A device and a method for managing a sample to be analyzed and a solid sample carrier and liquid sample carrier

A device for managing a sample to be analyzed comprises magnetizing equipment (302) for producing magnetic field capable of interacting, when the sample is moving to or located in a sample well, with magnetically amplifying material attached to the sample, where the magnetically amplifying material has relative magnetic permeability constant greater than one. With the aid of the magnetizing element the movement of the sample to the sample well and/or the position of the sample in the sample well can be monitored and/or controlled. The device can be, for example but not necessarily, an instrument for dispensing samples to sample wells or an optical measurement instrument.

A device and a method for managing a sample to be analyzed and a solid sample carrier and liquid sample carrier

A device for managing a sample to be analyzed comprises magnetizing equipment (302) for producing magnetic field capable of interacting, when the sample is moving to or located in a sample well, with magnetically amplifying material attached to the sample, where the magnetically amplifying material has relative magnetic permeability constant greater than one. With the aid of the magnetizing element the movement of the sample to the sample well and/or the position of the sample in the sample well can be monitored and/or controlled. The device can be, for example but not necessarily, an instrument for dispensing samples to sample wells or an optical measurement instrument.

Method for determining the risk of preeclampsia using PIGF-2 and PIGF-3 markers

The present invention relates to a method for determining the risk of a pregnant woman developing pre-eclampsia. The method comprises i) determining the level of one or more biochemical markers in a sample obtained from a pregnant woman, and ii) comparing the level of the at least one biochemical marker in the sample with the level of the same biochemical marker in a control sample. A difference in the level of the biochemical marker in the sample relative to the control sample is indicative of an increased risk of developing pre-eclampsia. The isoform biochemical markers are preferably PlGF-2 and PlGF-3. The present invention relates also to a method for determining whether a pregnant woman has pre-eclampsia and as well as a kit for assessing the risk or presence of pre-eclampsia. In addition, the invention relates also to a computer program used in these determinations.

Device and a method for managing a sample to be analyzed and a solid sample carrier and liquid sample carrier

A device for managing a sample to be analyzed comprises magnetizing equipment (302) for producing magnetic field capable of interacting, when the sample is moving to or located in a sample well, with magnetically amplifying material attached to the sample, where the magnetically amplifying material has relative magnetic permeability constant greater than one. With the aid of the magnetizing element the movement of the sample to the sample well and/or the position of the sample in the sample well can be monitored and/or controlled. The device can be, for example but not necessarily, an instrument for dispensing samples to sample wells or an optical measurement instrument.

Method for determining the risk of preeclampsia using PIGF-2 and PIGF-3 markers

Nucleic Acid Amplification Assay and Arrangement Therefor

A nucleic acid amplification assay for quantitative and/or qualitative analysis of the presence of a specific analyte or specific analytes in a biological sample, which analytes, if present, are contained in particles ( 4 ) of the sample ( 2 ), in which assay the sample is forced in a first direction through a filter ( 6 ) that retains the particles ( 4 ). The particles ( 4 ) retained in the filter ( 6 ) are flushed, by a flow ( 8 ), in a second opposite direction through the filter ( 6 ) out of the filter ( 6 ) and the flow ( 8 ) containing the particles ( 4 ) flushed out is analyzed for the analyte or analytes. An arrangement ( 12 ) for preparing the sample ( 2 ) for analysis according to the assay of the invention and to a kit of parts for analyzing the analyte or analytes, which kit includes the arrangement ( 12 ) is also disclosed.

Method for stabilizing assay reagents, reagent container with stabilized assay reagents and use thereof

A reagent container having an inner surface upon which at least two reagents are dried, with the first reagent dried on a first area separate from a second area where the second reagent is dried. The first and second reagents are a nucleic acid polymerase and its substrate. A method is disclosed which includes dispensing at least the first and second reagents onto separate areas of the inner surface of the reagent container, and removing excess water from the reagents. The reagent container can be used in a polymerase chain reaction (PCR) assay, an assay that utilizes a reverse transcriptase, a reverse transcriptase polymerase chain reaction, an immuno-PCR assay, a nucleic acid sequence based assay, a proximity ligation assay, a ligase chain reaction assay, a rolling circle amplification assay, and a strand displacement amplification assay.

Device and a method for managing a sample to be analyzed and a solid sample carrier and liquid sample carrier

A device for managing a sample to be analyzed comprises magnetizing equipment (302) for producing magnetic field capable of interacting, when the sample is moving to or located in a sample well, with magnetically amplifying material attached to the sample, where the magnetically amplifying material has relative magnetic permeability constant greater than one. With the aid of the magnetizing element the movement of the sample to the sample well and/or the position of the sample in the sample well can be monitored and/or controlled. The device can be, for example but not necessarily, an instrument for dispensing samples to sample wells or an optical measurement instrument.

Method for Stabilizing Assay Reagents, Reagent Container with Stabilized Assay Reagents and Use Thereof

This invention relates to a reagent container for detection and/or quantitation of at least one biological or chemical analyte from a sample, said reagent container comprising an inner surface enclosing a volume, wherein volume analytical reactions of at least one analysis for detection and/or quantitation of at least one analyte take place, and at least two reagents of an analysis of an analyte have been dried onto said inner surface and at least a first said reagent has been dried onto a first area of the inner surface distinctly separate, i.e. without any overlap, from a second area of the inner surface onto which at least a second said reagent has been dried. Characteristic for the reagent container is that the first reagent and the second reagent form a pair wherein the first reagent is an enzyme and the second reagent is a substrate of said enzyme, and said pair consists of a nucleic acid polymerase and substrate thereof. This invention also relates to a method for stabilising onto ...

DEVICE AND A METHOD FOR MANAGING A SAMPLE TO BE ANALYZED AND A SOLID SAMPLE CARRIER AND LIQUID SAMPLE CARRIER

A device for managing a sample to be analyzed comprises magnetizing equipment (302) for producing magnetic field capable of interacting, when the sample is moving to or located in a sample well, with magnetically amplifying material attached to the sample, where the magnetically amplifying material has relative magnetic permeability constant greater than one. With the aid of the magnetizing element the movement of the sample to the sample well and/or the position of the sample in the sample well can be monitored and/or controlled. The device can be, for example but not necessarily, an instrument for dispensing samples to sample wells or an optical measurement instrument.

A DEVICE AND A METHOD FOR MANAGING A SAMPLE TO BE ANALYZED AND A SOLID SAMPLE CARRIER AND LIQUID SAMPLE CARRIER

A device for managing a sample to be analyzed comprises magnetizing equipment (302) for producing magnetic field capable of interacting, when the sample is moving to or located in a sample well, with magnetically amplifying material attached to the sample, where the magnetically amplifying material has relative magnetic permeability constant greater than one. With the aid of the magnetizing element the movement of the sample to the sample well and/or the position of the sample in the sample well can be monitored and/or controlled. The device can be, for example but not necessarily, an instrument for dispensing samples to sample wells or an optical measurement instrument.

Method for determining the risk of preterm birth

The present invention relates to a method for determining risk of preterm birth (PTB) in a pregnant individual. The method comprises measuring in a biological sample obtained from the pregnant individual, levels of biomarkers AFP and free hCG-beta, and at least one biomarker selected from FSTL3, sTNR1, P1GF2, Activin A, Ue3 and sP-selectin and optionally cervical length; or levels of biomarkers AFP and free hCGbeta and cervical length, and determining a relative risk of the pregnant individual developing PTB. The invention relates also to a kit, apparatus and system for predicting risk of PTB.