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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 634. Отображено 127.
21-06-2012 дата публикации

Laufradnabe mit Flansch

Номер: DE102011087205A1
Принадлежит:

Es wird eine Laufradnabe mit einem sich entlang einer Achse erstreckenden Rohrteil mit einem Innendurchmesser und einem Außendurchmesser, wobei eine Längsbohrung den Innendurchmesser bildet, und mit einem sich vom Rohrteil aus in radialer Richtung erstreckenden Flansch beschrieben, wobei die Längsbohrung durch den Rohrteil und der Flansch durch ein Kaltumformverfahren gebildet werden.

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10-11-2011 дата публикации

Verfahren zur Abreicherung von Magnesium und Anreicherung von Lithium in chloridisch geprägten Salzlösungen

Номер: DE102010019554A1
Принадлежит:

Die vorliegende Erfindung betrifft ein Verfahren zur Anreicherung von Lithium bei gleichzeitiger Abreicherung von Magnesium aus Lösungen chloridischer Natur, die im Verhältnis zum Lithiumgehalt hohe Magnesiumgehalte aufweisen, wie es z. B. in den Brines des Salar de Uyuni oder den Brines (Bolivien) des Qaidam-Beckens (China) der Fall ist. Erfindungsgemäß wird dies dadurch erreicht, dass der Lösung ab einem Mindestgehalt an Li+ und Mg2+ für die weitere Aufkonzentrierung an Li+ so viel KCl zugeführt wird, so dass sich Kaliumcarnallit bildet und sich eine Lösungszusammensetzung annähernd im Bereich der Sättigung an Carnallit und KCl einstellt. Lithiumverlust durch die Bildung von Lithiumcarnallit wird auf diese Weise verhindert und das MgCl2 als Kaliumcarnallit durch fest-flüssig-Trennung ausgeschleust. Das KCl wird durch bekannte Verfahren der Zersetzung von Carnallit wieder gewonnen.

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21-03-2013 дата публикации

Kolbenblechverbindung mit Blindvernietung

Номер: DE112010004088T5

Ein Kupplungsaggregat für einen Drehmomentwandler mit einem Gehäuse, einem mit einer Bohrung versehenen Kolbenblech und einem in der Bohrung angeordneten Niet, wobei der Niet einen Nietkopf aufweist. Vor der Beaufschlagung des Niets mit Druck zur Befestigung des Niets am Kolbenblech wird der Nietkopf zwischen dem Kolbenblech und dem Gehäuse verklemmt. Ein Kupplungsaggregat für einen Drehmomentwandler mit einem Gehäuse, einem mit einer Bohrung versehenen Kolbenblech, einer Blattfeder, die ein fest am Gehäuse befestigtes erstes Ende und ein zweites Ende aufweist, und mit einem das zweite Ende der Blattfeder mit dem Kolbenblech verbindenden Niet. Der Niet weist einen zwischen dem zweiten Ende der Blattfeder und dem Gehäuse angeordneten Nietkopf und eine in der Bohrung des Kolbenblechs angeordneten Nietschaft auf. Das Kolbenblech oder das Gehäuse ist in der Weise auslenkbar, dass der Nietkopf vor der Verformung des Schafts in die Breite zwischen dem Gehäuse und dem Kolbenblech verklemmbar ist ...

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20-05-2021 дата публикации

ELEKTRODE UND ZUSAMMENSETZUNG MIT MASSGESCHNEIDERTER POROSITÄT FÜR EINE ELEKTROCHEMISCHE LITHIUM-IONEN-ZELLE

Номер: DE102020126758A1
Принадлежит:

Eine Elektrode für eine elektrochemische Zelle mit Lithiumionen enthält einen Stromabnehmer und eine erste Schicht, die aus einer ersten Elektrodenzusammensetzung gebildet wird, die auf dem Stromabnehmer angeordnet ist. Die erste Elektrodenzusammensetzung enthält eine Bindemittelkomponente; eine leitende Füllstoffkomponente, die in der Bindemittelkomponente dispergiert ist; und eine aktive Materialkomponente, die in der Bindemittelkomponente und der leitenden Füllstoffkomponente dispergiert ist. Die erste Elektrodenzusammensetzung hat eine erste Oberfläche und eine zweite Oberfläche, die von der ersten Oberfläche beabstandet und parallel zu ihr ist. Die erste Elektrodenzusammensetzung definiert eine Vielzahl von Poren zwischen der ersten Oberfläche und der zweiten Oberfläche mit einer maßgeschneiderten Porengrößenverteilung, die mindestens eine erste Porengröße und eine zweite Porengröße, die größer als die erste Porengröße ist, einschließt. Die erste Elektrodenzusammensetzung hat eine ...

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27-02-2020 дата публикации

VERFOLGUNG VON INTELLIGENTEN VORRICHTUNGEN IN FAHRZEUGEN

Номер: DE102019122394A1
Принадлежит:

Die Offenbarung stellt eine Verfolgung von intelligenten Vorrichtungen in Fahrzeugen bereit. Es werden Systeme, Verfahren und computerlesbare Medien zum Erkennen, dass eine intelligente Vorrichtung in Fahrzeugen vergessen wurde, und Erleichtern des Abholens derartiger Vorrichtungen offenbart. Beispielhafte Verfahren können Bestimmen, dass das Fahrzeug an einem Ziel angekommen ist, beinhalten. Das Verfahren kann ferner Bestimmen, dass eine erste Vorrichtung des Benutzers nicht mehr in dem Fahrzeug angeordnet ist, während eine zweite mit dem Benutzer assoziierte Vorrichtung immer noch in dem Fahrzeug angeordnet ist, beinhalten. Das Verfahren kann Austauschen von einer oder mehreren Angaben, die mit dem Abholen der ersten Vorrichtung assoziiert sind, beinhalten.

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30-12-2021 дата публикации

DICKE, FLEXIBLE KATHODEN FÜR LITHIUMIONEN-BATTERIEN

Номер: DE102021107784A1
Автор: Wang, K, Jimenez, Halalay
Принадлежит:

Eine Lithium-Metalloxid (LMO)-Kathode umfasst einen Stromkollektor mit einer Länge, die ein erstes Ende und ein zweites Ende definiert, einer Breite und einer ersten Seite sowie einer zweiten Seite, LMO-Aktivmaterial, das auf der ersten Seite und der zweiten Seite des Stromkollektors so aufgebracht ist, dass das auf jeder jeweiligen Seite des Stromkollektors aufgebrachte LMO-Aktivmaterial eine an den Stromkollektor angrenzende Innenfläche und eine Außenfläche aufweist, und eine Vielzahl von Kanälen, die sich in Breitenrichtung über die Kathode innerhalb des auf der ersten und zweiten Seite aufgebrachten LMO-Aktivmaterials erstrecken. Das LMO-Aktivmaterial auf jeder Stromkollektorseite kann eine Dicke von etwa 100 µm bis etwa 400 µm haben. Die Kanäle auf der gleichen Seite des Stromkollektors können im Abstand von 0,1 mm bis 10 mm voneinander angeordnet sein. Die Kanäle können Breiten von 10 µm bis 60 µm haben.

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29-11-2012 дата публикации

Verfahren zur Abreicherung von Magnesium und Anreicherung von Lithium in chloridisch geprägten Salzlösungen

Номер: DE102010019554B4

Verfahren zur Abreicherung von Magnesium und Anreicherung von Lithium in chloridischen Salzlösungen mit Mindestgehalten von 4 g/L Li+und 60 g/L Mg2+, bei dem der weiter einzudampfenden Lösung KCl zudosiert wird, das mit dem MgCl2der Lösung mindestens teilweise zu Carnallit umgesetzt wird, so dass MgCl2in Form von Carnallit (Kaliumcarnallit) abgeschieden wird, wobei die zugesetzte KCl-Menge so bemessen ist, dass sich die Zusammensetzung der Mutterlösung in der Nähe der Sättigung an Carnallit und KCl einstellt.

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22-10-2020 дата публикации

DROHNENLANDESYSTEM UND -VERFAHREN

Номер: DE102020106677A1
Принадлежит:

Ein Verfahren und ein System zur Landung von Drohnen sind vorgesehen. Das Verfahren umfasst eine Beleuchtungseinrichtung, die so eingerichtet ist, dass sie eine Position und eine Geschwindigkeit eines Fahrzeugs auf der Grundlage von Fahrzeuginformationen bestimmt, die über eine drahtlose Kommunikation empfangen werden, die Geschwindigkeit der Drohne mit der Geschwindigkeit des Fahrzeugs synchronisiert und eine Drohne auf der Grundlage der Fahrzeuginformationen zu einer Position oberhalb eines Landepunktes auf dem Fahrzeug manövriert und die Drohne am Landepunkt des Fahrzeugs landet.

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02-04-2015 дата публикации

Vorgespanntes Drehmomentwandler-Gehäuse

Номер: DE102014216090A1
Принадлежит:

Es wird ein Verfahren zum Herstellen eines Drehmomentwandler-Gehäuses bereitgestellt, um eine vorteilhafte Restspannung in einer Richtung eines Belastungszustands zu erzeugen, um die Haltbarkeit während zyklischer Druckerhöhungen zu verbessern. Das Verfahren beinhaltet ein Erzeugen einer vorteilhaften Restspannung auf einen Vorderdeckel, ein Laufradgehäuse oder sowohl auf den Vorderdeckel als auch das Laufradgehäuse, um die Haltbarkeit dieser Komponenten zu verbessern. Durch die erzeugten Restspannungen wird die Spannung verringert, die während des Betriebs auf diese Komponenten einwirkt. Der Vorderdeckel und das Laufradgehäuse werden zusammengeschweißt, um das Drehmomentgehäuse zu bilden.

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25-03-2021 дата публикации

VERPACKUNGSVORRICHTUNG UND SYSTEME

Номер: DE112019003075T5
Принадлежит: PACKSIZE LLC

Ein System zum Verpacken eines oder mehrerer Produkte beinhaltet eine Bestellungsanordnungsstation, in der das eine oder die mehreren Produkte zu einem Stapel mit einer gewünschten Konfiguration angeordnet werden können. Ein Abmessungsmechanismus ermittelt die Au-ßenabmessungen des Stapels und eine Umwandlungsanordnung erzeugt eine Schachtelvorlage, die, wenn sie aufgerichtet ist, eine Schachtel bildet, die nach Maß auf die Abmessungen des Stapels abgestimmt ist. Eine Vorschubanordnung hält und bewahrt den Stapel in der gewünschten Konfiguration, während die Schachtelvorlage zumindest teilweise um den Stapel herum gefaltet wird. Die Schachtelvorlage wird in der Form einer Schachtel um den Stapel herum festgemacht.

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01-07-2021 дата публикации

TAPETENKLEISTER

Номер: DE102019135824A1
Принадлежит:

Die vorliegende Erfindung betrifft einen Tapetenkleister, der einen Kautschuklatex und ein Kohlenhydrat umfasst, sowie die Verwendung eines solchen Tapetenkleisters zur Geräuschminderung.

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09-06-2016 дата публикации

Federhalterungsscheibe mit freigeschnittenen Nietzungen

Номер: DE102015223927A1
Принадлежит:

Torsionsschwingungsdämpfer, der enthält: eine Drehachse; eine Federhalterungsscheibe mit einer Vielzahl von Öffnungen, die durch ein Material, aus dem die Federhalterungsscheibe gebildet ist, verlaufen und von diesem vollständig umgeben sind, und eine Vielzahl Nietzungen, wobei jede Nietzunge einen entsprechenden Abschnitt enthält, der auf eine entsprechende Öffnung aus der Vielzahl von Öffnungen ausgerichtet ist, sodass eine Linie in einer zur Drehachse parallelen axialen Richtung durch den entsprechenden Abschnitt und die jeweilige Öffnung verläuft; eine Zwischenscheibe; eine Vielzahl durch die Vielzahl der Nietzungen verlaufender Niete, welche die Zwischenscheibe mit der Federhalterungsscheibe verbinden; und eine Vielzahl Federn, die mit der Federhalterungsscheibe verbunden sind.

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24-06-2021 дата публикации

Schmiernippeleinheit mit integriertem Schmiermitteldurchflussmesser

Номер: DE102019219996A1
Принадлежит:

Schmiernippeleinheit (10), die dazu ausgebildet ist, ein Schmiermittel an eine zu schmierende Vorrichtung (2) zu liefern, wobei die Einheit (10) einen Schmiermittelflusspfad (12a) und einen Schmiermitteldurchflussmesser (18) aufweist, der mit dem Schmiermittelflusspfad (12a) verbunden ist.

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27-11-2014 дата публикации

Verfahren zum Färben von Keramik über Kolloidale Dispersion

Номер: DE112013001245T5

Färben in einem Schlickergussprozess, bei dem ein Keramikschlicker in Körper im Grünzustand gegossen wird. Während dieses Schlickergießens wird eine aus Metallsalzen bestehende Färbelösung in den Schlicker eingebracht und anschließend schlickgegossen. Eine Färbelösung kann zum Beispiel, ein Metallsalz, ein Lösungsmittel, ein organisches Lösungsmittel, wie etwa Derivate von Propylenoxid, umfassen, und es kann eine Säure in den Schlickergussprozess eingebracht werden. Eine solche Färbelösung kann dem Schlickergussprozess zugegeben werden. Die Lösung wird gründlich mit dem Keramikschlicker vermischt, wonach der Keramikkörper gegossen, getrocknet und schließlich einem Sinterprozess unterworfen wird. Nach der abschließenden Sinterung besitzt der resultierende Keramikkörper eine eigene Farbe, die in seiner Zusammensetzung homogen ist. Das Verfahren ist besonders zum Färben von Zahnersatz aus Zirkonoxid nützlich.

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12-05-2016 дата публикации

Turbinengehäuse mit Aussparungen zum Aufnehmen der Zungen von Turbinenschaufeln

Номер: DE102015220255A1
Принадлежит:

Es wird eine Turbine für einen Drehmomentwandler bereitgestellt. Die Turbine enthält eine Turbinenschaufel, die eine erste Schaufelzunge aufweist, und ein Turbinengehäuse, das eine Innenfläche zum Haltern der Turbinenschaufeln und eine der Innenfläche entgegengesetzte Außenfläche aufweist. Das Turbinengehäuse weist einen ersten Schlitz, der von der Innenfläche durch das Turbinengehäuse zu der Außenfläche verläuft, und eine erste Aussparung auf, die sich nahe dem ersten Schlitz von der Außenfläche zu der Innenfläche erstreckt. Die erste Schaufelzunge verbindet die Turbinenschaufel mit dem Turbinengehäuse, indem sie durch den ersten Schlitz gesteckt und in die erste Aussparung umgebogen wird. Auch ein Verfahren zum Bilden einer Turbine für einen Drehmomentwandler wird bereitgestellt.

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27-04-2017 дата публикации

Kühlmodul für eine Photovoltaikeinheit

Номер: DE102015220984A1
Принадлежит:

Die Erfindung betrifft ein Kühlmodul für eine Photovoltaikeinheit. Erfindungsgemäß ist ein als plattenförmiges 3-D-Textil ausgebildeter Kern (1), der als Abstandsgewirke ausgebildet ist, vorgesehen, welches von einem Fluid (3) durchströmbar ist.

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15-03-2018 дата публикации

Kinderwagen

Номер: DE102016010884A1
Принадлежит:

Die vorliegende Erfindung betrifft einen zusammenklappbaren Kinderwagen vom Typ Buggy mit einem Rückenrahmen (1), einen mit diesem über eine erste Gelenkachse gelenkig verbundenen Sitzrahmen (2) und einem mit dem Sitzrahmen über eine zweite Gelenkachse gelenkig verbundenen unteren Hinterrahmen (3), weiter umfassend mindestens eine Stützstrebe (4), die beim Zusammenklappen des Buggys um eine dritte Gelenkachse schwenkend mit dem Rückenrahmen (1) verbunden ist und in einem zweiten Bereich um eine vierte Gelenkachse schwenkend mit dem unteren Hinterrahmen (3) gelenkig verbunden ist, wobei der Sitzrahmen (2) eine von der ersten Gelenkachse ausgehende durchgehende in der Vorderansicht des Buggys gesehen etwa U-förmige nach oben hin offene U-Strebe umfasst, wobei erfindungsgemäß die U-Strebe des Sitzrahmens (2) in der Seitenansicht des Buggys gesehen einen von der ersten Gelenkachse ausgehend zu den Vorderrädern (7) hin nach unten hin abgewinkelten Verlauf aufweist. Man erhält so eine stärker ...

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29-03-2012 дата публикации

Kolbendichtung mit Zentrierscheibe

Номер: DE102011111965A1
Принадлежит:

Ein erfindungsgemäßer Drehmomentwandler umfasst ein Kolbenblech für eine Wandlerüberbrückungskupplung, das eine eine axial mit einer Drehachse für den Drehmomentwandler ausgerichtete Umfangsfläche aufweist, ein fest am Kolbenblech angeordnetes ringförmiges Element und eine in Druckverbindung mit der Umfangsfläche stehende, axial mit dem ringförmigen Element fluchtende Dichtung mit einer radial nach innen weisenden Fläche zur Bildung einer Dichtung mit einer in den Drehmomentwandler eingefügten Eingangswelle.

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18-06-2014 дата публикации

Motor- und Zeigerelement-Anschlusselement

Номер: DE102013222710A1
Принадлежит:

Es wird ein Zeiger mit einer integrierten lichtemittierenden Diode (LED) bereitgestellt, welche mit einem Buchsenverbinder ausgebildet ist. Ein Motor weist den Stecker für die Buchse auf, wodurch die Welle des Motors ersetzt wird. Der Zeiger ist mit der in dem Motor integrierten Buchse zusammengesetzt. Der Zeiger ist als eine mit einer integrierten LED und Verbindungsbuchse eingegossene Komponente ausgebildet. LED-Anschlüsse sind mit der Buchse verbunden. Der Motor nimmt den Buchsenverbinder in integraler Weise auf, wodurch die Welle des Motors ersetzt wird. LED-Versorgungsspannungssignale (VCC, GND) gelangen zu der gedruckten Schaltkreisplatine (PTB) über den Buchsenverbinder, und zwar durch Einsetzen von neuen Kontaktfedern in der Basis des Motors. Innerhalb des Motors ist die Welle mit den Kontaktfedern über Bürstenkontakte verbunden.

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06-05-2021 дата публикации

Fahrradsattel

Номер: DE102018214016B4
Принадлежит: ERGON INT GMBH, Ergon International GmbH

Fahrradsattel miteiner Sattelschale (12),einem mit einer Oberseite (18) der Sattelschale verbundenen Sattelpolster (20),einen mit einer Unterseite (24) der Sattelschale (12) verbundenen Sattelgestell (10) undeiner im Bereich einer Sattelspitze (14) in der Sattelschale (12) vorgesehenen Vertiefung (26) zur Aufnahme eines Ansatzes (60) des Sattelpolsters (20),dadurch gekennzeichnet, dassin Seitenwänden der Vertiefung (26) Durchgangsöffnungen (34), (36), (38) vorgesehen sind.

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22-05-2014 дата публикации

Anordnung für eine Brennstoffeinspritzanlage mit einem Brennstoffeinspritzventil und einem Entkoppelelement

Номер: DE102012221134A1
Принадлежит:

Ein Entkoppelelement (3) dient zum Entkoppeln eines Brennstoffeinspritzventils (2) von einem Zylinderkopf. Das Entkoppelelement (3) weist einen Grundkörper (6), der im montierten Zustand zum Umschließen eines Gehäuses (5) des Brennstoffeinspritzventils (2) dient, auf. Dabei ist an dem Grundkörper (6) ein zylinderseitiger Auflagebereich (7) ausgestaltet, der zum Abstützen an dem Zylinderkopf (4) dient. Ferner ist an dem Grundkörper (6) ein ventilseitiger Stützbereich (8) ausgestaltet, der zum Abstützen des Brennstoffeinspritzventils (2) dient. Beim Abstützen des Brennstoffeinspritzventils (2) zwischen dem ventilseitigen Stützbereich (8) und dem zylinderseitigen Auflagebereich (7) wird der Grundkörper (6) auf Druck beaufschlagt. Hierbei ist nur der zylinderseitige Auflagebereich (7) des Grundkörpers (6) in Form eines geschlossenen Rings ausgestaltet, während der Grundkörper (6) über einen Umfang verteilte Segmente (1518) aufweist, die durch den geschlossenen Ring (20) des zylinderseitigen ...

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04-04-2019 дата публикации

Fahrradsattel

Номер: DE102018214016A1
Принадлежит:

Ein Fahrradsattel weist eine Sattelschale (12) auf, auf deren Oberseite (18) ein Sattelpolster (20) angeordnet ist. An einer Unterseite (24) der Sattelschale (12) ist über Befestigungselemente (50), (54) ein Sattelgestell (10) befestigt. In einem Bereich der Sattelspitze (14) weist die Sattelschale (12) eine Vertiefung (26) auf. In die Vertiefung (26) ragt ein Ansatz (60) des Sattelpolsters (20).

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21-09-2017 дата публикации

PRIMER-OBERFLÄCHENBESCHICHTUNG FÜR SILICIUM-BASIERTE HOCHLEISTUNGSELEKTRODEN

Номер: DE102017105307A1
Принадлежит:

Eine negative Elektrode für eine elektrochemische Batteriezelle (z. B. eine Lithium-Ionen-Batterie) wird bereitgestellt. Die Elektrode weist ein aktives Material auf, das eine volumetrische Ausdehnung während des Lithiierens und Delithiierens erfährt, z. B. silciumhaltige Materialien. Die Elektrode weist einen Stromabnehmer mit einer elektrisch leitfähigen flexiblen Primer-Oberflächenbeschichtung darauf angeordnet auf. Die Primer-Beschichtung umfasst ein Polymer mit einer Glasübergangstemperatur von < 85°C und ein elektrisch leitendes Teilchen. Nach dem Zusammensetzen dient die flexible Primer-Oberflächenbeschichtung zum Verringern von Belastung an der Grenzfläche zwischen dem aktiven Material und dem Stromabnehmer. Die Primer-Beschichtung und das elektroaktive Material bleiben auf der Oberfläche des Stromabnehmers nach mindestens einem Zyklus von Lithium-Ionen-Einlagern und -Auslagern in der Elektrode intakt und verhindern damit den Verlust von Ladekapazität in der elektrochemischen Zelle ...

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28-10-2021 дата публикации

Niet zur Verwendung mit einem abgewinkelten Befestigungselement und Verfahren dafür

Номер: DE112011103175B4

Verfahren zum Befestigen von Platten (104, 106) in einem Drehmomentwandler (101) mit einem Niet (108), wobei der Drehmomentwandler (101) einen vorderen Deckel (102) und eine erste und eine zweite Platte (104, 106) und der Niet (108) einen Schaft (110), einen Kopf (112) und eine Längsachse (114) enthält, die durch den Schaft (110) und den Kopf (112) verläuft, wobei das Verfahren beinhaltet:Bilden des Kopfes (112) des Niets (108) derart, dass eine Endfläche (116) des Kopfs (112) gekrümmt ist oder mehrere Ebenen bildet;Bilden eines Teils (118) einer Innenfläche (120) des Deckels (102), damit dieser in Bezug auf einen umgebenden Teil (122) der Innenfläche (120) erhaben oder vertieft ist;Anordnen des Schafts (110) des Niets (108) in entsprechenden Löchern (124, 126) in entsprechenden Teilen der ersten und der zweiten Platte (104, 106) derart, dass die Endfläche (116) des Nietkopfs (112) dem vorderen Deckel gegenüberliegt; undVerschieben der ersten und der zweiten Platte (104, 106) derart, dass ...

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11-07-2013 дата публикации

Niet zur Verwendung mit einem abgewinkelten Befestigungselement und Verfahren dafür

Номер: DE112011103175T5

Ein Verfahren zum Befestigen von Platten in einem Drehmomentwandler beinhaltet: das Bilden eines Kopfs eines Niets mit einer Endfläche, die gekrümmt ist oder mehrere Ebenen bildet; das Bilden eines Teils einer Innenfläche des Deckels, damit dieser in Bezug auf einen umgebenden Teil der Innenfläche erhaben oder vertieft ist; das Anordnen des Schafts des Niets in entsprechenden Löchern in entsprechenden Teilen der Platten; und das Verschieben der Platten derart, dass die Endfläche des Nietkopfs in Kontakt mit dem Teil der Innenfläche gelangt, die entsprechenden Teile der ersten und zweiten Platte unter einem spitzen Winkel in Bezug auf den umgebenden Teil der Innenfläche stehen und eine Längsachse des Niets unter einem spitzen Winkel in Bezug auf eine Linie steht, die senkrecht zu dem umgebenden Teil der Innenfläche ist.

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12-09-2013 дата публикации

Ventil zum Zumessen eines Fluids

Номер: DE102012203607A1
Принадлежит:

Es wird ein Ventil Zumessen eines Fluids, insbesondere zum Einspritzen von Kraftstoff in eine Kraftstoffeinspritzvorrichtung von Brennkraftmaschinen angegeben, das einen Zulauf (11) für das Fluid, eine Zumessöffnung (12) für das Fluid und einen vom Zulauf (11) zur Zumessöffnung (12) führenden, langgestreckten, hohlzylindrischen Strömungskanal (13) mit einer äußeren Kanalwand (13a) und innere Kanalwand (13b) aufweist. Um bauformbedingte Hydraulikresonanzen so zu beeinflussen, dass eine Anregung kritischer, einbaubedingter Strukturmoden nicht mehr erfolgen kann, ist der Strömungskanal in mindestens zwei voneinander getrennten Kanalabschnitte (131, 132) unterteilt und zwischen aufeinanderfolgenden Kanalabschnitten (131, 132) eine gedrosselte Strömungsverbindung für das Fluid hergestellt.

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02-05-2019 дата публикации

EINRICHTUNG ZUM AUFBEWAHREN EINER MOBILITÄTSVORRICHTUNG IN EINER HECKKLAPPE EINES FAHRZEUGS

Номер: DE112016007038T5

Diese Offenbarung stellt eine Einrichtung zum Aufbewahren einer Mobilitätsvorrichtung in einer Heckklappe eines Fahrzeugs bereit. Hierin sind Einrichtungen zum Aufbewahren einer Mobilitätsvorrichtung in einer Heckklappe eines Fahrzeugs beschrieben. Eine beispielhafte Einrichtung beinhaltet eine Heckklappe eines Fahrzeugs und eine Mobilitätsvorrichtung, die an ein Inneres der Heckklappe gekoppelt ist.

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05-04-2012 дата публикации

METHODS FOR THE CONVERSION OF A SUBSTITUTED FURAN TO A SUBSTITUTED PYRROLE

Номер: US20120083609A1
Принадлежит: CHEVRON PHILLIPS CHEMICAL COMPANY LP

The present invention discloses processes for producing substituted pyrrole compounds, such as 2,5-disubstituted pyrroles. Synthetic processes which directly convert substituted furan compounds to substituted pyrrole compounds, via a reaction of the substituted furan compound with ammonia and/or an ammonium salt in the presence of a catalyst, also are described. 1. (canceled)3. The process of claim 2 , wherein R claim 2 , R claim 2 , R claim 2 , and Rindependently are a hydrogen atom or a C-Chydrocarbyl group claim 2 , and{'sup': 2p', '3p', '4p', '5p, 'at least one of R, R, R, and Ris not a hydrogen atom.'}4. The process of claim 2 , wherein Rand Rindependently are a C-Chydrocarbyl group claim 2 , and Rand Rare hydrogen.5. The process of claim 2 , wherein Rand Rindependently are a methyl group claim 2 , an ethyl group claim 2 , an n-propyl group claim 2 , an iso-propyl group claim 2 , an n-butyl group claim 2 , a t-butyl group claim 2 , a phenyl group claim 2 , a benzyl group claim 2 , a tolyl group claim 2 , or a xylyl group.6. The process of claim 2 , wherein at least one of Rand Ris a hydrogen atom.8. The process of claim 24 , wherein the substituted pyrrole compound comprises 2 claim 24 ,5-dimethylpyrrole claim 24 , 2-methyl-5-ethylpyrrole claim 24 , 2 claim 24 ,5-diethylpyrrole claim 24 , 2-ethyl-5-methylpyrrole claim 24 , 2-ethyl-5-n-propylpyrrole claim 24 , 2 claim 24 ,5-di-n-propylpyrrole claim 24 , 2 claim 24 ,5-diisopropylpyrrole claim 24 , 2 claim 24 ,5-di-n-butylpyrrole claim 24 , 2 claim 24 ,5-di-n-pentylpyrrole claim 24 , 2 claim 24 ,5-di-n-hexylpyrrole claim 24 , 2 claim 24 ,5-di-n-heptylpyrrole claim 24 , 2 claim 24 ,5-di-n-octylpyrrole claim 24 , 2 claim 24 ,3 claim 24 ,5-triethylpyrrole claim 24 , 2 claim 24 ,3 claim 24 ,5-tri-n-butylpyrrole claim 24 , 2 claim 24 ,3 claim 24 ,5-tri-n-pentylpyrrole claim 24 , 2 claim 24 ,3 claim 24 ,5-tri-n-hexylpyrrole claim 24 , 2 claim 24 ,3 claim 24 ,5-tri-n-heptylpyrrole claim 24 , 2 claim 24 ,3 claim 24 ,5-tri ...

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26-07-2012 дата публикации

Generating a chemical agent in situ

Номер: US20120189986A1
Принадлежит: Colgate Palmolive Co

A method of cleaning teeth by providing a device for generating a chemical agent in situ on an as-needed basis via the application of an electrical potential across a pair of conductors in communication with an electrolyte. The chemical agents may include ozone, hydrogen peroxide, peroxide, chlorine and/or hypochlorite. The device may include a voltage source and a first set of electrodes for applying an electrical potential to the electrolyte. The device may also include a second set of electrodes disposed about an anode of the first set of electrodes. The first and second sets of anodes cooperate to produce ions, peroxides, ozone and/or other chemical agents via the application of electrical potential to the electrolyte.

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13-09-2012 дата публикации

METHOD OF MANUFACTURING TOOTHBRUSHES WITH COMMON CORE

Номер: US20120227199A1
Принадлежит: Colgate-Palmolive Company

A dental implement includes a rigid plastic core handle and an overmold. The overmold may have different exterior configurations for different users with the different configurations altered to anatomically fit the targeted user's hands and to appeal to the targeted user. The method for manufacturing the dental implement includes forming a plastic core in a first mold, removing the plastic core from the first mold, selecting one of a plurality of second molds, with each of the plurality of second molds having a different mold cavity such that an overmold formed by one of the plurality of the second modes and an overmold formed by another one of the plurality of second molds have different configurations, placing the plastic core into the selected one of the plurality of second molds, forming an overmold about the plastic core by injecting an material into the mold cavity, and removing the plastic core and overmold from the mold cavity. 1. A method of manufacturing a dental implement , the dental implement having a shaft with a plastic core , and an overmold , the method comprising:a) forming a plastic core in a first mold;b) removing the plastic core from the first mold;c) selecting one of a plurality of second molds, each of the plurality of second molds having a different mold cavity such that an overmold formed by one of the plurality of the second molds and an overmold formed by another one of the plurality of second molds have different configurations;d) placing the plastic core into the selected one of the plurality of second molds;e) forming an overmold about the plastic core by injecting a material into the mold cavity of the selected one of the plurality of second molds; andf) removing the plastic core and overmold from the mold cavity.2. The method of claim 1 , further comprising claim 1 , after Step e) claim 1 , chemically blending the injected material with the plastic core claim 1 , and cooling the overmold with the chemically blended injected material ...

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11-10-2012 дата публикации

ORAL CARE SYSTEM, KIT AND METHOD

Номер: US20120257920A1
Принадлежит: Colgale-Palmolive Company

An oral care dispenser and oral care system incorporating the system that includes a resilient applicator that optimizes application of the subject fluid to the desired oral surfaces. In one embodiment, the invention is a dispenser comprising a housing having an internal reservoir containing the fluid. The resilient applicator is coupled to the housing and comprises a dispensing orifice. The resilient applicator comprises a working surface that is oriented at an oblique angle to a longitudinal axis of the housing and is defined by a polygonal perimeter edge, the polygonal perimeter edge comprising a plurality of apex portions and a plurality of side portions, wherein one of the plurality of side portions forms a distal most-portion of the resilient applicator.

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01-11-2012 дата публикации

ORAL CARE DISPENSER & ORAL CARE SYSTEM IMPLEMENTING THE SAME

Номер: US20120272996A1
Принадлежит: Colgate-Palmolive Company

An oral care dispenser and oral care system implementing the same. In one embodiment, the dispenser may comprise a collar having an axial passageway in which a drive component is rotatably coupled. The collar comprises a segmented neck portion and a non-segmented body portion that comprises a plurality of protuberances extending into the axial passageway. The drive component comprises at least one resilient arm that interacts with the plurality of protuberances to generate an audible signal during relative rotation. 1. An oral care dispenser comprising:a housing having a longitudinal axis and an internal reservoir containing a fluid;a collar non-rotatably coupled to the housing, the collar comprising an axial passageway, a neck portion having an inner surface forming a first section of the axial passageway, a body portion forming a second section of the axial passageway, and a plurality of protuberances extending radially inward from an inner surface of the body portion, the neck portion formed by a plurality of segments that protrude axially from the body portion, wherein adjacent ones of the plurality of segments are separated by a gap;a drive component rotatably coupled to the collar, the drive component comprising a first annular flange located adjacent a distal edge of the neck portion, a drive screw extending from the first annular flange in a first axial direction, a post extending from the first annular flange in a second axial direction and through the axial passageway, and at least one resilient arm extending radially outward from the post in the second section of the axial passageway; andwherein rotation of an actuator in a first rotational direction causes: (1) an elevator to axially advance along the drive screw in the first axial direction to dispense the fluid from a dispensing orifice; and (2) the at least one resilient arm to move over the plurality of protuberances, the at least one resilient arm deforming when moving over each of the plurality of ...

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21-03-2013 дата публикации

Oxidized Alpha Olefins

Номер: US20130068134A1
Принадлежит: CHEVRON PHILLIPS CHEMICAL COMPANY LP

A method comprising contacting an olefin wax with an oxidizing agent to produce an oxidized olefin wax, contacting the oxidized olefin wax with an odor-reducing material to produce an odor-reduced oxidized olefin wax, and removing water from the odor-reduced oxidized olefin wax. A composition comprising a product of a mixture of an oxidized olefin wax and an odor-reducing material, wherein the needle penetration of the composition is less than the oxidized alpha olefin wax in the absence of the odor-reducing material. 1. A method comprising:i) contacting an olefin wax with an oxidizing agent to produce an oxidized olefin wax;ii) contacting the oxidized olefin wax with an odor-reducing material to produce an odor-reduced oxidized olefin wax; andiii) removing water from the odor-reduced oxidized olefin wax.2. The method of claim 1 , wherein the olefin wax comprises one or more of the following:a) greater than 90 wt % olefins having from 20 to 24 carbon atoms and greater than 75 mole % alpha olefins having from 20 to 24 carbon atoms;b) greater than 70 wt % olefins having from 24 to 28 carbon atoms and greater than 45 mole % alpha olefins having from 24 to 28 carbon atoms;c) greater than 90 wt % olefins having from 26 to 28 carbon atoms and greater than 75 mole % alpha olefins having from 26 to 28 carbon atoms;d) greater than 80 wt % olefins having at least 30 carbon atoms and greater than 45 mole % alpha olefins having at least 30 carbon atoms; ore) greater than 85 wt % olefins having at least 30 carbon atoms and greater than 75 mole % alpha olefins at least 30 carbon atoms.3. The method of claim 1 , wherein the oxidizing agent comprises an oxygen-containing gas.4. The method of claim 3 , wherein the oxygen-containing gas comprises pure oxygen claim 3 , oxygen diluted with an inert gas claim 3 , air claim 3 , or air diluted with an inert gas.5. The method of claim 1 , wherein the oxidized olefin wax is produced under conditions capable of forming an oxidized olefin wax ...

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18-04-2013 дата публикации

METHODS FOR IMPROVING SEED PRODUCTION IN MAIZE

Номер: US20130096004A1
Принадлежит: PIONEER HI-BRED INTERNATIONAL, INC.

Defoliation of maize plants, based on percent seed moisture, has advantageous outcomes including greater number of seeds per pound; increased volume or proportion of saleable seed per field and per female acre; decreased discard of seed due to commercially undesirable size or shape; lower moisture content of seed at harvest; earlier harvest date; less fuel and time expended in drying seed for storage; improved performance in laboratory tests for germination at cold temperatures; improved seed treatment efficacy; improved emergence under stress in field conditions; improved plantability in mechanical systems; more uniform stand; fewer runt plants and improved grain yield. 1. A method of increasing production of saleable maize seed from a hybrid seed production field , comprising treating said field with a defoliation means.2. The method of claim 1 , wherein defoliation is by chemical means.3. The method of claim 1 , wherein multiple defoliation treatments are made.4. The method of claim 1 , wherein the proportion of flat seed is increased.5. The method of claim 1 , wherein the number of kernels per pound is increased.6. The method of claim 1 , wherein the harvested seed exhibits claim 1 , relative to a control claim 1 , one or more of: earlier harvest; reduced moisture at harvest; reduced post-harvest dry-down requirement; greater size consistency; improved germination percent or emergence rate under laboratory stress test; improved mechanical plantability; increased emergence percent or emergence rate in field conditions; more uniform emergence in field conditions; fewer runt or stunted seedlings; and increased grain yield.7. The method of claim 1 , wherein the seed is harvested at between about 20% and 45% moisture.8. The method of claim 1 , wherein the % seed moisture is between about 50% and 70%.9. The method of claim 1 , wherein the plant comprises a transgenic event conferring a trait selected from the group consisting of male sterility claim 1 , site-specific ...

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18-04-2013 дата публикации

AUTOMATED TELLER MACHINE WITH VIRTUAL BANK SHARING

Номер: US20130097077A1

An automated teller machine (ATM) which includes a plurality of peripherals including a user interface for interacting with a user providing user information; a plurality of virtual automated teller machines (VATMs) resident in the ATM, the VATMs networked to a plurality of financial institutions, each VATM capable of using its own ATM software application and capable of providing its own menu of banking options to the user ; and an interface to communicate between the VATMs and the plurality of peripherals, receive the user information from the user interface, identify the user's financial institution, link the user with the user's financial institution through a selected VATM corresponding to the user's financial institution and provide the menu of banking options to the user as if the user were using an ATM dedicated to the user's financial institution. 1. An automated teller machine (ATM) comprising:a plurality of peripherals including a user interface for interacting with a user providing user information;a plurality of virtual automated teller machines (VATMs) resident in the ATM, the VATMs networked to a plurality of financial institutions, each VATM having its own ATM software application resident in the ATM and its own menu of banking options resident in the ATM for providing to the user; andan interface to communicate between the VATMs and the plurality of peripherals, receive the user information from the user interface, identify the user's financial institution, link the user with the user's financial institution through a selected VATM corresponding to the user's financial institution and provide the menu of banking options to the user as if the user were using an ATM dedicated to the user's financial institution.2. The ATM of wherein responsive to user input to the selected VATM claim 1 , the interface communicating with the peripherals to provide an output to the user.3. The ATM of wherein the output is a printed receipt.4. The ATM of wherein the ...

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13-06-2013 дата публикации

ORAL CARE INSTRUMENT INCLUDING AN ORAL CARE AGENT

Номер: US20130149663A1
Принадлежит: Colgate-Palmolive Company

An oral care instrument includes at least one oral care agent. In one embodiment, the oral care agent can be provided on one or more surfaces of the oral care instrument or included within cavities within the head or in one or more surfaces of a head. In other embodiment, the oral care agent can be provided in or on a thin slab subsequently bonded onto a surface, or applied as a stable coating. The oral care instrument can also be provided with a wear indicator. The oral care agents can be released during one use, during multiple uses, or throughout the life of the instrument. Water, oral secretions and/or chemicals within the mouth can activate the oral care agents. 1. An oral care instrument comprising:a head, at least a portion of the head including at least one oral care agent;a wear indicator secured to a surface of the oral care instrument, the wear indicator comprising a first chamber containing a first material and a second chamber containing a second material;a membrane positioned between the first chamber and the second chamber to separate the first material from the second material; andwherein upon the membrane being removed, the first material contacts the second material and causes a perceptible change that indicates that the oral care agent is depleted.2. The oral care instrument of wherein the membrane is removed by dissolving over time during use of the oral care instrument.3. The oral care instrument of wherein the oral care agent is stored within a capsule that is located on the head.4. The oral care instrument of wherein the capsule bursts under pressure to release the oral care agent into an oral cavity.5. The oral care instrument of wherein the capsule dissolves over time to release the oral care agent into an oral cavity.6. The oral care instrument of further comprising a cavity formed into a surface of the head claim 1 , wherein the at least one oral care agent is located within the cavity.7. The oral care instrument of wherein a first oral ...

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13-06-2013 дата публикации

Preparation of Transition Metal Carboxylates

Номер: US20130150605A1
Принадлежит: CHEVRON PHILLIPS CHEMICAL COMPANY LP

This disclosure provides a process for making transition metal carboxylate compositions by combining in an polar aprotic first solvent a transition metal precursor and a Group 1 or Group 2 metal carboxylate under substantially acid-free and substantially anhydrous conditions, to generate a mixture comprising the transition metal carboxylate composition. Optionally, the transition metal carboxylate composition can be purified, for example, by substantially removing the first solvent provide a residue comprising the transition metal carboxylate composition, and also optionally, further by extracting the transition metal carboxylate composition from the residue with a non-coordinating second solvent to provide an extract comprising the transition metal carboxylate composition. 2. The composition of claim 1 , wherein the transition metal precursor has the formula MXLwhere Mis a transition metal in the x oxidation state and x is an integer from 1 to 6; each X independently is a monoanionic ligand; each L independently is a neutral ligand; and l is an integer from 0 to 7.3. The composition of claim 1 , wherein Mis Ti claim 1 , Zr claim 1 , V claim 1 , Nb claim 1 , Cr claim 1 , Mn claim 1 , Fe claim 1 , Co or Cu.4. The composition of claim 1 , wherein each X independently is a halide claim 1 , nitrate claim 1 , sulfate claim 1 , or phosphate and each L independently is a C-Cether claim 1 , a C-Cthioether claim 1 , a C-Cnitrile claim 1 , a C-Camine claim 1 , a C-Cphosphine claim 1 , or any combination thereof.5. The composition of claim 1 , wherein the Group 1 or Group 2 metal carboxylate has the formula (M)[(OC)R]where Mis a Group 1 or Group 2 metal; (OC)Ris a C-Ccarboxylate where r is an integer from 1 to 4 and Ris a hydrocarbon group or a substituted hydrocarbon group; q is r divided by the greatest common divisor of r and the oxidation state of M; and s is the oxidation state of Mdivided by the greatest common divisor of r and the oxidation state of M.6. The composition ...

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13-06-2013 дата публикации

Preparation of an Olefin Oligomerization Catalyst

Номер: US20130150642A1
Принадлежит: CHEVRON PHILLIPS CHEMICAL COMPANY LP

This disclosure provides for new catalyst systems and new methods for preparing and using the catalyst systems for generating a trimerization product. In an aspect, the new catalyst systems comprise a chromium carboxylate that is prepared by anhydrous metathesis. In another aspect, the catalyst system comprise a chromium carboxylate that is prepared by anhydrous metathesis and a metal pyrrolide compound. The catalyst systems imparts improved performance and/or reduced catalyst system cost to an olefin trimerization process. 1. A composition comprising:{'sub': 3', '25, 'claim-text': [{'sub': asym', '2', 'sym', '2', 'asym', '2, 'sup': −1', '−1', '−1, 'i) having a KBr pellet infrared spectrum with a υ(CO) infrared absorbance peak within 110 cmof the υ(CO) infrared peak and having an infrared absorbance peak height ratio of a υ(CO) infrared absorbance peak at 1516±15 cmto infrared absorbance peak located at 700±50 cmgreater than or equal to 3:1,'}, {'sup': '2', 'sub': 3', '25, 'ii) having a goodness of fit test value, R, of at least 0.6 when comparing high-energy X-ray diffraction g(r) data points of the chromium(III) C-Ccarboxylate composition to calculated high energy X-ray diffraction g(r) data points of a theoretical model of mononuclear chromium(III) acetate over an r range from 1.3 Angstroms to 4 Angstroms, or'}, [{'sub': 3', 'l', '2', '10', '2', '10', '2', '5', '1', '30', '3', '30, '1) a chromium(III) precursor having a formula CrXLwhere each X independently is a halide, each L independently is a C-Cether, a C-Cthioether, a C-Cnitrile, a C-Camine, or a C-Cphosphine, or any combination thereof, and l ranges from 0 to 7,'}, {'sub': 3', '25, '2) a Group 1 or Group 2 metal C-Ccarboxylate, and'}, '3) a first solvent;, 'contacting under substantially anhydrous and substantially acid-free conditions'}, 'iii) produced by a process comprising'}], 'a) a chromium(III) C-Ccarboxylate composition'}b) a pyrrole compound; andc) a metal hydrocarbyl compound.2. The composition of ...

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18-07-2013 дата публикации

DISPATCHABLE RENEWABLE ENERGY GENERATION, CONTROL AND STORAGE FACILITY

Номер: US20130184884A1
Принадлежит: Inventus Holdings, LLC

The present invention includes a system and method for generating, controlling and storing dispatchable renewable energy. The system may include one or more wind power generation facilities and one or more solar power generation facilities to generate power that can be stored by one or more storage facilities. The power can be supplied to a power grid at a level determined by actual or predicted weather conditions, based on variable power demands. The power generated by the renewable energy sources may be combined with power generated by conventional power generation facilities to provide power in a dispatchable manner. 1. An electrical power generation system comprising: said first output terminals having an electrical connection to a contractor, said contractor having an electrical connection to a circuit breaker, said circuit breaker having an electrical connection to a transformer, said transformer having an electrical connection to an electrical grid;', 'said second output terminals having an electrical connection to a power converter, said power converter further comprising first and second rectifier-inverters having alternating current (AC) and direct current (DC) terminals, a generator control unit and a capacitor, said AC terminals of said first rectifier-inverter having an electrical connection to said second output terminals of said generator, said DC terminals of said first rectifier-inverter having an electrical connection to said DC terminals of said second rectifier-inverter, said capacitor being electrically connected across said electrical connections between said DC terminals of said first and second rectifier-inverters;, 'a wind turbine mechanically connected to an electrical generator having at least first and second electrical output terminals,'}a turbine control unit having means for controlling said wind turbine;an energy storage device having input and output terminals, said input terminals having an electrical connection to DC terminals of a ...

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17-10-2013 дата публикации

Oral care implement

Номер: US20130269128A1
Автор: Eduardo J. Jimenez
Принадлежит: Colgate Palmolive Co

An oral care implement that rotates about a longitudinal axis. In one aspect, the invention can be an oral care implement comprising: a head; a handle extending along a longitudinal axis and having a flat base surface; a mechanical vibratory device operatively connected to a power source, the mechanical vibratory device comprising an eccentric imparting movement to the head when activated; and wherein the flat base surface is oriented relative to the longitudinal axis of the handle so that the oral care implement can stand in a self-supporting upright orientation on a horizontal flat surface, and wherein when the oral care implement stands in the self-supporting upright orientation and the mechanical vibratory device is activated, the oral care implement rotates about the longitudinal axis while maintaining the self-supporting upright orientation.

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17-10-2013 дата публикации

ORAL CARE IMPLEMENT

Номер: US20130274774A1
Автор: Jimenez Eduardo J.
Принадлежит: COLGATE-PALMOLLIVE COMPANY

An oral care implement for cleaning a user's tongue and/or soft tissue surfaces. In one aspect, the invention can be an oral care implement comprising: a handle extending along a longitudinal axis; first and second prong members extending from a distal end of the handle, each of the first and second prong members diverging from the longitudinal axis and having a distal end; a blade for scraping soft tissue, the blade extending between the distal ends of the first and second prong members; and the blade integrally formed with the first and second prong members, the first and second prong members transitioning into the blade at the distal ends of the first and second prong members. 1. An oral care implement comprising:a handle extending along a longitudinal axis;first and second prong members extending from a distal end of the handle, each of the first and second prong members having a distal end;a blade for scraping soft tissue, the blade extending between the distal ends of the first and second prong members; andthe blade integrally formed with the first and second prong members, the first and second prong members transitioning into the blade at the distal ends of the first and second prong members.2. The oral care implement according to wherein the first and second prong members diverge from the longitudinal axis with distance from the distal end of the handle.3. The oral care implement according to any one of to wherein the blade comprises a base formed of a first material and a layer formed of a second material overlying at least a portion of the base claim 1 , the first material having a hardness that is greater than a hardness of the second material.4. The oral care implement according to wherein the blade comprises a first edge and a second edge claim 3 , wherein the first edge is formed by the second material and the first material forms the second edge.5. The oral care implement according to any one of to wherein the layer is integrally formed with a ...

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14-11-2013 дата публикации

Oral care dispenser & oral care system implementing the same

Номер: US20130298341A1
Принадлежит: Colgate Palmolive Co

An oral care system comprising a toothbrush and a dispenser is disclosed. In one embodiment, the dispenser comprises a housing having a longitudinal axis and an internal reservoir containing an oral care material; a drive component rotatably disposed within the housing and comprising a drive screw, the drive component being axially retained relative to the housing through mechanical interference; and an elevator coupled to the drive screw so that rotation of the drive component in a first rotational direction causes the elevator to axially advance along the drive screw in a first axial direction to dispense the oral care material from a dispensing orifice.

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21-11-2013 дата публикации

Oral Care Implement Having Fluid Delivery System

Номер: US20130305471A1
Принадлежит: Colgate-Palmolive Company

An oral care implement has a head portion with tooth cleaning elements on one surface thereof and a reservoir containing at least one active agent. A capillary channel extends through at least a portion of the oral care implement to deliver active agent(s) to one or more outlets. In one aspect, a vibration-producing device is provided to vibrate at least a portion of the implement to enhance the function of tooth cleaning elements and the delivery of the active agent through capillary action. A variety of active agents can be administered for therapeutic, hygienic, and/or other benefits, such as fresh breath, tooth whitening, or producing sensations of heat, cool, or tingling. 1. An oral care implement , comprising:a handle;a head containing at least one tooth cleaning element;a reservoir for storing a fluid containing at least one active agent;an overflow chamber, wherein the overflow chamber is separated from the reservoir; anda capillary channel constructed from a fibrous material, ceramic, porous plastic, or combination thereof, wherein the capillary channel extends through at least a portion of the implement and delivers the active agent from the reservoir to at least one outlet by capillary action.2. The oral care implement of claim 1 , wherein the outlet is located within or adjacent to the tooth cleaning element or elements.3. The oral care implement of claim 1 , wherein the outlet is integral with an elastomeric tooth cleaning element.4. The oral care implement of claim 1 , wherein the active agent is selected from the group consisting of antibacterial agents; oxidative or whitening agents; supercharged fluoride delivery ingredients; tooth sensitivity ingredients; gum health actives; nutritional ingredients; tartar control or anti-stain ingredients; enzymes; sensate ingredients; flavors or flavor ingredients; anti-cavity or enamel repair agents; breath freshening ingredients; oral malodor reducing agents; anti-attachment agents; diagnostic solutions; ...

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21-11-2013 дата публикации

Oral Care Implement Having Multiple Soft Tissue Cleaner Components

Номер: US20130307187A1
Принадлежит: Colgate-Palmolive Company

An oral care implement with a soft tissue cleaner. The inventive oral care implement comprises different kinds of soft tissue cleaners that offer expanded in-mouth cleaning. In one aspect, the invention can be an oral care implement comprising: a handle; a head having a structural body having a front surface and a rear surface opposite the front surface; a basin formed into the rear surface of the structural body, the structural body comprising a protuberance extending upward from a recessed floor of the basin, the basin surrounding the protuberance; a first cleaner formed of a resilient material for cleansing soft oral tissue located within the basin, the protuberance of the structural body extending through a central hole of the first cleaner; and a second cleaner formed of a resilient material for cleansing soft oral tissue, the second cleaner located on the protuberance of the structural body. 1. A method of manufacturing a head of an oral care implement comprising:a) forming a structural body of the head out of a hard plastic, the main structural body having a front surface, a rear surface, a basin formed into the rear surface, and a protuberance extending upward from a recessed floor of the basin, the basin surrounding the protuberance;b) injecting a first shot of thermoplastic elastomer via a first port into the basin of the structural body of the head to form a first cleaner for cleansing soft oral tissue; andc) injecting a second shot of a thermoplastic elastomer via a second port onto the protuberance of the structural body of the head to form a second cleaner for cleansing soft oral tissue.2. The method of wherein the second cleaner is spaced from and isolated from the first cleaner.3. The method of wherein the first shot is a first type of thermoplastic elastomer and the second shot is a second type of thermoplastic elastomer.4. The method of wherein the first and second types of thermoplastic elastomer are different colors.5. The method of wherein the ...

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21-11-2013 дата публикации

ORAL CARE IMPLEMENT WITH FLUID APPLICATOR AND METHOD OF ASSEMBLING THE SAME

Номер: US20130309629A1
Принадлежит: Colgate-Palmolive Company

An oral care implement, e.g., toothbrush, having a wick applicator and a method of assembling the same is disclosed. The implement includes a head, a handle connected to the head by a neck portion, and a recess. The recess is arranged for receipt of the wick applicator. The handle includes an internal fluid reservoir holding a fluid in communication with the recess. The wick applicator is arranged to enable a fluid to pass therethrough by capillary action and has a first end portion and a second end portion. The second portion of the wick applicator comprises at least one projection for engaging at least one cooperating portion of the recess to secure the wick applicator in the recess at an operative position, whereupon the wick applicator is in fluid communication with the fluid in the reservoir. 1. An oral care implement comprising:a head;a handle connected to the head by a neck portion, said handle including an internal fluid reservoir for holding a fluid therein;a recess, said recess including a first portion extending along said head and a second portion extending into said neck and in fluid communication with said fluid reservoir; a member comprising a material arranged to enable a fluid to pass therethrough by capillary action and having a first end portion and a second end portion;', 'wherein said first end portion of said wick applicator is arranged to be located within said first portion of said recess and with said second end portion being arranged to be located within said second portion of said recess; and, 'a wick applicator comprisingwherein said second portion of said wick applicator comprises at least one projection for engaging at least one cooperating portion of said recess to secure said wick applicator in said recess at an operative position, whereupon said wick applicator is in fluid communication with said internal fluid reservoir.2. The oral care implement of wherein said recess has a central longitudinal axis and wherein said wick applicator ...

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21-11-2013 дата публикации

ORAL CARE IMPLEMENT

Номер: US20130310860A1
Автор: Jimenez Eduardo J.
Принадлежит: Colgate-Palmolive Company

An oral care implement for cleaning soft oral tissue. In one aspect, the invention can be an oral care implement comprising: a handle extending along a longitudinal axis; first and second prong members extending from a distal end of the handle; a pad for engaging soft tissue, the pad having a first major surface and a second major surface, the pad positioned between and coupled to the first and second prong members. 1. An oral care implement comprising:a handle extending along a longitudinal axis;first and second prong members extending from a distal end of the handle;a pad for engaging soft tissue, the pad having a first major surface and a second major surface, the pad positioned between and coupled to the first and second prong members; anda plurality of protuberances protruding from the first major surface of the pad.2. The oral care implement of wherein the pad comprises a base formed of a first material and a layer formed of a second material overlying at least a portion of the base claim 1 , the first material having a hardness that is greater than a hardness of the second material claim 1 , the plurality of protuberances integrally formed with the second material.3. The oral care implement of any one of to further comprising a plurality of protuberances protruding from the second major surface of the pad claim 1 , wherein the protuberances of the second major surface form a different topography than the protuberances of the first major surface.4. The oral care implement of wherein the protuberances of the second major surface are ridges and the protuberances of the first major surface are nubs.5. The oral care implement of any one of the preceding claims wherein the pad is coupled to the first and second prong members at an axial location claim 3 , and wherein the first and second prong members are adjustable between (1) a normal state having a first distance between the first and second prong members at the axial location; and (2) a flexed state having a ...

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21-11-2013 дата публикации

Oral Care Implement with Customizable Element and Related Methods

Номер: US20130311321A1
Принадлежит: Colgate-Palmolive Company

An oral care implement including a customizable element and related methods are described. A method of marketing an oral care implement and a face plate may include exposing a primary oral care implement for sale and exposing a plurality of distinct faceplates each removably attachable to the oral care implement. A user may be permitted to select at least one of the removable faceplates. Upon selection of the at least one of the removable faceplates by the user, the oral care implement and the selected faceplate may be provided to the user. 1. A method of marketing an oral care implement and a face plate , the method comprising the steps of:exposing a primary oral care implement for sale;exposing a plurality of distinct faceplates each removably attachable to the oral care implement;permitting a user to select at least one of the removable faceplates; andproviding the oral care implement and the selected faceplate to the user.2. The method of claim 1 , wherein the oral care implement and the at least one of the removable faceplates are packaged together.3. The method of claim 1 , wherein the oral care implement and the at least one of the removable faceplates are packaged separately.4. The method of claim 1 , further comprising the step of exposing a plurality of sets of thematically related faceplates and permitting a user to select at least one of the sets of thematically related faceplates.5. The method of claim 4 , wherein the plurality of sets of thematically related faceplate includes faceplates associated with athletic teams.6. The method of claim 4 , wherein the plurality of sets of thematically related faceplate includes faceplates associated with television claim 4 , radio claim 4 , movie claim 4 , or internet celebrity personalities. The present application is a divisional of U.S. patent application Ser. No. 13/416,694, filed on Mar. 9, 2012, now U.S. Pat. No. 8,499,397, which is a divisional of U.S. patent application Ser. No. 12/159,313, filed on Jun. ...

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28-11-2013 дата публикации

DEVICE TO PROVIDE ENHANCED FLOSSING BENEFITS

Номер: US20130316070A1
Принадлежит: Colgate-Palmolive Company

A dental floss dispenser having a wicking delivery system with a reservoir for storing a solution of oral care ingredients generally in fluid form. The reservoir includes an absorbent wicking porous pad that extends through at least a portion of the floss dispensing device to deliver the solution to the dental floss. When the floss is pulled through the porous pad holding the oral care ingredient(s), the porous pad activates (e.g., coats, impregnates, saturates) the floss, providing the consumer with new benefits such as enhanced deep cleaning, new flavors, better plaque dissolving capabilities, ease of floss use and maneuverability, whitening, and deposition of therapeutic actives into the gum pockets. 1. A dental floss device comprising:a housing having a floss access port;a dental floss positioned within the housing and extending through the floss access port; anda wicking member containing an oral care fluid, wherein a portion of the dental floss is in contact with the wicking member.2. The dental floss dispenser of claim 1 , wherein the wicking member comprises an ingress end and an exit end claim 1 , further wherein the dental floss extends through the wicking member via the ingress end and the exit end toward the floss access port.3. The dental floss dispenser of any one of the preceding claims claim 1 , wherein the wicking member is held by the housing claim 1 , the wicking member having a channel internally disposed through the wicking member for passage of the dental floss therethrough.4. The dental floss dispenser of any one of the preceding claims claim 1 , wherein the wicking member is a porous pad.5. The dental floss dispenser of claim 4 , wherein the porous pad is a sponge.6. The dental floss dispenser of any one of the preceding claims claim 4 , further comprising a second wicking member containing a second oral care fluid claim 4 , a portion of the dental floss is in contact with the second wicking member.7. The dental floss dispenser of claim 6 , ...

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28-11-2013 дата публикации

Oral Care System, Kit and Method

Номер: US20130316300A1
Принадлежит: Colgate-Palmolive Company

An oral care dispenser and oral care system incorporating the system that includes a resilient applicator that optimizes application of the subject fluid to the desired oral surfaces. In one embodiment, the invention is a dispenser comprising a housing having an internal reservoir containing the fluid. The resilient applicator is coupled to the housing and comprises a dispensing orifice. The resilient applicator comprises a working surface that is oriented at an oblique angle to a longitudinal axis of the housing and is defined by a polygonal perimeter edge, the polygonal perimeter edge comprising a plurality of apex portions and a plurality of side portions, wherein one of the plurality of side portions forms a distal most-portion of the resilient applicator. 1. An oral care kit comprising:a toothbrush; and a housing having an internal reservoir containing fluid, the housing extending from a proximal end to a distal end along a longitudinal axis;', 'a resilient applicator coupled to the distal end of the housing, the resilient applicator comprising a dispensing orifice for dispensing the fluid from the reservoir and a working surface that is oriented at an oblique angle to the longitudinal axis of the housing and defined by a polygonal perimeter edge; and', 'a removable cap coupled to the housing and enclosing the resilient applicator, the removable cap comprising an axial plug that extends through and seals the dispensing orifice of the resilient applicator., 'a dispenser comprising2. The oral care kit according to wherein the polygonal perimeter edge comprises a plurality of rounded apex portions and a plurality of side portions claim 1 , and wherein one of the plurality of side portions forms a distal most-portion of the resilient applicator and one of the plurality of apex portions forms a proximal-most portion of the working surface.3. The oral care kit according to wherein the plurality of side portions are substantially linear.4. The oral care kit according ...

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28-11-2013 дата публикации

Oligomerization of Alpha Olefins Using Metallocene-SSA Catalyst Systems and Use of the Resultant Polyalphaolefins to Prepare Lubricant Blends

Номер: US20130317265A1
Принадлежит: CHEVRON PHILLIPS CHEMICAL COMPANY LP

This disclosure provides for alpha olefin oligomers and polyalphaolefins (or PAOs) and methods of making the alpha olefin oligomers and PAOs. This disclosure encompasses metallocene-based alpha olefin oligomerization catalyst systems, including those that include at least one metallocene and an activator comprising a solid oxide chemically-treated with an electron withdrawing anion. The alpha olefin oligomers and PAOs prepared with these catalyst systems can have a high viscosity index combined with a low pour point, making them particularly useful in lubricant compositions and as viscosity modifiers. 1. An oligomerization method , comprising:{'sub': 4', '20, 'claim-text': 1) a metallocene,', '2) a first activator comprising a chemically-treated solid oxide, and', {'sup': 10', '11', '10', '11, 'sub': n', '3−n', '1', '20', '1', '20, '3) a second activator comprising an organoaluminum compound having a formula: Al(X)(X)wherein Xis independently a Cto Chydrocarbyl, Xis independently a halide, a hydride, or a Cto Chydrocarboxide, and n is a number from 1 to 3; and'}], 'a) contacting a Cto Calpha olefin monomer and a catalyst system, the catalyst system comprising'}b) forming an oligomer product under oligomerization conditions.225-. (canceled)26. A method for producing a polyalphaolefin , the method comprising:{'sub': 4', '20, 'claim-text': 1) a metallocene, and', '2) a first activator comprising a chemically-treated solid oxide, and', {'sup': 10', '11', '10', '11, 'sub': n', '3−n', '1', '20', '1', '20, '3) a second activator comprising an organoaluminum compound having the formula: Al(X)(X)wherein Xis independently a Cto Chydrocarbyl, Xis independently a halide, a hydride, or a Cto Chydrocarboxide, and n is a number from 1 to 3;'}], 'a) contacting a Cto Calpha olefin monomer and a catalyst system, the catalyst system comprisingb) forming an oligomer product comprising dimers, trimers, and higher oligomers under oligomerization conditions;c) separating an ...

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05-12-2013 дата публикации

AUTOMATED TELLER MACHINE WITH VIRTUAL BANK SHARING

Номер: US20130325717A1

An automated teller machine (ATM) which includes a plurality of peripherals including a user interface for interacting with a user providing user information; a plurality of virtual automated teller machines (VATMs) resident in the ATM, the VATMs networked to a plurality of financial institutions, each VATM capable of using its own ATM software application and capable of providing its own menu of banking options to the user; and an interface to communicate between the VATMs and the plurality of peripherals, receive the user information from the user interface, identify the user's financial institution, link the user with the user's financial institution through a selected VATM corresponding to the user's financial institution and provide the menu of banking options to the user as if the user were using an ATM dedicated to the user's financial institution. 1. An automated teller machine (ATM) comprising:a host operating system to host a plurality of virtual automated teller machines (VATMs) resident in the ATM;a user interface for interacting with a user providing user information;the VATMs networked to a plurality of financial institutions, each VATM having its own operating system separate from the host operating system, its own ATM software application resident in the ATM and its own menu of banking options resident in the ATM for providing to the user; andan interface to receive the user information from the user interface, identify the user's financial institution, link the user with the user's financial institution through a selected VATM corresponding to the user's financial institution and provide the menu of banking options to the user as if the user were using an ATM dedicated to the user's financial institution.2. The ATM of further comprising a plurality of peripherals claim 1 , each VATM further comprising its own virtual peripheral modules to control access of the each VATM to the plurality of peripherals and wherein the interface communicates between ...

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26-12-2013 дата публикации

INTERDENTAL CLEANING DEVICE

Номер: US20130340185A1
Принадлежит: Colgate-Palmolive Company

An interdental cleaning device that delivers an oral care fluid to a cleaning element via capillary action. The invention can be an interdental cleaning device comprising: a housing forming an internal reservoir containing an oral care fluid; an applicator extending from the housing, the applicator comprising a stem and at least one cleaning element extending from the stem; and wherein the stem comprises a capillary material that extends into the reservoir to be in fluid communication with the oral care fluid so that the capillary material of the stem delivers the oral care fluid from the reservoir to the at least one cleaning element via capillary action. 1. An interdental cleaning device comprising:a housing forming an internal reservoir containing an oral care fluid; andan applicator extending from the housing, the applicator comprising a stem and at least one cleaning element extending from the stem;wherein the stem of the applicator extends along a longitudinal axis, and the at least one cleaning element extends transversely from the stem; andwherein the stem comprises a capillary material that extends into the reservoir to be in fluid communication with the oral care fluid so that the capillary material of the stem delivers the oral care fluid from the reservoir to the at least one cleaning element via capillary action.2. The interdental cleaning device according to wherein the housing is formed of a material that fluidicly contains the oral care fluid within the reservoir.3. The interdental cleaning device according to further comprising a mass of capillary material disposed in the reservoir and containing at least a portion of the oral care fluid.4. The interdental cleaning device according to wherein the mass of capillary material fills a substantial entirety of the reservoir.5. The interdental cleaning device according to wherein the mass of capillary material has a first pore size and the stem has a second pore size claim 1 , the first pore size being ...

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26-12-2013 дата публикации

TOOTHBRUSH INCLUDING A DEVICE FOR INDICATING BRUSHING FORCE

Номер: US20130340188A1
Принадлежит: Colgate-Palmolive Company

A toothbrush that includes a piezochromic polymer or a proximity dye based polymer effective to emit an optical signal indicative of brushing force. 1. A toothbrush comprising a piezochromic polymer effective to emit an optical signal indicative of brushing force , wherein the piezochromic polymer is an electrocylic ring-opening mechanophore.2. The toothbrush of claim 1 , further comprising:(a) a handle;(b) a head;(c) bristles positioned on the head; and(d) a neck joining the handle to the head,wherein at least one of the handle, the head, the bristles and the neck comprises the piezochromic polymer.3. The toothbrush of any preceding claim 1 , wherein the piezochromic polymer is contained in a cavity within the toothbrush claim 1 , and at least a portion of the toothbrush overlying the cavity is transparent or translucent such that the piezochromic polymer is visible.4. The toothbrush of claim 3 , wherein the portion of the toothbrush overlying the cavity is a window located on a back side of the toothbrush claim 3 , such that the piezochromic polymer is visible when teeth of a user are being brushed in front of a mirror.5. The toothbrush of any preceding claim 1 , wherein the piezochromic polymer comprises spiropyran.6. The toothbrush of claim 5 , wherein the electrocylic ring-opening mechanophore comprises poly(methyl acrylate) or poly(methyl methacrylate).7. The toothbrush of claim 1 , wherein the optical signal is at least one color change indicative of at least one of excessive brushing force claim 1 , acceptable brushing force and inadequate brushing force.8. The toothbrush of claim 1 , wherein the toothbrush is free of a power supply and electrical circuitry.9. The toothbrush of claim 2 , further comprising an elongated bladder adapted to transmit force from the head to the piezochromic polymer claim 2 , wherein the piezochromic polymer is located in or on the neck.10. The toothbrush of claim 2 , further comprising a lever inside the head and neck claim 2 , ...

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02-01-2014 дата публикации

Toothbrush having oral care fluid delivery

Номер: US20140000047A1
Принадлежит: Colgate Palmolive Co

A fluid dispensing toothbrush ( 100 ). In one aspect, the toothbrush comprises a body ( 105 ) having a reservoir ( 135 ) containing an oral care fluid ( 136 ) therein, the oral care fluid being delivered to an applicator ( 132 ) via capillary action. The toothbrush comprises an actuator ( 130 ) for moving either the applicator and/or the reservoir between different positions.

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09-01-2014 дата публикации

ORAL CARE IMPLEMENT HAVING ROLL-ON APPLICATOR

Номер: US20140010583A1
Принадлежит: Colgate-Palmolive Company

A fluid dispensing oral care implement (). In one aspect, the oral care implement comprises a body () comprising a handle (), a head () coupled to the handle, and an internal cavity () containing an oral care material; and a roll-on applicator () rotatably mounted to the body, such that the oral care material is delivered from the internal cavity to an exposed portion of the roll-on applicator () due to rotation of the roll-on applicator. 1. An oral care implement comprising:a body comprising a handle, a head coupled to the handle, and an internal cavity containing an oral care material; anda roll-on applicator rotatably mounted to the body, such that the oral care material is delivered from the internal cavity to an exposed portion of the roll-on applicator due to rotation of the roll-on applicator.2. The oral care implement according to wherein the exposed portion of the roll-on applicator protrudes from an outer surface of the body and an internal portion of the roll-on applicator contacts the oral care material within the internal cavity.3. The oral care implement according to wherein the roll-on applicator comprises at least one spherical element rotatably mounted to the body.4. The oral care implement according to wherein the at least one spherical element is mounted in a socket formed in the body.5. The oral care implement according to wherein the roll-on applicator comprises at least one cylindrical element rotatably mounted to the body.6. The oral care implement according to wherein the roll-on applicator is located on the head.7. The oral care implement according to further comprising a field of tooth cleaning elements extending from a front surface of the head claim 1 , wherein the roll-on applicator is located on a rear surface of the head opposite the front surface.8. The oral care implement according to further comprising a field of tooth cleaning elements extending from a front surface of the head claim 1 , wherein the roll-on applicator is located on ...

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16-01-2014 дата публикации

NO-RELEASING GUANIDINE-COXIB ANTI-CANCER AGENTS

Номер: US20140018403A1
Принадлежит:

The present disclosure provides NO-releasing guanidine-coxib anti-cancer agents, having the structure of Formula (I): 2. Compound of claim 1 , wherein n is 1 or 2; and Ris H.3. Compound of claim 2 , wherein Ris selected from the group consisting of H claim 2 , acyl claim 2 , and aroyl.4. Compound of claim 3 , which is selected from the group consisting of:(S)-2-Amino-5-guanidino-N-((4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)sulfonyl)pentanamide;(S)-2-Acetamido-5-guanidino-N-((4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)sulfonyl)pentanamide;(S)-2-Formamido-5-guanidino-N-((4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)sulfonyl)pentanamide;(S)-5-Guanidino-2-propionamido-N-((4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)sulfonyl)pentanamide;(S)—N-(5-Guanidino-1-oxo-1-(4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenylsulfonamido)pentan-2-yl)benzamide;(S)-2-Amino-6-guanidino-N-((4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)sulfonyl)hexanamide;(S)-2-Acetamido-6-guanidino-N-((4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)sulfonyl)hexanamide;(S)-2-Formamido-6-guanidino-N-((4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)sulfonyl)hexanamide;(S)-6-Guanidino-2-propionamido-N-((4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)sulfonyl)hexanamide; and(S)—N-(6-Guanidino-1-oxo-1-(4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenylsulfonamido)hexan-2-yl)benzamide.5. Compound of claim 1 , wherein n is 1 or 2; and Ris hydroxy.6. Compound of claim 5 , wherein Ris selected from the group consisting of H claim 5 , acyl and aroyl.7. Compound of claim 6 , which is selected from the group consisting of:(S)-2-Amino-5-(2-hydroxyguanidino)-N-((4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)sulfonyl)pentanamide;(S)-2-Acetamido-5-(2-hydroxyguanidino)-N-((4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)sulfonyl)pentanamide;(S)-2-formamido-5-(2-hydroxyguanidino)-N-(( ...

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16-01-2014 дата публикации

NO-RELEASING NONOATE(NITROGEN-BOUND)SULFONAMIDE-LINKED-COXIB ANTI-CANCER AGENTS

Номер: US20140018544A1
Принадлежит:

The present invention provides NO-releasing NONOate(nitrogen bound)sulfonamide-linked-coxib anti-cancer agents, having the structure of Formula (I): 18. Compound of claim 7 , which is selected from the group consisting of:(Z)-1-((1,3-Dioxoisoindolin-2-yl)methoxy)-3-methyl-3-(2-((((4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)sulfonyl)carbamoyl)oxy)ethyl)triaz-1-ene 2-oxide;(Z)-1-(1-(1,3-Dioxoisoindolin-2-yl)ethoxy)-3-methyl-3-(2-((((4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)sulfonyl)carbamoyl)oxy)ethyl)triaz-1-ene 2-oxide;(Z)-1-((1,3-Dioxoisoindolin-2-yl)methoxy)-3-ethyl-3-(2-((((4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)sulfonyl)carbamoyl)oxy)ethyl)triaz-1-ene 2-oxide;(Z)-1-((1,3-Dioxoisoindolin-2-yl)methoxy)-3-isopropyl-3-(2-((((4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)sulfonyl)carbamoyl)oxy)ethyl)triaz-1-ene 2-oxide; and(Z)-3-(tert-Butyl)-1-((1,3-dioxoisoindolin-2-yl)methoxy)-3-(2-((((4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)sulfonyl)carbamoyl)oxy)ethyl)triaz-1-ene 2-oxide.19. Compound of claim 15 , wherein the compound is (Z)-1-(1-(1 claim 15 ,3-Dioxoisoindolin-2-yl)ethoxy)-3-methyl-3-(3-oxo-3-(4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenylsulfonamido)propyl)triaz-1-ene 2-oxide.20. Compound of claim 9 , which is selected from the group consisting of:(Z)-5-Ethyl-13-methyl-1,1-dioxo-1-(4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenylsulfonamido)-2,8,10,12-tetraoxa-5,6,7-triazatetradec-6-ene 6-oxide;(Z)-5-Ethyl-9,13-dimethyl-1,11-dioxo-1-(4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenylsulfonamido)-2,8,10,12-tetraoxa-5,6,7-triazatetradec-6-ene 6-oxide;(Z)-5,9,13,13-Tetramethyl-1,11-dioxo-1-(4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenylsulfonamido)-2,8,10,12-tetraoxa-5,6,7-triazatetradec-6-ene 6-oxide;(Z)-5-Ethyl-9,13,13-trimethyl-1,11-dioxo-1-(4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenylsulfonamido)-2,8,10,12-tetraoxa-5,6,7- ...

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13-03-2014 дата публикации

Oral Care Implement Having Fluid Delivery System

Номер: US20140068882A1
Принадлежит: Colgate-Palmolive Company

An oral care implement has a head portion with tooth cleaning elements on one surface thereof and a reservoir containing at least one active agent. A capillary channel extends through at least a portion of the oral care implement to deliver active agent(s) to one or more outlets. In one aspect, a vibration-producing device is provided to vibrate at least a portion of the implement to enhance the function of tooth cleaning elements and the delivery of the active agent through capillary action. A variety of active agents can be administered for therapeutic, hygienic, and/or other benefits, such as fresh breath, tooth whitening, or producing sensations of heat, cool, or tingling. 1. An oral care implement , comprising:a handle;a head containing at least one tooth cleaning element;a reservoir for storing a fluid containing at least one active agent;an overflow chamber, wherein the overflow chamber is separated from the reservoir; anda capillary channel constructed from a fibrous material, ceramic, porous plastic, or combination thereof, wherein the capillary channel extends through at least a portion of the implement and delivers the active agent from the reservoir to at least one outlet by capillary action.2. The oral care implement of claim 1 , wherein the outlet is located within or adjacent to the tooth cleaning element or elements.3. The oral care implement of claim 1 , wherein the outlet is integral with an elastomeric tooth cleaning element.4. The oral care implement of claim 1 , wherein the active agent is selected from the group consisting of antibacterial agents; oxidative or whitening agents; supercharged fluoride delivery ingredients; tooth sensitivity ingredients; gum health actives; nutritional ingredients; tartar control or anti-stain ingredients; enzymes; sensate ingredients; flavors or flavor ingredients; anti-cavity or enamel repair agents; breath freshening ingredients; oral malodor reducing agents; anti-attachment agents; diagnostic solutions; ...

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02-01-2020 дата публикации

Remote Collaboration Methods and Systems

Номер: US20200005538A1
Автор: Neeter Eduardo J.
Принадлежит:

Apparatus and associated methods relate to immersive collaboration based on configuring a real scene VRE operable from a real scene and a remote VRE operable remote from the real scene with an MR scene model of the real scene, creating an MR scene in each of the real scene VRE and remote VRE based on augmenting the MR scene model with an object model, calibrating the remote MR scene to correspond in three-dimensional space with the real scene MR scene model, and automatically providing immersive collaboration based on the MR scene in the remote VRE and updating the real scene VRE with changes to the remote VRE. In an illustrative example, the MR scene model of the real scene may be determined as a function of sensor data scanned from the real scene. In some embodiments, the MR scene model may be augmented with an object model identified from the real scene. The object model identified from the real scene may be, for example, selected from a known object set based on matching sensor data scanned from the real scene with an object from a known object set. In some embodiments, the remote MR scene may be calibrated based on applying a three-dimensional transform calculated as a function of the real MR scene and remote MR scene geometries. Some designs may recreate a subset of the real scene in the remote VRE and update the real scene VRE with changes to the remote VRE. Various embodiments may advantageously provide seamless multimedia collaboration based on updates to the remote VRE in response to physical changes to the real scene, and updating the real scene VRE in response to changes in the remote VRE. 1. A process to provide immersive collaboration , comprising:configuring a real scene VRE operable from a real scene and a remote VRE operable remote from the real scene with an MR scene model of the real scene;creating an MR scene in each of the real scene VRE and remote VRE based on augmenting the MR scene model with an object model;calibrating the remote MR scene to ...

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14-01-2016 дата публикации

Oral Care Implement Having Fluid Delivery System

Номер: US20160007728A1
Принадлежит:

An oral care implement has a head portion with tooth cleaning elements on a front surface thereof and a reservoir containing a fluid. A delivery member extends through at least a portion of the oral care implement to deliver the fluid from the reservoir to an applicator that may be positioned on the rear surface of the head. In one aspect, the applicator and the delivery member may be separate components that are fluidly coupled to one another. The applicator and the delivery member may both be formed of a capillary material. 1. An oral care implement comprising:a head and a handle, the head having a front surface and an opposing rear surface, at least one tooth cleaning element extending from the front surface;a reservoir storing a fluid;an applicator positioned on the rear surface of the head;a delivery member extending from the reservoir to the applicator; andwherein the applicator and the delivery member comprise a capillary material.2. The oral care implement of wherein the delivery member is fluidly coupled to the reservoir and to the applicator.3. The oral care implement of wherein the applicator and the delivery member are separate elements that are fluidly coupled together to facilitate flowing the fluid from the reservoir to the applicator through the delivery member via capillary action.4. The oral care implement of wherein the applicator and the delivery member are in direct surface contact with one another.5. The oral care implement of wherein the applicator has a proximal end and a distal end and the delivery member has a proximal end and a distal end claim 4 , and wherein the proximal end of the delivery member is directly coupled to the reservoir and the distal end of the delivery member is in direct surface contact with the proximal end of the applicator.6. The oral care implement of wherein the delivery member is located within a passageway that extends through the handle from the reservoir to the applicator.7. The oral care implement of wherein an ...

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09-01-2020 дата публикации

ELECTRONIC SEATBELT

Номер: US20200008538A1
Принадлежит: FORD GLOBAL TECHNOLOGIES, LLC

A seatbelt buckle that includes a housing, an attracting member, an attractable element, and a plate adapted to retain a seatbelt clip within the housing. The member, the element, and the plate may be carried by the housing. The buckle is adapted so that when the member is electronically actuated, the element causes the plate to move toward the member and thereby release the clip. 120.-. (canceled)21. A seatbelt buckle , comprising:a housing having an opening;an attracting member;an attractable element;an actuator that comprises an actuator plate coupled to a pushbutton, wherein the pushbutton is located relative to the opening; anda base plate adapted to retrain a seatbelt clip within the housing, wherein the attracting member, the attractable element, the actuator, and the base plate are carried by the housing, when the attracting member is electronically actuated and attracts the attractable element, or', 'when the pushbutton is displaced inwardly with respect to the housing., 'wherein the seatbelt clip is released22. The seatbelt buckle of claim 21 , wherein claim 21 , when the attracting member is electronically actuated claim 21 , the attractable element causes the base plate to move toward the attracting member and thereby release the seatbelt clip.23. The seatbelt buckle of claim 22 , wherein the actuator plate extends longitudinally along a first axis of the housing claim 22 , wherein the base plate also extends along the first axis claim 22 , wherein the base plate moves to release the clip along a second axis of the housing claim 22 , wherein the second axis is transverse to the first axis.24. The seatbelt buckle of claim 21 , wherein claim 21 , when an inwardly-directed force is applied to the pushbutton by a user of the seatbelt buckle claim 21 , the actuator plate moves the base plate to thereby release the seatbelt clip.25. The seatbelt buckle of claim 21 , wherein the actuator further comprises a flange extending from the actuator plate claim 21 , ...

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17-04-2014 дата публикации

GENERATING A CHEMICAL AGENT IN SITU

Номер: US20140106309A1
Принадлежит: Colgate-Palmolive Company

A method of cleaning teeth by providing a device for generating a chemical agent in situ on an as-needed basis via the application of an electrical potential across a pair of conductors in communication with an electrolyte. The chemical agents may include ozone, hydrogen peroxide, peroxide, chlorine and/or hypochlorite. The device may include a voltage source and a first set of electrodes for applying an electrical potential to the electrolyte. The device may also include a second set of electrodes disposed about an anode of the first set of electrodes. The first and second sets of anodes cooperate to produce ions, peroxides, ozone and/or other chemical agents via the application of electrical potential to the electrolyte. 1. A method of generating ozone proximate an application site , the method comprising:placing an anode of a first set of electrodes proximate the application site;generating oxygen at the anode; andapplying an electrical potential across a second set of electrodes proximate the anode while in the presence of the generated oxygen to generate ozone from the oxygen.2. The method of claim 1 , wherein generating oxygen comprises applying an electrical potential across the first set of electrodes while in the presence of water.3. The method of claim 2 , wherein claim 2 , for the step of applying an electrical potential across the first set of electrodes claim 2 , the electrical potential is about 1.5 volts.4. The method of claim 3 , wherein claim 3 , for the step of applying an electrical potential across the second set of electrodes claim 3 , the electrical potential is about 0.7 volts. This application is a divisional of U.S. application Ser. No. 13/435,726, filed Mar. 30, 2012, which is a divisional of U.S. application Ser. No. 11/549,497, filed Oct. 13, 2006, now U.S. Pat. No. 8,156,202 issued Apr. 17, 2012, which in turn claims the benefit of priority to U.S. Provisional Application No. 60/726,732, filed Oct. 14, 2005, the contents of which are ...

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10-02-2022 дата публикации

METAL SALTS AND USES THEREOF

Номер: US20220041541A1
Принадлежит:

The present invention relates to metal salts of 2-[3-[(3R)-3-[[2-chloro-3-(trifluoromethyl)phenyl]methyl-(2,2-diphenylethyl)amino]butoxy]phenyl]acetic acid which exhibit improved physical properties and stability. The invention also relates to pharmaceutical compositions including an effective amount of the metal salts, as well as methods of treating cancer including administration of a pharmaceutical composition including a salt of the invention to a subject in need thereof. 1. A pharmaceutical composition for oral administration comprising (i) a zinc salt of 2-[3-[(3R)-3-[[2-chloro-3-(trifluoromethyl)phenyl]methyl-(2 ,2-diphenylethyl)amino]butoxy]phenyl]acetic acid (Compound 1) , wherein the zinc salt is a 2:1 (Compound 1:zinc) salt , and (ii) a pharmaceutically acceptable excipient.2. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition is in the form of an emulsion claim 1 , an aqueous suspension claim 1 , a dispersion claim 1 , or a solution.3. The pharmaceutical composition of claim 2 , wherein the pharmaceutical composition is in unit dosage form.4. The pharmaceutical composition of claim 3 , wherein the pharmaceutical composition is in unit dosage form a capsule or a tablet.5. The pharmaceutical composition of claim 4 , wherein the pharmaceutical composition is a unit dosage form comprising a solution of the zinc salt.6. A method of modulating LXRβ activity in a subject in need thereof claim 4 , the method comprising administering to the subject an effective amount of a zinc salt of 2-[3-[(3R)-3-[[2-chloro-3-(trifluoromethyl)phenyl]methyl-(2 claim 4 ,2-diphenylethyl)amino]butoxy]phenyl]acetic acid (Compound 1) claim 4 , wherein the zinc salt is a 2:1 (Compound 1:zinc) salt.7. The method of claim 6 , wherein the method comprises orally administering the zinc salt formulated as a pharmaceutical composition for oral administration comprising (i) the zinc salt of 2-[3-[(3R)-3-[[2-chloro-3-(trifluoromethyl)phenyl]methyl-(2 claim 6 ,2 ...

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24-01-2019 дата публикации

Ph-sensitive chemicals for downhole fluid sensing and communication with the surface

Номер: US20190024503A1
Принадлежит: Halliburton Energy Services Inc

The invention provides a method and system for treating a subterranean formation by detecting the displacement and position of a downhole fluid having a pH through the fluids reaction with a pH-sensitive material, mobilizing a plug assembly comprising the material to contact one or more constrictions in a wellbore casing.

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31-01-2019 дата публикации

PROCEDURE FOR REDUCING CONTAMINANTS IN VEGETABLE PROTEIN MATTER

Номер: US20190029295A1
Принадлежит:

This invention refers to a procedure for reducing inorganic (heavy metals) and organic (aflatoxins, molds, etc.) contaminants in high-protein vegetable matter, mainly originating from rice. Applying said procedure to raw vegetable matter results in the obtainment of derivatives presenting levels of these contaminants significantly lower than the legal limits set by health authorities. Following the procedure set out in this invention, high-quality protein derivatives are obtained usable for vitamin and nutritional supplements, milk formula for babies, sports nutrition, clinical nutrition, animal feed ingredients, etc. 1. A procedure for reducing contaminants in vegetable protein which includes performing each of the following steps at least once:a) Mixing the initial vegetable matter with water and at least one type of protease enzyme, bringing the mixture to a pH of between 3 and 10 and keeping it in agitation for a period of at least 20 minutes, at a temperature of between 20 and 90° C.,b) Optionally, performing a wash and a solid-liquid separation of the product obtained in the previous stage,c) Optionally, subjecting the hydrolysate obtained in the previous stage to a sterilization process.2. A procedure according to where the pH of the mixture obtained from stage (a) is between 5 and 8.3. A procedure according to where the pH of the mixture from stage (a) is 7.5.4. A procedure according to where the time of agitation at stage (a) is from 60 to 180 minutes.5. A procedure according to where the time of agitation at stage (a) is 70 minutes.6. A procedure according to where temperature during stage (a) is between 50 and 80° C.7. A procedure according to where the temperature during stage (a) is 60° C.8. A procedure according to where the sterilization process during stage (c) can be either UHT sterilization or pasteurization.9. A procedure for reducing contaminants in vegetable protein which includes performing each of the following steps at least once:a1) Mixing ...

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31-01-2019 дата публикации

OLEFIN OLIGOMERIZATIONS USING CHEMICALLY-TREATED SOLID OXIDES

Номер: US20190031577A1
Принадлежит:

Disclosed is a polyalphaolefin made up of hydrogenated oligomers. The oligomers include at least 80 wt. % of a Cto Cnormal alpha olefin monomer. The polyalphaolefin has a viscosity index greater than or equal to 110 and a kinematic viscosity at −40° C. of less than or equal to 1750 cSt. 1. A polyalphaolefin consisting essentially of hydrogenated oligomers , the oligomers comprising at least 80 wt. % of a Cto Cnormal alpha olefin monomer , wherein the polyalphaolefin has a viscosity index greater than or equal to 110 and a kinematic viscosity at −40° C. of less than or equal to 1750 cSt.216. The polyalphaolefin of claim , wherein the oligomers comprise at least 92.5 wt. % of a Cto Cnormal alpha olefin monomer.316. The polyalphaolefin of claim , wherein:the viscosity index is in a range from 110 to 125; andthe kinematic viscosity at −40° C. is in a range from 1300 to 1700 cSt.416. The polyalphaolefin of claim , wherein the polyalphaolefin has a kinematic viscosity at 40° C. in a range from 9 to 15 cSt.516. The polyalphaolefin of claim , wherein the polyalphaolefin has a kinematic viscosity at 100° C. in a range from 1.8 to 12 cSt.6. The polyalphaolefin of claim 1 , wherein:the viscosity index is in a range from 110 to 150; andthe kinematic viscosity at −40° C. is in a range from 1200 to 1750 cSt.7. The polyalphaolefin of claim 6 , wherein the polyalphaolefin has a kinematic viscosity at 40° C. in a range from 9 to 18 cSt.8. The polyalphaolefin of claim 6 , wherein the polyalphaolefin has a kinematic viscosity at 100° C. in a range from 1.8 to 10.4 cSt.9. The polyalphaolefin of claim 6 , wherein the viscosity index is in a range from 112 to 150.10. A process comprising:{'sub': 12', '16, '(i) introducing a monomer comprising a Cto Colefin and a chemically-treated solid oxide into a reaction zone, the chemically-treated solid oxide comprising sulfated alumina; and'}(ii) oligomerizing the monomer to form an oligomer product in the reaction zone.11. The process of claim 10 ...

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01-05-2014 дата публикации

ORAL CARE IMPLEMENT

Номер: US20140119809A1
Принадлежит: ColgatepPalmolive Company

An oral care implement having an internal reservoir. In one embodiment, the invention can be a toothbrush comprising: a handle having an internal reservoir containing an oral care fluid; a head coupled to the handle; an applicator located on the head; a partition member positioned within the internal reservoir that divides the internal reservoir into a storage chamber and an overflow chamber; a passageway extending through the partition member from the storage chamber to the overflow chamber, the passageway terminating as a first opening in a first surface of the partition member and as a second opening in a second surface of the partition member; and a wick member having a first end in fluid communication with the applicator and a second end terminating in an end surface that abuts the second surface of the partition member to prohibit axial movement of the wick member in a first axial direction. 1. A toothbrush comprising:a handle extending along a longitudinal axis and having an internal reservoir containing an oral care fluid;a head coupled to the handle and having a plurality of tooth cleaning elements;an applicator located on the head;a partition member positioned within the internal reservoir that divides the internal reservoir into a storage chamber and an overflow chamber, the partition member comprising a first surface facing the storage chamber and a second surface facing the overflow chamber;a passageway extending through the partition member from the storage chamber to the overflow chamber, the passageway terminating as a first opening in the first surface of the partition member and as a second opening in the second surface of the partition member; anda wick member having a first end in fluid communication with the applicator and a second end terminating in an end surface that abuts the second surface of the partition member to prohibit axial movement of the wick member in a first axial direction.2. The toothbrush according to wherein the tooth ...

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16-02-2017 дата публикации

Methods of Preparation of an Olefin Oligomerization Catalyst

Номер: US20170044275A9
Принадлежит:

A method of making a catalyst for use in oligomerizing an olefin comprising a chromium-containing compound, a pyrrole-containing compound, a metal alkyl, a halide-containing compound, and optionally a solvent, the method comprising contacting a composition comprising the chromium-containing compound and a composition comprising the metal alkyl, wherein the composition comprising the chromium-containing compound is added to the composition comprising the metal alkyl. 1. A method of making a catalyst for use in oligomerizing an olefin , the catalyst comprising a chromium-containing compound , a pyrrole-containing compound , a metal alkyl , a halide-containing compound , and optionally a solvent , the method comprising: abating all or a portion of water from a composition comprising the chromium-containing compound by contacting the composition comprising the chromium-containing compound with an azeotropic solvent to form a solution and subjecting the solution to an azeotropic distillation.2. The method of claim 1 , wherein the azeotropic solvent comprises an aromatic compound claim 1 , a halogenated compound claim 1 , a paraffin claim 1 , or combinations thereof.3. The method of claim 2 , wherein the aromatic compound comprises benzene claim 2 , toluene claim 2 , ethylbenzene claim 2 , mixed xylenes claim 2 , ortho-xylene claim 2 , meta-xylene claim 2 , para-xylene claim 2 , or combinations thereof.4112. The method of claim 1 , wherein the azeotropic solvent comprises ethylbenzene claim 1 , benzene claim 1 , meta-xylene claim 1 , ortho-xylene claim 1 , para-xylene claim 1 , mixed xylenes claim 1 , toluene claim 1 , octane claim 1 , nonane claim 1 , heptane claim 1 , hexane claim 1 , mixed hexanes claim 1 , cyclohexane claim 1 , carbon tetrachloride claim 1 , chloroform claim 1 , dichloromethane claim 1 , claim 1 , claim 1 , trichloroethane claim 1 , or combinations thereof.5. The method of claim 1 , wherein the amount of water removed is monitored by infrared analysis ...

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23-02-2017 дата публикации

INHIBITORS OF CREATINE TRANSPORT AND USES THEREOF

Номер: US20170050924A1
Принадлежит:

This invention relates to compounds that inhibit creatine transport and/or creatine kinase, pharmaceutical compositions including such compounds, and methods of utilizing such compounds and compositions for the treatment of cancer. 2. The compound of claim 1 , wherein Ris hydrogen.4. The compound of any one of to claim 1 , wherein Rcombines with Rwith the atoms to which they are attached to form an optionally substituted C-Ccycloalkyl ring.7. The compound of any one of to claim 1 , wherein Ris hydrogen claim 1 , hydroxyl claim 1 , or NH.8. The compound of any one of to claim 1 , wherein Ris hydrogen.9. The compound of any one of to claim 1 , wherein m is 1 and Ris deuterium claim 1 , optionally substituted C-Calkyl claim 1 , optionally substituted C-Calkenyl claim 1 , optionally substituted C-Calkynyl claim 1 , or Rand Rcombine with the atoms to which they are attached to form an optionally substituted C-Ccycloalkyl ring.10. The compound of claim 9 , wherein Ris deuterium.11. The compound of claim 10 , wherein Ris deuterium.12. The compound of or claim 10 , wherein Rand Rare both deuterium.13. The compound of claim 9 , wherein Ris optionally substituted C-Calkyl claim 9 , optionally substituted C-Calkenyl claim 9 , optionally substituted C-Calkynyl.14. The compound of claim 13 , wherein Ris methyl claim 13 , ethyl claim 13 , n-propyl claim 13 , iso-propyl claim 13 , —CD claim 13 , —CF claim 13 , —CHF claim 13 , —CHF claim 13 , —CH═CH claim 13 , or —C≡CH.15. The compound of or claim 13 , wherein Ris hydrogen or methyl.16. The compound of any one of to claim 13 , wherein Ris hydrogen.17. The compound of any one of to claim 13 , wherein Ris hydrogen claim 13 , NH claim 13 , or methyl.18. The compound of claim 9 , wherein Rand Rcombine with the atoms to which they are attached to form an optionally substituted C-Ccycloalkyl ring.19. The compound of claim 18 , wherein said optionally substituted C-Ccycloalkyl ring is an optionally substituted C-Ccycloalkyl ring.20. The ...

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02-03-2017 дата публикации

TISSUE CLEANER AND ORAL CARE IMPLEMENT

Номер: US20170055693A1
Принадлежит:

An oral care implement having a tissue cleaning pad. In one aspect, the oral care implement includes a head having a front surface and an opposite rear surface. A plurality of tooth cleaning elements extend from the front surface of the head. A tissue cleaning pad is positioned on the rear surface of the head. The tissue cleaning pad has a planar top surface bounded by a perimetric edge and a plurality of protrusions extending from the planar top surface. The perimetric edge of the planar top surface of the tissue cleaning pad has a first portion that is flush with the rear surface of the head and a second portion that is raised relative to the rear surface of the head. 1. An oral care implement comprising:a head having a front surface and an opposite rear surface;a plurality of tooth cleaning elements extending from the front surface of the head;a tissue cleaning pad positioned on the rear surface of the head and comprising a planar top surface bounded by a perimetric edge;a plurality of protrusions extending from the planar top surface of the tissue cleaning pad; andwherein the perimetric edge of the planar top surface of the tissue cleaning pad comprises a first portion that is flush with the rear surface of the head and a second portion that is raised relative to the rear surface of the head.2. The oral care implement according to wherein the perimetric edge of the planar top surface of the tissue cleaning pad comprises a first edge claim 1 , a second edge claim 1 , and a third edge claim 1 , an entirety of the first edge is flush with the rear surface of the head claim 1 , each of the second and third edges extend from the first edge to an intersection point claim 1 , and a distance measured between each of the second and third edges and the rear surface of the head continuously increases with increasing distance from the first edge towards the intersection point.3. The oral care implement according to further comprising a first wall extending from the second ...

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02-03-2017 дата публикации

PHARMACEUTICALLY ACCEPTABLE SALTS OF beta-GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF

Номер: US20170056352A1
Принадлежит: Rgenix Inc

The present invention relates to new pharmaceutical salts of β-GPA which exhibit improved physical properties. In particular, the invention relates to salts of β-GPA with improved flow properties (e.g., improved Carr's index and/or Hausner ratio) such as fumarate salts, succinate salts, and oxalate salts. The invention also relates to pharmaceutical compositions including a pharmaceutically effective amount of one or more salts of β-GPA, as well as methods of treating cancer including administration of a formulation including a β-GPA salt of the invention to a subject in need thereof.

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02-03-2017 дата публикации

PHARMACEUTICALLY ACCEPTABLE SALTS OF ss-GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF

Номер: US20170056353A1
Принадлежит:

The present invention relates to new pharmaceutical salts of β-GPA which exhibit improved physical properties. In particular, the invention relates to salts of β-GPA with improved flow properties (e.g., improved Carr's index and/or Hausner ratio) such as fumarate salts, succinate salts, and oxalate salts. The invention also relates to pharmaceutical compositions including a pharmaceutically effective amount of one or more salts of β-GPA, as well as methods of treating cancer including administration of a formulation including a β-GPA salt of the invention to a subject in need thereof. 1. A pharmaceutically acceptable salt of β-guanidinopropionic acid , wherein said pharmaceutically acceptable salt is a 2:1 succinate salt.2. The pharmaceutically acceptable salt of claim 1 , wherein said salt is crystalline.3. The pharmaceutically acceptable salt of comprising less than 40% by weight of amorphous compound.4. The pharmaceutically acceptable salt of having an endothermic onset at about 130° C. in differential scanning calorimetry (DSC) profile.5. The pharmaceutically acceptable salt of having an endothermic onset at about 163° C. in differential scanning calorimetry (DSC) profile.6. The pharmaceutically acceptable salt of having an exothermic onset at about 179° C. in differential scanning calorimetry (DSC) profile.7. The pharmaceutically acceptable salt of having an endothermic onset at about 232° C. in differential scanning calorimetry (DSC) profile.8. The pharmaceutically acceptable salt of having at least one peak at diffraction angle 2θ (°) of 26.7±0.5 as measured by X-ray powder diffractometry.9. The pharmaceutically acceptable salt of having at least one peak at diffraction angle 2θ (°) of 20.0±0.5 as measured by X-ray powder diffractometry.10. The pharmaceutically acceptable salt of having at least one diffraction angle 2θ (°) of 20.6±0.5 as measured by X-ray powder diffractometry.11. The pharmaceutically acceptable salt of having at least one diffraction angle ...

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09-03-2017 дата публикации

LXR AGONISTS AND USES THEREOF

Номер: US20170066791A1
Принадлежит:

This invention features compounds that modulate the activity of liver X receptors, pharmaceutical compositions including the compounds of the invention, and methods of utilizing those compositions for modulating the activity of liver X receptors in the treatment of cancer. 2. The compound of claim 1 , wherein c is 0.3. The compound of claim 1 , wherein b is 1.4. The compound of claim 1 , wherein b is 0.5. The compound of claim 1 , wherein each Rand Ris hydrogen.6. The compound of claim 1 , wherein Ris hydrogen.7. The compound of claim 1 , wherein Ris fluorine.8. The compound of claim 1 , wherein Ris optionally substituted C-Calkyl.9. The compound of claim 8 , wherein said optionally substituted C-Calkyl is methyl10. The compound of claim 1 , wherein Ris phenyl or 4-fluorophenyl.11. The compound of claim 1 , wherein Ris hydrogen claim 1 , halogen claim 1 , optionally substituted C-Caryl claim 1 , optionally substituted C-Ccycloalkyl claim 1 , or optionally substituted C-Calkyl.12. The compound of claim 11 , wherein Ris hydrogen claim 11 , fluorine claim 11 , phenyl claim 11 , cyclohexyl claim 11 , or methyl.13. The compound of claim 12 , wherein Ris hydrogen claim 12 , phenyl claim 12 , or methyl.14. The compound of claim 1 , wherein d is 1.15. The compound of claim 1 , wherein each Rand Ris hydrogen.19. The compound of claim 1 , wherein B is optionally substituted C-Caryl.20. The compound of claim 19 , wherein said optionally substituted C-Caryl is 2-chloro-3-trifluoromethyl-phenyl claim 19 , 2-fluoro-3-trifluoromethyl-phenyl claim 19 , 3-(1 claim 19 ,1 claim 19 ,2 claim 19 ,2-tetrafluoroethoxy)-phenyl claim 19 , 3-trifluoromethyl-phenyl claim 19 , 3-trifluoromethyl-4-fluoro-phenyl claim 19 , 3-trifluoromethoxy-phenyl claim 19 , or 2 claim 19 ,2-difluoro-1 claim 19 ,3-benzodioxole.21. The compound of claim 20 , wherein B is 2-chloro-3-trifluoromethyl-phenyl claim 20 , 2-fluoro-3-trifluoromethyl-phenyl claim 20 , or 3-trifluoromethyl-phenyl.22. The compound of claim ...

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12-06-2014 дата публикации

PERSONAL CARE IMPLEMENT HAVING A DISPLAY

Номер: US20140157538A1
Принадлежит: Colgate-Palmolive Company

A personal care implement or toothbrush includes a sensor for detecting a position of the toothbrush and orientation display for providing content to a user. The display may be configured to present content in a mirror-image format. The personal care implement may be configured to operate in one or more modes of operation. One or more components may be included for setting variables associated with the modes of operation, for changing an orientation of the displayed content between a mirror-image format and forward-facing format, and for changing the particular mode of operation. 1. A personal care implement defining a longitudinal axis and comprising:a head;a handle coupled to the head by a neck portion;a display configured to present visual content for viewing by a user;a sensor arranged on the personal care implement and configured to detect a relative change in orientation of the personal care implement about an axis normal to the longitudinal axis; anda control system operatively connected to the sensor and the display, wherein the control system is configured to receive and process signals from the sensor indicative of the relative change in orientation of the personal care implement, and wherein the control system is configured to change the visual content on the display depending on the detected orientation of the personal care implement.2. The personal care implement of claim 1 , wherein the sensor is selected from the group consisting of an accelerometer claim 1 , a gyroscopic sensor claim 1 , a MEMS accelerometer device claim 1 , and a combination thereof.3. The personal care implement of claim 1 , wherein the personal care implement comprises a toothbrush and the head includes tooth cleaning elements extending therefrom in a first direction.4. The personal care implement of claim 3 , wherein the display is oriented in a second direction opposed to the first direction.5. The personal care implement of claim 3 , wherein the display is included within the ...

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23-03-2017 дата публикации

Optic Green Light Illumination System

Номер: US20170082852A1
Принадлежит:

A frame housing green LEDs can be positioned adjacent to a lens in order to illuminate the lens at a glancing angle. The green light allows better visualization of particulates on a surface of the lens. The particulates can then be removed with a polymer solution applied to the lens. The polymer traps the particulates, and can be removed from the lens to remove the particulates. 1. A structure comprising:a frame surrounding an inner space; anda plurality of green LEDs attached to the frame, the green LEDs oriented towards the inner space and configured to illuminate the inner space with green light.2. The structure of claim 1 , wherein the frame is configured to surround a surface of the lens in the inner space.3. The structure of claim 2 , wherein the plurality of LEDs is configured to illuminate the surface of the lens at a glancing angle.4. The structure of claim 3 , wherein the plurality of LEDs entirely encircles surface of the lens.5. The structure of claim 4 , wherein the frame comprises a sliding mechanism to regulate a distance between the frame and the lens.6. The structure of claim 5 , further comprising a gas nozzle oriented towards the surface of the lens and configured to direct gas towards the surface of the lens.7. The structure of claim 6 , wherein the lens is under vacuum.8. A method comprising:positioning a frame with a plurality of green LEDs adjacent to a surface of a lens; andilluminating the lens with the plurality of green LEDs at a glancing angle between the surface of the lens and green light emitted from the plurality of green LEDs, thereby illuminating particulates on the surface of the lens.9. The method of claim 8 , further comprising removing the particulates from the surface of the lens.10. The method of claim 9 , wherein removing the particulates comprises:applying a polymer solution to the surface of the lens;trapping the particulates with the polymer solution;drying the polymer solution; andremoving the polymer solution with the ...

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16-04-2015 дата публикации

Preparation of Transition Metal Carboxylates

Номер: US20150105574A1
Принадлежит:

This disclosure provides a process for making transition metal carboxylate compositions by combining in an polar aprotic first solvent a transition metal precursor and a Group 1 or Group 2 metal carboxylate under substantially acid-free and substantially anhydrous conditions, to generate a mixture comprising the transition metal carboxylate composition. Optionally, the transition metal carboxylate composition can be purified, for example, by substantially removing the first solvent provide a residue comprising the transition metal carboxylate composition, and also optionally, further by extracting the transition metal carboxylate composition from the residue with a non-coordinating second solvent to provide an extract comprising the transition metal carboxylate composition. 1. A transition metal carboxylate composition produced by the process comprising: [{'sup': B', 'm', 'c', 'a, 'sub': y1', 'x1', 'l', 'q', 'm1', 'm2, 'claim-text': [{'sup': 'B', 'Mis a transition metal in the +x oxidation state where x is an integer from +1 to +6;'}, 'each X independently is an anionic ligand having charge y where y is an integer from −3 to −1;', 'each L independently is a neutral ligand;', 'l is an integer from 0 to 7;', 'm is an integer from −4 to 4;', 'm=(y*x1)+(x*y1);', 'C is a cationic species having a charge c and c is an integer from +1 to +3;', 'A is an anionic species having a charge a and a is an integer from −1 to −3;', 'when m<0, |m*q|=c*m1 and m2=0;', 'when m=0, m1=0 and m=0; and', 'when m>0, m*q=|a*m2| and m1=0,, '1) a transition metal precursor having the formula [((M)XL)][C][A]where'}, {'sub': 3', '25, '2) a Group 1 or Group 2 metal C-Ccarboxylate, and'}, '3) a first solvent, 'contacting under substantially anhydrous and substantially acid-free conditions'}to form a transition metal carboxylate.2. The composition of claim 1 , wherein the transition metal precursor has the formula MXLwhere Mis a transition metal in the x oxidation state and x is an integer from 1 to ...

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12-04-2018 дата публикации

VARIABLE REFRIGERANT PACKAGE

Номер: US20180100674A1
Принадлежит: Friedrich Air Conditioning, LLC

A variable refrigerant package air conditioner is shown that is easy to install in new construction with a unique base that causes collected mixture that overflows to drain outside the building. A control system is shown that has motors and compressor that are pulse width modulated so the air conditioner is infinitely variable while maintaining the highest possible power factor. Dehumidification of outside air occurs as it is mixed with inside air. By gradually approaching a temperature set point and even reheating after dehumidification, moisture is removed from the room. 1: A method of installing a variable refrigerant package through a door in a closet located adjacent an outside wall in new construction of rooms for hotels/motels having a building drain , a power source and heating/cooling ducts , said method including the following steps:first installing a plenum through said outside wall to an inside of said closet;second installing a duct adapter on an end of said heating/cooling duct near a top of said closet;securing a base in a bottom of said closet, said base having a drain basin in a top thereof connected to said building drain, said drain basin overlapping said plenum to provide secondary drainage through said plenum if said building drain becomes clogged;locating a wall controller inside said room with a connection to a thermostat plug inside said closet;third installing said variable refrigerant package through said door of said closet so that (a) said variable refrigerant package presses against a plenum gasket, (b) said variable refrigerant package rests on a base gasket of said base with an evaporator drain terminating above said drain basin, (c) said duct adapter is connected to supply duct flanges, and (d) said variable refrigerant package is plugged into said power plug and said thermostat plug.2: The method of installing a variable refrigerant package as cited in wherein said third installing step has installation rails mounted under said ...

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19-04-2018 дата публикации

VARIABLE REFRIGERANT PACKAGE

Номер: US20180106506A1
Принадлежит: Friedrich Air Conditioning, LLC

A variable refrigerant package air conditioner is shown that is easy to install in new construction with a unique base that causes collected mixture that overflows to drain outside the building. A control system is shown that has motors and compressor that are pulse width modulated so the air conditioner is infinitely variable while maintaining the highest possible power factor. Dehumidification of outside air occurs as it is mixed with inside air. By gradually approaching a temperature set point and even reheating after dehumidification, moisture is removed from the room. 1: A method of installing a variable refrigerant package through a door in a closet located adjacent an outside wall in new construction of rooms for hotels/motels having a building drain , a power source and heating/cooling ducts , said method including the following steps:first installing a plenum through said outside wall to an inside of said closet;second installing a duct adapter on an end of said heating/cooling duct near a top of said closet;securing a base in a bottom of said closet, said base having a drain basin in a top thereof connected to said building drain, said drain basin overlapping said plenum to provide secondary drainage through said plenum if said building drain becomes clogged;locating a wall controller inside said room with a connection to a thermostat plug inside said closet;third installing said variable refrigerant package through said door of said closet so that (a) said variable refrigerant package presses against a plenum gasket, (b) said variable refrigerant package rests on a base gasket of said base with an evaporator drain terminating above said drain basin, (c) said duct adapter is connected to supply duct flanges, and (d) said variable refrigerant package is plugged into said power plug and said thermostat plug.2: The method of installing a variable refrigerant package as cited in wherein said third installing step has installation rails mounted under said ...

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19-04-2018 дата публикации

VARIABLE REFRIGERANT PACKAGE

Номер: US20180106507A1
Принадлежит: Friedrich Air Conditioning, LLC

A variable refrigerant package air conditioner is shown that is easy to install in new construction with a unique base that causes collected mixture that overflows to drain outside the building. A control system is shown that has motors and compressor that are pulse width modulated so the air conditioner is infinitely variable while maintaining the highest possible power factor. Dehumidification of outside air occurs as it is mixed with inside air. By gradually approaching a temperature set point and even reheating after dehumidification, moisture is removed from the room. 1. A method of installing a variable refrigerant package through a door in a closet located adjacent an outside wall in new construction of rooms for hotels/motels having a building drain , a power source and heating/cooling ducts , said method including the following steps:first installing a plenum through said outside wall to an inside of said closet;second installing a duct adapter on an end of said heating/cooling duct near a top of said closet;securing a base in a bottom of said closet, said base having a drain basin in a top thereof connected to said building drain, said drain basin overlapping said plenum to provide secondary drainage through said plenum if said building drain becomes clogged;locating a wall controller inside said room with a connection to a thermostat plug inside said closet;third installing said variable refrigerant package through said door of said closet so that (a) said variable refrigerant package presses against a plenum gasket, (b) said variable refrigerant package rests on a base gasket of said base with an evaporator drain terminating above said drain basin, (c) said duct adapter is connected to supply duct flanges, and (d) said variable refrigerant package is plugged into said power plug and said thermostat plug.2. The method of installing a variable refrigerant package as cited in wherein said third installing step has installation rails mounted under said ...

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17-07-2014 дата публикации

Protective devices and methods for precision application of cleaning polymer to optics

Номер: US20140196748A1

Novel devices and methods for cleaning optics are disclosed. A polymer can be sprayed onto the surface of an optic to capture contaminants. A spray cone can be used to limit the area of the polymer application. As the polymer solidifies, contaminants are captured and subsequently removed together with the polymer.

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25-08-2022 дата публикации

COMBINATION OF A CHROMENE COMPOUND AND A SECOND ACTIVE AGENT

Номер: US20220265602A1
Принадлежит:

The present disclosure provide a combination of a chromene compound having the structure of Formula (I), or pharmaceutically acceptable salts, and a second compound that can be selected from a PD-1 inhibitor, PD-L1 inhibitor, CTLA-4 inhibitor, OX-40 agonist, CD137 agonist, LAG-3 inhibitor, IDO inhibitor, bi-specific protein, EGFR inhibitor, HER2 inhibitor, and immune stimulating therapy and a method of using the combination for treating or preventing cancer. 124.-. (canceled)25. A method for treating cancer , comprising: (S)-6-bromo-8-trideuteromethyl-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid, or a pharmaceutically acceptable salt or solvate thereof and', 'a checkpoint modulator selected from the group consisting of PD-1 inhibitors, PD-L1 inhibitors, and CTLA-4 inhibitors., 'administering to a subject in need thereof a therapeutically effective amount of26. The method of claim 25 , wherein the (S)-6-bromo-8-trideuteromethyl-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid claim 25 , or a pharmaceutically acceptable salt or solvate thereof and the compound causes an at least 70% reduction in PGE-M in the urine.27. The method of claim 25 , further comprising determining expression of PD-L1 in the cancer in said subject.28. The method of claim 25 , further comprising determining the level of urinary PGE-M levels in the subject.29. The method of claim 28 , wherein the subject has colorectal cancer claim 28 , non-small cell lung cancer claim 28 , breast cancer claim 28 , gastric cancer claim 28 , pancreatic cancer claim 28 , prostate cancer claim 28 , or head and neck squamous cell carcinoma.30. The method of claim 25 , wherein the cancer is selected from the group consisting of melanoma claim 25 , non-small cell lung cancer claim 25 , colorectal cancer claim 25 , head and neck cancer claim 25 , renal cell carcinoma claim 25 , urothelial carcinoma claim 25 , Merkel cell carcinoma claim 25 , pancreatic cancer claim 25 , breast cancer claim 25 , gastric cancer ...

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10-05-2018 дата публикации

Olefin Oligomerizations Using Chemically-Treated Solid Oxides

Номер: US20180127331A1
Принадлежит:

The present invention discloses processes for oligomerizing a monomer containing Cto Colefins using a chemically-treated solid oxide, such as fluorided silica-coated alumina and fluorided-chlorided silica-coated alumina. 111-. (canceled)12. A process comprising:{'sub': 12', '16, '(i) introducing a monomer comprising a Cto Colefin and a chemically-treated solid oxide into a reaction zone, the chemically-treated solid oxide comprising sulfated alumina; and'}(ii) oligomerizing the monomer to form an oligomer product in the reaction zone.13. The process of claim 13 , wherein the oligomer product comprises from 30 to 98 wt. % dimers and/or a weight ratio of dimers to trimers in the oligomer product is from 2:1 to 6:1.14. The process of claim 13 , wherein the oligomer product comprises from 55 to 95 wt. % dimers and/or a weight ratio of dimers to trimers in the oligomer product is from 1.5:1 to 8:1.15. (canceled)16. A polyalphaolefin comprising hydrogenated oligomers of a Cto Colefin claim 13 , wherein the polyalphaolefin has a viscosity index greater than or equal to 110 and a kinematic viscosity at −40° C. of less than or equal to 1750 cSt.17. The polyalphaolefin of claim 16 , wherein:the viscosity index is in a range from 110 to 125; andthe kinematic viscosity at −40° C. is in a range from 1300 to 1700 cSt.18. The polyalphaolefin of claim 16 , wherein the polyalphaolefin has a kinematic viscosity at 40° C. in a range from 9 to 15 cSt.19. The polyalphaolefin of claim 16 , wherein the polyalphaolefin has a kinematic viscosity at 100° C. in a range from 1.8 to 12 cSt.20. The polyalphaolefin of claim 16 , wherein the polyalphaolefin comprises hydrogenated dimers and trimers of 1-dodecene and has a weight ratio of C:Csaturated hydrocarbons in a range from 2:1 to 6:1.21. The polyalphaolefin of claim 16 , wherein:the viscosity index is in a range from 110 to 150; andthe kinematic viscosity at −40° C. is in a range from 1200 to 1750 cSt.22. The polyalphaolefin of claim 21 , ...

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02-05-2019 дата публикации

TREATMENT AND DIAGNOSIS OF CANCER

Номер: US20190125745A1
Принадлежит:

This invention features compounds that modulate the activity of liver X receptors, pharmaceutical compositions including the compounds of the invention, and methods of utilizing those compositions for modulating the activity of liver X receptors for the treatment of cancer. 1. A method of treating cancer comprising administering an effective amount of a compound of any one of Formula I-XXVI , any one of compounds 1-107 , or pharmaceutically acceptable salts thereof to a subject in need thereof.2. A method of treating cancer comprising contacting a cell with an effective amount of a compound of any one of Formula I-XXVI , any one of compounds 1-107 , or pharmaceutically acceptable salts thereof.3. A method of slowing the spread of a migrating cancer comprising administering an effective amount of a compound of any one of Formula I-XXVI , any one of compounds 1-107 , or pharmaceutically acceptable salts thereof to a subject in need thereof.46-. (canceled)7. The method of claim 1 , wherein said effective amount is an amount sufficient to increase the expression level or activity level of ApoE to a level sufficient to slow the spread of metastasis of said cancer.8. The method of claim 1 , wherein said cancer is drug resistant or has failed to respond to a prior therapy.9. The method of claim 1 , wherein said cancer is metastatic.10. The method of claim 1 , wherein said cancer is breast cancer claim 1 , colon cancer claim 1 , renal cell cancer claim 1 , non-small cell lung cancer claim 1 , hepatocellular carcinoma claim 1 , gastric cancer claim 1 , ovarian cancer claim 1 , pancreatic cancer claim 1 , esophageal cancer claim 1 , prostate cancer claim 1 , sarcoma claim 1 , glioblastoma claim 1 , diffuse large B-cell lymphoma claim 1 , acute myeloid leukemia claim 1 , or melanoma.11. The method of claim 1 , wherein said method further comprises administration of an additional anticancer therapy.12. The method of claim 11 , wherein said additional anticancer therapy is any ...

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28-05-2015 дата публикации

2,5-DIALKYL-4-H/HALO/ETHER-PHENOL COMPOUNDS

Номер: US20150148430A1
Принадлежит:

The present disclosure provides phenolic compounds useful in the treatment of neurological conditions such as convulsions and tremors, having the structure of Formula (I): 2. The method of claim 1 , wherein each of Rand Rhas between one and five carbons.3. The method of claim 1 , wherein the condition is epilepsy claim 1 , seizures claim 1 , or convulsions.4. The method of claim 1 , wherein the condition is neuropathic pain or fibromyalgia.5. The method of claim 1 , wherein the condition is a psychological disorder.6. The method of claim 1 , wherein the condition is Alzheimer's Disease claim 1 , Huntington's Disease claim 1 , multiple sclerosis claim 1 , Parkinson's Disease claim 1 , Tourette's Syndrome claim 1 , tinnitus claim 1 , and tremors7. The method of claim 1 , wherein:{'sup': '2', 'Ris selected from the group consisting of alkyl, haloalkyl, and cycloalkyl;'}{'sup': '4', 'Ris halo.'}8. The method of claim 7 , wherein Ris selected from the group consisting of Br claim 7 , Cl claim 7 , and F.9. The method of claim 7 , wherein the compound is selected from a group consisting of: 4-chloro-5-tert-butyl-2-methyl-phenol; 4-chloro-2-isopropyl-5-methyl-phenol; 4-fluoro-2-iso propyl-5-methyl-phenol; 4-chloro-2 claim 7 ,5-diisopropyl-phenol; 4-bromo-5-isopropyl-2-methylphenol; 4-bromo-2-isopropyl-5-methyl-phenol; 4-bromo-2-tert-butyl-5-isopropyl-phenol; 4-bromo-5-tert-butyl-2-methyl-phenol; and 4-fluoro-5-tert-butyl-2-methyl-phenol.12. The method of claim 10 , wherein:{'sup': '2', 'Ris selected from the group consisting of alkyl, haloalkyl, and cycloalkyl;'}{'sup': '5', 'claim-text': {'sub': '7', 'Ris alkyl.'}, 'Ris selected from the group consisting of alkyl, haloalkyl, and cycloalkyl; and'}14. The method of claim 13 , wherein:{'sup': '2', 'Ris selected from the group consisting of alkyl and cycloalkyl; and'}{'sup': '5', 'Ris selected from the group consisting of alkyl and cycloalkyl.'}16. A compound of claim 15 , wherein:{'sup': '2', 'Ris selected from the group ...

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14-08-2014 дата публикации

DIAGNOSIS AND TREATMENT OF PROSTATE CANCER

Номер: US20140227172A1

The methods of the present disclosure are directed toward methods of diagnosis and treatment of cancer in a subject. The present disclosure provides methods of diagnosing abnormal cells in a subject by measuring the level of Hexim-1 in a sample from the subject, where elevated levels of Hexim-1 indicate abnormal cells. This disclosure further provides methods of treating cancer or hyperplasia, comprising administering to a subject in need thereof a therapeutically effective amount of Hexim-1 or an activator of Hexim-1 expression or activity. 1. A method of detecting abnormal cells in a sample , which comprises measuring the level of Hexim-1 in a cell sample obtained from a subject , wherein abnormal cells are present when elevated levels of Hexim-1 are identified in said sample.2. The method of claim 1 , wherein abnormal cells are detected by a 10% or greater elevation of Hexim-1 levels.3. The method of claim 1 , wherein the sample is a blood claim 1 , urine claim 1 , or tissue sample.4. The method of claim 1 , wherein the cells are prostate claim 1 , breast claim 1 , colon claim 1 , pancreatic claim 1 , lung claim 1 , gastric claim 1 , or bladder cells.5. The method of claim 1 , wherein the levels of Hexim-1 are measured by electrochemical immunosensor assay (EIA) claim 1 , enzyme-linked immunosorbent assay (ELISA) claim 1 , or polymerase chain reaction (PCR).6. A method of detecting cancer or hyperplasia in a subject claim 1 , which comprises measuring Hexim-1 levels in the nucleus and cytoplasm of a cell sample obtained from the subject claim 1 , wherein hyperplasia is identified in said subject by elevated levels of Hexim-1 in the nucleus but not the cytoplasm claim 1 , and cancer is identified in said subject by elevated levels of Hexim-1 in at least the cytoplasm.7. The method of claim 6 , wherein the cells are prostate claim 6 , breast claim 6 , colon claim 6 , pancreatic claim 6 , lung claim 6 , gastric claim 6 , or bladder cells.8. The method of claim 6 , ...

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04-06-2015 дата публикации

Hexim-1 as a target of leptin signaling to regulate obesity and diabetes

Номер: US20150152421A1
Принадлежит: MEDHEXIM LLC

Provided are Hexim-1 inhibitor compositions, and methods and kits using said compositions for the treating and regulating obesity and/or diabetes, comprising administering an effective amount of a Hexim-1 inhibitor. Additionally provided are methods for screening for inhibitors of Hexim-1.

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10-06-2021 дата публикации

DATA PROCESSING SYSTEMS AND METHODS FOR REPURPOSING DRUGS

Номер: US20210174912A1
Принадлежит:

Data processing systems for repurposing a drug can include a computer-readable memory including computer-executable instructions; and at least one processor configured to execute executable logic including the computer-executable instructions and at least one machine learning model to perform one or more operations. The one or more operations can include receiving data representing medical records of a plurality of patients; selecting a set of patients; determining a plurality of patient characteristics of the set of patients; grouping, in accordance with the plurality of patient characteristics, the set of patients to generate a plurality of distinct groups, each of the distinct groups including at least one patient of the set of patients; selecting, based on one or more group selection criteria, a set of distinct groups of the plurality of distinct groups; and identifying one or more relevant patient characteristics by analyzing each distinct group of the set of distinct groups. 1. A computer-implemented method for repurposing a drug , comprising:receiving, by a computer system, data representing medical records of a plurality of patients; determining at least one target signaling pathway associated with the drug; and', 'determining one or more indicators based on one or more factors corresponding to a diagnosis linked to the target signaling pathway;, 'selecting, based on the medical records, a set of patients bydetermining a plurality of patient characteristics of the set of patients, each patient of the set of patients exhibiting at least one of the plurality of patient characteristics;grouping, by the computer system, in accordance with the plurality of patient characteristics, the set of patients to generate a plurality of distinct groups, each of the distinct groups including at least one patient of the set of patients;selecting, based on one or more group selection criteria, a set of distinct groups of the plurality of distinct groups; andidentifying one or ...

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07-05-2020 дата публикации

PHARMACEUTICALLY ACCEPTABLE SALTS OF BETA-GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF

Номер: US20200138759A1
Принадлежит:

The present invention relates to new pharmaceutical salts of β-GPA which exhibit improved physical properties. In particular, the invention relates to salts of β-GPA with improved flow properties (e.g., improved Carr's index and/or Hausner ratio) such as fumarate salts, succinate salts, and oxalate salts. The invention also relates to pharmaceutical compositions including a pharmaceutically effective amount of one or more salts of β-GPA, as well as methods of treating cancer including administration of a formulation including a β-GPA salt of the invention to a subject in need thereof. 1. A method of treating cancer in a subject in need thereof , the method comprising administering an effective amount of a pharmaceutically acceptable salt of β-guanidinopropionic acid to the subject , wherein the pharmaceutically acceptable salt of β-guanidinopropionic acid is a 2:1 succinate salt , wherein the cancer is gastrointestinal , esophageal , colorectal , liver , pancreatic , or gastric cancer , or the cancer expresses CKB.2. The method of claim 1 , wherein the cancer is gastrointestinal cancer.3. The method of claim 2 , wherein the gastrointestinal cancer expresses CKB.4. The method of claim 1 , wherein the cancer is esophageal cancer.5. The method of claim 1 , wherein the cancer is colorectal cancer.6. The method of claim 1 , wherein the cancer is liver cancer.7. The method of claim 1 , wherein the cancer is pancreatic cancer.8. The method of claim 1 , wherein the cancer is gastric cancer.9. The method of claim 1 , wherein the cancer expresses CKB.10. The method of claim 1 , wherein the cancer is metastatic cancer.11. The method of claim 10 , wherein the effective amount comprises an amount effective to suppress metastatic colonization of the cancer.12. The method of claim 1 , wherein the 2:1 succinate salt is administered prior to one or more therapeutically effective treatments or medical procedures.13. The method of claim 1 , wherein the 2:1 succinate salt is ...

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17-06-2021 дата публикации

METAL SALTS AND USES THEREOF

Номер: US20210179539A1
Принадлежит:

The present invention relates to metal salts of 2-[3-[(3R)-3-[[2-chloro-3-(trifluoromethyl)phenyl]methyl-(2,2-diphenylethyl)amino]butoxy]phenyl]acetic acid which exhibit improved physical properties and stability. The invention also relates to pharmaceutical compositions including an effective amount of the metal salts, as well as methods of treating cancer including administration of a pharmaceutical composition including a salt of the invention to a subject in need thereof. 1. A zinc salt of 2-[3-[(3R)-3-[[2-chloro-3-(trifluoromethyl)phenyl]methyl-(2 ,2-diphenylethyl)amino]butoxy]phenyl]acetic acid (Compound 1).2. The zinc salt of claim 1 , wherein the zinc salt is a 2:1 (Compound 1:zinc) salt.3. The zinc salt of claim 1 , wherein the zinc salt is amorphous.4. The zinc salt having less than 1% mass loss up to decomposition as measured by thermal gravimetric analysis.5. A pharmaceutical composition comprising the zinc salt of and a pharmaceutically acceptable excipient.6. The pharmaceutical composition of claim 5 , wherein the pharmaceutical composition comprises less than 1.5 weight % of sodium.7. The pharmaceutical composition of claim 6 , wherein the pharmaceutical composition is substantially free of the 1:1 sodium salt of Compound 1.8. The pharmaceutical composition of claim 6 , wherein the pharmaceutical composition is in unit dosage form.9. A method of treating cancer claim 5 , the method comprising administering an effective amount of the pharmaceutical composition of .10. The method of claim 9 , wherein the cancer is breast cancer claim 9 , colon cancer claim 9 , renal cell cancer claim 9 , lung cancer claim 9 , hepatocellular carcinoma claim 9 , gastric cancer claim 9 , ovarian cancer claim 9 , pancreatic cancer claim 9 , esophageal cancer claim 9 , prostate cancer claim 9 , sarcoma claim 9 , bladder cancer claim 9 , head and neck cancer claim 9 , glioblastoma claim 9 , diffuse large B-cell lymphoma claim 9 , leukemia claim 9 , or melanoma.11. The method ...

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14-06-2018 дата публикации

Unauthorized Usage Detection Using Transaction Management and Analytics Platforms

Номер: US20180165681A1
Принадлежит: Bank of America Corporation

Aspects of the disclosure relate to detection of unauthorized usage in debit card transactions using a transaction management computing platform and an analytics computing platform. A computing platform may monitor a plurality of transactions at an automated teller machine. Subsequently, the computing platform may identify at least one unusual activity in the plurality of transactions at the automated teller machine. In response to identifying the at least one unusual activity in the plurality of transactions, the computing may analyze each account corresponding to the plurality of transactions to identify a common point of purchase for a subset of accounts. Thereafter, the computing platform may flag the subset of accounts for unauthorized usage. 1. A computing platform , comprising:at least one processor;a communication interface communicatively coupled to the at least one processor; and monitor a plurality of transactions at an automated teller machine;', 'identify, by the at least one processor, at least one unusual activity in the plurality transactions at the automated teller machine;', 'in response to identifying the at least one unusual activity in the plurality of transactions at the automated teller machine, analyze, by the at least one processor, each account corresponding to the plurality of transactions to identify a common point of purchase for a subset of accounts; and', 'in response to identifying the common point of purchase, flag the subset of accounts., 'memory storing computer-readable instructions that, when executed by the at least one processor, cause the computing platform to2. The computing platform of claim 1 , wherein the memory stores additional computer-readable instructions that claim 1 , when executed by the at least one processor claim 1 , cause the computing platform to:transmit, via the communication interface, a notification to each user device associated with users of the subset of accounts.3. The computing platform of claim 1 , ...

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22-06-2017 дата публикации

Olefin Oligomerizations Using Chemically-Treated Solid Oxides

Номер: US20170174584A1
Принадлежит:

Oligomerization processes include the steps of introducing a monomer containing a Cto Colefin and a chemically-treated solid oxide into a reaction zone, and oligomerizing the monomer to form an oligomer product in the reaction zone. Fluorided silica-coated alumina and fluorided-chlorided silica-coated alumina are illustrative chemically-treated solid oxides that can be used in the oligomerization processes. 1. A process comprising:{'sub': 3', '30, '(i) introducing a monomer comprising a Cto Colefin and a chemically-treated solid oxide into a reaction zone, the chemically-treated solid oxide comprising a silica-coated alumina treated with an electron-withdrawing anion; and'}(ii) oligomerizing the monomer to form an oligomer product in the reaction zone;wherein the oligomerizing step is conducted in the substantial absence of organoaluminum compounds and the absence of metallocene compounds; andwherein the oligomer product comprises at least 30 wt. % dimers.2. The process of claim 1 , wherein the chemically-treated solid oxide comprises fluorided silica-coated alumina.3. The process of claim 2 , wherein a conversion of the monomer to the oligomer product is greater than that of a comparable process using sulfated alumina claim 2 , under the same oligomerization conditions.4. The process of claim 1 , wherein the chemically-treated solid oxide comprises fluorided-chlorided silica-coated alumina.5. The process of claim 4 , wherein a conversion of the monomer to the oligomer product is greater than that of a comparable process using sulfated alumina claim 4 , under the same oligomerization conditions.6. The process of claim 1 , wherein:the silica-coated alumina comprises from 20 to 45 wt. % silica, based on the weight of the silica-coated alumina; andthe electron-withdrawing anion comprises sulfate, fluoride, chloride, or any combination thereof.7. The process of claim 1 , wherein the monomer comprises at least 75 wt. % Cto Calpha olefins.8. The process of claim 1 , ...

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22-06-2017 дата публикации

2,5-DIALKYL-4-H/HALO/ETHER-PHENOL COMPOUNDS

Номер: US20170174600A1
Принадлежит:

The present disclosure provides phenolic compounds useful in the treatment of neurological conditions such as convulsions and tremors, having the structure of Formula (I): 110-. (canceled)12. The method of claim 11 , wherein Ris alkyl.14. The method of claim 13 , wherein:{'sup': '2', 'Ris selected from the group consisting of alkyl and cycloalkyl; and'}{'sup': '5', 'Ris selected from the group consisting of alkyl and cycloalkyl.'}16. A compound of claim 15 , wherein:{'sup': '2', 'Ris selected from the group consisting of trifluoroalkyl and cycloalkyl.'}17. The compound of claim 15 , wherein the compound is selected from the group consisting of: 5-(1 claim 15 ,2-dimethyl-propyl)-2-methyl-phenol; 5-isobutyl-2-methyl-phenol; 5-cyclopentyl-2-methyl-phenol; 5-sec-butyl-2-ethyl-phenol; 5-butyl-2-propyl-phenol; 5-isopropyl-2-propyl-phenol; 5-sec-butyl-2-propyl-phenol; 5-tert-butyl-2-propyl-phenol; 2-butyl-5-isopropyl-phenol; 2-butyl-5-sec-butyl-phenol; 5-(tert-butyl)-2-butylphenol; 2-isopropyl-5-propyl-phenol claim 15 , 5-sec-butyl-2-isopropyl-phenol; 2-sec-butyl-5-ethyl-phenol; 2-sec-butyl-5-propyl-phenol; 5-butyl-1-sec-butyl-phenol; 2-sec-butyl-5-isopropyl-phenol; 5-sec-butyl-2-tert-butyl-phenol; 5-isopropyl-2-(1-methyl-butyl)-phenol; 2-isopropyl-5-isopropyl-phenol; 2-cyclopropyl-5-isopropyl-phenol claim 15 , and 2 claim 15 ,5-dicyclopropyl-phenol.19. The compound of claim 18 , wherein Ris selected from the group consisting of Br claim 18 , Cl claim 18 , and F.20. (canceled)21. The method of claim 11 , wherein the neurological condition is convulsions.22. The method of claim 11 , wherein the neurological condition is epilepsy. The present application claims the benefit of and priority to U.S. provisional application Nos. 61/907,899, 61/907,921, 61/907,928, and 61/907,932, all filed 22 Nov. 2013. Each of the aforementioned applications are hereby incorporated by reference in their entirety.This invention was made with government support under Grant Number 1R43NS076358-01 ...

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22-06-2017 дата публикации

Variable Refrigerant Package

Номер: US20170176027A1
Принадлежит: Friedrich Air Conditioning Co., Ltd.

A variable refrigerant package air conditioner is shown that is easy to install in new construction with a unique base that causes collected mixture that overflows to drain outside the building. A control system is shown that has motors and compressor that are pulse width modulated so the air conditioner is infinitely variable while maintaining the highest possible power factor. Dehumidification of outside air occurs as it is mixed with inside air. By gradually approaching a temperature set point and even reheating after dehumidification, moisture is removed from the room. A snorkel that delivers fresh air to be mixed with inside entering air in front of the evaporator for a maximum dehumidification is also shown. 1. A packaged terminal air conditioner (PTAC) for heating/cooling a room , said PTAC extending through an outside wall of said room , said PTAC having a heating cycle and a cooling cycle , during said cooling cycle said PTAC having:a condenser;a condenser fan for drawing outside air into an outside air chamber and discharging most of said outside air through said condenser;an evaporator;a blower for drawing indoor air through a return air filter;a compressor located in refrigerant lines connecting said condenser to said evaporator to compress refrigerant flowing there through;a reversing valve assembly in said refrigerant lines for reversing direction of flow of said refrigerant;a dividing wall separating outside air from said indoor air; a mixing chamber located behind said return air filter and in front of said evaporator;', 'a fresh air fan drawing a portion of said outside air from said outside air chamber through an opening in said dividing wall;', 'a snorkel connecting said opening to said mixing chamber;', 'a fresh air filter located in said snorkel for filtering said portion of said outside air;, 'the improvement comprisingsaid fresh air fan forcing said portion of said outside air through said snorkel and said fresh air filter into said mixing ...

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22-06-2017 дата публикации

Variable Refrigerant Package

Номер: US20170176056A1
Принадлежит: Friedrich Air Conditioning Co., Ltd.

A variable refrigerant package air conditioner is shown that is easy to install in new construction with a unique base that causes collected mixture that overflows to drain outside the building. A control system is shown that has motors and compressor that are pulse width modulated so the air conditioner is infinitely variable while maintaining the highest possible power factor. Dehumidification of outside air occurs as it is mixed with inside air. By gradually approaching a temperature set point and even reheating after dehumidification, moisture is removed from the room. 1. A method of installing a variable refrigerant package through a door in a closet located adjacent an outside wall in new construction of rooms for hotels/motels having a building drain , a power source and heating/cooling ducts , said method including the following steps:first installing a plenum through said outside wall to an inside of said closet;second installing a duct adapter on an end of said heating/cooling duct near a top of said closet;securing a base in a bottom of said closet, said base having a drain basin in a top thereof connected to said building drain, said drain basin overlapping said plenum to provide secondary drainage through said plenum if said building drain becomes clogged;locating a wall controller inside said room with a connection to a thermostat plug inside said closet;third installing said variable refrigerant package through said door of said closet so that (a) said variable refrigerant package presses against a plenum gasket, (b) said variable refrigerant package rests on a base gasket of said base with an evaporator drain terminating above said drain basin, (c) said duct adapter is connected to supply duct flanges, and (d) said variable refrigerant package is plugged into said power plug and said thermostat plug.2. The method of installing a variable refrigerant package as cited in wherein said third installing step has installation rails mounted under said ...

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16-07-2015 дата публикации

NO-RELEASING NITROOXY-METHYLENE-LINKED-COXIB CONJUGATES

Номер: US20150197494A1
Принадлежит:

The present invention provides NO-releasing nitrooxy-alkylene-linked-celecoxib conjugates, having the structure of Formula (I): 3. Compound of claim 2 , wherein:{'sup': '2', 'Ris selected from the group consisting of H and alkyl;'}{'sub': 1-6', '2, 'sup': '3', '-L- is Calkylene, wherein one —CH— radical may be optionally replaced with —CH(R)—; and'}{'sup': '3', 'Ris selected from the group consisting of H, alkyl, and aryl.'}4. Compound of claim 3 , wherein:{'sup': '1', 'Ris acetyl;'}{'sup': '2', 'Ris H or methyl;'}{'sub': 14', '2, 'sup': '3', '-L- is Calkylene, wherein one —CH— radical may be optionally replaced with —CH(R)—; and'}{'sup': '3', 'Ris selected from the group consisting of H, methyl, or phenyl.'}5. Compound of claim 4 , selected from the group consisting of:(N-((4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)sulfonyl)acetamido)methyl 2-(nitrooxy)acetate;1-(N-((4- (5- (p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)sulfonyl)acetamido)ethyl 2-(nitrooxy)acetate;(N-((4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)sulfonyl)acetamido)methyl 2-(nitrooxy)propanoate;(N-((4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)sulfonyl)acetamido)methyl 3-(nitrooxy)propanoate(N-((4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)sulfonyl)acetamido)methyl 4-(nitrooxy)butanoate;(N-((4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)sulfonyl)acetamido)methyl 5-(nitrooxy)pentanoate; and(N-((4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)sulfonyl)acetamido)methyl 2-(nitrooxy)-2-phenylacetate.7. Compound of claim 6 , wherein:{'sup': '2', 'Ris selected from the group consisting of H and alkyl;'}{'sub': 2-6', '2, 'sup': '3', '-L- is Calkylene, wherein one —CH— radical may be optionally replaced with —CH(R)—; and'}{'sup': '3', 'sub': '1-3', 'Ris selected from the group consisting of H, alkyl, aryl, and nitrooxy Calkylene.'}8. Compound of claim 7 , wherein:{'sup': '1', 'Ris acetyl;'}{'sup': '2', 'Ris H or methyl;'}{' ...

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16-07-2015 дата публикации

NO-RELEASING GUANIDINE-CHROMENE CONJUGATES

Номер: US20150197500A1
Принадлежит:

The present disclosure provides NO-releasing guanidine-chromene conjugates, having the structure of Formula (I): 2. Compound of claim 1 , wherein:{'sup': '1', 'Ris selected from the group consisting of H, alkyl, and halo;'}{'sup': '2', 'Ris selected from the group consisting of alkyl, halo, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, and pentafluorosulfanyl;'}{'sup': '3', 'Ris selected from the group consisting of H, alkyl, cycloalkyl, halo, haloalkyl, hydroxyalkyl, and trialkylsilyl; and'}{'sup': '4', 'Ris selected from the group consisting of H, alkyl, halo, alkynyl, and alkenyl.'}4. Compound of claim 3 , wherein:{'sup': '1', 'Ris H or methyl;'}{'sup': '2', 'Ris selected from the group consisting of Cl, Br, methyl, trifluoromethoxy, and pentafluorosulfanyl;'}{'sup': '3', 'Ris selected from the group consisting of H, methyl, and tert-butyl;'}{'sup': '4', 'Ris selected from the group consisting of H, Cl, methyl, and ethyl;'}{'sub': 1', '2', '3', '4, 'W is selected from the group consisting of Calkylene, Calkylene, Calkylene, and Calkylene;'}{'sup': '5', 'Ris H or methyl;'}{'sup': '6', 'sub': 3', '4, 'Ris Calkylene or Calkylene;'}{'sup': '7', 'Ris H or acetyl; and'}{'sup': '10', 'Ris H or OH.'}5. Compound of claim 4 , wherein W is Calkylene.6. Compound of claim 5 , selected from the group consisting of:(S)—(((S)-2-acetamido-5-guanidinopentanoyl)oxy)methyl 6-chloro-8-methyl-2-(trifluoromethyl)-2H-chromene-3-carboxylate;(S)—(((S)-2-acetamido-5-guanidinopentanoyl)oxy)methyl 6-bromo-8-methyl-2-(trifluoromethyl)-2H-chromene-3-carboxylate;(S)—(((S)-2-acetamido-5-guanidinopentanoyl)oxy)methyl 8-ethyl-6-(trifluoromethoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylate; and(S)—(((S)-2-acetamido-5-guanidinopentanoyl)oxy)methyl 7-(tert-butyl)-6-chloro-2-(trifluoromethyl)-2H-chromene-3-carboxylate.7. Compound of claim 4 , wherein W is Calkylene.8. Compound of claim 7 , selected from the group consisting of:(S)-2-(((S)-2-acetamido-5-guanidinopentanoyl)oxy)ethyl 6- ...

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15-07-2021 дата публикации

Predicting Rates of Hypoglycemia by a Machine Learning System

Номер: US20210216894A1
Принадлежит:

Systems, methods, and computer products can predict rates of hypoglycemia in patients. One of the methods includes receiving data representing medical records of a patient, the patient having been diagnosed with diabetes mellitus. The method includes determine an predicted rate of hypoglycemic events using a machine learning system, the machine being trained using data representing the medical records of a plurality of patients and the corresponding rate of hypoglycemic events for the respective patients. The methods also includes producing the predicted rate for the patient. 1. A method comprising:receiving data representing medical records of a patient, the patient having been diagnosed with diabetes mellitus;determine a predicted rate of hypoglycemic events using a machine learning system, the machine being trained using data representing the medical records of a plurality of patients and the corresponding rate of hypoglycemic events for the respective patients; andproducing the predicted rate for the patient.2. The method of claim 1 , wherein each of the plurality of patients uses the same type of basal insulin.3. The method of claim 1 , where in the method further comprises:determining a second predicted rate of hypoglycemic events using a second machine learning system, the second machine being trained using data representing the medical records of a second plurality of patients and the corresponding rate of hypoglycemic events for the respective second patients, wherein each of the second plurality of patients using the second type of basal insulin, the second type of basal insulin being different from the first type of basal insulin; andcomparing the first predicted rate to the second predicted rate.4. The method of claim 3 , further comprising recommending a basal insulin for the patient based on the comparing.5. The method of claim 1 , further comprising determining a plurality of predicted rates of hypoglycemic events for a second plurality of patients by ...

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22-07-2021 дата публикации

METHODS FOR TREATING DIGITALLY-IDENTIFIED IL-4/IL-13 RELATED DISORDERS

Номер: US20210220470A1
Принадлежит:

Disclosed are methods of treating various disorders with anti-IL-4Rα antibodies and fragments thereof. 1. A method of treating a subject exhibiting at least one symptom of , or determined to be susceptible to , an anti-interleukin-4 receptor alpha (IL-4Rα)-related disorder with an anti-IL-4Rα antibody , comprising:(a) selecting a characteristic or a plurality of characteristics related to an IL-4/IL-13 pathway in a set of data representing medical records of a plurality of patients;(b) clustering, by a computer system, in accordance with the characteristic or the plurality of characteristics related to the IL-4/IL-13 pathway, a subset of patients from the plurality of patients, wherein the subset comprises the characteristic or the plurality of characteristics;(c) identifying in the subset clustered in step (b) the IL-4Rα-related disorder based on symptoms associated with the characteristic or the plurality of characteristics related to the IL-4/IL-13 pathway;(d) selecting the subject exhibiting at least one symptom of, or determined to be susceptible to, the IL-4Rα-related disorder identified in step (c), with the proviso that the IL-4Rα-related disorder is not selected from the group consisting of atopic dermatitis, asthma, chronic rhinosinusitis with nasal polyposis, eosinophilic esophagitis, peanut allergy, grass allergy, chronic obstructive pulmonary disease (COPD), prurigo nodularis, bullous pemphigoid, chronic spontaneous urticaria (CSU) and allergic bronchopulmonary aspergillosis (ABPA); and(e) administering a therapeutically effective amount of the anti-IL-4Rα antibody to the subject, a variable heavy chain CDR1 of SEQ ID NO:1 (GFTFRDYA);', 'a variable heavy chain CDR2 of SEQ ID NO:2 (ISGSGGNT);', 'a variable heavy chain CDR3 of SEQ ID NO:3 (AKDRLSITIRPRYYGLDV);', 'a variable light chain CDR1 of SEQ ID NO:4 (QSLLYSIGYNY);', 'a variable light chain CDR2 of SEQ ID NO:5 (LGS); and', 'a variable light chain CDR3 of SEQ ID NO:6 (MQALQTPYT)., 'wherein the anti-IL ...

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05-07-2018 дата публикации

Preventing Unauthorized Access to Secured Information Systems Using Proactive Controls

Номер: US20180191712A1
Принадлежит:

Systems and arrangements for detecting unauthorized activity and implementing proactive controls to avoid future occurrences of unauthorized activity are provided. The system may receive one or more occurrences of unauthorized activity and may identify similar pairs of occurrences. The pairs of occurrences may then be compared to generate occurrence clusters. The occurrence clusters may be analyzed to determine a common merchant or other attribute. This common merchant or other attribute may be used to query a database to identify one or more devices also associated with the merchant or attribute. One or more proactive controls may then be implemented on the identified devices. 1. An unauthorized activity detection and control computing platform , comprising:at least one processor;a communication interface communicatively coupled to the at least one processor; and receive a plurality of occurrences of unauthorized activity;', 'identify a plurality of events associated with each occurrence of the plurality of occurrences of unauthorized activity;', 'generate a data structure including the plurality of occurrences and the plurality of events;', 'compare a first occurrence of the plurality of occurrences to a second occurrence of the plurality of occurrences to determine a first similarity rating;', 'determine whether the first similarity rating is within a first predefined threshold of similarity;', 'responsive to determining that the first similarity rating is within the first predefined threshold, pairing the first occurrence and the second occurrence and generating a data element associated with the pairing of the first occurrence and the second occurrence;', 'storing the data element in the generated data structure;', 'compare the paired first occurrence and second occurrence with a third occurrence to determine a second similarity rating;', 'determine whether the second similarity rating is within a second predefined threshold;', 'responsive to determining that ...

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13-07-2017 дата публикации

Combination of a chromene compound and a second active agent

Номер: US20170196835A1
Принадлежит: Euclises Pharmaceuticals Inc

The present disclosure provide a combination of a chromene compound having the structure of Formula (I), or pharmaceutically acceptable salts, and a second compound that can be selected from a PD-1 inhibitor, PD-L1 inhibitor, CTLA-4 inhibitor, OX-40 agonist, CD137 agonist, LAG-3 inhibitor, IDO inhibitor, bi-specific protein, EGFR inhibitor, HER2 inhibitor, and immune stimulating therapy and a method of using the combination for treating or preventing cancer.

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06-08-2015 дата публикации

TISSUE CLEANER AND ORAL CARE IMPLEMENT

Номер: US20150216291A1
Принадлежит: Colgate-Palmolive Company

An oral care implement is provided, in one embodiment, with a plurality of spaced-apart tissue cleaning pads () radially arranged around a central axis () to form a grouping on one side of the head. A bridge () is positioned between each pad (). Each pad () further preferably includes one or more protrusions () along an upper surface thereof. There also is provided a plurality of cleaning elements () extending from an opposite side of the head of the oral care implement and connected to the cleaning pads through the head. 1. An oral care implement comprising:a) a head having a first side including a plurality of first cleaning elements and a second side including a plurality of second cleaning elements;b) the plurality of first cleaning elements being spaced apart on the first side;c) the plurality of second cleaning elements being connected on the second side by a bridge; andd) the plurality of first cleaning elements being connected to the plurality of second cleaning elements through the head;e) wherein the plurality of first cleaning elements are connected through the bridge that connects the plurality of second cleaning elements, and wherein the second cleaning elements further comprise a plurality of spaced-apart wedge-shaped elements radially arranged around a central axis, each wedge-shaped element having an inner region close to the central axis and an outer region spaced away from the central axis, the inner region being raised relative to the outer region.2. The oral care implement of claim 1 , wherein the first cleaning elements extend along a first plane and the second cleaning elements along a second plane that is substantially perpendicular to the first plane.3. The oral care implement of claim 1 , wherein each of the plurality of second cleaning elements further comprises a tissue cleaning pad having an outer surface with a plurality of edge regions that are at least partially raised from the second side and at least one additional edge region that ...

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11-07-2019 дата публикации

SYSTEM AND METHOD FOR ANIMATING A PLANT

Номер: US20190208932A1
Принадлежит:

A device and method that support and animate a plant disposed in an inner plant pot having an inner plant pot interior volume in such a way that the inner plant pot moves relative to an outer plant pot having an outer plant pot interior volume, and a gimbal mechanism disposed within the outer plant pot interior volume, controlling and instantiating, vertical longitudinal movement and rotational movement of the inner plant pot relative to the outer plant pot, programmable to provide physical response in the form of animation of the gimbal mechanism and the inner plant pot in response to receipt of predetermined data by the electronic processor control module from a plurality of sensors in communication with the electronic processor control module providing data collected by the plurality of sensors. 1. A plant supporting and animating device , comprising:an outer plant pot having an outer plant pot interior volume;an inner plant pot having an inner plant pot interior volume, the inner plant pot mounted within the outer plant pot interior volume and sized, dimensioned, and configured to house a plant therein; anda gimbal mechanism disposed within the outer plant pot interior volume and supporting the inner plant pot in such a way that the inner plant pot moves relative to the outer plant pot.2. The plant supporting and animating device of claim 1 , further comprising a motor actuator mechanically coupled with the gimbal mechanism.3. The plant supporting and animating device of claim 2 , wherein the motor actuator controls and instantiates vertical longitudinal movement of the inner plant pot relative to the outer plant pot.4. The plant supporting and animating device of claim 2 , wherein the motor actuator controls and instantiates rotational movement of the inner plant pot relative to the outer plant pot.5. The plant supporting and animating device of claim 1 , further comprising an electronic processor control module.6. The plant supporting and animating device of ...

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23-08-2018 дата публикации

Systems and Method for Reverse Cementing

Номер: US20180238139A1
Принадлежит: Halliburton Energy Services Inc

A material detection and sealing device includes a body comprising a bottom end and a top end, and configured to fit within a casing string. The device includes a valve located within the body configured to open and close an orifice formed through the body. The device also includes a density meter located on or within the body configured to continuously sense the density of a neighboring fluid. The valve is configured to close upon the density meter sensing a certain density condition.

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01-09-2016 дата публикации

Methods of Preparation of an Olefin Oligomerization Catalyst

Номер: US20160251455A1
Принадлежит:

A method of making a catalyst for use in oligomerizing an olefin comprising a chromium-containing compound, a pyrrole-containing compound, a metal alkyl, a halide-containing compound, and optionally a solvent, the method comprising contacting a composition comprising the chromium-containing compound and a composition comprising the metal alkyl, wherein the composition comprising the chromium-containing compound is added to the composition comprising the metal alkyl. 1. A method of making a catalyst for use in oligomerizing an olefin , the catalyst comprising a chromium-containing compound , a pyrrole-containing compound , a metal alkyl , a halide-containing compound , and optionally a solvent , the method comprising: abating all or a portion of water from a composition comprising the chromium-containing compound by contacting the composition comprising the chromium-containing compound with an azeotropic solvent to form a solution and subjecting the solution to an azeotropic distillation.2. The method of claim 1 , wherein the azeotropic solvent comprises an aromatic compound claim 1 , a halogenated compound claim 1 , a paraffin claim 1 , or combinations thereof.3. The method of claim 2 , wherein the aromatic compound comprises benzene claim 2 , toluene claim 2 , ethylbenzene claim 2 , mixed xylenes claim 2 , ortho-xylene claim 2 , meta-xylene claim 2 , para-xylene claim 2 , or combinations thereof.4112. The method of claim 1 , wherein the azeotropic solvent comprises ethylbenzene claim 1 , benzene claim 1 , meta-xylene claim 1 , ortho-xylene claim 1 , para-xylene claim 1 , mixed xylenes claim 1 , toluene claim 1 , octane claim 1 , nonane claim 1 , heptane claim 1 , hexane claim 1 , mixed hexanes claim 1 , cyclohexane claim 1 , carbon tetrachloride claim 1 , chloroform claim 1 , dichloromethane claim 1 , claim 1 , claim 1 , trichloroethane claim 1 , or combinations thereof.5. The method of claim 1 , wherein the amount of water removed is monitored by infrared analysis ...

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30-08-2018 дата публикации

PHARMACEUTICALLY ACCEPTABLE SALTS OF B-GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF

Номер: US20180243248A1
Принадлежит:

The present invention relates to new pharmaceutical salts of β-GPA which exhibit improved physical properties. In particular, the invention relates to salts of β-GPA with improved flow properties (e.g., improved Carr's index and/or Hausner ratio) such as fumarate salts, succinate salts, and oxalate salts. The invention also relates to pharmaceutical compositions including a pharmaceutically effective amount of one or more salts of β-GPA, as well as methods of treating cancer including administration of a formulation including a β-GPA salt of the invention to a subject in need thereof. 1. A pharmaceutically acceptable salt of β-guanidinopropionic acid having a Carr's Index of less than 20 and/or a Hausner ratio of less than 1.25.2. The pharmaceutically acceptable salt of claim 1 , wherein said pharmaceutically acceptable salt is a salt of β-guanidinopropionic acid and a dicarboxylic acid.3. The pharmaceutically acceptable salt of claim 1 , wherein said pharmaceutically acceptable salt is a 1:1 fumarate salt claim 1 , a 2:1 succinate salt claim 1 , or a 1:1 oxalate salt.4. The pharmaceutically acceptable salt of claim 1 , wherein said salt is crystalline.5. The pharmaceutically acceptable salt of comprising less than 40% by weight of amorphous compound.613-. (canceled)14. A composition comprising a pharmaceutically acceptable salt of which contains less than 10% by weight of amorphous compound and a pharmaceutically acceptable excipient.1516-. (canceled)17. A pharmaceutical composition in unit dosage form comprising a pharmaceutically acceptable salt of and a pharmaceutically acceptable excipient.18. A pharmaceutical composition comprising a pharmaceutically acceptable salt of and a pharmaceutically acceptable excipient claim 1 , wherein said pharmaceutical composition is formulated for intravenous infusion.19. A method of treating cancer in a subject in need thereof claim 1 , said method comprising administering an effective amount of a pharmaceutically acceptable ...

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30-08-2018 дата публикации

Swellable technology for downhole fluids detection

Номер: US20180245427A1
Принадлежит: Halliburton Energy Services Inc

A method of detecting the presence of a downhole fluid at a particular location in a wellbore including pumping an activating fluid into a wellbore; contacting a flow controlling device in a pipe string casing with the activating fluid, the flow controlling device comprising at least one swellable element; activating the at least one swellable element in the flow controlling device; blocking fluids or controlling the flow of fluids entering or leaving the casing with the activated flow controlling device; allowing the pressure to change; and detecting the pressure change. An apparatus includes a pipe string in a wellbore and a flow controlling device in the pipe string casing, wherein the flow controlling device includes at least one swellable element, wherein upon activation, the at least one swellable element swells and fully or partially seals off the flow area of the flow controlling device.

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15-09-2016 дата публикации

Oligomerization of Alpha Olefins Using Metallocene-SSA Catalyst Systems and Use of the Resultant Polyalphaolefins to Prepare Lubricant Blends

Номер: US20160264493A1
Принадлежит:

This disclosure provides for alpha olefin oligomers and polyalphaolefins (or PAOs) and methods of making the alpha olefin oligomers and PAOs. This disclosure encompasses metallocene-based alpha olefin oligomerization catalyst systems, including those that include at least one metallocene and an activator comprising a solid oxide chemically-treated with an electron withdrawing anion. The alpha olefin oligomers and PAOs prepared with these catalyst systems can have a high viscosity index combined with a low pour point, making them particularly useful in lubricant compositions and as viscosity modifiers. 150-. (canceled)51. An oligomerization method comprising:{'sub': 4', '20, 'claim-text': 1) a metallocene,', '2) a first activator comprising a solid oxide chemically-treated with an electron withdrawing anion, and', {'sup': 10', '11', '10', '11, 'sub': n', '3-n', '1', '20', '1', '20, '3) a second activator comprising an organoaluminum compound having a formula: Al(X)(X), wherein Xis independently a Cto Chydrocarbyl, Xis independently a halide, a hydride, or a Cto Chydrocarboxide, and n is a number from 1 to 3; and'}], 'a) contacting a Cto Calpha olefin monomer and a catalyst system, the catalyst system comprisingb) forming an oligomer product under oligomerization conditions.52. The oligomerization method of claim 51 , wherein the solid oxide chemically-treated with an electron withdrawing anion comprises a fluorided solid oxide.53. The oligomerization method of claim 51 , wherein the solid oxide chemically-treated with an electron withdrawing anion comprises a sulfated solid oxide.54. The oligomerization method of claim 51 , wherein the second activator comprises a trialkylaluminum claim 51 , an alkylaluminum sesquihalide claim 51 , an alkylaluminum halide claim 51 , or any combination thereof.55. The oligomerization method of claim 51 , wherein:{'sub': 6', '16, 'the alpha olefin monomer comprises a Cto Cnormal alpha olefin;'}the solid oxide chemically-treated with an ...

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18-12-2014 дата публикации

IDENTIFYING THE INTRODUCTION OF A SOFTWARE FAILURE

Номер: US20140372983A1
Принадлежит:

The subject disclosure is directed towards a technology in which a first software version (e.g., build or check-in) that corresponds to a failure/regression is automatically identified. Software versions associated with a development order are automatically loaded and tested according to a search plan that narrows in on which version a failure condition first appears. For example, a binary search may be used that looks back to a previous version when a failure is detected on a tested version, or moves to a subsequent version when the failure is not detected. The search plan allows multiple test machines run tests in parallel on different versions, and adapts to the number of test machines available for testing. 1. A method performed at least in part on at least one processor , comprising , searching among software versions to determine a software version that corresponds to a failure condition , including loading a plurality of machines with different versions , in which different versions are based upon a search plan and a number of machines available , running a test on one or more of the loaded versions to detect whether the failure condition occurs on each tested machine , and if so , narrowing the search based upon the search plan until a version or range of versions is identified corresponding to where the failure condition first occurred.2. The method of wherein the search plan specifies a binary search claim 1 , and further comprising claim 1 , dividing a search space into a plurality of subspaces based upon the number of machines available and searching each subspace with a binary search.3. The method of wherein the search plan specifies a binary search claim 1 , and further comprising claim 1 , selecting a version for loading in a machine based upon where the binary search is to begin claim 1 , and selecting one or more other versions for loading in one or more other machines in anticipation of where the binary search is able to branch in subsequent tests. ...

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15-10-2015 дата публикации

MULTIDIMENSIONAL PERSONAL BEHAVIORAL TOMOGRAPHY

Номер: US20150294336A1

A method and computer program product for identifying attributes of customers and potential customers, allowing marketing to be directed at such consumers. Information is received regarding each of a number of consumers. This information can include demographic information, data regarding spending habits, and information as to how such attributes may have changed over time. Once attributes have been determined, and any changes over time to such attributes have been determined, a correlation of the attributes is performed. Such combined attributes are denoted as composite dimensions. Given the composite dimensions, as well as attributes that may not have been correlated with any other attributes, consumers are plotted in the resulting multi-dimensional space. Sets of consumers that appear to be grouped in this multi-dimensional space are then identified. Common attributes of this consumer group are identified. Unique attributes of a given consumer in such a group are also identified. 1. A method comprising: wherein the change attributes comprise trends,', 'wherein the change attributes comprise extent of change and rates of change of the consumer attributes;', 'wherein the composite dimensions are established based on a positive correlation between the consumer attributes and the change attributes;, 'organizing, by a computer based system configured for grouping consumers, consumer attributes and change attributes according to correlations of the consumer attributes and the change attributes, to create a set of composite dimensions,'}plotting, by the computer based system, consumers relative to the set of composite dimensions on a multi-dimensional space; andgrouping consumers, by the computer based system, according to location within the multidimensional space to create a consumer group.2. The method of claim 1 , further comprising directing claim 1 , by the computer based system claim 1 , marketing tactics at the consumer based on a common attribute of the ...

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20-10-2016 дата публикации

DISPENSER

Номер: US20160302562A1
Принадлежит: Colgate-Palmolive Company

A dispenser that includes a resilient applicator that optimizes application of a subject fluid to a desired surface. In one embodiment, the invention is a dispenser comprising a housing having an internal reservoir containing the fluid. The resilient applicator is coupled to the housing and comprises a dispensing orifice. The resilient applicator comprises a working surface that is oriented at an oblique angle to a longitudinal axis of the housing and is defined by a polygonal perimeter edge, the polygonal perimeter edge comprising a plurality of apex portions and a plurality of side portions, wherein one of the plurality of side portions forms a distal most-portion of the resilient applicator. 1. A dispenser comprising:a housing having an internal reservoir containing a fluid, the housing extending from a proximal end to a distal end along a longitudinal axis, the distal end of the housing comprising a transverse end wall having a top surface;a resilient applicator coupled to the distal end of the housing, the resilient applicator comprising a main body portion and a dispensing orifice for dispensing the fluid from the reservoir, the main body portion having a bottom surface that is in contact with the top surface of the transverse end wall of the housing; andwherein the resilient applicator comprises a working surface that is oriented at an oblique angle to the longitudinal axis of the housing.2. The dispenser according to wherein the working surface of the resilient applicator comprises a polygonal perimeter edge claim 1 , the polygonal perimeter edge comprising a plurality of apex portions and a plurality of side portions claim 1 , wherein one of the plurality of side portions forms a distal most-portion of the resilient applicator and one of the plurality of apex portions forms a proximal-most portion of the working surface.3. The dispenser according to wherein the polygonal perimeter edge is generally triangular having three apex portions and three side ...

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20-10-2016 дата публикации

Oral Care Implement with Cover Member

Номер: US20160302563A1
Автор: Jimenez Eduardo J.
Принадлежит:

An oral care implement having a cover member. In one aspect, the invention is an oral care implement comprising: a body comprising a handle and a head coupled the handle, the head comprising a first coupling element, and the handle comprising a second coupling element; a store of oral care material located within the body; an outlet located on the head; a cover member comprising a cap portion, a mounting portion, and a third coupling element, the cover member alterable between: (1) a first state in which the first and third coupling elements cooperate with one another to detachably couple the cover member to the head to seal the outlet; and (2) a second state in which the second and third coupling elements cooperate with one another to detachably couple the cover member to the handle so that the mounting portion can operate as a stand. 1. An oral care implement comprising:a body comprising a handle and a head coupled to a distal end of the handle, the head comprising a first coupling element, and the handle comprising a second coupling element located at a proximal end of the body;a store of oral care material located within the body;an outlet located on the head and in fluid communication with the store;a cover member comprising a cap portion, a mounting portion, and a third coupling element; andwherein the cover member is alterable between: (1) a first state in which the first and third coupling elements cooperate with one another to detachably couple the cover member to the head to seal the outlet with the cap portion; and (2) a second state in which the second and third coupling elements cooperate with one another to detachably couple the cover member to the proximal end of the body so that the mounting portion can operate as a stand to maintain the oral care implement in an upright orientation.2. The oral care implement according to wherein the outlet comprises an opening formed into a rear surface of the head and further comprising an applicator positioned ...

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20-10-2016 дата публикации

Oral Care Implement with Cover Member

Номер: US20160302564A1
Автор: Jimenez Eduardo J.
Принадлежит:

An oral care implement having a cover member. In one aspect, the invention is an oral care implement comprising: a body comprising a handle and a head, the head comprising a coupling element; a store of oral care material located within the body; an outlet located on the head and in fluid communication with the store; a cover member comprising a cap portion, a mounting portion, and a coupling element; and wherein the cover member is detachably coupled to the head via cooperation between the coupling element of the cover member and the coupling element of the head, and the mounting portion is configured to mount the oral care implement to a vertical surface. 1. An oral care implement comprising:a body comprising a handle and a head, the head comprising a coupling element;a store of oral care material located within the body;an outlet located on the head and in fluid communication with the store;a cover member comprising a cap portion, a mounting portion, and a coupling element; andwherein the cover member is detachably coupled to the head via cooperation between the coupling element of the cover member and the coupling element of the head, and the mounting portion is configured to mount the oral care implement to a vertical surface.2. The oral care implement of according to wherein the cover member comprises the mounting portion and a sealing portion claim 1 , and wherein the sealing portion comprises the cap portion and the coupling element.3. The oral care implement according to wherein the sealing portion of the cover member is detachable from the mounting portion of the cover member.4. The oral care implement according to wherein when the mounting portion of the cover member is detached from the sealing portion of the cover member claim 3 , the mounting portion remains coupled to the vertical surface and the sealing portion remains coupled to the head to seal the outlet.5. The oral care implement according to wherein the cap portion of the cover member comprises ...

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12-11-2015 дата публикации

ORAL CARE IMPLEMENT WITH PRODUCT APPLICATOR

Номер: US20150320193A1
Принадлежит:

An oral care implement with product application is disclosed. In one embodiment, the implement is a fluid dispensing toothbrush having a body comprised of a handle, a head, and an internal cavity containing an oral care material. The head includes tooth cleaning elements and an applicator in fluid communication with the internal cavity. In one embodiment, the applicator includes at least one spring-actuated valve operable to dispense the fluidic oral care material upon engagement with a user's oral tissue. The oral care material is delivered from the internal cavity upon applying a pressing force to a moveable sealing element of the valve. In certain embodiments, a pressurizer may be provided to pressurize the oral care material for positive dispensing. In one embodiment, the applicator is disposed in a soft tissue cleaner on the toothbrush head. 1. A toothbrush comprising:a body comprising a handle, a head coupled to the handle, and an internal cavity containing an oral care material;a plurality of tooth cleaning elements extending from the head; andan applicator disposed in the head and in fluid communication with the internal cavity,the applicator comprising at least one spring-actuated valve movable from the closed non-dispensing position to an open dispensing position upon applying a pressing force against an externally exposed portion of the valve wherein oral care material is dispensed from the internal cavity.2. The toothbrush according to claim 1 , wherein the at least one spring-actuated valve includes a linearly moveable sealing element and a spring member biasing the sealing element into the closed non-dispensing position.3. The toothbrush according to claim 2 , wherein the sealing element has an externally exposed portion accessible from an outer surface of the toothbrush and an internal portion in contact with the oral care material contained in the internal cavity.4. The toothbrush according to wherein the sealing element is a spherical element ...

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19-11-2015 дата публикации

TISSUE CLEANER AND ORAL CARE IMPLEMENT

Номер: US20150327660A1
Принадлежит: Colgate-Palmolive Company

An oral care implement is provided, in one embodiment, with a plurality of spaced-apart tissue cleaning pads () radially arranged around a central axis () to form a grouping, each pad having an inner region () close to the central axis and an outer region spaced away from the central axis, the inner region () being raised relative to the outer region and having scraping surfaces along certain edge regions for improved cleaning of the soft tissue in an oral cavity Each pad further preferably includes one or more protrusions () along an upper surface thereof.

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17-10-2019 дата публикации

INHIBITORS OF CREATINE TRANSPORT AND USES THEREOF

Номер: US20190315680A1
Принадлежит:

This invention relates to compounds that inhibit creatine transport and/or creatine kinase, pharmaceutical compositions including such compounds, and methods of utilizing such compounds and compositions for the treatment of cancer. 3. The method of claim 2 , wherein said method comprises the suppression of metastatic colonization of said migrating cancer in the liver.4. The method of claim 2 , wherein said migrating cancer is metastatic cancer.5. The method of claim 4 , wherein the metastatic cancer comprises cells exhibiting migration and/or invasion of migrating cells.6. The method of claim 4 , wherein said metastatic cancer comprises cells exhibiting endothelial recruitment and/or angiogenesis.7. The method of claim 2 , wherein said migrating cancer spreads via seeding the surface of the peritoneal claim 2 , pleural claim 2 , pericardial claim 2 , or subarachnoid spaces.8. The method of claim 2 , wherein said migrating cancer spreads via the lymphatic system.9. The method of claim 2 , wherein said migrating cancer spreads hematogenously.10. The method of claim 2 , wherein said migrating cancer is a cell migration cancer.11. The method of claim 10 , wherein said cell migration cancer is a non-metastatic cell migration cancer.12. The method of claim 11 , where said cell migration cancer is ovarian cancer claim 11 , mesothelioma claim 11 , or primary lung cancer.13. The method of claim 1 , wherein said cancer is breast cancer claim 1 , colon cancer claim 1 , renal cell cancer claim 1 , non-small cell lung cancer claim 1 , hepatocellular carcinoma claim 1 , gastric cancer claim 1 , ovarian cancer claim 1 , pancreatic cancer claim 1 , esophageal cancer claim 1 , prostate cancer claim 1 , sarcoma claim 1 , or melanoma.14. The method of claim 1 , wherein said cancer is gastrointestinal cancer.15. The method of claim 14 , wherein said gastrointestinal cancer is esophageal cancer claim 14 , stomach cancer claim 14 , pancreatic cancer claim 14 , liver cancer claim 14 , ...

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24-11-2016 дата публикации

NO-RELEASING NITROOXY-CHROMENE CONJUGATES

Номер: US20160340330A1
Принадлежит:

The present invention provides NO-releasing nitrooxy-alkylenyl-linked-chromene conjugates, having the structure of Formula (1) wherein R1, R2, R3, R4, X, and L are as defined in the detailed description; pharmaceutical compositions comprising at least one compound o Formula (I); and methods useful for healing wounds, preventing and treating cancer and treating actinic keratosis, cystic fibrosis, and acne, using a compound of Formula (1). 117-. (canceled)19. The compound claim 18 , salt claim 18 , or solvate of claim 18 , wherein:{'sup': 8', '9, 'Rand Rare each hydrido; and'}{'sup': '10', 'Ris selected from the group consisting of hydrido, halo, methyl, halomethyl, ethyl, haloethyl, propyl, halopropyl, and butyl.'}20. The compound claim 19 , salt claim 19 , or solvate of claim 19 , wherein the compound is (S)-6-pentafluorosulfanyl-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid claim 19 , or a salt or solvate thereof.21. The compound claim 19 , salt claim 19 , or solvate of claim 19 , wherein the compound is (S)-6-pentafluorosulfanyl-8-methyl-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid claim 19 , or a salt or solvate thereof.22. The compound claim 19 , salt claim 19 , or solvate of claim 19 , wherein the compound is (S)-6-pentafluorosulfanyl-8-ethyl-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid claim 19 , or a salt or solvate thereof.23. A pharmaceutical composition comprising a therapeutically effective amount of a compound of and a pharmaceutically acceptable carrier.24. The pharmaceutical composition of claim 23 , further comprising a therapeutically effective amount of an active pharmaceutical ingredient selected from the group consisting of anti-inflammatory drugs claim 23 , cytostatic drugs claim 23 , cytotoxic drugs claim 23 , anti-proliferative agents and angiogenesis inhibitors.25. A method for treating claim 18 , preventing claim 18 , or ameliorating a disease condition comprising administering to a mammalian subject in need thereof a ...

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30-11-2017 дата публикации

Palladium Catalyst System Comprising Zwitterion And/Or Acid-Functionalyzed Ionic Liquid

Номер: US20170341067A1
Принадлежит: Danmarks Tekniskie Universitet

The present invention concerns a catalyst system in particular a catalyst system comprising Palladium (Pd), a zwitterion and/or an acid-functionalized ionic liquid, and one or more phosphine ligands, wherein the Pd catalyst can be provided by a complex precursor, such as Pd(CH 3 COO) 2 , PdCl 2 , Pd(CH 3 COCHCOCH 3 ), Pd(CF 3 COO) 2 , Pd(PPh 3 ) 4 or Pd 2 (dibenzylideneacetone) 3 . Such catalyst systems can be used for e.g. alkoxycarbonylation reactions, carboxylation reactions, and/or in a co-polymerization reaction, e.g. in the production of methyl propionate and/or propanoic acid, optionally in processes forming methyl methacrylate and/or methacrylic acid. Catalyst systems according to the invention are suitable for reactions forming separable product and catalyst phases and supported ionic liquid phase SILP applications.

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08-12-2016 дата публикации

ORAL CARE DEVICE

Номер: US20160354188A1
Принадлежит:

An oral care device such as an oral care implement or a toothbrush. The oral care device may include a handle and a head. The head may have a plurality of cleaning elements extending therefrom. The head may comprise an open space or cavity. A plurality of electrodes may be located within the open space or cavity. The electrodes may be coupled to a voltage source. The electrodes may be used to generate a chemical agent via the application of an electrical potential across the electrodes when in communication with an electrolyte. The chemical agents may include ozone, hydrogen peroxide, peroxide, chlorine hypochlorite, ions, peroxides, and/or other chemical agents. 1. An oral care device comprising:a handle;a head coupled to the handle, the head defining an open space and having a front surface and an opposite rear surface;a plurality of cleaning elements extending from the front surface of the head; anda plurality of electrodes located within the open space of the head.2. The oral care device according to further comprising an opening in the front surface of the head that provides a passageway into the open space claim 1 , and wherein the open space is located between the front and rear surfaces of the head.3. The oral care device according to wherein the open space is a channel extending entirely through the head from the front surface of the head to the rear surface of the head.4. The oral care device according to wherein the open space is located between the front and rear surfaces of the head claim 1 , and wherein each of the plurality of electrodes is located entirely within the open space.5. The oral care device according to wherein no portion of any of the electrodes protrudes from the front or rear surfaces of the head.6. The oral care device according to wherein the open space is bounded by a sidewall of the head claim 1 , and wherein the plurality of electrodes are coupled to the sidewall of the head in a spaced apart manner.7. The oral care device ...

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19-11-2020 дата публикации

LEAD ACID BATTERY SEPARATOR AND LEAD ACID BATTERY

Номер: US20200365947A1
Принадлежит:

A separator for a battery is disclosed. The separator is an envelope separator. At least one aperture is provided in any of the first sealed edge, second sealed edge, and third sealed edge of the envelope separator, wherein the at least one aperture forms an electrolyte conduit which assists in the reduction of acid stratification. A battery and a plate and separator assembly are also disclosed. 1. A separator for a battery comprising:a first separator segment having a first edge, a second edge, a third edge, and a fourth edge;a second separator segment having a first edge, a second edge, a third edge, and a fourth edge; the second separator segment sealed to the first separator segment along the first edge of the first separator segment and the first edge of the second separator segment thereby forming a first sealed edge, the second edge of the first separator segment and the second edge of the second separator segment thereby forming a second sealed edge, and the third edge of the first separator segment and the third edge of the second separator segment thereby forming a third sealed edge; andat least one aperture in any of the first sealed edge, the second sealed edge, and the third sealed edge, wherein the at least one aperture forms an electrolyte conduit which assists in the reduction of acid stratification.2. The separator of claim 1 , further comprising a plurality of apertures claim 1 , the plurality of apertures in one of the first sealed edge claim 1 , the second sealed edge claim 1 , or the third sealed edge.3. The separator of claim 1 , further comprising a plurality of apertures claim 1 , the plurality of apertures comprising at least one first aperture being located in at least one of the first sealed edge claim 1 , the second sealed edge claim 1 , or the third sealed edge claim 1 , and at least one second aperture being located in at least one of the first sealed edge claim 1 , the second sealed edge claim 1 , or the third sealed edge claim 1 , but ...

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12-12-2019 дата публикации

GRIP SUPPORT HARNESS

Номер: US20190376763A1
Автор: Neyra Eduardo J.
Принадлежит:

A grip support harness is described that may enable a person with limited grip strength or hand control to grip and operate sporting equipment such as firearms. The grip support harness may include a wrist cuff or forearm support to secure the harness to the arm or hand, and one or more straps that wrap around the hand to support the grip. The grip support harness may enable some people to engage in activities that may not be practical otherwise. This may result in additional opportunities for entertainment, physical therapy or rehabilitation. 1. An apparatus for sporting equipment , comprising:a wrist cuff;a primary support strap connected to the wrist cuff, the primary support strap comprising a primary tensioning component;a primary connecting component connected to the wrist cuff;a secondary support strap connected to the wrist cuff, the secondary support strap comprising a secondary tensioning component; anda secondary connecting component connected to the wrist cuff.2. The apparatus of claim 1 , further comprising:a firing lanyard connected to the primary support strap.3. The apparatus of claim 2 , wherein:the firing lanyard comprises a high visibility color distinct from a color of the wrist cuff, a color of the primary support strap, and a color of the secondary support strap.4. The apparatus of claim 1 , further comprising:one or more finger loops connected to the primary support strap.5. The apparatus of claim 1 , further comprising:a thumb protector connected to the secondary support strap.6. The apparatus of claim 5 , wherein:the thumb protector comprises a leather strip.7. The apparatus of claim 1 , wherein:the secondary support strap is offset from the primary support strap at an angle between 0 degrees and 45 degrees.8. The apparatus of claim 1 , wherein:the wrist cuff comprises a forearm support.9. The apparatus of claim 1 , wherein:the wrist cuff, the primary support strap, the secondary support strap, or any combination thereof comprises a webbing ...

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19-06-2012 дата публикации

Oligomerizacion de alfa oleifinas usando sistemas de catalizador de metaloceno-ssa y uso de las polialfaolefinas resultantes para preparar mezclas lubricantes.

Номер: MX2011013662A
Принадлежит: Chevron Phillips Chemical Co

Esta descripción proporciona oligómeros de alfa olefina y polialfaolefinas (o PAOs) y métodos para elaborar los oligómeros de alfa olefina y PAOs. Esta descripción abarca sistemas catalizadores de oligomerización de alfa olefina a base de metaloceno, que incluyen los que comprenden por lo menos un metaloceno y un activador que comprende un óxido sólido tratado químicamente con un anión de extracción de electrones. Los oligómeros de alfa olefina y las PAOs preparados con estos sistemas catalizadores pueden tener un índice de viscosidad alto combinado con un bajo punto de vertido, haciéndolos particularmente útiles en las composiciones lubricantes y como modificadores de viscosidad.

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14-04-2011 дата публикации

Oligomerization of olefin waxes using metallocene-based catalyst systems

Номер: WO2011044150A1
Принадлежит: CHEVRON PHILLIPS CHEMICAL COMPANY LP

This disclosure provides for olefin wax oligomer compositions, methods of producing olefin wax oligomer composition, and methods for oligomerizing olefin waxes. This disclosure encompasses metallocene-based olefin wax oligomerization catalyst systems, including those that include a metallocene and an aluminoxane, a metallocene and a solid oxide chemically-treated with an electron withdrawing anion, and a metallocene, a solid oxide chemically-treated with an electron withdrawing anion, and an organoaluminum compound. The olefin wax oligomers prepared with these catalyst systems can decreased needle penetrations, increased viscosity, and an increased drop melt, making them useful as an additive in candles, stone polishes, liquid polishes, and mold release formulations.

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23-12-2010 дата публикации

Oligomerization of alpha olefins using metallocene-ssa catalyst systems and use of the resultant polyalphaolefins to prepare lubricant blends

Номер: WO2010147993A1
Принадлежит: CHEVRON PHILLIPS CHEMICAL COMPANY LP

This disclosure provides for alpha olefin oligomers and polyalphaolefins (or PAOs) and methods of making the alpha olefin oligomers and PAOs. This disclosure encompasses metallocene- based alpha olefin oligomerization catalyst systems, including those that include at least one metallocene and an activator comprising a solid oxide chemically-treated with an electron withdrawing anion. The alpha olefin oligomers and PAOs prepared with these catalyst systems can have a high viscosity index combined with a low pour point, making them particularly useful in lubricant compositions and as viscosity modifiers.

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01-01-2020 дата публикации

Compositions comprising polyalphaolefins

Номер: EP3587458A1
Принадлежит: Chevron Phillips Chemical Co LP

Compositions comprising polyalphaolefins are disclosed. The polyalphaolefin may be produced from a C 6 to C 16 normal alpha olefin and the polyalphaolefin may comprise less than 1 weight % saturated alpha olefin monomer; less than 3 weight % saturated dimers; and greater than 80 weight % saturated higher oligomers; and have a 100 °C kinematic viscosity of at least 25 cSt; a viscosity index greater than 160; and a pour point less than -35°C. Alternatively, the polyalphaolefin may be produced from a C 6 to C 16 normal alpha olefin comprising at least 80 weight percent of a C 8 normal alpha olefin and the polyalphaolefin may have a pour point less than 0°C; and a Bernoulli index less than 1.65. Alternatively, the polyalphaolefins may be alpha olefin oligomers that may be produced from a C 6 to C 16 normal alpha olefin comprising at least 90 weight percent of a C 8 normal alpha olefin and the alpha olefin oligomer product may comprise less than 1 weight % residual alpha olefin monomer; less than 3 weight % dimers; and greater than 80 weight % higher oligomers; and have a 100 °C kinematic viscosity of at least 25 cSt; and a viscosity index greater than 170. The polyalphaolefins have no discernable crystallization as determined by differential scanning calorimetry using ASTM D 3418.

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08-05-1996 дата публикации

Phosphonosulfonate squalene synthetase inhibitor salts and method

Номер: EP0710665A1
Принадлежит: Bristol Myers Squibb Co

New salt forms of the phosphonosulfonate squalene synthetase inhibitor are provided which include the calcium, the t-butylamine salt, t-octylamine salt and the dehydroabietylamine salt. These salts inhibit cholesterol biosynthesis and therefore are used in lowering serum cholesterol and in treating atherosclerosis.

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24-01-2017 дата публикации

Methods of preparation of an olefin oligomerization catalyst

Номер: US9550841B2
Принадлежит: Chevron Phillips Chemical Co LP

A method of making a catalyst for use in oligomerizing an olefin comprising a chromium-containing compound, a pyrrole-containing compound, a metal alkyl, a halide-containing compound, and optionally a solvent, the method comprising contacting a composition comprising the chromium-containing compound and a composition comprising the metal alkyl, wherein the composition comprising the chromium-containing compound is added to the composition comprising the metal alkyl.

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27-01-2011 дата публикации

Methods of Preparation of an Olefin Oligomerization Catalyst

Номер: US20110021343A1
Принадлежит: Chevron Phillips Chemical Co LP

A method of making a catalyst for use in oligomerizing an olefin comprising a chromium-containing compound, a pyrrole-containing compound, a metal alkyl, a halide-containing compound, and optionally a solvent, the method comprising contacting a composition comprising the chromium-containing compound and a composition comprising the metal alkyl, wherein the composition comprising the chromium-containing compound is added to the composition comprising the metal alkyl.

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