ELEKTRODENSTABILISIERTE HOCHDRUCKENTLADUNGSLAMPE MIT LEUCHTZUSAETZEN

Stabilisieren von hochmolekularen Polyoxymethylenen

Rodent station

A rodent station for capturing or trapping mice, rats or other rodents may provide one or more rodent entry points and is sized to receive one or more rodent suppression devices, such as conventional snap traps, ramp traps, glue boards, etc. The rodent station may present a high contrast entrance that is relatively darker than the station enclosure. The station opening size may be adjustable to accommodate both mice and/or rats. An interior receptacle for station maintenance records or other printed material may also be included.

Apparatus for controlling discharge of material from a railroad hopper car

An apparatus for controlling the discharge of materials from a railcar having a hopper carried on a mobile frame. The hopper defines a longitudinally disposed discharge opening. The railcar has a door pivotally mounted for movement between an open position and a closed position relative to the discharge opening. The apparatus for controlling the discharge of materials from the railcar includes an operating shaft and a drive operably coupled between the door and the operating shaft for causing the door to move from the closed position toward the open position in response to rotation of the operating shaft. The drive also includes a lost motion connection for protecting the operating shaft as the door freely pivots toward the open position during collapsing movement of the lost motion connection and after the operating shaft has been rotated a predetermined amount to open the door.

Method of providing heating to a user

A method of providing heat to a user, comprising an energy retailer offering a supply energy over a contract period at a given amount of energy per use period.

Tissue specimen stage for an optical sectioning microscope

A tissue specimen stage is provided having a window with surface curvature upon which an excised tissue specimen is locatable, a carriage having a tissue specimen receptacle to which the window is mounted, and a platform supporting the carriage and presenting the window to the objective lens of an optical sectioning microscope. The carriage is mounted to the platform for movement along two rotational axes so that the carriage's movement follows the curvature of all or part of the window while maintaining the same optical geometry of the window with respect to the objective lens. The window has surface curvature adapted to at least approximate the shape or curvature of the non-histologically prepared tissue specimen to be placed thereupon.

Surface coating system and method of using surface coating system

A coating system for a surface (such as a floor) including a liquid adhesive layer composition including a heat-activated adhesive that forms an adhesive layer upon drying after application to a surface, and a liquid maintenance layer composition comprising a dispersible polymer that forms a maintenance layer upon drying after application to the adhesive layer. The adhesive layer and the maintenance layer may form a peelable coating. An adhesive strength between the adhesive layer and the maintenance layer may be greater than an adhesive strength between the adhesive layer and the surface. The peelable coating may have a tensile strength that is greater than the adhesive strength between the adhesive layer and the surface. The peelable coating may be configured to be peeled from the surface without the adhesive layer and the maintenance layer separating from one another.

Effective generation of tumor-targeted t cells derived from pluripotent stem cells

The present invention relates to the field of adoptive immunotherapy. The invention provides methods for generating phenotypically defined, functional, and/or expandable T cells from pluripotent stem cells engineered through safe genetic modifications. The engineered cells may provide one or more of: 1) targeting a specific predetermined antigen expressed on the cell surface of a target cell in an HLA independent manner, 2) enhanced survival and functional potential 3) “off-the-shelf” T cells for administration to multiple recipients, eventually across immunogenic barriers, and/or 4) cytotoxic potential and anti-tumor activity.

Fully Distributed Routing over a User-Configured On-Demand Virtual Network for Infrastructure-as-a-Service (IaaS) on Hybrid Cloud Networks

A layer-3 virtual router connects two or more virtual networks. Virtual networks are overlaid upon physical networks. Each virtual network (VN) is a layer-2 network that appears to expand an organization's LAN using virtual MAC addresses. The network stack forms a virtual-network packet with a virtual gateway MAC address of the virtual router to reach a remote virtual network. A VN device driver shim intercepts packets and their virtual MAC and IP addresses and encapsulates them with physical packets sent over the Internet. A VN switch table is expanded to include entries for nodes on the remote virtual network so that all nodes on both virtual networks are accessible. A copy of the VN switch table is stored on each node by a virtual network management daemon on the node. A Time-To-Live field in the virtual-network packet is decremented for each virtual hop and a checksum recalculated.

Shaped charge utilizing polymer coated petn

A shaped charge for perforating a formation surrounding a wellbore. The shaped charge including a casing having a section with polymer-coated explosives and a liner encapsulating the section with the polymer coated explosives. The polymer-coated explosives includes a booster explosive and a main load explosive. The booster explosive and the main load explosive are PETN. The polymer is a low-density polyethylene.

Brake-by-wire system

A vehicle includes a plurality of brake assemblies and a plurality of electronic brake system (EBS) controllers. The brake assemblies each include an electro-mechanical actuator configured to adjust a torque force applied to a wheel of the vehicle. The EBS controllers are located remotely from one another. Each EBS controller has integrated therein an electronic actuator driver unit that includes an electronic power circuit configured to drive at least one of the electro-mechanical actuators. A first EBS controller is configured to drive a first group of electro-mechanical actuators, and a second EBS controller is configured to drive a second group of electro-mechanical actuators that exclude the electro-mechanical actuators of the first group.

Portland cement manufacture using municipal solid waste incineration ash

Various examples related to portland cement manufacturing using municipal solid waste incineration (MSWI) ash are provided. In one example, a method includes providing a raw kiln feed including MSWI to a kiln, forming ash-amended clinker (ACK) by heating the raw kiln feed in the kiln, and preparing ash-amended cement (AAC) from the ACK. The MSWI bottom ash can make up about 5% by mass or less of the raw kiln feed. The ACK can have a chemical composition that meets ASTM C150/ASTM C595, and the AAC can include arsenic, barium, copper, and lead consistent with defined Soil Cleanup Target Levels. In another example, a system includes a kiln, a kiln feed system that supplies raw kiln feed including MSWI bottom ash to the kiln, and a finish mill that grinds ACK formed by heating the raw kiln feed in the kiln to form AAC.

Confocal microscope with positionable imaging head

A confocal microscope for imaging tissue having an imaging head for capturing optically formed microscopic sectional images of tissue samples, a platform upon which is disposed a linear stage for moving the imaging head along a vertical dimension, and a rotary stage to rotate the linear stage and imaging head about the vertical dimension. A mounting arm couples the imaging head to the linear stage to adjust tilt of the imaging head and to rotate the imaging head about a normal axis perpendicular to an optical axis of an objective lens of the imaging head. In a first mode of operation, the imaging head is positioned to image an ex-vivo or in-vivo tissue sample upon the platform, such as ex-vivo tissue sample mounted upon a movable specimen stage, and in a second mode of operation the imaging head is positioned to image an in-vivo tissue sample beside the platform.

Cascode Amplifier Bias Circuits

Bias circuits and methods for silicon-based amplifier architectures that are tolerant of supply and bias voltage variations, bias current variations, and transistor stack height, and compensate for poor output resistance characteristics. Embodiments include power amplifiers and low-noise amplifiers that utilize a cascode reference circuit to bias the final stages of a cascode amplifier under the control of a closed loop bias control circuit. The closed loop bias control circuit ensures that the current in the cascode reference circuit is approximately equal to a selected multiple of a known current value by adjusting the gate bias voltage to the final stage of the cascode amplifier. The final current through the cascode amplifier is a multiple of the current in the cascode reference circuit, based on a device scaling factor representing the relative sizes of the transistor devices in the cascode amplifier and in the cascode reference circuit.

Ice handling container

The invention is an improved ice handling container and methods for using the container. The container includes a bottom wall with upstanding sidewalls terminating in a mouth. A bail having an apex and opposing ends is pivotally attached to opposing sidewalls of the container. The bail has a handle generally at the apex and a hook extending generally outwardly from the bail generally near the apex of the bail for hanging the container with the mouth facing generally upward. One sidewall has a handle generally adjacent the bottom wall and a hook generally adjacent the handle extending generally outwardly and upwardly from the sidewall for hanging the container with the mouth facing generally downward.

Cross-domain content-lifecycle management

A content-lifecycle management system (CLMS) intercepts a request to perform an action upon a data object in a domain of a multi-domain computing environment during a certain phase of the object's lifecycle. The CLMS retrieves data and rules from a cross-domain distributed ledger that is accessible throughout the multi-domain environment. The retrieved information includes content-lifecycle management policies that control which actors can perform certain types of actions upon specific data objects during various lifecycle phases. The ledger also describes and classifies actors, dependency relationships between storage and infrastructure components of the environment, and the results of past requests. If the CLMS, using the ledger information, determines that performing the requested action would neither disrupt access to the data object nor be prohibited by the policies, the CLMS directs an appropriate content-management technology to perform the action, updates the ledger, and reports any rejected requests to other lifecycle-management components.

Non-aerosol foaming alcohol hand sanitizer

A non-aerosol, foaming high alcohol content hand sanitizer is provided which has excellent antimicrobial activity and tolerance for organic load and excellent residual activity, as well as enhanced moisturization and skin-feel properties over currently marketed alcohol-based sanitizers. The inventive composition achieves an unexpectedly large amount of quality, stable foam even in the presence of significant quantities of skin conditioning agents through the use of novel silicone surfactants and achieves enhanced and prolonged antimicrobial efficacy through the combination of high alcohol content and activity enhancing components.

Compositions and methods for immunotherapy

The present invention provides immunoresponsive cells, including T cells, cytotoxic T cells, regulatory T cells, and Natural Killer (NK) cells, expressing at least one of an antigen recognizing receptor and one of a chimeric costimulatory receptor. Methods of using the immunoresponsive cell include those for the treatment of neoplasia and other pathologies where an increase in an antigen-specific immune response is desired.

Compositions and methods for immunotherapy

The present invention provides immunoresponsive cells, including T cells, cytotoxic T cells, regulatory T cells, and Natural Killer (NK) cells, expressing at least one of an antigen recognizing receptor and one of a chimeric costimulatory receptor. Methods of using the immunoresponsive cell include those for the treatment of neoplasia and other pathologies where an increase in an antigen-specific immune response is desired.

EFFECTIVE GENERATION OF TUMOR-TARGETED T CELLS DERIVED FROM PLURIPOTENT STEM CELLS

The present invention relates to the field of adoptive immunotherapy. The invention provides methods for generating phenotypically defined, functional, and/or expandable T cells from pluripotent stem cells engineered through safe genetic modifications. The engineered cells may provide one or more of: 1) targeting a specific predetermined antigen expressed on the cell surface of a target cell in an HLA independent manner, 2) enhanced survival and functional potential 3) “off-the-shelf” T cells for administration to multiple recipients, eventually across immunogenic barriers, and/or 4) cytotoxic potential and anti-tumor activity. 149.-. (canceled)50. A pluripotent stem cell that comprises a rearranged T-cell receptor (TCR) locus and expresses a chimeric antigen receptor (CAR) , wherein the pluripotent stem cell is derived from a T cell.51. The pluripotent stem cell of claim 50 , wherein (i) the pluripotent stem cell is transduced with the CAR; (ii) pluripotent stem cell does not express TCR on the cell surface; and/or (iii) said CAR binds to a tumor antigen.52. The pluripotent stem cell of claim 51 , wherein said tumor antigen is selected from the group consisting of carbonic anhydrase IX (CA1X) claim 51 , carcinoembryonic antigen (CEA) claim 51 , CD5 claim 51 , CD7 claim 51 , CD10 claim 51 , CD19 claim 51 , CD20 claim 51 , CD22 claim 51 , CD30 claim 51 , CD33 claim 51 , CD34 claim 51 , CD38 claim 51 , CD41 claim 51 , CD44 claim 51 , CD49f claim 51 , CD56 claim 51 , CD74 claim 51 , CD123 claim 51 , CD133 claim 51 , CD138 claim 51 , an antigen of a cytomegalovirus (CMV) infected cell (e.g. claim 51 , a cell surface antigen) claim 51 , epithelial glycoprotein2 (EGP 2) claim 51 , epithelial glycoprotein-40 (EGP-40) claim 51 , epithelial cell adhesion molecule (EpCAM) claim 51 , receptor tyrosine-protein kinases erb-B2 claim 51 ,3 claim 51 ,4 claim 51 , folate-binding protein (FBP) claim 51 , fetal acetylcholine receptor (AChR) claim 51 , folate receptor-a claim 51 , ...

Oriented Detection Perforating Device

A perforating system and method includes a perforating gun with shaped charges and an orientation device. The orientation device provides an orientation datum. Sensors associated with the perforating gun detect relative alignment of each perforating gun as compared to the orientation datum. A detonation signal can be either sent or not sent to the perforating gun in response to the signal received from the orientation sensor.

Methods for synthesis of encoded libraries

The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

Compositions and methods for immunotherapy

The present invention provides immunoresponsive cells, including T cells, cytotoxic T cells, regulatory T cells, and Natural Killer (NK) cells, expressing at least one of an antigen recognizing receptor and one of a chimeric costimulatory receptor. Methods of using the immunoresponsive cell include those for the treatment of neoplasia and other pathologies where an increase in an antigen-specific immune response is desired.

Mechanically driven modular diaphragm pump

Modular mechanically driven diaphragm pump features are presented herein. Such a diaphragm pump can include a motor, a drive mechanism, and a coupling mounted on a wheeled frame. A diaphragm pump can be mounted to the coupling by forming mechanical static and dynamic connections to brace a housing of the diaphragm pump relative to a drive rod which is moved by the drive mechanism to operate the pump. These mechanical static and dynamic connections can be broken to dismount the pump for replacement or servicing. In some cases, a gas charge can be introduced on the non-working fluid side of the diaphragm to boost performance and/or a dampener can be integrated into the housing of the diaphragm pump and mounted/dismounted with the diaphragm pump.

Handheld sanitary fluid sprayer having resilient polymer pump cylinder

A pump draws fluid from a reservoir and drives the fluid downstream to a spray tip where the fluid is applied to a surface. The pump includes a polymer pump body and a metallic piston configured to reciprocate relative to and within the polymer pump body. The metallic piston interfaces with an inner cylinder formed within the polymer pump body and pumps fluid through the polymer pump body to a spray nozzle downstream of the inner cylinder.

Constant Vds1 bias control for stacked transistor configuration

Various methods and circuital arrangements for biasing one or more gates of stacked transistors of an amplifier are presented, where the amplifier can have a varying supply voltage. According to one aspect, the gate of the input transistor of the amplifier is biased with a fixed voltage whereas the gates of the other transistors of the amplifier are biased with variable voltages that are linear functions of the varying supply voltage. According to another aspect, the linear functions are such that the variable voltages coincide with the fixed voltage at a value of the varying supply voltage for which the input transistor is at the edge of triode. According to another aspect, biasing of the stacked transistors is such that, while the supply voltage varies, the drain-to-source voltage of the input transistor is maintained to a fixed value whereas the drain-to-source voltages of all other transistors are equal to one another.

Surface coating system and method

The present invention provides coating systems for surfaces and methods for coating and repairing surfaces.

Surface coating system and method of using surface coating system

A coating system for a surface (such as a floor) including a liquid adhesive layer composition including a heat-activated adhesive that forms an adhesive layer upon drying after application to a surface, and a liquid maintenance layer composition comprising a dispersible polymer that forms a maintenance layer upon drying after application to the adhesive layer. The adhesive layer and the maintenance layer may form a peelable coating. An adhesive strength between the adhesive layer and the maintenance layer may be greater than an adhesive strength between the adhesive layer and the surface. The peelable coating may have a tensile strength that is greater than the adhesive strength between the adhesive layer and the surface. The peelable coating may be configured to be peeled from the surface without the adhesive layer and the maintenance layer separating from one another.

Railroad hopper car door assembly

A discharge door assembly for a bottom dump covered railroad hopper car is provided. The discharge door assembly includes a plurality of longitudinally mounted discharge doors arranged in end-to-end relation across a bottom of the hopper car; with each discharge door being movable between open and closed positions about a pivot axis disposed parallel to and adjacent a longitudinal axis of the hopper car. A door operating mechanism including a single powered actuator operates all of the discharge doors substantially simultaneously to effect rapid discharge of matter from the hopper with significantly less operator involvement. The door operating mechanism further includes a lock for releasably holding the discharge doors in a closed position. A venting system inhibits imploding of the walls of the hopper car upon discharge of particulate matter from the car. Deflectors are arranged on opposite sides of the hopper car to combine with the pivoted discharge doors in limiting the discharge pattern of material from the hopper car to a relatively narrow pattern or stream disposed between the rails on which the hopper car moves.

Railroad hopper car door assembly

An apparatus for controlling discharge of material from a bottom dump railroad car having a centersill defining a longitudinal axis for the hopper car is disclosed. The apparatus includes a plurality of longitudinally mounted discharge door assemblies. Each door assembly comprises a pair of longitudinally mounted discharge doors disposed to opposite lateral sides of the longitudinal axis of the car for movement between open and closed positions relative to respective discharge openings on a bottom of the car. Each discharge door is mounted for movement about an axis disposed adjacent and extending generally parallel to the longitudinal axis of the car. A door operating mechanism including a positively driven actuator is carried on the hopper car for operating at least one of the discharge door assemblies independently of at least one other discharge door assembly on the car. The door operating mechanism includes a primary lock for inhibiting inadvertent movement of the discharge doors of each door assembly to an open position. A secondary lock, operable in timed relation to the door operating mechanism, is disclosed for releasably maintaining the discharge doors of each discharge door assembly in a closed position.

Pump/intermediate heat exchanger assembly for a liquid metal reactor

A heat exchanger and electromagnetic pump assembly is disclosed as comprising a heat exchanger including a housing for defining an annularly shaped cavity and supporting therein a plurality of tubes. An electromagnetic pump is disposed beneath the heat exchanger and is comprised of a plurality of flow couplers disposed in a circular array. Each flow coupler is comprised of a pump duct for receiving primary liquid metal, and a generator duct for receiving an intermediate liquid metal. A downcomer tube is disposed centrally of the assembly and passes through the annularly shaped cavity and the array of flow couplers to discharge the intermediate fluid into a first plenum chamber. The first plenum chamber is disposed in communication with the generator ducts of all of the flow couplers, thus permitting the intermediate liquid metal to flow upward therethrough. The generator ducts exit their flows of the intermediate liquid metal in common to a second plenum chamber, which is disposed in communication with the annularly shaped cavity to permit the flow of the intermediate liquid metal therethrough, whereby the intermediate liquid metal is heated by the flow of the primary liquid metal through the tubes. A third plenum chamber receives collectively the flows of the primary liquid metals from the tube and for directing the primary liquid metal to the pump ducts of the flow couplers, whereby a force is exerted on the primary liquid metal, pumping it through the pump ducts.

Systems and methods for introducing elements into tissue

Systems, devices and methods for securing tissue including the annulus of a mitral valve. The systems, devices and methods may employ catheter based techniques and devices to plicate tissue and perform an annuloplasty.

Secreted proteins and uses thereof

The invention provides isolated nucleic acid molecules, designated TANGO 228 nucleic acid molecules, which encode secreted proteins with homology to the rat MCA-32 protein, isolated nucleic acid molecules, designated TANGO 240 nucleic acid molecules, which encode secreted proteins with homology to the Mycobacterium tuberculosis hypothetical protein Rv0712, and isolated nucleic acid molecules, designated TANGO 243 nucleic acid molecules, which encode proteins with homology to human PLAP (phospholipase A2-activating protein). The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic polypeptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

Secreted proteins and uses thereof

The invention provides isolated nucleic acid molecules, designated TANGO 228 nucleic acid molecules, which encode secreted proteins with homology to the rat MCA-32 protein, isolated nucleic acid molecules, designated TANGO 240 nucleic acid molecules, which encode secreted proteins with homology to the Mycobacterium tuberculosis hypothetical protein Rv0712, and isolated nucleic acid molecules, designated TANGO 243 nucleic acid molecules, which encode proteins with homology to human PLAP (phospholipase A2-activating protein). The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic polypeptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

Method of producing tertiary amyl ethyl ether

A process for the production of tertiary ethers, including: feeding a hydrocarbon stream comprising isoolefins and propionitrile to a distillation column reactor system containing at least one etherification reaction zone; feeding a C 2 to C 6 monoalcohol or mixture thereof to the distillation column reactor; concurrently in the distillation column reactor system: reacting a portion of the isoolefins with a portion of the alcohols to form a tertiary ether; and separating the tertiary ether from unreacted isoolefins; withdrawing the tertiary ether and propionitrile from the distillation column reactor system as a bottoms; withdrawing the unreacted isoolefins from the distillation column reactor system as an overheads; and operating the distillation column reactor system such that the etherification reaction zone is substantially free of propionitrile.

Modulators of β-amyloid peptide aggregation comprising D-amino acids

Compounds that modulate natural β amyloid peptide aggregation are provided. The modulators of the invention comprise a peptide, preferably based on a β amyloid peptide, that is comprised entirely of D-amino acids. Preferably, the peptide comprises 3-5 D-amino acid residues and includes at least two D-amino acid residues independently selected from the group consisting of D-leucine, D-phenylalanine and D-valine. In a particularly preferred embodiment, the peptide is a retro-inverso isomer of a β amyloid peptide, preferably a retro-inverso isomer of Aβ 17-21 . In certain embodiments, the peptide is modified at the amino-terminus, the carboxy-terminus, or both. Preferred amino-terminal modifying groups include cyclic, heterocyclic, polycyclic and branched alkyl groups. Preferred carboxy-terminal modifying groups include an amide group, an alkyl amide group, an aryl amide group or a hydroxy group. Pharmaceutical compositions comprising the compounds of the invention, and diagnostic and treatment methods for amyloidogenic diseases using the compounds of the invention, are also disclosed.

methods for synthesizing a molecule comprising a functional portion operably linked to a coding oligonucleotide

"MÉTODOS PARA A SINTESE DE BIBLIOTECAS CODIFICADAS". A presente invenção proporciona um método de síntese de bibliotecas de moléculas as quais incluem um rótulo de oligonucleotídeo de codificação. "METHODS FOR THE SYNTHESIS OF CODED LIBRARIES". The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide label.

Methods for synthesis of encoded libraries

The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

Methods for synthesis of encoded libraries

The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

Methods for synthesis of encoded libraries

The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

Methods for synthesis of encoded libraries

P:\OPER\MAL1X O671702 Div doc-1/9/2lx9 Abstract The present invention provides a method of synthesizing libraries of molecules 5 which include an encoding oligonucleotide tag.

Methods for synthesis of encoded libraries

The present invention provides methods of synthesizing a molecule comprising a functional moiety which is operatively linked to an encoding oligonucleotide. The methods include providing an initiator compound comprising an initial functional moiety comprising n building blocks, wherein the initial functional moiety comprises at least one reactive group, and is operatively linked to an initial oligonucleotide; reacting the initiator compound with a building block comprising at least one complementary reactive group, under conditions suitable for reaction of the complementary reactive group to form a covalent bond; and reacting the initial oligonucleotide with an incoming oligonucleotide corresponding to the building block in the presence of an enzyme which catalyzes ligation of the initial oligonucleotide and the incoming oligonucleotide, under conditions suitable for ligation of the incoming oligonucleotide and the initial oligonucleotide to form an encoding oligonucleotide.

Methods for synthesis of encoded libraries

The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

Methods for synthesis of encoded libraries

The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

Methods for identifying compounds of interest using encoded libraries

The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.

Methods for synthesis of encoded libraries

The present invention provides methods of synthesizing libraries of molecules comprising a functional moiety which is operatively linked to an encoding oligonucleotide. The methods generally include providing a solution comprising initiator compounds comprising an initial functional moiety which comprises n building blocks which comprise at least one reactive group, which is operatively linked to an initial oligonucleotide; dividing the solution into reaction vessels; reacting the initiator compounds in each reaction vessel with a building block comprising a complementary reactive group to form a covalent bond; and reacting the initial oligonucleotide in each aliquot with a distinct incoming oligonucleotide in the presence of an enzyme which catalyzes the ligation of the incoming oligonucleotide and the initial oligonucleotide, under conditions suitable for enzymatic ligation of the incoming oligonucleotide and the initial oligonucleotide to form an encoding oligonucleotide which identifies the structure of the functional moiety.

Methods for synthesis of encoded libraries

The present invention provides methods of synthesizing libraries of molecules comprising a functional moiety which is operatively linked to an encoding oligonucleotide, wherein the encoding oligonucleotide comprises a capping sequence containing degenerate nucleotides. The methods generally include providing a solution comprising initiator compounds comprising an initial functional moiety comprising n building blocks which is operatively linked to an initial oligonucleotide; dividing the solution into reaction vessels; reacting the initiator compounds in each reaction vessel with a building block comprising a complementary reactive group to form a covalent bond; and reacting the initial oligonucleotide in each aliquot with a distinct incoming oligonucleotide in the presence of an enzyme which catalyzes the ligation of the incoming oligonucleotide and the initial oligonucleotide, under conditions suitable for enzymatic ligation of the incoming oligonucleotide and the initial oligonucleotide to form an encoding oligonucleotide.

World-wide-web server with delayed resource-binding for resource-based load balancing on a distributed resource multi-node network

A multi-node server transmits world-wide-web pages to network-based browser clients. A load balancer receives all requests from clients because they use a virtual address for the entire site. The load balancer makes a connection with the client and waits for the URL from the client. The URL specifies the requested resource. The load balancer waits to perform load balancing until after the location of the requested resource is known. The connection and URL request are passed from the load balancer to a second node having the requested resource. The load balancer re-plays the initial connection packet sequence to the second node, but modifies the address to that for the second node. The network software is modified to generate the physical network address of the second node, but then changes the destination address back to the virtual address. The second node transmits the requested resource directly to the client, with the virtual address as its source. Since all requests are first received by the load balancer which determines the physical location of the requested resource, nodes may contain different resources. The entire contents of the web site is not mirrored onto all nodes. Network bottlenecks are avoided since the nodes transmit the large files back to the client directly, bypassing the load balancer. Client browsers can cache the virtual address, even though different nodes with different physical addresses service requests.

Methods for synthesis of encoded libraries

The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

Methods for synthesis of encoded libraries

The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

Methods for synthesis of encoded libraries

The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

Method for identifying compounds which bind to biological target molecule

The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag, and identifying compounds which bind to said biological target.

Methods for synthesis of encoded libraries

The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

Methods for synthesis of encoded libraries

The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotides tag.

Methods for identifying compounds of interest using encoded libraries

The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.

Methods for identifying compounds of interest using encoded libraries

The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.

Methods for identifying compounds of interest using encoded libraries

The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.

Methods for synthesis of encoded libraries

The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

Methods for synthesis of encoded libraries

The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

Methods for synthesis of encoded libraries

Methods for synthesis of encoded libraries

Methods for synthesis of encoded libraries

The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

Methods for synthesis of encoded libraries

The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

Methods for identifying compounds of interest using encoded libraries

Methods for synthesis of encoded libraries

C NRPorb\DCC\RXS3772649 1 DOC-22AI7/201I The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

Methods for synthesis of encoded libraries

C \NRPonbl\DCC\RXSU7799lt_1.DOC-27/7/2011 The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

Liquid-Chromatography Conduit Assemblies Having High-Pressure Seals

A method for making a liquid-chromatography apparatus includes inserting two inner conduits into an intermediate tube, inserting the intermediate tube into an outer tube, forming a proximal seal between the intermediate tube and at least one of the inner conduits, and forming a distal seal between the intermediate tube and at least one of the inner conduits. A liquid-chromatography apparatus includes an outer tube, an intermediate tube disposed in the outer tube, two inner conduits disposed in the intermediate tube, a proximal seal between the intermediate tube and at least one of the inner conduits, and a distal seal between the intermediate tube and at least one of the inner conduits.

Liquid-chromatography conduit assemblies having high-pressure seals

A method for making a liquid-chromatography apparatus includes inserting two inner conduits into an intermediate tube, inserting the intermediate tube into an outer tube, forming a proximal seal between the intermediate tube and at least one of the inner conduits, and forming a distal seal between the intermediate tube and at least one of the inner conduits. A liquid-chromatography apparatus includes an outer tube, an intermediate tube disposed in the outer tube, two inner conduits disposed in the intermediate tube, a proximal seal between the intermediate tube and at least one of the inner conduits, and a distal seal between the intermediate tube and at least one of the inner conduits.

Liquid-chromatography conduit assemblies having high-pressure seals

A method for making a liquid-chromatography apparatus includes inserting two inner conduits into an intermediate tube, inserting the intermediate tube into an outer tube, forming a proximal seal between the intermediate tube and at least one of the inner conduits, and forming a distal seal between the intermediate tube and at least one of the inner conduits. A liquid-chromatography apparatus includes an outer tube, an intermediate tube disposed in the outer tube, two inner conduits disposed in the intermediate tube, a proximal seal between the intermediate tube and at least one of the inner conduits, and a distal seal between the intermediate tube and at least one of the inner conduits.

Modulators of β-amyloid peptide aggregation comprising D-amino acids

Compounds that modulate natural β amyloid peptide aggregation are provided. The modulators of the invention comprise a peptide, preferably based on a β amyloid peptide, that is comprised entirely of D-amino acids. Preferably, the peptide comprises 3-5 D-amino acid residues and includes at least two D-amino acid residues independently selected from the group consisting of D-leucine, D-phenylalanine and D-valine. In a particularly preferred embodiment, the peptide is a retro-inverso isomer of a β amyloid peptide, preferably a retro-inverso isomer of Aβ 17-21 . In certain embodiments, the peptide is modified at the amino-terminus, the carboxy-terminus, or both. Preferred amino-terminal modifying groups include cyclic, heterocyclic, polycyclic and branched alkyl groups. Preferred carboxy-terminal modifying groups include an amide group, an alkyl amide group, an aryl amide group or a hydroxy group. Pharmaceutical compositions comprising the compounds of the invention, and diagnostic and treatment methods for amyloidogenic diseases using the compounds of the invention, are also disclosed.

Sliding door, method of installing a sliding door and office furniture assembly

An office furniture assembly includes a reinforced metal sheet structure and a sliding door assembly. The reinforced metal sheet structure includes a metal sheet having a folded edge, and a reinforcing member for reinforcing the metal sheet at the folded edge. The reinforcing member has an extended thin edge and is attached to the metal sheet so that the extended thin edge abuts the folded edge of the metal sheet. The sliding door assembly is for attachment to a door frame and includes a lower track (42) for attachment to a base of the door frame, an upper track (42) for attachm ent to the top of a door frame, a sliding door means (22) for installation on a lower track (42) and the upper track (42), and a track-securing means for securing the upper track and the lower track having the sliding door means (22) mounted therebetween to the doorframe. The sliding door means (22) has a lower track-engaging means (36) for slidingly engaging the lower track and an upper track-engaging (35) means for slidingly engaging the upper track.

Ceramic-based chromatography apparatus and methods for making same

A high-performance liquid-chromatography apparatus includes a substrate that defines a separation column in fluidic communication with an inlet port of the processing unit. The processing unit is formed of sintered inorganic particles. The apparatus also includes a pump that delivers a solvent to the inlet port at a pressure sufficient for high-performance liquid-chromatography.

Localization by using skyline data

Methods, systems, and computer code on computer-readable media are provided that are directed to generating area skyline data using a digital elevation or surface models (DEMs or DESs) and shadow casting techniques. Some embodiments use an area of maximum shadow line overlap, for shadow line images based on target location skyline azimuth and elevation angle data, as the best approximation for the position of the target location in an area. Some embodiments select the location showing the best fit to the target skyline azimuth and elevation angle data as the best approximation for the target location.

Seed planting machine

Distributed transaction event matching

Methods, data structures, and systems for tracking network events that occur across multiple platforms are disclosed. Entities may enter into business agreements for products and services to be conducted across different platforms and register the terms of those agreements with a tracking computer. The tracking computer can monitor network events and determine settlement amounts to be distributed between the entities involved in a given network event based on the terms of one or more agreements that may be stored in a database.

PERFORATOR COMPRISING MOBILE GROUPS OF PERFORATION GUNS

La présente invention concerne un appareil comprenant un premier groupe de canons de perforation positionné de manière circonférentielle autour d'un axe longitudinal central à une première position axiale. L'appareil comprend un second groupe de canons de perforation positionné de manière circonférentielle autour de l'axe longitudinal central à une seconde position axiale. Les premier et second groupes sont configurés dans une position fermée pendant que l'appareil est descendu jusqu'à une position de perforation dans un puits de forage. Après la descente de l'appareil jusqu'à la position de perforation, les premier et second groupes doivent passer à une position déployée et le premier groupe doit se déplacer axialement de façon que le premier groupe et le second groupe se chevauchent au moins partiellement. An apparatus includes a first group of perforation guns positioned circumferentially about a central longitudinal axis at a first axial position. The apparatus includes a second group of perforation guns positioned circumferentially about the central longitudinal axis at a second axial position. The first and second groups are configured in a closed position while the apparatus is lowered to a perforation position in a wellbore. After the descent of the apparatus to the piercing position, the first and second groups must move to an extended position and the first group must move axially so that the first group and the second group overlap at least partially.

Fluid sprayer and components of a fluid sprayer

An air-assisted airless spray gun includes a valve cartridge configured to control a flow of air or spray fluid through the spray gun. The valve cartridge includes a housing configured to interface with the spray gun body and fully supporting the flow control components of the valve cartridge. The housing is secured within a bore of the spray gun body. The valve member is supported by the housing and actuatable relative to a seat. The valve is formed between the seal end of the valve member and the seat.

Low odor, hard surface sporicides and chemical decontaminants

A low odor, liquid disinfectant composition comprising multiple components, which, upon mixing, provide an aqueous solution comprising low levels of peracetic acid for use in decontaminating articles and surfaces contaminated with bacteria, viruses, fungi and other chemical and biological contaminants including, but not limited to, spores, such as Clostridium difficile (C.diff), Clostridium sporogenes, and anthrax, mouse parvo virus, and mustard, nerve and other chemical and biological warfare agents. The disinfectant composition is prepared just prior to use by combining two or more separately packaged components, one component which is an acetyl donor comprising TAED or DAMA, and the other component which is a hydrogen peroxide solution.

Railroad car hatch cover hinge structure and method for connecting a hatch cover to a railcar

A hinge structure including a universal adapter located toward one end of and for allowing the hinge structure to be pivotally connected to different stationary brackets having differing pivot axes. The universal adapter defines multiple openings disposed in spaced, generally parallel relation relative to each other.

Hand operated device for controlled deployment of a tissue anchor and method of using the same

A tissue anchoring system includes a tissue anchor member that is suitable for anchoring against tissue. The system also includes a tensioning member operatively connected to the anchor member such that the anchor member can slide relative to the tensioning member, the tensioning member capable of being pulled to cause the anchor member to move relative to the tensioning member into a position seated against the tissue. A hand operated deployment catheter is operable to extend and deploy the anchor member therefrom. The deployment catheter includes a rotatable member about which the tensioning member is routed and a clutch assembly for limiting tension within the tensioning member to prevent the deployed anchor from being pulled through the tissue.

Effective generation of tumor-targeted t-cells derived from pluripotent stem cells

The present invention relates to the field of adoptive immunotherapy. The invention provides methods for generating phenotypically defined, functional, and/or expandable T cells from pluripotent stem cells engineered through safe genetic modifications. The engineered cells may provide one or more of: 1) targeting a specific predetermined antigen expressed on the cell surface of a target cell in an HLA independent manner, 2) enhanced survival and functional potential 3) "off-the-shelf T cells for administration to multiple recipients, eventually across immunogenic barriers, and/or 4) cytotoxic potential and anti-tumor activity.

Water vapor distillation apparatus, method and system.

Un aparato de destilación de vapor de fluido; el aparato incluye una entrada de fluido fuente y un aparato evaporador condensador; el aparato evaporador condensador incluye un alojamiento sustancialmente cilíndrico y una pluralidad de tubos en el alojamiento; la entrada de fluido fuente está en comunicación de fluido con el evaporador condensador, y el evaporador condensador transforma el fluido fuente en vapor y transforma el vapor comprimido en fluido producto; también se incluye en el aparato de destilación de vapor de fluido un intercambiador de calor en comunicación de fluido con la entrada de fluido fuente y una salida de fluido producto; el intercambiador de calor incluye un tubo externo y por lo menos un tubo interno; también se incluye en el aparato de destilación de vapor de fluido un ventilador regenerativo en comunicación de fluido con el evaporador condensador; el ventilador regenerativo comprime vapor, y el vapor comprimido fluye al condensador evaporativo en donde el vapor comprimido es transformado en fluido producto.

Biodegradable alkaline disinfectant cleaner with analyzable surfactant

An aqueous, alkaline cleaning composition for use on hard-to-clean soils, encountered in pharmaceutical, personal care, food and cosmetic manufacturing, comprising a source of alkalinity, a biodegradable surfactant system further comprising one or more surfactants, one or more hydrotropes, and a UV-analyzable surfactant, and a biodegradable chelating agent. The composition offers unique advantages of stability over the expected shelf life, low-foaming property, phosphate-free and biodegradable components, and unexpectedly enhanced antimicrobial, including virucidal, activity in one cleaning composition. The UV-analyzable surfactant allows for validation of cleaning processes using known techniques for manufacturers who are required or desire to do so.

Portable fluid sprayer having a tube dampener

A tube dampener (12) for a fluid sprayer (10) is disposed downstream of the pump (18) to receive spray fluid output by the pump. The tube dampener includes a rigid body (24) and a flexible tube (26) disposed within the rigid body. The flexible tube is resilient to smooth pressure fluctuations in the spray fluid output by the pump, providing consistent pressure at a spray nozzle (28) downstream of the tube dampener (12).

Lock detection for multipath wireless receiver

A wireless receiver receiving multipath Walsh-code symbols determines which of fingers (402, 410) have locked on a signal. Measurements of the correlation energies between the received signal and all possible symbols are stored in energy storage units (404, 412). The actual signals are combined in combiner (408). A maximum determiner (416) determines the most likely combined symbol, and an index for this symbol is fed back to the energy storage units. Lock detectors (406, 414) use the measurement for this fed-back symbol to determine whether the finger has locked onto a path. This determination is used to decide whether the next signal detected by that finger should be applied to the combiner.

A non-aerosol foaming alcohol hand sanitizer

A non-aerosol, foaming high alcohol content hand sanitizer is provided which has excellent antimicrobial activity and tolerance for organic load and excellent residual activity, as well as enhanced moisturization and skin-feel properties over currently marketed alcohol-based sanitizers. The inventive composition achieves an unexpectedly large amount of quality, stable foam even in the presence of significant quantities of skin conditioning agents through the use of novel silicone surfactants and achieves enhanced and prolonged antimicrobial efficacy through the combination of high alcohol content and activity enhancing components.

Pressure cycle device

Provided is a pressure cycle actuation assembly. The pressure cycle actuation assembly, in one aspect, includes a housing, a reciprocating piston located within the housing and defining first and second fluid chambers, and a check valve positioned between the first and second fluid chambers, the check valve permitting fluid flow from the first fluid chamber to the second fluid chamber but preventing fluid flow from the second fluid chamber to the first fluid chamber. The A pressure cycle actuation assembly, according to this aspect, further includes a flow restrictor positioned between the first and second fluid chambers, the flow restrictor restricting fluid flow between the first fluid chamber and the second fluid chamber, and a rotating collet coupled to the reciprocating piston, the rotating collet translating reciprocal axial motion of the reciprocating piston into one-direction rotation and axial lengthening or shortening of the rotating collet relative to the reciprocating piston.

Methionine aminopeptidase-2 inhibitors and methods of use thereof

The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present invention also provides methods of treating an angiogenic disease, e.g., cancer, in a subject by administering to the subject a therapeutically effective amount of one or mo re of the angiogenesis inhibitor compounds of the invention.

Compositions and methods for immunotherapy

COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY Abstract The present invention provides immunoresponsive cells, including T cells, cytotoxic T cells, regulatory T cells, and Natural Killer (NK) cells, expressing at least one of an antigen recognizing receptor and one of a chimeric costimulatory receptor. Methods of using the immunoresponsive cell include those for the treatment of neoplasia and other pathologies where an increase in an antigen-specific immune response is desired.

INTRANASAL ADMINISTRATIVE DEVICE FOR ANIMALS AND SYSTEMS

Low odor, hard surface sporicides and chemical decontaminants

A low odor, liquid disinfectant composition comprising multiple components, which, upon mixing, provide an aqueous solution comprising low levels of peracetic acid for use in decontaminating articles and surfaces contaminated with bacteria, viruses, fungi and other chemical and biological contaminants including, but not limited to, spores, such as Clostridium difficile (C.diff), Clostridium sporogenes, and anthrax, mouse parvo virus, and mustard, nerve and other chemical and biological warfare agents. The disinfectant composition is prepared just prior to use by combining two or more separately packaged components, one component which is an acetyl donor comprising TAED or DAMA, and the other component which is a hydrogen peroxide solution.

File-case drawer.

BRAKE-BY-WIRE SYSTEM

Ein Fahrzeug mit einem fehlertoleranten elektronischen Brake-by-Wire(BBW)-System beinhaltet eine Vielzahl von Bremsanlagen, die das Bremse des jeweiligen Rades des Fahrzeugs steuern. Die Bremsanlagen beinhalten eine erste Bremsanlage und eine zweite Bremsanlage. Die erste Bremsanlage ist in mindestens eine verbesserte Bremsstellgliedanordnung integriert, die eine erste elektronische Stellglied-Treiberschaltung in Signalverbindung mit einem ersten elektromechanischen Stellglied aufweist. Die erste Bremsanlage ist dazu konfiguriert, um eine auf ein erstes Rad des Fahrzeugs aufgebrachte Bremskraft anzupassen. Die zweite Bremsanlage ist in mindestens eine verbesserte intelligente Bremsstellgliedanordnung integriert, die eine erste Stellgliedsteuerung in Signalverbindung mit einer zweiten elektronischen Stellglied-Treiberschaltung enthält. Die zweite elektronische Stellglied-Treiberschaltung steht in Signalverbindung mit einem zweiten elektromechanischen Stellglied, das dazu konfiguriert ist, eine auf ein zweites Rad des Fahrzeugs aufgebrachte Bremskraft anzupassen. A vehicle with a fault tolerant electronic brake-by-wire (BBW) system includes a plurality of brake systems that control the brake of the respective wheel of the vehicle. The brake systems include a first brake system and a second brake system. The first brake system is integrated with at least one improved brake actuator assembly having a first electronic actuator driver circuit in signal communication with a first electromechanical actuator. The first brake system is configured to adjust a braking force applied to a first wheel of the vehicle. The second brake system is integrated with at least one improved smart brake actuator assembly that includes first actuator control in signal communication with a second electronic actuator driver circuit. The second electronic actuator driver circuit is in signal communication with a second electromechanical actuator configured to adjust a braking force applied to a ...

Power amplifier self-heating compensation circuit

Temperature compensation circuits and methods for adjusting one or more circuit parameters of a power amplifier (PA) to maintain approximately constant Gain versus time during pulsed operation sufficient to substantially offset self-heating of the PA. Some embodiments compensate for PA Gain “droop” due to self-heating using a Sample and Hold (S&H) circuit. The S&H circuit samples and holds an initial temperature of the PA at commencement of a pulse. Thereafter, the S&H circuit generates a continuous measurement that corresponds to the temperature of the PA during the remainder of the pulse. A Gain Control signal is generated that is a function of the difference between the initial temperature and the operating temperature of the PA as the PA self-heats for the duration of the pulse. The Gain Control signal is applied to one or more adjustable or tunable circuits within a PA to offset the Gain droop of the PA.

Thick film heater for injection mold runner nozzle

Hot runner injection molding systems with externally heated injection runner nozzles for such systems. The heater is preferably a tubular heater with the resistive element applied to the exterior surface by fine film printing. The heater is adapted to externally heat a hot runner injection mold runner nozzle.

A method and apparatus for compressing signals in a fixed point format without introducing a bias

Inhibitors of methionine aminopeptidase-2 and uses thereof

The instant invention provides compositions and methods for treating a subject suffering from one of a number of conditions, including an angiogenic disease, such as cancer, an autoimmune disorder or a parasitic infection.

Boron doped cement and concrete

Aspects of the present disclosure provide for cement, cement paste, cementitious paste, cementitious mortar, and concrete, methods of making cement, cement paste, cementitious paste, cementitious mortar, and concrete, structures incorporating the concrete, and the like, where the cement, cement paste, cementitious paste, cementitious mortar, and the concrete include elemental boron and/or one or more boron compounds (e.g., boron-doped cement, cement paste, cementitious paste, cementitious mortar, and concrete). The boron and/or a boron compound can be homogeneously distributed throughout the cement, cement paste, cementitious paste, cementitious mortar and/or concrete.

Cushion system for mobile subject

Method of producing tertiary amyl ethyl ether

A process for the production of tertiary ethers, including: feeding a hydrocarbon stream comprising isoolefins and propionitrile to a distillation column reactor system containing at least one etherification reaction zone; feeding a C2 to C6 monoalcohol or mixture thereof to the distillation column reactor; concurrently in the distillation column reactor system: reacting a portion of the isoolefins with a portion of the alcohols to form a tertiary ether; and separating the tertiary ether from unreacted isoolefins; withdrawing the tertiary ether and propionitrile from the distillation column reactor system as a bottoms; withdrawing the unreacted isoolefins from the distillation column reactor system as an overheads; and operating the distillation column reactor system such that the etherification reaction zone is substantially free of propionitrile.

Broad spectrum disinfectant

A broad spectrum disinfectant includes a quaternary ammonium halogen, an alkaline agent, a chelating agent, a nonionic surfactant coupler, at least one alkoxylated nonionic surfactant, and water or any aliphatic alcohol. The disinfectant composition is phenol-free, is effective in eradicating microorganisms such as various fungi, and is stable to gamma-irradiation.

Tissue thickness compensators for circular surgical staplers.

Varios compensadores de grosor de tejido (19100, 19200, 19300, 19400, 19500, 10601, 19700, 19800, 19900, 20000, 20100, 20200, 20300, 20500, 20600, 20700, 20800, 20900) se describen para desplegarse entre un cabezal de la engrapadora de una engrapadora circular quirúrgica y un yunque unido a esta para adecuar variaciones en el grosor del tejido durante el engrapado; algunas disposiciones de compensador de grosor de tejido incluyen medios y configuraciones para el despliegue de agentes de curativos para mejorar el proceso curativo; los compensadores de grosor de tejido (19100) se unen al yunque por miembros de unión (19112, 19130, 19070).