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Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Применить Всего найдено 28. Отображено 26.
08-08-2017 дата публикации

Sclareol and labdenediol diphosphate synthase polypeptides, encoding nucleic acid molecules and uses thereof

Номер: US0009725740B2
Автор: Grace Eunyoung Park, Bryan N. Julien, Richard Burlingame, PARK GRACE EUNYOUNG, JULIEN BRYAN N, BURLINGAME RICHARD, Park Grace Eunyoung, Julien Bryan N., Burlingame Richard
Принадлежит: EVOLVA, INC., EVOLVA INC

Provided are labdenediol diphosphate synthase polypeptides, sclareol synthase polypeptides, nucleic acid molecules encoding the labdenediol diphosphate synthase polypeptides and sclareol synthase polypeptides, and methods of using the labdenediol diphosphate synthase polypeptides, sclareol synthase polypeptides. Also provided are methods for producing labdenediol diphosphate, sclareol and (−)-ambroxide.

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Номер записи: 1
15-09-2016 дата публикации

Sclareol and Labdenediol Diphosphate Synthase Polypeptides, Encoding Nucleic Acid Molecules and Uses Thereof

Номер: US20160265002A1
Автор: Grace Eunyoung Park, Bryan N. Julien, Richard Burlingame, PARK GRACE EUNYOUNG, JULIEN BRYAN N, BURLINGAME RICHARD, Park Grace Eunyoung, Julien Bryan N., Burlingame Richard
Принадлежит: Evolva AG, Evolva Inc

Provided are labdenediol diphosphate synthase polypeptides, sclareol synthase polypeptides, nucleic acid molecules encoding the labdenediol diphosphate synthase polypeptides and sclareol synthase polypeptides, and methods of using the labdenediol diphosphate synthase polypeptides, sclareol synthase polypeptides. Also provided are methods for producing labdenediol diphosphate, sclareol and (−)-ambroxide.

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Номер записи: 2
24-05-2012 дата публикации

Novel fragrance and methods for production of 5-EPI-ß- vetivone, 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one, and 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-1,6-dien-8-one

Номер: US20120129235A1
Автор: Julien Bryan N., Wallace David M.
Принадлежит:

The present invention is directed to novel methods for production of 5-epi-β-vetivone, 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one and 2-isopropyl-6,10-dimethylspiro[4.5]deca-1,6-dien-8-one, which are useful for their fragrant qualities. Provided are methods for production of premnaspirodiene from a terpene substrate, methods for production of 5-epi-β-vetivone from premnaspirodiene as starting material, and methods for production of 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one and 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-1,6-dien-8-one from premnaspirodiene as starting material. 1. A method for producing (−)-premnaspirodiene from a terpene substrate , comprising the steps of:(a) providing a terpene substrate to a host cell transformed or transfected with a vector comprising a sequence encoding a premnaspirodiene synthase gene;(b) culturing the host cell under conditions suitable to produce (−)-premnaspirodiene from the terpene substrate; and(c) isolating the (−)-premnaspirodiene.2. The method of claim 1 , wherein the step of providing the terpene substrate is performed by synthesis of the terpene substrate by the host cell.3. The method of claim 2 , wherein the terpene substrate is farnesyl diphosphate.4. The method of claim 1 , wherein the host cell is a eukaryotic cell.5. The method of claim 4 , wherein the host cell is a yeast cell.6Saccharomyces cerevisiae. The method of claim 5 , wherein the host cell is a cell.7. The method of claim 1 , wherein the step of isolating the (−)-premnaspirodiene is performed by:(i) sequestering the (−)-premnaspirodiene by binding it to a hydrophobic resin; and(ii) isolating the (−)-premnaspirodiene from the hydrophobic resin.8. The method of claim 1 , wherein the step of isolating the (−)-premnaspirodiene is performed by:(i) sequestering the (−)-premnaspirodiene in a non-polar solvent phase of a two-phase system during fermentation wherein the non-polar solvent phase is substantially immiscible with an ...

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Номер записи: 3
27-09-2012 дата публикации

Modified valencene synthase polypeptides, encoding nucleic acid molecules and uses thereof

Номер: US20120246767A1
Автор: Amick Jean Davin, BURLINGAME Richard P., Julien Bryan N., PARK Eunyoung
Принадлежит:

Provided are modified valencene synthase polypeptides and methods of using the modified valencene synthase polypeptides. Also provided are methods for producing modified terpene synthases. 1. A nucleic acid molecule encoding a modified valencene synthase polypeptide , wherein:the modified valencene synthase polypeptide comprises a sequence of amino acids that has less than 100% or has 100% identity to the modified valencene synthase polypeptide set forth in SEQ ID NO:3;the modified valencene synthase polypeptide comprises a sequence of amino acids that has less than 95% identity to the valencene synthase polypeptide set forth in SEQ ID NO:2; andthe modified valencene synthase polypeptide comprises a sequence of amino acids that has greater than 62% sequence identity to the valencene synthase set forth in SEQ ID NO:2.2. The nucleic acid molecule of claim 1 , wherein the modified valencene polypeptide comprises a sequence of amino acids that has at least or at last about 82% sequence identity to the valencene synthase set forth in SEQ ID NO:2.3. The nucleic acid molecule of claim 1 , wherein the modified valencene synthase polypeptide comprises a sequence of amino acids that has sequence identity to the valencene synthase set forth in SEQ ID NO:2 that is selected from among less than 95% and more than 75%; less than 94% and more than 75%; less than 93% and more than 75%; less than 92% and more than 75%; less than 95% and more than 80%; less than 94% and more than 80%; less than 93% and more than 80%; less than 92% and more than 80%; less than 95% and more than 85%; less than 94% and more than 85%; less than 93% and more than 85%; and less than 92% and more than 85%.4. A nucleic acid molecule encoding a modified valencene synthase polypeptide claim 1 , wherein:the modified valencene synthase polypeptide does not contain a sequence of amino acids set forth in any of SEQ ID NOS: 289-291, 346, 347, 752, 882, 883 or 886; andthe modified valencene synthase polypeptide ...

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Номер записи: 4
16-05-2013 дата публикации

Novel fragrance and methods for production fo 5-epi-ß-vetivone, 2-isopropyl-6, 10-dimethyl-spiro[4.5]deca-2,6-dien-8-one, and 2-isopropyl-6, 10-dimethyl-spiro[4.5]deca-1, 6-dien-8-one

Номер: US20130122560A1
Автор: Julien Bryan N., Wallace David M.
Принадлежит:

The present invention is directed to novel methods for production of 5-epi-β-vetivone, 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one and 2-isopropyl-6,10-dimethylspiro[4.5]deca-1,6-dien-8-one, which are useful for their fragrant qualities. Provided are methods for production of premnaspirodiene from a terpene substrate, methods for production of 5-epi-β-vetivone from premnaspirodiene as starting material, and methods for production of 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one and 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-1,6-dien-8-one from premnaspirodiene as starting material. 1. A method for synthesizing 5-epi-β-vetivone , comprising the steps of:(a) subjecting (−)-premnaspirodiene to oxidation of an allylic carbon to form (−)-solavetivone; and(b) subjecting the (−)-solavetivone formed in step (a) to acid-catalyzed isomerization to form 5-epi-β-vetivone, wherein time and temperature conditions for step (b) are such that the predominant product is 5-epi-β-vetivone.2. The method of claim 1 , wherein the oxidation of the allylic carbon is performed using a metal oxidant.3. The method of claim 2 , wherein the metal oxidant is selected from among chromium claim 2 , copper claim 2 , rhodium claim 2 , cobalt claim 2 , manganese claim 2 , and vanadium oxidants.4. The method of claim 3 , wherein the oxidation of the allylic carbon is performed using CrOClas an oxidizing agent.5. The method of claim 4 , wherein the oxidation of the allylic carbon is performed in the presence of 3 claim 4 ,5-dimethylpyrazole as a catalyst.6. The method of claim 1 , wherein the oxidation of the allylic carbon is performed using t-butyl hydroperoxide and sodium chlorite.7. The method of claim 1 , wherein the acid-catalyzed isomerization is performed with an acidic isomerization agent.8. The method of claim 7 , wherein the acidic isomerization agent is a mineral acid.9. The method of claim 7 , wherein the acidic isomerization agent is an organic protonic acid.10. The ...

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Номер записи: 5
13-03-2014 дата публикации

Sclareol and labdenediol diphosphate synthase polypeptides, encoding nucleic acid molecules and uses thereof

Номер: US20140073020A1
Автор: Burlingame Richard, Julien Bryan N., Park Grace Eunyoung
Принадлежит: Allylix, Inc.

Provided are labdenediol diphosphate synthase polypeptides, sclareol synthase polypeptides, nucleic acid molecules encoding the labdenediol diphosphate synthase polypeptides and sclareol synthase polypeptides, and methods of using the labdenediol diphosphate synthase polypeptides, sclareol synthase polypeptides. Also provided are methods for producing labdenediol diphosphate, sclareol and (−)-ambroxide. 1Nicotiana glutinosa. An isolated recombinant labdenediol diphosphate synthase.2Nicotiana glutinosa. An isolated nucleic acid molecule encoding a labdenediol diphosphate synthase polypeptide of claim 1 , wherein the nucleic acid molecule is cDNA.3. The isolated nucleic acid molecule of claim 2 , wherein:the labdenediol diphosphate synthase polypeptide comprises a sequence of amino acids set forth in any of SEQ ID NOS:2, 4, 6, 8, 10, 12, 14 and 54; orthe labdenediol diphosphate synthase polypeptide comprises a sequence of amino acids that has at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% sequence identity to a labdenediol diphosphate synthase polypeptide set forth in any of SEQ ID NOS:2, 4, 6, 8, 10, 12, 14 and 54, and the labdenediol diphosphate synthase catalyzes the formation of labdenediol diphosphate from an acyclic pyrophosphate terpene precursor.4. The isolated nucleic acid molecule of claim 3 , comprising a sequence of nucleic acids set forth in any of SEQ ID NOS:1 claim 3 , 3 claim 3 , 5 claim 3 , 7 claim 3 , 9 claim 3 , 11 claim 3 , 13 and 53.5Nicotiana glutinosa. A host cell claim 3 , comprising the labdenediol diphosphate synthase of or a nucleic acid molecule of claim 3 , wherein:{'i': 'Nicotiana glutinosa', 'the labdenediol diphosphate synthase is heterologous to the host cell; and'}the labdenediol diphosphate synthase catalyzes production of a terpene from an acyclic pyrophosphate terpene precursor in the host cell.6. The host cell of claim 5 , wherein:{'i': 'Nicotiana glutinosa', ...

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Номер записи: 6
07-03-2019 дата публикации

COMPOSITIONS AND METHODS FOR REPELLING AND KILLING TICKS AND DETACHMENT OF FEEDING TICKS

Номер: US20190069542A1
Автор: Bradbury Roderick Stephen, Dolan Marc C., Julien Bryan N.
Принадлежит:

Methods for repelling and killing ticks as well as for detaching attached and feeding ticks from the skin of a subject by application of a composition comprising nootkatone to the tick are disclosed. 1. A method for detaching a tick attached to skin of a subject , comprising the steps of:applying a therapeutically effective amount of nootkatone to the attached tick; anddetaching the tick from the skin of the subject.2. A method of preventing tick attachment , or for detaching or killing attached and feeding ticks from skin of an animal , comprising applying a therapeutically effective amount of a nootkatone-containing composition to the animal ,wherein the composition comprises nootkatone ex valencene.3. The method of claim 2 , wherein nootkatone is applied to an exterior surface of the animal.4. The method of or claim 2 , wherein the exterior surface is one or more of fur claim 2 , hair claim 2 , skin claim 2 , hide claim 2 , or scalp.5. The method according to any of the preceding claims further comprising the step of removing the tick from the skin of the animal.6. The method of further comprising applying the nootkatone-containing composition to the tick.7. A method for preventing the attachment of a tick to the skin of a subject claim 5 , comprising the steps of:applying a composition comprising a therapeutically effective amount of nootkatone formulated for topical administration to the skin of the subject; andpreventing the attachment of a tick that contacts the skin of the subject.8. A method for detaching a tick from skin claim 5 , comprising the steps of:providing a composition comprising at least 2% nootkatone formulated for topical administration;applying the composition to a tick attached to a subject's skin; anddetaching the tick from the skin.9. A method for removing a tick attached to a subject's skin claim 5 , comprising:providing a composition comprising at least 2% nootkatone formulated for topical administration; andapplying the composition to ...

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Номер записи: 7
07-03-2019 дата публикации

USE OF NOOTKATONE TO KILL SAP-SUCKING INSECTS

Номер: US20190069543A1
Автор: Amick Jean Davin, Julien Bryan N., Meyer Henrik
Принадлежит:

Compositions comprising nootkatone and a carrier as well as methods for treating and preventing infestations of sap-sucking insects in plants are disclosed herein. 1. A method of treating or preventing sap-sucking infestation of a plant , comprising applying a nootkatone-containing composition to a surface , wherein the surface is a surface of the plant , soil , a planting bed , hydroponics equipment , harvesting equipment , an agricultural tool , a storage container , or a shipping container.2. The method of claim 1 , wherein the nootkatone-containing composition is applied to the surface by an aerosol container with a spray nozzle claim 1 , a spray gun claim 1 , an impregnated sheet claim 1 , a film claim 1 , a matrix claim 1 , a pump sprayer claim 1 , a trigger sprayer claim 1 , a pressurized spraying device claim 1 , a sponge claim 1 , a brush claim 1 , or a roller claim 1 , a tractor claim 1 , an irrigation spray claim 1 , a helicopter claim 1 , or a crop duster or airplane.3. A method of treating or preventing a sap-sucking insect infestation of a plant claim 1 , comprising:(a) providing a nootkatone-containing composition;(b) optionally reducing the concentration of the nootkatone-containing composition to a working concentration with a carrier; and(c) applying the composition to a surface or area to be treated.4. The method of claim 3 , wherein the surface is either a surface of a plant to be treated or a surface of a dispenser.5. The method of further comprising applying the dispenser to a surface to be treated claim 4 , to a plant surface or to an area susceptible to infestation by sap-sucking insects.6. The method of any of claim 4 , claim 4 , or claim 4 , wherein the plant surface claim 4 , the surface to be treated claim 4 , or the area susceptible to infestation by sap-sucking insects is within an agricultural area claim 4 , an agricultural field claim 4 , an arable field claim 4 , a greenhouse claim 4 , an area for mushroom cultivation claim 4 , an ...

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Номер записи: 8
05-05-2022 дата публикации

METHODS AND COMPOSITIONS FOR THE PREVENTION OF INFECTIONS AND ARTHROPOD INFESTATION

Номер: US20220132841A1
Автор: Amick Jean Davin, Greenbaum Kim Thu Le, Julien Bryan N.
Принадлежит:

The invention relates to biting arthropod repellent compositions comprising nootkatone. The application also relates to a method of repelling said biting arthropods by application of the nootkatone composition to a hard or soft surface, to a method of treating an arthropod infestation and to a method of reducing the transmission of a parasite or disease pathogen spread by a biting arthropod using the nootkatone composition.

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Номер записи: 9
28-03-2019 дата публикации

COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING DUST MITE INFESTATION

Номер: US20190090482A1
Автор: Amick Jean Davin, Julien Bryan N.
Принадлежит:

Compositions comprising nootkatone, benzyl benzoate and a carrier as well as methods for treating and preventing dust mite infestations are disclosed herein. 1. A method of treating or preventing dust mite infestation of a surface , comprising applying a nootkatone-containing composition to a surface.2. A method of treating or preventing a dust mite infestation , comprising:(a) providing a nootkatone-containing composition;(b) optionally reducing the concentration of the nootkatone-comprising composition to a working concentration with a carrier; and(c) applying the composition to a surface.3. The method of or , wherein the surface is either the surface to be treated or a surface of a dispenser.4. The method of or , wherein the carrier is a liquid or a powder.5. The method of any of the preceding claims , wherein the nootkatone-comprising composition is a concentrate.6. A method of treating or preventing a dust mite infestation , comprising:applying a nootkatone-containing composition to a surface by a dispenser,wherein the dispenser concomitantly applies the composition to the surface and removes from the surface at least one of dust, dirt, dust mite food, a dust mite allergen, grease, oil, lint, animal hair, an odor, and a stain.7. The method of claim 6 , wherein the dispenser is a brush claim 6 , a sponge claim 6 , a soft-tipped marking device with reservoir claim 6 , a pressurized dispenser claim 6 , an aerosol can claim 6 , a roll on bottle claim 6 , a mop claim 6 , a dust mop claim 6 , a broom claim 6 , a wipe claim 6 , a tissue claim 6 , a duster claim 6 , a duster sheet claim 6 , a wet wipe claim 6 , a wet pad claim 6 , a vacuum rotor claim 6 , a steam cleaner claim 6 , a lint brush claim 6 , a paint brush claim 6 , a paint roller claim 6 , a washing machine claim 6 , or a clothes drier.8. A method of treating or preventing a dust mite infestation claim 6 , comprising:(a) applying a nootkatone-containing composition to a surface; and(b) cleaning the surface ...

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Номер записи: 10
04-04-2019 дата публикации

METHODS AND COMPOSITIONS FOR THE PREVENTION OF INFECTIONS AND ARTHROPOD INFESTATION

Номер: US20190098897A1
Автор: Amick Jean Davin, Greenbaum Kim Thu Le, Julien Bryan N.
Принадлежит:

The invention relates to biting arthropod repellent compositions comprising nootkatone. The application also relates to a method of repelling said biting arthropods by application of the nootkatone composition to a hard or soft surface, to a method of treating an arthropod infestation and to a method of reducing the transmission of a parasite or disease pathogen spread by a biting arthropod using the nootkatone composition. 1. A method of repelling a biting arthropod , comprising:applying an effective amount of a nootkatone composition to a surface,wherein the composition comprises nootkatone ex valencene.2. The method of claim 1 , wherein the composition is applied to an exterior surface of an animal.3. The method of claim 2 , wherein the exterior surface is fur claim 2 , hair claim 2 , skin claim 2 , hide claim 2 , or scalp.4. The method of claim 1 , wherein the composition is applied to a hard surface.5. The method of claim 4 , wherein the hard surface is untreated lumber claim 4 , treated lumber claim 4 , a wood beam claim 4 , a wood board claim 4 , cardboard claim 4 , particle board claim 4 , joist claim 4 , a stud claim 4 , a baseboard claim 4 , wood trim claim 4 , a hardwood floor claim 4 , a window sill claim 4 , a screen claim 4 , a porch floor claim 4 , a deck claim 4 , a door claim 4 , a wall claim 4 , a ceiling claim 4 , interior furniture claim 4 , or exterior furniture.6. The method of claim 1 , wherein the composition is applied to a soft surface.7. The method of claim 6 , wherein the soft surface is one or more of a carpet claim 6 , a curtain claim 6 , a rug claim 6 , padded furniture claim 6 , a cushion claim 6 , a mattress claim 6 , a box spring claim 6 , a mattress cover claim 6 , a bedbug repellent mattress pad claim 6 , a bed sheet claim 6 , a blanket claim 6 , a pillow claim 6 , a doll claim 6 , a stuffed animal claim 6 , or a net.8. The method of or claim 6 , wherein the composition is applied to a bracelet claim 6 , a necklace claim 6 , a ...

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Номер записи: 11
27-11-2014 дата публикации

Sclareol and labdenediol diphosphate synthase polypeptides, encoding nucleic acid molecules and uses thereof

Номер: US20140349352A9
Автор: Bryan N. Julien, Grace Eunyoung Park, Richard Burlingame
Принадлежит: Allylix Inc

Provided are labdenediol diphosphate synthase polypeptides, sclareol synthase polypeptides, nucleic acid molecules encoding the labdenediol diphosphate synthase polypeptides and sclareol synthase polypeptides, and methods of using the labdenediol diphosphate synthase polypeptides, sclareol synthase polypeptides. Also provided are methods for producing labdenediol diphosphate, sclareol and (−)-ambroxide.

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Номер записи: 12
01-10-2015 дата публикации

MODIFIED SANTALENE SYNTHASE POLYPEPTIDES, ENCODING NUCLEIC ACID MOLECULES AND USES THEREOF

Номер: US20150275196A1
Автор: Amick Jean Davin, Julien Bryan N.
Принадлежит:

Provided are modified santalene synthase polypeptides, nucleic acid molecules encoding the modified santalene synthase polypeptides, and methods of using the modified santalene synthase polypeptides. The modified santalene synthase polypeptides include those that catalyze production of increased levels of terpenes or altered profiles thereof or both. 1. A nucleic acid molecule encoding a modified santalene synthase polypeptide or catalytically active fragment thereof , wherein:the modified santalene synthase polypeptide comprises an amino acid modification(s) in the unmodified santalene synthase polypeptide comprising the sequence of amino acids set forth in SEQ ID NO:1, or in a catalytically active fragment thereof;the amino acid modification(s) are selected from among amino acid replacement(s), deletion(s) and insertion(s);the modified santalene synthase polypeptide exhibits at least 75% sequence identity to the santalene synthase set forth in SEQ ID NO:1; i) catalyzes the production of total terpene product(s) from farnesyl diphosphate (FPP) in a host cell in an amount that is greater than the amount of the same total terpene products produced from FPP by the santalene synthase encoded by the sequence of nucleotides set forth in SEQ ID NO:3 in the same host cell and under the same conditions; and', 'ii) catalyzes the production of terpene product(s) from farnesyl diphosphate (FPP) in a host cell with an altered product profile compared to the profile of the terpene products produced from FPP by the santalene synthase encoded by the sequence of nucleotides set forth in SEQ ID NO:3 in the same host cell and under the same conditions;, 'the encoded modified santalene synthase polypeptidethe host cell is a cell that produces FPP; andthe terpene product or products is a sesquiterpene.2. The nucleic acid molecule of claim 1 , wherein the terpene product(s) comprise α-santalene claim 1 , α-exo-bergamotene claim 1 , epi-β-santalene claim 1 , β-santalene claim 1 , or ...

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Номер записи: 13
25-07-2017 дата публикации

Modified santalene synthase polypeptides, encoding nucleic acid molecules and uses thereof

Номер: US9714418B2
Автор: Bryan N. Julien, Jean Davin Amick
Принадлежит: Evolva Inc

Provided are modified santalene synthase polypeptides, nucleic acid molecules encoding the modified santalene synthase polypeptides, and methods of using the modified santalene synthase polypeptides. The modified santalene synthase polypeptides include those that catalyze production of increased levels of terpenes or altered profiles thereof or both.

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Номер записи: 14
08-02-2017 дата публикации

Modified santalene synthase polypeptides, encoding nucleic acid molecules and uses thereof

Номер: EP3126492A2
Автор: Bryan N. Julien, Jean Davin Amick
Принадлежит: Evolva Inc

Provided are modified santalene synthase polypeptides, nucleic acid molecules encoding the modified santalene synthase polypeptides, and methods of using the modified santalene synthase polypeptides. The modified santalene synthase polypeptides include those that catalyze production of increased levels of terpenes or altered profiles thereof or both.

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Номер записи: 15
18-12-2008 дата публикации

NOVEL METHODS FOR PRODUCTION OF 5-EPI-β-VETIVONE, 2-ISOPROPYL-6,10-DIMETHYL-SPIRO[4.5]DECA-2,6-DIEN-8-ONE, AND 2-ISOPROPYL-6,10-DIMETHYL-SPIRO[4.5]DECA-1,6-DIEN-8-ONE

Номер: WO2008116056A3
Автор: Bryan N Julien, David M Wallace
Принадлежит: Allylix Inc, Bryan N Julien, David M Wallace

The present invention is directed to novel methods for production of 5-epi-β-vetivone, 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one and 2-isopropyl-6,10-dimethyl-spiro[4,5]deca-1,6-dien-8-one, which are useful for their fragrant qualities, in one embodiment the present invention describes a method for production of 5-epi-β-vetivone by the use of premnaspirodiene as starting material. In another embodiment the present invention describes a method for production of 2-isopropyl-6,10-dimethyl- spiro[4.5]deca-2,6-dien-8-one and 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-1,6-dien-8-one by the use of premnaspirodiene as starting material. In yet another embodiment the present invention describes a novel method for production of premnaspirodiene from a terpene substrate.

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Номер записи: 16
30-01-2019 дата публикации

Compositions and methods for treating and preventing dust mite infestation

Номер: EP3432710A1
Автор: Bryan N Julien, Jean Davin Amick
Принадлежит: Evolva AG

Compositions comprising nootkatone, benzyl benzoate and a carrier as well as methods for treating and preventing dust mite infestations are disclosed herein.

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Номер записи: 17
02-08-2012 дата публикации

Novel Methods for Production of 5-epi-beta-vetivone, 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one, and 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-1,6-dien-8-one

Номер: AU2012204126A1
Автор: Bryan N. Julien, David M. Wallace
Принадлежит: Allylix Inc

The present invention is directed to novel methods for production of 5-epi-p-vetivone, 2-isopropyl 6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one and 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-1,6 dien-8-one, which are useful for their fragrant qualities. In one embodiment the present invention describes a method for production of 5-epi-p-vetivone by the use of premnaspirodiene as starting material. In another embodiment the present invention describes a method for production of 2 isopropyl-6,1 0-dimethyl-spiro[4.5]deca-2,6-dien-8-one and 2-isopropyl-6, 1 0-dimethyl spiro[4.5]deca-1,6-dien-8-one by the use of premnaspirodiene as starting material. In yet another embodiment the present invention describes a novel method for production of premnaspirodiene from a terpene substrate. Use of the fragrant components or any composition containing the component can be advantageously employed in the perfumery industry. Fig ure 4 ~~~S CrO2CI2, t-BuOH o DMP, CH2CI2 0EtOll0 (-)-Premnaspirodiefle (+)SolaveivoilC 45 min (-ei',-etv (2) .(5)(1 DMP=3,5-dimethylpyrazole [1-liAmberlyst- 15 ion exchangeren Fig ure 5 O_ shorter time (-)-premnaspirodiefle (2) (-)-solavetivone (5) (2) 5-epi-f3-vetivone (1) longer tim (21 b) 2,6-diene isomer (3) i ,6-diene isomer (4)

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Номер записи: 18
27-05-2010 дата публикации

Novel fragrance and methods for production of 5-epi-beta-vetivone, 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one, and 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-1,6-dien-8-one

Номер: US20100129306A1
Автор: Bryan N. Julien, David M. Wallace
Принадлежит: Allylix Inc

The present invention is directed to novel methods for production of 5-epi-β-vetivone, 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one and 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-1,6-dien-8-one, which are useful for their fragrant qualities. In one embodiment the present invention describes a method for production of 5-epi-β-vetivone by the use of premnaspirodiene as starting material. In another embodiment the present invention describes a method for production of 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one and 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-1,6-dien-8-one by the use of premnaspirodiene as starting material. In yet another embodiment the present invention describes a novel method for production of premnaspirodiene from a terpene substrate. Use of the fragrant components or any composition containing the component can be advantageously employed in the perfumery industry.

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Номер записи: 19
03-05-2012 дата публикации

Modified valencene synthase polypeptides, encoding nucleic acid molecules and uses thereof

Номер: CA2815829A1
Автор: Bryan N. Julien, Grace Eunyoung Park, Jean Davin Amick, Richard P. Burlingame
Принадлежит: Allylix Inc

Provided are modified valencene synthase polypeptides and methods of using modified valencene synthase polypeptides. Also provided are methods for producing modified terpene synthases.

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Номер записи: 20
29-12-2021 дата публикации

Sclareol and labdenediol diphosphate synthase polypeptides, encoding nucleic acid molecules and uses thereof

Номер: EP3929289A1
Автор: Bryan N Julien, Grace Eunyoung Park, Richard Burlingame
Принадлежит: Evolva Inc

Provided are labdenediol diphosphate synthase polypeptides, sclareol synthase polypeptides, nucleic acid molecules encoding the labdenediol diphosphate synthase polypeptides and sclareol synthase polypeptides, and methods of using the labdenediol diphosphate synthase polypeptides, sclareol synthase polypeptides. Also provided are methods for producing labdenediol diphosphate, sclareol and (-)-ambroxide.

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Номер записи: 21
28-09-2017 дата публикации

Use of nootkatone to kill sap-sucking insects

Номер: WO2017162887A1
Автор: Bryan N. Julien, Henrik Meyer, Jean Davin Amick
Принадлежит: EVOLVA SA

Compositions comprising nootkatone and a carrier as well as methods for treating and preventing infestations of sap-sucking insects in plants are disclosed herein.

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Номер записи: 22
30-01-2019 дата публикации

Compositions and methods for repelling and killing ticks and detachment of feeding ticks

Номер: EP3432712A1
Автор: Bryan N. Julien, Marc C. Dolan, Roderick Stephen Bradbury
Принадлежит: Evolva AG, US Department of Health and Human Services

Methods for repelling and killing ticks as well as for detaching attached and feeding ticks from the skin of a subject by application of a composition comprising nootkatone to the tick are disclosed.

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Номер записи: 23
31-10-2023 дата публикации

Methods of repelling biting arthropods, reducing pathogen spread and treating arthropod infestation

Номер: US11800867B2
Автор: Bryan N. Julien, Jean Davin Amick, Kim Thu Le Greenbaum
Принадлежит: Evolva AG

The invention relates to biting arthropod repellent compositions comprising nootkatone. The application also relates to a method of repelling said biting arthropods by application of the nootkatone composition to a hard or soft surface, to a method of treating an arthropod infestation and to a method of reducing the transmission of a parasite or disease pathogen spread by a biting arthropod using the nootkatone composition.

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Номер записи: 24
28-09-2017 дата публикации

Compositions and methods for repelling and killing ticks and detachment of feeding ticks

Номер: WO2017162886A1
Автор: Bryan N. Julien, Marc C. Dolan, Roderick Stephen Bradbury
Принадлежит: Centers for Disease Control and Prevention, EVOLVA SA

Methods for repelling and killing ticks as well as for detaching attached and feeding ticks from the skin of a subject by application of a composition comprising nootkatone to the tick are disclosed.

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Номер записи: 25
16-11-2017 дата публикации

Methods and compositions for the prevention of infections and arthropod infestation

Номер: WO2017162883A9
Автор: Bryan N. Julien, Jean Davin Amick, Kim Thu Le Greenbaum
Принадлежит: EVOLVA SA

The invention relates to biting arthropod repellent compositions comprising nootkatone. The application also relates to a method of repelling said biting arthropods by application of the nootkatone composition to a hard or soft surface, to a method of treating an arthropod infestation and to a method of reducing the transmission of a parasite or disease pathogen spread by a biting arthropod using the nootkatone composition.

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Номер записи: 26