAL. OTRA TECNICA PARA ESTIMAR LA POSICION ANGULAR EXACTA DE UN RECEPTOR, CON RESPECTO A LAS COORDENADAS DEL SISTEMA ESPACIAL DE ANTENAS EN FASE TRANSPORTADAS, SE BASA EN LA SUPOSICION DE QUE LA GEOMETRIA DEL SISTEMA ES CONOCIDA, Y DE QUE LA ORIENTACION DEL RECEPTOR SE CONOCE BURDAMENTE O ESTA DISPONIBLE. DESPUES DE HACER UNA ESTIMACION DEL CONJUNTO DE GANANCIAS VALORADAS-COMPLEJAS, QUE DEFINEN LA CONTRIBUCION RECTATRANSVERSAL DE CADA UNO DE LOS ELEMENTOS A UNA SEÑAL COMPUESTA QUE SE MIDE EN LA UBICACION DEL RECEPTOR, SE UTILIZA UNA ESTRATEGIA DE OPTIMIZACION PARA DETERMINAR LA DIRECCION DEL RECEPTOR, QUE ESTA CERCA DE LA DIRECCION QUE SE CONOCE DE FORMA BURDA, QUE ES MAS CONSISTENTE CON EL ULTIMO CONJUNTO DE VALORES DE GANANCIA RECTA-TRANSVERSAL.

位相調整アレー・アンテナの３軸姿勢推定方法および受信機の角位置推定方法

(57)【要約】 【課題】 宇宙飛行体搭載の位相調整アレー・アンテナ の精密な３軸姿勢を推定する。 【解決手段】 素子数および３次元の相対的な素子間隔 を含むアレーの幾何学的な関係が判り、アレーの位置並 びに姿勢の大まかな情報が先験的に利用できると仮定し て、遠隔の較正地点の各々で受信される信号に対する各 素子の直通寄与分を定める１組の複素数値の利得を推定 し、次いで最適化方式を使って、大まかに判っている姿 勢の近隣にあるどのアレー姿勢が、完全な１組の直通利 得の値と最もよく見合っているかを決定する。位相調整 アレー・アンテナの座標に対する受信機の精密な角位置 を推定する別の方法では、アレーの幾何学的な関係およ び大まかな受信機方位が判っているとして、受信機地点 での測定複合信号に対する各素子の直通寄与分を定める １組の複素数値の利得を推定した後、最適化方式を用い て、大まかな方向の近隣にあるどの受信機方向が、該１ 組の直通利得の値と最もよく見合っているかを決定す る。

Methode zur Abschätzung der präzisen Orientierung einer auf einem Satelliten montierten phasengesteuerten Antenne und eines entfernt gelegenen Empfängers

Combined neuromodulation techniques

Combined neuromodulation techniques are disclosed to treat metabolic disorders. The combined neuromodulation techniques may include dual-site neuromodulation or single-site neuromodulation. In embodiments, the neuromodulation may be administered as a combined therapy with a pharmaceutical treatment.