28-06-2018 дата публикации
Номер: US20180177597A1
A bone repair scaffold having two moduli that match those of the cancellous and cortical bone in a patient receiving a bone graft/implant. The bone repair scaffold possesses increased mechanical properties to sustain physiological loading and biologically active capability to facilitate bone fusion. The bone repair scaffold may be 3D-printed, which allows for a variety of scaffold designs and configurations. Pore size, interconnected porosity, shape, and modulus of the bone repair scaffold may be modified for different bone graft applications, whether it is used as filler for bone cancer resections or trauma, or as a fusion device in cases of surgery. Depending on the defect location of the bone shaft, the relative porosity of the scaffold may be modified to account for changes in cortical bone thickness. A method for treating a bone defect using the bone repair scaffold is also disclosed. 1. A bone repair scaffold , comprising an inner core and an outer core circumferentially engaging said inner core , said inner core having a first porosity and a first modulus , and said outer core having a second porosity and a second modulus , wherein said second porosity is lower than said first porosity , whereby said second modulus is greater than said first modulus.2. The bone repair scaffold of claim 1 , wherein said first modulus is similar to that of cancellous bone claim 1 , and wherein said second modulus is similar to that of cortical bone.3. The bone repair scaffold of claim 1 , wherein said first porosity claim 1 , said second porosity and a transition between said first and second porosities constitute a pattern that emulates the porosity pattern of bone.4. The bone repair scaffold of claim 1 , further comprising a plurality of horizontal conduits and a plurality of vertical conduits claim 1 , so as to emulate the internal architecture of bone.5. The bone repair scaffold of claim 4 , wherein said plurality of horizontal conduits includes a first set of horizontal ...
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