28-02-2019 дата публикации
Номер: US20190060513A1
Принадлежит:
Disclosed are methods of delivering an agent to the lumen of the vas deferens under guidance of ultrasound imaging. The methods include vas-occlusive contraception in which the vas deferens is non-surgically isolated and an occlusive substance is percutaneously administered into the lumen of the vas deferens under ultrasound. Also disclosed are methods of reversal of vas-occlusive contraception and methods of delivering an agent to the lumen of the vas deferens. Also disclosed are compositions for use in the methods of the invention. 1. A composition comprising:one or more species with a diameter of 0.1 to 1 μm in solvent;wherein the one or more species are capable of forming an implantable network with pores with a diameter of less than or equal to 3 μm;wherein the one or more species and/or the implantable network are capable of being injected into a bodily lumen; andwherein the implantable network has a permanent lifespan in vivo.2. The composition of claim 1 , wherein one or more of the species comprises one or more of natural or synthetic monomers claim 1 , polymers claim 1 , copolymers or block copolymers claim 1 , biocompatible monomers claim 1 , polymers claim 1 , copolymers or block copolymers claim 1 , polystyrene claim 1 , neoprene claim 1 , polyetherether 10 ketone (PEEK) claim 1 , carbon reinforced PEEK claim 1 , polyphenylene claim 1 , polyetherketoneketone (PEKK) claim 1 , polyaryletherketone (PAEK) claim 1 , polyphenylsulphone claim 1 , polysulphone claim 1 , polyurethane claim 1 , polyethylene claim 1 , low-density polyethylene (LDPE) claim 1 , linear low-density polyethylene (LLDPE) claim 1 , high-density polyethylene (HDPE) claim 1 , polypropylene claim 1 , polyetherketoneetherketoneketone (PEKEKK) claim 1 , nylon claim 1 , fluoropolymers claim 1 , polytetrafluoroethylene (PTFE or TEFLON®) claim 1 , TEFLON® TFE (tetrafluoroethylene) claim 1 , polyethylene terephthalate (PET or PETE) claim 1 , TEFLON® FEP (fluorinated ethylene propylene) claim 1 , ...
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