12-08-2021 дата публикации
Номер: US20210244801A1
Принадлежит:
One or more quorum silencing enzymes entrapped in an organopolysiloxane matrix, formulations comprising the enzymes, methods for obtaining the entrapped enzymes by co-gelation and methods of treating intestinal diseases. 135-. (canceled)36. One or more quorum silencing enzymes entrapped in an organopolysiloxane matrix.37. The quorum silencing enzymes of claim 36 , wherein:the quorum silencing enzymes comprise an acyl-homoserine lactone hydrolase, acyl-homoserine-lactone acylase organophosphate hydrolase, trypsin-like protease, or a combination thereof; andthe organopolysiloxane matrix comprises tetra-alkoxy siloxane moieties, trialkoxy-organosiloxane moieties, or a combination thereof.38. The quorum silencing enzymes of claims 36 , wherein the organopolysiloxane matrix is obtained by gelating a hydrated siloxane pre-polymer mixture with a ratio of 50-100 mol % Si(OR)to 50-0 mol % Si(OR)R′ claims 36 , wherein R is an alkoxy group and R′ is selected from the group consisting of methyl claims 36 , ethyl claims 36 , propyl claims 36 , isopropyl claims 36 , butyl claims 36 , octyl claims 36 , hexadecyl claims 36 , octadecyl claims 36 , phenyl claims 36 , trimethylaminopropyl claims 36 , aminopropyl claims 36 , aminobutyl claims 36 , alkyl claims 36 , mercaptopropyl claims 36 , and methylphosphonyl.39. The quorum silencing enzymes of in the form of a lyophilized powder.40. A formulation comprising the quorum silencing enzymes of .41. The formulation of claim 40 , wherein the formulation is in the form of a tablet claim 40 , gel capsule claim 40 , powder claim 40 , suspension claim 40 , slurry claim 40 , injectable liquid formulation claim 40 , gel claim 40 , cream claim 40 , chewable claim 40 , suppository or syrup.42. A method of obtaining a quorum silencing enzyme entrapped in an organopolysiloxane matrix claim 40 , the method comprising:hydrolyzing a siloxane pre-polymer with water under acidic conditions, and thereby obtaining a hydrolyzed siloxane pre-polymer; ...
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