P EF-TU expression units

Method of modifying the genome of gram-positive bacteria by means of a novel conditionally negative dominant marker gene

METHOD FOR THE PRODUCTION OF SULPHUR-CONTAINING FINE CHEMICALS BY FERMENTATION

Pyrimidine or triazine carboxylic acid derivatives to be used as medicaments

Corynebacterium glutamicum genes encoding stress, resistance and tolerance proteins

Orynebacterium glutamicum genes encoding phosphoenolpyruvate: sugar phosphotransferase system proteins

Genetic products of ashbya gossypii, associated with transmembrane transport

Corynebacterium glutamicum genese encoding proteins involved in carbon metabolism and energy production

Corynebacterium glutamicum genese encoding proteins involved in carbon metabolism and energy production

Genes from the corynebacterium glutamicum coding for regulatory proteins

Mutated gene from corynebacterium glutamicum

Corynebacterium glutamicum genese encoding proteins involved in carbon metabolism and energy production

Corynebacterium glutamicum genese encoding proteins involved in carbon metabolism and energy production

Corynebacterium glutamicum genes encoding metabolic pathway proteins

Method for the production of sulphur-containing fine chemicals by fermentation

PROCESS FOR THE PRODUCTION OF AMINO ACIDS WITHOUT TREHALOSE

Corynebacterium glutamicum genes encoding stress, resistance and tolerance proteins

Methods for the preparation of a fine chemical by fermentation

Corynebacterium glutamicum genes encoding proteins involved in homeostasis and adaptation

Genes encoding for carbon metabolism and energy-producing proteins

Novel genetic products from ashbya gossypii, associated with the structure of the cell wall or the cytoskeleton

corynebacterium glutamicum genes encoding stress, resistance and tolerance proteins

Genes coding for dna replication proteins and for proteins related to pathogenesis

USE OF THE REPRESSOR GLXR FOR THE SYNTHESIS OF LYSINE IN CORYNEBACTERIUM GLUTAMICUM

Coryneracterium glutamicum genes encoding metabolic pathway proteins

Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport

METHOD FOR THE PRODUCTION BY FERMENTATION OF SULPHUR-CONTAINING FINE CHEMICALS (METF)

Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport

Ashbya gossypii enzymes

METHOD FOR REMOVING HORN SUBSTANCES FROM ANIMAL SKIN

Corynebacterium glutamicum genes encoding phosphoenolpyruvate: sugar phosphotransferase system proteins

Process for the Production of Amino Acids without Trehalose

The invention relates to a method for producing an amino acid comprising culturing a microorganism of the genus Corynebacterium or Brevibacterium wherein said microorganism is partially or completely deficient in at least one of the gene loci of the group which is formed by otsAB, treZ and treS, and subsequent isolation of the amino acid from the culture medium.

Genes from corynebacterium glutamicum that code for homeostasis proteins and for adaptation proteins

Genes coding for stress resistance and tolerance proteins

Methods for the preparation of lysine by fermentation of corynebacterium glutamicum

Corynebacterium Glutamicum genes encoding phosphoenolpyruvate: sugar phosphotransferase system proteins

ANALYTICAL MEASUREMENT METHOD AND ITS USE

Disclosed is an analytical measurement method for use in diagnosis, in research looking for active substances, in combinatorial chemistry, in crop protectio n, in toxicology or in environmental protection. This method makes a solid support which is essentially composed of an inert solid support material on which hydrophilic measurement zones which may be provided with a surface loading, are separated from one another by at least one hydrophobic coating in the fo rm of separate zones around the hydrophilic measurement zones, where hte number of measurement points applied per cm2 of the support is greater than or equal to 10. In practise, the following steps are carried out: a) application one or more times of mutually different reagents singly or in a mixture to the individual hydrophilic measurement zones on the support, b) treatment of the support with at least one reagent common to all the hydrophilic measurement zones so that the reagent is placed simultaneously on a plurality or all ...

METHOD FOR ZYMOTIC PRODUCTION OF FINE CHEMICALS (META) CONTAINING SULPHUR

Use of the repressor glxr for the synthesis of lysine in corynebacterium glutamicum

Corynebacterium glutamicum genese encoding proteins involved in carbon metabolism and energy production

METHOD FOR REMOVING HORN SUBSTANCES FROM ANIMAL SKIN

Horny substances are removed from animal hides by a process wherein animal hides are treated in a liquor comprising from 0.05 to 5% by weight, based on the salted weight, of one or more compounds of the formula I or the corresponding alkali metal or alkaline earth metal or ammonium or phosphonium salts thereof, the variables being defined as follows: R¹ is selected from hydrogen and C₁-C₁₂-alkyl, unsubstituted or substituted by one or more S-H or O-H groups; X¹ to X⁴ are identical or different and are selected from hydrogen, C₁-C₄-alkyl, O-H, S-H and N-HR², R² is hydrogen or C₁-C₁₂-alkyl or a C₁-C₄-alkyl-C-O group, at least one of the radicals X¹ to X⁴ being S-H, and, if R¹ contains neither O-H nor S-H, at least one further radical from among X¹ to X⁴ is selected from S-H, OH and NH-R^{2 Подробнее}

Cornebacterium Glutamicum genes encoding proteins involved in homeostasis and adaption

Methods for the preparation of a fine chemical by fermentation

Corynebacterium glutamicum genes encoding phosphoenolpyruvate: sugar phosphotransferase system proteins

Gene variants coding for proteins from the metabolic pathway of fine chemicals

Corynebacterium glutamicum genes encoding stress, resistance and tolerance proteins

THE USE OF CARBOXYLIC ACID DERIVATIVES AS DRUGS

The invention concerns the use of carboxylic acid derivatives of formula I ( I) in which R means a formyl group, a CO2H group or a residue which can be hydrolysed to form COOH; X means nitrogen or CR14, wherein R14 means hydroge n or, together with R3, forms a 3- to 4-member alkylene or alkenylene chain in each of which a methyl group can be replaced by oxygen; Y means sulphur or oxygen or a single bond; Z means sulphur or oxygen; and the other substituen ts have the meanings given in the description. These derivatives can be used fo r preparing medicaments.

Coryneracterium glutamicum genes encoding metabolic pathway proteins

Method for modifying the genome of corynebacteria

Stress-associated genetic products from ashbya gossypii

Corynebacterium glutamicum genes encoding proteins involved in carbon metabolism and energy production

Endothelin-converting enzyme

Pyrimidine or triazine carboxylic acid derivatives to be used as medicaments

Corynebacterium glutamicum genes encoding metabolic pathway proteins

Genes coding for phosphoenopyruvate-sugar-phosphotransferase proteins

Method for the Production of Sulpher-Containing Fine Chemicals by Fermentation

The invention relates to methods for the production of sulfur-containing fine chemicals, in particular L-methionine, by fermentation using bacteria in which a nucleotide sequence encoding an S-adenosylmethionine synthase (metK) gene is expressed.

METHOD FOR ZYMOTIC PRODUCTION OF FINE CHEMICALS (METY) CONTAINING SULPHUR

Corynebacterium Glutamicum genes encoding phosphoenolpyruvate: sugar phosphotransferase system proteins

Corynebacterium glutamicum genese encoding proteins involved in carbon metabolism and energy production

Receptor from the superfamily of tnt-receptors from the human lung

GENE WHICH CODES FOR NOVEL PROTEINS

Genes of corynebacterium glutamicum encoding for genetic stability, gene expression and folding proteins

Methods for producing sulphurous fine chemicals by fermentation using meth-coding coryneform bacteria

Genes encoding for membrane synthesis and membrane transport proteins

Genes coding for metabolic pathway proteins

Corynebacterium glutamicum genes encoding metabolic pathway proteins

Gene Coding for Glucose-6-Phosphate-Dehydrogenase Proteins

The present invention relates to isolated nucleic acid molecules encoding mutants of glucose-6-phosphate dehydrogenase, and vectors and hosts cells including such nucleic acid molecules. These nucleic acid molecules are involved in the biosynthesis of a fine chemical, e.g., an amino acid such as lysine. The present invention also relates to methods of producing and modulating the production of fine chemicals, e.g., lysine, by culturing recombinant microorganisms containing these nucleic acid molecules under conditions such that the fine chemical is produced.

Poly(adp-ribose)polymerase gene

METHODS FOR PRODUCING SULPHUROUS FINE CHEMICALS

Corynebacterium glutamicum genese encoding proteins involved in carbon metabolism and energy production

Corynebacterium glutamicum genese encoding proteins involved in carbon metabolism and energy production

PEF-TS expression units

The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.

PGRO EXPRESSION UNITS

Genes encoding carbon metabolism and energy-producing proteins

The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.

Corynebacterium glutamicum genes encoding proteins involved in carbon metabolism and energy production

Isolated nucleic acid molecules, designated SMP nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SMP proteins, mutated SMP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SMP genes in this organism.

PSOD EXPRESSION UNITS

The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.

Corynebacterium glutamicum genes encoding proteins involved in homeostasis and adaptation

Isolated nucleic acid molecules, designated HA nucleic acid molecules, which encode novel HA proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing HA nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated HA proteins, mutated HA proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of HA genes in this organism.

ORYNEBACTERIUM GLUTAMICUM GENES ENCODING PHOSPHOENOLPYRUVATE: SUGAR PHOSPHOTRANSFERASE SYSTEM PROTEINS

Genes encoding genetic stability, gene expression and folding proteins

The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.

P Ef-Tu Expression Units

The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.

Method for removing horn substances from animal skin

The invention relates to a method for removing horn substances from animal skin. Said method is characterised in that animal skins are treated in an aqueous bath containing between 0.05 and 5 wt. %-in relation to the weight of the salt-of at least one compound of general formula I or the corresponding alkali metallic salts or alkaline-earth metallic salts thereof or ammonium or phosphonium salts, the variables having the following definitions: R1 is selected from hydrogen or C1-C12 alkyl, unsubstituted or substituted by at least one S-H group or one O-H group; X1 to X4 are the same or different and selected from hydrogen, C1-C4 alkyl, O-H, S-H or N-HR2; and R2 represents hydrogen or C1-C12 alkyl or a C1-C4-alkyl-C-O group, at least one X1 to X4 representing S-H. If R1 contains neither O-H nor S-H, at least one other X1 to X4 is selected from S-H, OH or NH-R2. Said aqueous bath also comprises at least one compound which catalyses the hydrolysis of peptide compounds.

Corynebacterium glutamicum genes encoding regulatory proteins

Isolated nucleic acid molecules, designated MR nucleic acid molecules, which encode novel MR proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MR nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MR proteins, mutated MR proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MR genes in this organism.

Genes encoding genetic stability, gene expression and folding proteins

The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.

Corynebacterium glutamicum genes encoding proteins involved in carbon metabolism and energy production

Isolated nucleic acid molecules, designated SMP nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SMP proteins, mutated SMP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SMP genes in this organism.

Methods for the Preparation of a Fine Chemical by Fermentation

The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i. e., glycerol kinase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of glycerol kinase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.

Use of the repressor glxr for the synthesis of lysine in corynebacterium glutamicum

Isolated polypeptide sequence having the sequence of SEQ ID NO: 1 or muteins thereof having the ability to bind cAMP and repress the expression of the aceB gene of C. glutamicum and which can be obtained from SEQ ID NO: 1 by inserting, deleting or substituting up to 20% of the amino acids.

Corynebacterium glutamicum genes encoding novel proteins

Isolated nucleic acid molecules, designated MCP nucleic acid molecules, which encode novel MCP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MCP proteins, mutated MCP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MCP genes in this organism.

Genes encoding genetic stability, gene expression and folding proteins

The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.

Psod expression unit

The invention relates to the use of nucleic acid sequences for regulating gene transcription and expression, said novel promoters and expression units, methods for modifying or inducing the gene transcription rate and/or expression rate, expression cassettes containing said expression units, genetically modified microorganisms having a modified or induced transcription rate and/or expression rate, and methods for producing biosynthetic products by cultivating said genetically modified microorganisms.

Corynebacterium glutamicum genes encoding metabolic pathway proteins

Isolated nucleic acid molecules, designated MP nucleic acid molecules, which encode novel MP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MP proteins, mutated MP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MP genes in this organism.

Corynebacterium glutamicum genes encoding phosphoenolpyruvate: sugar phosphotransferase system proteins

Isolated nucleic acid molecules, designated PTS nucleic acid molecules, which encode novel PTS proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PTS nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated PTS proteins, mutated PTS proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of PTS genes in this organism.

Corynebacterium glutamicum genes encoding proteins involved in carbon metabolism and energy production

Isolated nucleic acid molecules, designated SMP nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SMP proteins, mutated SMP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SMP genes in this organism.

Novel genetic products from ashbya gossypii, associated with the structure of the cell wall or the cytoskeleton

The invention relates to novel polynucleotides from Ashbya gossypii; to oligonucleotides hybridizing therewith; to expression cassettes and vectors which comprise these polynucleotides; to microorganisms transformed therewith; to polypeptides encoded by these polynucleotides; and to the use of the novel polypeptides and polynucleotides as targets for modulating the properties of the cell wall or of the cytoskeleton and, in particular, improving vitamin B2 production in microorganisms of the genus Ashbya.

ORYNEBACTERIUM GLUTAMICUM GENES ENCODING PHOSPHOENOLPYRUVATE: SUGAR PHOSPHOTRANSFERASE SYSTEM PROTEINS

Corynebacterium glutamicum genes encoding phosphoenolpyruvate: sugar phosphotransferase system proteins

Isolated nucleic acid molecules, designated PTS nucleic acid molecules, which encode novel PTS proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PTS nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated PTS proteins, mutated PTS proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of PTS genes in this organism.

Genetic products of ashbya gossypii, associated with transmembrane transport

The invention relates to novel polynucleotides from Ashbya gossypii; to oligonucleotides hybridizing therewith; to expression cassettes and vectors which comprise these polynucleotides; to microorganisms transformed therewith; to polypeptides encoded by these polynucleotides; and to the use of the novel polypeptides and polynucleotides as targets for improving transmembrane transport and, in particular, improving vitamin B2 production in microorganisms of the genus Asbya.

Corynebacterium glutamicum genes encoding regulatory proteins

Isolated nucleic acid molecules, designated MR nucleic acid molecules, which encode novel MR proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MR nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MR proteins, mutated MR proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MR genes in this organism.

Method for zymotic production of fine chemicals (mety) containing sulphur

The invention relates to methods for the fermentative production of sulfur-containing fine chemicals, in particular L-methionine, by using bacteria which express a nucleotide sequence coding for a methionine synthase (metH) gene.

Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport

Gene which codes for novel proteins