14-11-2013 дата публикации
Номер: US20130302351A1
The disclosure relates to inhibition of the VIP signaling pathway. In certain embodiments, the disclosure relates to methods of treating or preventing a viral infection comprising administering a VIP antagonist to a subject in need thereof. 1. A method of treating or preventing a viral infection comprising administering a VIP antagonist to a subject in need thereof.2. The method of claim 1 , wherein the subject is immune compromised.3. The method of claim 1 , wherein the subject is a transplant recipient.4. The method of claim 1 , wherein the viral infection is a virus selected from the group consisting of an influenza A virus including subtype H1N1 claim 1 , influenza B virus claim 1 , influenza C virus claim 1 , rotavirus A claim 1 , rotavirus B claim 1 , rotavirus C claim 1 , rotavirus D claim 1 , rotavirus E claim 1 , SARS coronavirus claim 1 , human adenovirus types (HAdV-1 to 55) claim 1 , human papillomavirus (HPV) Types 16 claim 1 , 18 claim 1 , 31 claim 1 , 33 claim 1 , 35 claim 1 , 39 claim 1 , 45 claim 1 , 51 claim 1 , 52 claim 1 , 56 claim 1 , 58 claim 1 , 59 claim 1 , parvovirus B19 claim 1 , molluscum contagiosum virus claim 1 , JC virus (JCV) claim 1 , BK virus claim 1 , Merkel cell polyomavirus claim 1 , coxsackie A virus claim 1 , norovirus claim 1 , Rubella virus claim 1 , lymphocytic choriomeningitis virus (LCMV) claim 1 , yellow fever virus claim 1 , measles virus claim 1 , mumps virus claim 1 , respiratory syncytial virus claim 1 , rinderpest virus claim 1 , California encephalitis virus claim 1 , hantavirus claim 1 , rabies virus claim 1 , ebola virus claim 1 , marburg virus claim 1 , herpes simplex virus-1 (HSV-1) claim 1 , herpes simplex virus-2 (HSV-2) claim 1 , varicella zoster virus (VZV) claim 1 , Epstein-Barr virus (EBV) claim 1 , cytomegalovirus (CMV) claim 1 , herpes lymphotropic virus claim 1 , roseolovirus claim 1 , Kaposi's sarcoma-associated herpesvirus claim 1 , hepatitis A (HAV) claim 1 , hepatitis B (HBV) claim 1 , hepatitis C ( ...
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