20-12-2012 дата публикации
Номер: US20120321709A1
Disclosed are a complex formulation for oral administration comprising probiotic formulation and 5-HT4 receptor agonist, and a method for the preparation thereof. 1. A complex formulation for oral administration which comprises a capsule comprising a core containing a probiotic and a pharmaceutically acceptable excipient;an enteric coating layer coated on the capsule; anda 5-HT4 receptor agonist layer containing a 5-HT4 receptor agonist, which is formed on the surface of the enteric coating layer.2Bacillus cereus, Bacillus licheniformis, Bacillus subtilis, Bifidobacterium bifidum, Bifidobacterium infantis, Bifidobacterium longum, Enterococcus faecium, Enterococcus faecalis, Lactobacillus acidopilus, Lactobacillus alimentarius, Lactobacillus bulgaricus, Lactobacillus casei, Lactobacillus curvatus, Lactobacillus delbrukii, Lactobacillus johnsonii, Lactobacillus farciminus, Lactobacillus gasseri, Lactobacillus helveticus, Lactobacillus rhamnosus, Lactobacillus reuteri, Lactobacillus sake, Lactococcus lactis, Streptococcus faecium, Streptococcus faecalis, Streptococcus agalactiae, Streptococcus mutans. The complex formulation for oral administration of claim 1 , wherein the probiotic is selected from the group consisting of claim 1 , and a mixture thereof.3. The complex formulation for oral administration of claim 1 , wherein the core contains the probiotic in an amount of at least one billion cells.4. The complex formulation for oral administration of claim 1 , wherein the enteric coating layer comprises an enteric coating material selected from the group consisting of an enteric cellulose derivative selected from the group consisting of hydroxypropylmethylcellulose acetate succinate claim 1 , hydroxypropylmethylcellulose phthalate claim 1 , hydroxymethylethylcellulose phthalate claim 1 , celluloseacetate phthalate claim 1 , celluloseacetate malate claim 1 , celluloseacetate succinate claim 1 , cellulosebenzoate phthalate claim 1 , cellulosepropionate phthalate claim 1 ...
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