ICEMAKER FOR REFRIGERATORS AND CONTROL METHOD THEREOF

A control method includes receiving an output value from an optical sensor to determine whether an ice bank is full of ice, driving the sensor heater for a first drive time to heat the optical sensor upon determining that the ice bank is full of ice, driving the optical sensor to receive an output value from the optical sensor after lapse of the first drive time, comparing the output value with the output value received to determine whether the ice bank is full of ice to calculate variation of the output value, and driving the sensor heater for a second drive time to heat the optical sensor so that the optical sensor is defrosted if the calculated variation of the output value is equal to or greater than a reference variation.

INHIBITORS OF HISTONE DEMETHYLASES

Compounds of the form 2. A compound according to claim 1 , wherein A is selected from —CHRC(O)— claim 1 , Calkylene claim 1 , and heterocyclylene.3. A compound according to claim 1 , wherein Y is —NRR.4. A compound according to claim 3 , wherein A is —CHRC(O)—.5. A compound according to claim 4 , wherein A is —CH—C(O)—.9. A compound according to claim 1 , wherein Y is selected from heterocyclyl claim 1 , heteroaryl and aryl claim 1 , each of which may be optionally substituted with one or more R.10. A compound according to claim 1 , wherein Ris H.12. A compound according to claim 1 , wherein the moiety -A-Y includes 1-3 cyclic moieties selected from monocylic cycloalkyl claim 1 , monocyclic heterocyclyl claim 1 , monocylic heteroaryl claim 1 , dicyclic heteroaryl and monocyclic aryl.14. A compound according to claim 13 , in the form of an oxalate salt.15. A compound according to claim 13 , in the form of a citrate salt.16. A compound according to claim 13 , in the form of a fumarate salt.17. A compound according to claim 13 , in the form of an ascorbate salt.18. (canceled)19. A pharmaceutical composition comprising at least one compound of and one or more pharmaceutically acceptable excipients claim 1 , diluents or carriers.20. A pharmaceutical composition according to claim 19 , which comprises one or more further active substances.2123.-. (canceled)24. A method of treating a histone demethylase (HDME) dependent disease in a subject claim 1 , comprising administering to said subject a therapeutically effective amount of at least one compound of . The present invention relates to compounds capable of modulating the activity of histone demethylases (HDMEs), which compounds are useful for the prevention and/or the treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer.The DNA of eukaryotic cells is packaged into chromatin by winding of the DNA around histone proteins to form nucleosomes, the basic unit of chromatin. ...

Refrigerator

A refrigerator includes a body, a storage compartment provided in the body, a door to open and close the storage compartment, an icemaker provided to one side of the storage compartment, an ice bucket provided under the icemaker, and a crusher provided to the rear surface of the door and having an inlet disposed under the outlet of the ice bucket when the door is closed. The crusher may be provided separately from the ice bucket and may independently mounted and detached to and from the rear surface of the door. The ice bucket may have a slimmer design. The space utilization and usability of the storage compartments and the rear surface of the doors may be enhanced.

Refrigerator

The invention provides a refrigerator. A structure of an ice making compartment of the refrigerator capable of enlarging the volume of a storage compartment by reducing a width of an ice making compartment, and capable of easily discharging the whole ice separately from pieces of ice, the refrigerator including an opening/closing member configured to open and close a portion of a discharge hole and having a cover portion to prevent the whole ice from being discharged in a state that the portion of the discharge hole is closed, the refrigerator including an opening/closing member integrally formed with a fixed blade configured to crush ice in cooperation with a rotary blade.

Inhibitors of histone demethylases

Compounds of the form In which Q is selected from —CH═NR 12 , —W, —CH 2 NHR 13 , —CH═O and —CH(OR 17 ) 2 capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer and formulations and methods of use of such compounds.

Ice making apparatus and refrigerator having the same

Disclosed is an ice making apparatus and a refrigerator having the same. The refrigerator includes an ice making tray in which ice cubes are made, an ejector to discharge the ice cubes from the ice making tray, an ice bin to store the ice cubes discharged by the ejector, an auger to move the ice cubes in the ice bin, a first drive unit to provide the ejector with rotational force, a second drive unit to provide the auger with rotational force, an emitter to output optical signals so as to sense whether or not the ice cubes in the ice bin are at a full ice level, and a receiver to receive the optical signals output from the emitter, wherein any one of the emitter and the receiver is installed at the first drive unit, and the other one is installed at the second drive unit.

REFRIGERATOR

A structure of an ice making compartment of a refrigerator capable of enlarging the volume of a storage compartment by reducing a width of an ice making compartment, and capable of easily discharging the whole ice separately from pieces of ice, the refrigerator including an opening/closing member configured to open and close a portion of a discharge hole and having a cover portion to prevent the whole ice from being discharged in a state that the portion of the discharge hole is closed, the refrigerator including an opening/closing member integrally formed with a fixed blade configured to crush ice in cooperation with a rotary blade. 1. A refrigerator comprising:an ice maker configured to generate ice;an ice bucket comprising an ice storage space configured to store the ice being generated from the ice maker, and an ice crushing space formed at a front of the ice storage space, the ice crushing space provided with a lower portion having a discharge hole;an auger configured to deliver the ice stored in the ice storage space to the ice crushing space;at least one rotary blade coupled to the auger so as to rotate together with the auger;at least one fixed blade configured to crush ice in cooperation with the at least one rotary blade; andan opening/closing member configured to rotate on a hinge shaft, and configured to close a portion of the discharge hole to discharge ice being crushed or open the discharge hole to discharge uncrushed ice,wherein the opening/closing member comprises a cover portion protruding from one end of the opening/closing member to prevent the uncrushed ice from being discharged through the discharge hole in a state that the opening/closing member closes the portion of the discharge hole.2. The refrigerator of claim 1 , wherein the cover portion is located at a region between the ice storage space and a fixed blade claim 1 , disposed at a nearest position to the ice storage space claim 1 , among the at least one fixed blade.3. The refrigerator ...

REFRIGERATOR

A refrigerator is provided. The refrigerator includes an insulation structure and fastening structure of an ice-making compartment refrigerant pipe disposed at an inside an ice-making compartment configured to directly supply cooling energy by being in contact with an ice-making tray. The refrigerator includes an insulation member configured to surround the ice-making compartment refrigerant pipe, and a fixing member coupled to an outer circumferential surface of the insulation member in a shape of a loop to prevent the insulation member from being widened. 1. A refrigerator , comprising:an ice-making compartment;an ice-maker having an ice-making tray at which ice is generated, and a drain duct to collect defrost water of the ice-making tray;an ice-making compartment refrigerant pipe disposed at the ice-making compartment to directly supply cooling energy to the ice-making tray, the ice-making compartment refrigerant pipe configured to make contact with the ice-making tray;an insulation member configured to surround the ice-making compartment refrigerant pipe to thermally insulate the ice-making compartment refrigerant pipe, and formed as a first insulation member and a second insulation member are coupled to each other; anda fixing member coupled to the insulation member to prevent the first insulation member and the second insulation member from moving away from each other.2. The refrigerator of claim 1 , wherein:the fixing member is coupled to an outer circumferential surface of the insulation member in a shape of a loop, so as to surround the insulation member.3. The refrigerator of claim 1 , wherein:the first insulation member is coupled to an upper side of the second insulation member.4. The refrigerator of claim 1 , wherein:a through-hole is formed in between the first insulation member and the second insulation member, so that the ice-making compartment refrigerant pipe passes through the through-hole.5. The refrigerator of claim 4 , wherein:a first groove ...

REFRIGERATOR

A structure of an ice making compartment of a refrigerator capable of enlarging the volume of a storage compartment by reducing a width of an ice making compartment, and capable of easily discharging the whole ice separately from pieces of ice, the refrigerator including an opening/closing member configured to open and close a portion of a discharge hole and having a cover portion to prevent the whole ice from being discharged in a state that the portion of the discharge hole is closed, the refrigerator including an opening/closing member integrally formed with a fixed blade configured to crush ice in cooperation with a rotary blade. 1an ice maker configured to generate ice;an ice bucket including an ice storage space configured to store the ice being generated from the ice maker, and an ice crushing space formed at a front of the ice storage space, the ice crushing space provided with a lower portion having a discharge hole;an auger configured to deliver the ice stored in the ice storage space to the ice crushing space;at least one rotary blade coupled to the auger so as to rotate together with the auger;at least one fixed blade configured to crush ice in cooperation with the at least one rotary blade; andan opening/closing member configured to rotate on a hinge shaft, and configured to close a portion of the discharge hole to discharge ice being crushed or open the discharge hole to discharge uncrushed ice,wherein the opening/closing member includes a cover portion protruding from one end of the opening/closing member to prevent the uncrushed ice from being discharged through the discharge hole in a state that the opening/closing member closes the portion of the discharge hole.. A refrigerator comprising: This application is a continuation of U.S. patent application Ser. No. 13/733,539, filed on Jan. 3, 2013, which claims the benefit of Korean Patent Application No. 10-2012-0002141, filed on Jan. 6, 2012 in the Korean Intellectual Property Office, the disclosure ...

Apparatus and method for configuring a communication link

An apparatus and method are provided for configuring a communication link. The apparatus has a plurality of antenna elements to support RF communication over a communication link using a plurality of frequency channels, a plurality of RF processing circuits, and configuration circuitry to apply a selected configuration from a plurality of different configurations, where each configuration identifies which RF processing circuit each antenna element is coupled to, and which frequency channel is allocated to each RF processing circuit. The configuration circuitry is arranged to employ a reinforcement learning process in order to dynamically alter which of the plurality of different configurations to apply as a currently selected configuration. The reinforcement learning process comprises maintaining a future rewards record having a plurality of entries, where each entry maintains, for an associated combination of link state and configuration, an estimated future rewards indication determined using a discounted rewards mechanism. A selection policy is employed to select a configuration for a current link state, and then a new reward is observed that is dependent on how the selected configuration alters a chosen performance metric for the communication link. The estimated future rewards indication in the associated entry is then updated in dependence on the new reward. The updating comprises, when the associated entry is first encountered following a reset event, the storing in the associated entry of a predicted estimated future rewards indication generated by assuming, when using the discounted rewards mechanism, that all rewards that will be used in future to update the estimated future rewards indication in the associated entry will have the same value as the new reward.

APPARATUS AND METHOD FOR CONFIGURING A COMMUNICATION LINK

An apparatus and method are provided for configuring a communication link. The apparatus has a plurality of antenna elements to support RF communication over a communication link using a plurality of frequency channels, a plurality of RF processing circuits, and configuration circuitry to apply a selected configuration from a plurality of different configurations, where each configuration identifies which RF processing circuit each antenna element is coupled to, and which frequency channel is allocated to each RF processing circuit. The configuration circuitry is arranged to employ a reinforcement learning process in order to dynamically alter which of the plurality of different configurations to apply as a currently selected configuration. The reinforcement learning process comprises maintaining a future rewards record having a plurality of entries, where each entry maintains, for an associated combination of link state and configuration, an estimated future rewards indication determined using a discounted rewards mechanism. A selection policy is employed to select a configuration for a current link state, and then a new reward is observed that is dependent on how the selected configuration alters a chosen performance metric for the communication link. The estimated future rewards indication in the associated entry is then updated in dependence on the new reward. The updating comprises, when the associated entry is first encountered following a reset event, the storing in the associated entry of a predicted estimated future rewards indication generated by assuming, when using the discounted rewards mechanism, that all rewards that will be used in future to update the estimated future rewards indication in the associated entry will have the same value as the new reward. 1. An apparatus comprising:a plurality of antenna elements to support radio frequency (RF) communication over a communication link using a plurality of frequency channels;a plurality of RF processing ...

SYSTEMS AND METHODS FOR OPERATIONS AND INCIDENT MANAGEMENT

The present disclosure provides methods and systems for managing safety and risk in a remote workplace. The method may comprise: collecting, via a local network, data stream from one or more sensors and a user device; transmitting the data stream to an edge computing device via the local network, wherein the data stream is stored in a local database; processing, at the edge computing device, the data stream to identify a hazardous condition and a health condition of a user associated with the user device; and automatically generating a dynamic geofencing area in the remote workplace base at least in part on the hazardous condition and the health condition. 1. A method for managing safety and risk in a remote workplace comprising:(a) collecting, via a local network, data stream from one or more sensors and a user device;(b) transmitting the data stream to an edge computing device via the local network, wherein the data stream is stored in a local database;(c) processing, at the edge computing device, the data stream to identify a hazardous condition and a health condition of a user associated with the user device; and(d) automatically generating a dynamic geofencing area in the remote workplace base at least in part on the hazardous condition and the health condition.2. The method of claim 1 , wherein the one or more sensors comprise at least one sensor located onboard the user device and at least one sensor deployed in the remote workplace.3. The method of claim 2 , wherein the user device is a wearable device and the data stream collected from the at least one sensor located onboard the user device includes a heart rate of the user.4. The method of claim 3 , wherein the data stream collected from the at least one sensor located onboard the user device further comprises an activity level of the user.5. The method of claim 4 , further comprising calculating a work and rest hour of the user based on the data stream.6. The method of claim 3 , wherein the data stream ...

INHIBITORS OF HISTONE DEMETHYLASES

The present application discloses compounds capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament. The compounds take the form (I) 2. A compound according to claim 1 , wherein A is selected from —CHRC(O)— claim 1 , Calkylene claim 1 , and heterocyclylene.3. A compound according to claim 1 , wherein Y is —NRR.4. A compound according to claim 3 , wherein A is —CHRC(O)—.5. A compound according to claim 4 , wherein A is —CH—C(O)—.8. A compound according to claim 1 , wherein Y is selected from heterocyclyl claim 1 , heteroaryl and aryl claim 1 , which may be optionally substituted with one or more R.9. (canceled)10. A compound according to claim 1 , wherein the moiety -A-Y includes 1-3 cyclic moieties selected from monocylic cycloalkyl claim 1 , monocyclic heterocyclyl claim 1 , monocylic heteroaryl claim 1 , dicyclic heteroaryl and monocyclic aryl.11. A pharmaceutical composition comprising at least one compound of Formula (I) as defined in and one or more pharmaceutically acceptable excipients claim 1 , diluents or carriers.12. A pharmaceutical composition according to claim 11 , which comprises one or more further active substances.1315-. (canceled)16. A method of treating a histone demethylase-(HDME) dependent disease in a subject claim 1 , said method comprising administering to said subject a therapeutically effective amount of at least one compound of Formula (I) as defined in .17. The method of claim 16 , wherein the HDME dependent disease is a proliferative or hyperproliferative disease.18. The method of claim 16 , wherein the HDME dependent disease is a cancer.20. The compound of claim 19 , wherein Ris (R)N and at least one Ris H. The present invention relates to ...

OVEN

An oven with an enhanced structure to keep a cooking space clean includes a main body, a cooking chamber formed inside the main body and including a bottom wall, a burner provided at an outer lower part of the cooking chamber to heat up the cooking chamber, a door arranged to open or close the cooking chamber, a bottom plate coupled to the bottom wall of the cooking chamber with a gap from the bottom wall such that the bottom plate is located inside the cooking chamber, and an outlet for heated air formed between one end of the bottom plate facing the door and the bottom wall of the cooking chamber such that heated air generated from the burner is supplied to the door. 1. An oven comprising:a main body;a cooking chamber formed inside the main body and including a bottom wall;a burner provided below the bottom wall of the cooking chamber and configured to generate heated air;a door arranged to open or close the cooking chamber;a bottom plate provided to cover the bottom wall of the cooking chamber and to be spaced apart from the bottom wall of the cooking chamber; andan outlet for heated air formed between an end of the bottom plate facing the door and the bottom wall of the cooking chamber, such that the heated air generated from the burner is discharged toward the door.2. The oven of claim 1 , further comprising:a supporting plate coupled to the bottom wall of the cooking chamber between the bottom plate and the bottom wall, and including at least one moving hole for heated air formed at an end of the supporting plate facing the door.3. The oven of claim 2 , further comprising:a guide bracket provided between the bottom plate and the supporting plate to guide the heated air from the at least one moving hole for heated air to the outlet for heated air.4. The oven of claim 3 , wherein the guide bracket is coupled to the supporting plate to cover the at least one moving hole for heated air.5. The oven of claim 3 , wherein the guide bracket comprisesa first portion ...

OVEN

Provided herein is an oven in which a door has a double door structure that includes a first door formed of a transparent material and a second door formed of an opaque material to simultaneously ensure visibility and heat insulation. The oven includes a main body, a cooking compartment provided inside the main body and having an open front surface, a first door rotatably coupled to the main body to open and close the cooking compartment, formed of a transparent material to make an inside of the cooking compartment visible from the outside, and locked to and unlocked from the main body by a locking device, and a second door formed of an opaque material, rotatably coupled to a front surface of the first door, and locked to and unlocked from the first door by the locking device. 1. An oven comprising:a main body;a cooking compartment provided inside the main body and having an open front surface;a locking device;a first door rotatably coupled to the main body to open and close the cooking compartment, formed of a transparent material to make an inside of the cooking compartment visible from an outside thereof, and locked to and unlocked from the main body by the locking device; anda second door formed of an opaque material, rotatably coupled to a front surface of the first door, and locked to and unlocked from the first door by the locking device.2. The oven of claim 1 , further comprising:a handle coupled to a front surface of the second door, a support coupled to the handle,', 'a rotary lever coupled to the support to be rotatable in a horizontal direction,', 'a lever unit engaged with the rotary lever to rotate in a vertical direction,', 'a bracket having the lever unit rotatably coupled thereto, and', 'a locking member having the lever unit locked and unlocked thereto and therefrom., 'wherein the locking device includes3. The oven of claim 2 , wherein the locking member includes:a first locking member provided at the first door, anda second locking member provided ...

REFRIGERATOR

A refrigerator includes a body, a storage compartment provided in the body, a door to open and close the storage compartment, an icemaker provided to one side of the storage compartment, an ice bucket provided under the icemaker, and a crusher provided to the rear surface of the door and having an inlet disposed under the outlet of the ice bucket when the door is closed. The crusher may be provided separately from the ice bucket and may independently mounted and detached to and from the rear surface of the door. The ice bucket may have a slimmer design. The space utilization and usability of the storage compartments and the rear surface of the doors may be enhanced. 1. A refrigerator comprising:a body;a storage compartment provided in the body;a door rotatably coupled to the body to open and close the storage compartment;a dispenser provided to the door to allow water or ice in the storage compartment to be supplied to an exterior of the storage compartment without opening the door;an icemaker provided in the storage compartment to produce ice;an ice bucket provided in the storage compartment to store ice produced by the icemaker;a transport unit provided to the ice bucket to transport the ice stored in the ice bucket toward the dispenser; anda crusher to crush the ice transported by the transport unit and to supply the same to the dispenser, the crusher being provided separately from the ice bucket and the transport unit and mounted to a rear surface of the door.2. The refrigerator according to claim 1 , wherein the crusher is detachable from the rear surface of the door.3. The refrigerator according to claim 1 , wherein the crusher is mounted to a dyke protruding from the rear surface of the door to allow mounting of a door pocket.4. The refrigerator according to claim 3 , wherein the dyke is provided with a fitting groove claim 3 , and the crusher is provided with a fitting protrusion claim 3 ,wherein the crusher is mounted to the dyke by fitting the fitting ...

INHIBITORS OF HISTONE DEMETHYLASES

The present application discloses compounds capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament. The compounds take the form 3. The compound of claim 1 , wherein the compound is an acid addition salt.4. The compound of claim 3 , wherein the acid is selected from succinic claim 3 , maleic claim 3 , acetic claim 3 , fumaric claim 3 , citric claim 3 , tartaric claim 3 , benzoic claim 3 , trifluoroacetic claim 3 , malic claim 3 , lactic claim 3 , formic claim 3 , propionic claim 3 , glycolic claim 3 , gluconic claim 3 , camphorsulfuric claim 3 , isothionic claim 3 , mucic claim 3 , gentisic claim 3 , isonicotinic claim 3 , saccharic claim 3 , glucuronic claim 3 , furoic claim 3 , glutamic claim 3 , ascorbic claim 3 , anthranilic claim 3 , salicylic claim 3 , phenylacetic claim 3 , mandelic claim 3 , embonic (pamoic) claim 3 , ethanesulfonic claim 3 , pantothenic claim 3 , stearic claim 3 , sulfinilic claim 3 , alginic and galacturonic acid; and arylsulfonic claim 3 , for example benzenesulfonic claim 3 , p-toluenesulfonic claim 3 , oxalic claim 3 , methanesulfonic and naphthalenesulfonic acid5. The compound of claim 4 , wherein the acid is p-toluenesulfonic or oxalic.6. The compound of claim 2 , wherein the compound is an acid addition salt.7. The compound of claim 5 , wherein the acid is selected from succinic claim 5 , maleic claim 5 , acetic claim 5 , fumaric claim 5 , citric claim 5 , tartaric claim 5 , benzoic claim 5 , trifluoroacetic claim 5 , malic claim 5 , lactic claim 5 , formic claim 5 , propionic claim 5 , glycolic claim 5 , gluconic claim 5 , camphorsulfuric claim 5 , isothionic claim 5 , mucic claim 5 , gentisic claim 5 , isonicotinic claim 5 , saccharic claim ...

INHIBITORS OF HISTONE DEMETHYLASES

Compounds of the form 5. The compound of claim 1 , wherein the compound is an acid addition salt.6. The compound of claim 5 , wherein the acid is selected from succinic claim 5 , maleic claim 5 , acetic claim 5 , fumaric claim 5 , citric claim 5 , tartaric claim 5 , benzoic claim 5 , trifluoroacetic claim 5 , malic claim 5 , lactic claim 5 , formic claim 5 , propionic claim 5 , glycolic claim 5 , gluconic claim 5 , camphorsulfuric claim 5 , isothionic claim 5 , mucic claim 5 , gentisic claim 5 , isonicotinic claim 5 , saccharic claim 5 , glucuronic claim 5 , furoic claim 5 , glutamic claim 5 , ascorbic claim 5 , anthranilic claim 5 , salicylic claim 5 , phenylacetic claim 5 , mandelic claim 5 , embonic (pamoic) claim 5 , ethanesulfonic claim 5 , pantothenic claim 5 , stearic claim 5 , sulfinilic claim 5 , alginic and galacturonic acid; and arylsulfonic claim 5 , for example benzenesulfonic claim 5 , p-toluenesulfonic claim 5 , oxalic claim 5 , methanesulfonic and naphthalenesulfonic acid7. The compound of claim 6 , wherein the acid is p-toluenesulfonic or oxalic.8. The compound of claim 2 , wherein the compound is an acid addition salt.9. The compound of claim 8 , wherein the acid is selected from succinic claim 8 , maleic claim 8 , acetic claim 8 , fumaric claim 8 , citric claim 8 , tartaric claim 8 , benzoic claim 8 , trifluoroacetic claim 8 , malic claim 8 , lactic claim 8 , formic claim 8 , propionic claim 8 , glycolic claim 8 , gluconic claim 8 , camphorsulfuric claim 8 , isothionic claim 8 , mucic claim 8 , gentisic claim 8 , isonicotinic claim 8 , saccharic claim 8 , glucuronic claim 8 , furoic claim 8 , glutamic claim 8 , ascorbic claim 8 , anthranilic claim 8 , salicylic claim 8 , phenylacetic claim 8 , mandelic claim 8 , embonic (pamoic) claim 8 , ethanesulfonic claim 8 , pantothenic claim 8 , stearic claim 8 , sulfinilic claim 8 , alginic and galacturonic acid; and arylsulfonic claim 8 , for example benzenesulfonic claim 8 , p-toluenesulfonic claim 8 , ...

Inhibitors of histone demethylases

The present application discloses compounds capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament. The compounds take the form

Inhibitors of histone demethylases

Inhibitors of histone demethylases

Inhibitors of histone demethylases

Inhibitors of histone demethylases

Refrigerator

Ice making apparatus and refrigerator having the same

Disclosed is an ice making apparatus and a refrigerator having the same. The refrigerator includes an ice making tray in which ice cubes are made, an ejector to discharge the ice cubes from the ice making tray, an ice bin to store the ice cubes discharged by the ejector, an auger to move the ice cubes in the ice bin, a first drive unit to provide the ejector with rotational force, a second drive unit to provide the auger with rotational force, an emitter to output optical signals so as to sense whether or not the ice cubes in the ice bin are at a full ice level, and a receiver to receive the optical signals output from the emitter, wherein any one of the emitter and the receiver is installed at the first drive unit, and the other one is installed at the second drive unit.

Substituted pyridine derivatives and compositions thereof useful as inhibitors of histone demethylases

87210600 ABSTRACT The present application discloses compounds capable of modulating the activity of histone demethylases (HDMEs), including: H3C00 0 CH3 1 H I NN NN,Ci.i3 ,..,,_, ,..-.113 / or a pharmaceutically acceptable salt thereof. The compounds may be used for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament. Date Recue/Date Received 2020-10-01

Inhibitors of histone demethylases

Ice-making unit and refrigerator having the same

Disclosed herein are an ice-making unit (105), which uses a cooling unit (110) in which a refrigerant pipe is received, and a refrigerator having the same. The cooling unit (110) includes a cooler (115) for conduction of coldness, an inner surface of the cooler coming into direct contact with the refrigerant pipe (112), realizing a direct cooling type ice making operation. A rotatable tray (150) is provided under the cooling unit (110), so that an ice-separating member (130) attached to the cooling unit (110) pushes ice upon rotation of the tray (150), allowing the ice to be discharged in a direction opposite to the rotating direction of the tray.

HISTONE DEMETILASE INHIBITORS

La invencion describe compuestos de formula (I) capaces de modular la actividad de las histona demetilasas (HDME), que son utiles para la prevencion y/o el tratamiento de enfermedades en donde la desregulacion genomica esta implicada en la patogenia, como por ejemplo el cancer. La invencion describe tambien las composiciones farmaceuticas que comprenden dichos compuestos y el uso de dichos compuestos como un medicamento. Los compuestos preferidos son: Acido 2-{[({[1-(3-fenilpropil) piperidin-4-il] carbamoil}metil) amino]metil}piridina-4-carboxilico; metil 2-({[3-(pirrolidin-1-il)propil]amino}metil) piridina-4-carboxilato; entre otros The invention describes compounds of formula (I) capable of modulating the activity of histone demethylases (HDME), which are useful for the prevention and / or treatment of diseases where genomic dysregulation is involved in the pathogenesis, such as, for example, Cancer. The invention also describes pharmaceutical compositions comprising said compounds and the use of said compounds as a medicine. Preferred compounds are: 2 - {[({[1- (3-phenylpropyl) piperidin-4-yl] carbamoyl} methyl) amino] methyl} pyridine-4-carboxylic acid; methyl 2 - ({[3- (pyrrolidin-1-yl) propyl] amino} methyl) pyridine-4-carboxylate; among others

cooler

refrigerador. é divulgado um aparelho de fazer gelo e um refrigerador tendo o mesmo. o refrigerador inclui uma bandeja de fazer gelo na qual cubos de gelo são feitos, um ejetor para descarregar os cubos de gelo da bandeja de fazer gelo, um depósito de gelo para armazenar os cubos de gelo descarregados pelo ejetor, uma verruma para mover os cubos de gelo no depósito de gelo, uma primeira unidade de movimentação para fornecer ao ejetor força rotacional, uma segunda unidade de movimentação para fornecer a verruma força rotacional, um emissor para emitir sinais ópticos, de modo a detectar se ou não os cubos de gelo no depósito de gelo estão em um nível de gelo cheio e um receptor para receber os sinais ópticos emitidos do emissor do emissor, em que qualquer um do emissor e do receptor está instalado na primeira unidade de movimentação e ou outro está instalado na segunda unidade de movimentação. cooler. an ice maker and a refrigerator having the same is disclosed. the refrigerator includes an ice maker on which ice cubes are made, an ejector to unload ice cubes from the ice maker, an ice tank to store the ice cubes discharged from the ejector, an auger to move the cubes of ice in the ice tank, a first drive unit to provide the ejector with rotational force, a second drive unit to provide the auger with rotational force, an emitter to emit optical signals, in order to detect whether or not the ice cubes in the ice tanks are at a full ice level and a receiver to receive the optical signals emitted from the emitter of the emitter, where either the emitter and the receiver is installed in the first handling unit and or another is installed in the second handling unit .

Refrigerator

A refrigerator includes a body, a storage compartment provided in the body, a door to open and close the storage compartment, an icemaker provided to one side of the storage compartment, an ice bucket provided under the icemaker, and a crusher provided to the rear surface of the door and having an inlet disposed under the outlet of the ice bucket when the door is closed. The crusher may be provided separately from the ice bucket and may independently mounted and detached to and from the rear surface of the door. The ice bucket may have a slimmer design. The space utilization and usability of the storage compartments and the rear surface of the doors may be enhanced.

Inhibitors of histone demethylases

Il:\sxdInterwovn\NRPortbl\DCC\SXD\ 6389646 _docx-6/02 2018 N-A--Y N (I) The present application discloses compounds capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament. The compounds take the form (I).

Inhibitors of histone demethylases

Substitued pyridine derivatives and compositions thereof useful as inhibitors of histone demethylases

The present application discloses compounds capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament. The compounds take the form (I).

Ice-making unit and refrigerator having the same

Disclosed herein are an ice-making unit (105), which uses a cooling unit (110) in which a refrigerant pipe is received, and a refrigerator having the same. The cooling unit (110) includes a cooler (115) for conduction of coldness, an inner surface of the cooler coming into direct contact with the refrigerant pipe (112), realizing a direct cooling type ice making operation. A rotatable tray (150) is provided under the cooling unit (110), so that an ice-separating member (130) attached to the cooling unit (110) pushes ice upon rotation of the tray (150), allowing the ice to be discharged in a direction opposite to the rotating direction of the tray.

Inhibitors of histone demethylases

The present application discloses compounds capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament. The compounds take the form (I).

Ice making apparatus and refrigerator having the same

Disclosed is an ice making apparatus and a refrigerator having the same. The refrigerator includes an ice making tray in which ice cubes are made, an ejector to discharge the ice cubes from the ice making tray, an ice bin to store the ice cubes discharged by the ejector, an auger to move the ice cubes in the ice bin, a first drive unit to provide the ejector with rotational force, a second drive unit to provide the auger with rotational force, an emitter to output optical signals so as to sense whether or not the ice cubes in the ice bin are at a full ice level, and a receiver to receive the optical signals output from the emitter, wherein any one of the emitter and the receiver is installed at the first drive unit, and the other one is installed at the second drive unit.

Refrigerator

A structure of an ice making compartment of a refrigerator capable of enlarging the volume of a storage compartment by reducing a width of an ice making compartment, and capable of easily discharging the whole ice separately from pieces of ice, the refrigerator including an opening/closing member configured to open and close a portion of a discharge hole and having a cover portion to prevent the whole ice from being discharged in a state that the portion of the discharge hole is closed, the refrigerator including an opening/closing member integrally formed with a fixed blade configured to crush ice in cooperation with a rotary blade.

Inhibitors of histone demethylases

I: \sxd\Interwoven\NRPortbl\DCC\SXD\ 6389646 _docx-6 02 2018 N-A--Y N (I) The present application discloses compounds capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament. The compounds take the form (I).

Dual antiplatelet/anticoagulant pyridoxine analogs

Pyridoxine analogs , particularly bis-amidine pyridoxine analogs with antiplatelet and anticoagulant characteristics for the treatment of cardiovascular, cerebrovascular and cardiovascular related diseases and symptoms are described. The methods are directed to administering pharmaceutical compositions comprising substituted bis-amidine pyridoxine analogs having the following formulas:(I),(II),(III). wherein at least two of substituents R1- R6 have amidine groups.

Cooking apparatus

A cooking apparatus is disclosed. The cooking apparatus according to an embodiment of the present disclosure may comprise: an outer case with a lower surface including a first inlet hole and a second inlet hole; an inner case which is accommodated in the outer case and in which a cooking chamber is formed; a fan which is disposed above the first inlet hole and suctions air introduced through the first inlet hole so as to allow air to be suctioned through the first and second inlet holes; and a rear flow channel which is formed at the rear of the inner case to communicate with the fan so as to allow air suctioned through the first inlet hole to be guided to the fan.

Range hood and cooking apparatus having same

Disclosed herein is a cooking appliance including a case having a front surface, side surfaces, and a lower surface on which an inlet is formed, a main fan disposed within the case and configured to draw in air through the inlet, a blade disposed in front of a front end of the inlet and protruding from the front surface of the case towards a front side of the case, and an auxiliary fan module including an auxiliary fan disposed within the case and an outlet disposed on the lower surface of the case to allow air blown by the auxiliary fan to be discharged downwardly from the case, wherein the outlet is disposed laterally outwardly of the case than a side end of the inlet on the lower surface of the case.

Systems and methods for operations and incident management

Apparatus and method for configuring a communication link

An apparatus and method are provided for configuring a communication link. Wherein the apparatus has a plurality of antenna elements to support RF communication using a plurality of frequency channels, a plurality of RF processing circuits, and configuration circuitry to apply a selected configuration from a plurality of different configurations, where each configuration identifies which RF processing circuit each antenna element coupled to, and which channel allocated to each RF processing circuit. The configuration circuitry arranged to a reinforcement learning process in order to dynamically alter which of the plurality of different configurations to apply a currently selected configuration. The reinforcement learning process maintaining a future rewards record having a plurality of entries, where each entry maintains, for an associated combination of link state and configuration, an estimated future rewards indication determined using a discounted rewards mechanism. A selection policy is to select a configuration for a current link state, and a new reward is observed is dependent on how the selected configuration alters a chosen performance metric for the communication link. The estimated future rewards indication in the associated entry is then updated in dependence on the new reward.

Ventilation hood

A ventilation hood includes a main frame which faces an appliance accessible from a front of the appliance, the main frame defining a through-hole passing through the main frame, a motor module on the main frame and configured to suck in air through the through-hole, the motor module including a duct, a motor having an axis, and an exhaust fan driven by the motor and defining a blowing direction perpendicular to the axis of the motor, and a controller configured to control operation of the ventilation hood and a rotation velocity of the exhaust fan. The axis of the motor is in a direction from the front of the appliance to a rear of the appliance which is opposite to the front. The controller is on the main frame and at a front of the duct which corresponds to the front of the appliance.

Apparatus and method for configuring a communication link

Antenna elements support RF communication over a communication link using frequency channels, RF processing circuits, and configuration circuitry to apply a selected configuration. Each configuration identifies processing circuit to antenna element couplings, and which frequency channel is allocated to each RF processing circuit. A reinforcement learning process is applied to dynamically alter which configuration to apply as a currently selected configuration. The reinforcement learning process maintains a future rewards record having entries that maintain, for an associated combination of link state and configuration, an estimated future rewards indication determined using a discounted rewards mechanism. A selection policy selects a configuration for a current link state, and then a new reward is observed that is dependent on how the selected configuration alters a chosen performance metric for the communication link. The estimated future rewards indication is updated by storing in the associated entry a predicted estimated future rewards indication generated by assuming, when using the discounted rewards mechanism, that all rewards that will be used in future to update the estimated future rewards indication in the associated entry will have the same value as the new reward.

Cooking appliance

Dual antiplatelet/anticoagulant pyridoxine analogs

Pyridoxine analogs , particularly bis-amidine pyridoxine analogs with antiplatelet and anticoagulant characteristics for the treatment of cardiovascular, cerebrovascular and cardiovascular related diseases and symptoms are described. The methods are directed to administering pharmaceutical compositions comprising substituted bis-amidine pyridoxine analogs having the following formulas:(I),(II),(III). wherein at least two of substituents R1- R6 have amidine groups.

Hair dryer

A hair dryer including a main body; a fan inside the main body to generate a flow of air; and a nozzle connected to the main body so that the air flows into the nozzle. The nozzle includes a nozzle body having an inner space, a nozzle partition wall inside the nozzle body dividing the inner space into first and second nozzle passages, a plurality of first nozzle holes formed in the nozzle body to communicate with the first nozzle passage, and a plurality of second nozzle holes formed in the nozzle body to communicate with the second nozzle passage. The nozzle is configured so that air flowing into the first nozzle passage is discharged through the first nozzle holes in a first direction, and air flowing into the second nozzle passage is discharged through the second nozzle holes in a second direction that is different from the first direction.

Oven

An oven with an enhanced structure to keep a cooking space clean includes a main body, a cooking chamber formed inside the main body and including a bottom wall, a burner provided at an outer lower part of the cooking chamber to heat up the cooking chamber, a door arranged to open or close the cooking chamber, a bottom plate coupled to the bottom wall of the cooking chamber with a gap from the bottom wall such that the bottom plate is located inside the cooking chamber, and an outlet for heated air formed between one end of the bottom plate facing the door and the bottom wall of the cooking chamber such that heated air generated from the burner is supplied to the door.

An apparatus and method for configuring a communication link

An apparatus and method are provided for configuring a communication link. The apparatus has a plurality of antenna elements to support RF communication over a communication link using a plurality of frequency channels, a plurality of RF processing circuits, and configuration circuitry to apply a selected configuration from a plurality of different configurations, where each configuration identifies which RF processing circuit each antenna element is coupled to, and which frequency channel is allocated to each RF processing circuit. The configuration circuitry is arranged to employ a reinforcement learning process in order to dynamically alter which of the plurality of different configurations to apply as a currently selected configuration. The reinforcement learning process comprises maintaining a future rewards record having a plurality of entries, where each entry maintains, for an associated combination of link state and configuration, an estimated future rewards indication determined using a discounted rewards mechanism. A selection policy is employed to select a configuration for a current link state, and then a new reward is observed that is dependent on how the selected configuration alters a chosen performance metric for the communication link. The estimated future rewards indication in the associated entry is then updated in dependence on the new reward. The updating comprises, when the associated entry is first encountered following a reset event, the storing in the associated entry of a predicted estimated future rewards indication generated by assuming, when using the discounted rewards mechanism, that all rewards that will be used in future to update the estimated future rewards indication in the associated entry will have the same value as the new reward.

An apparatus and method for configuring a communication link

An apparatus and method are provided for configuring a communication link such as in a micro cell that provides a backhaul connection to a mobile network. The apparatus 10 has several reconfigurable antenna elements (12, 14, 16) for communication over wireless links using various frequency channels, and configuration means to apply a configuration selected from several different configurations. Each configuration identifies which RF processing circuit each antenna element is coupled to and which frequency channel is allocated to each circuit. The configuration means employs a reinforcement learning process to dynamically select which of the different configurations to apply. The reinforcement learning process comprises observing how chosen configurations effect the current link state metrics (e.g. throughput) and applies rewards (i.e. weightings) to different configuration settings - depending on their observed effects. A future rewards record is maintained for combinations of link state and configuration and is used to determine optimal future configuration settings. Updates of configuration may be initiated based on events, such as resetting the device or moving the device to a new location, or based on time. The macro cell (e.g. donor eNodeB) may be installed in to a building to optimise utilisation of a mobile network.

An apparatus and method for configuring a communication link

Topopyrones: dual topoisomerase inhibitors

The present invention provides for topopyrones and their derivatives which act as poisons of both human DNA topoisomerase I and human DNA topoisomerase II. The topopyrones thus represent a rare example of molecules capable of interacting effectively with more than one DNA topoisomerase.

Systems and methods for operations and incident management

The present disclosure provides methods and systems for managing safety and risk in a remote workplace. The method may comprise: collecting, via a local network, data stream from one or more sensors and a user device; transmitting the data stream to an edge computing device via the local network, wherein the data stream is stored in a local database; processing, at the edge computing device, the data stream to identify a hazardous condition and a health condition of a user associated with the user device; and automatically generating a dynamic geofencing area in the remote workplace base at least in part on the hazardous condition and the health condition.

Ventilation hood

A ventilation hood includes a main frame which faces an appliance accessible from a front of the appliance, the main frame defining a through-hole passing through the main frame, a motor module on the main frame and configured to suck in air through the through-hole, the motor module including a duct, a motor having an axis, and an exhaust fan driven by the motor and defining a blowing direction perpendicular to the axis of the motor, and a controller configured to control operation of the ventilation hood and a rotation velocity of the exhaust fan. The axis of the motor is in a direction from the front of the appliance to a rear of the appliance which is opposite to the front. The controller is on the main frame and at a front of the duct which corresponds to the front of the appliance.

Hood system and method of controlling the same

A hood system including a main body comprising an exhaust duct, a fan configured to generate airflow in the exhaust duct, an arm including an intake port and configured to allow air to be sucked into the intake port so as to pass through the arm and thereafter in the exhaust duct, a driving unit configured to be driven to move the arm, a sensor module configured to sense an environmental state of the hood system, and at least one processor configured to control driving of the driving unit based on the sensed environmental state to move the arm and thereby position the intake port based on the sensed environmental state.

Pyridoxal-5-phosphate (p5p) analogs

Disclosed are compound, its stereoisomer, salt, hydrate, solvate, isotope or crystalline form thereof, represented by Formula (I), with X, R1, R2, R3, R4 and R5 as disclosed herein. Also, disclosed is a process for their preparation, compositions containing such compounds, methods of medical treatment or prophylaxis of a disease by such compounds and uses thereof. The compounds of Formula (I) are pyridoxal-5-phosphate (P5P) analogs, and can act as prodrugs.

Food waste disposer

A food waste disposer including a housing, a container disposed inside the housing and provided to accommodate food waste, an exhaust duct communicating with the container and provided to allow exhaust gas generated in the container to flow therein, a filter device including a catalytic filter part configured to filter the exhaust gas passed through the exhaust duct, and a deodorizing filter part configured to filter the exhaust gas passed through the catalytic filter part and communicating with an outside of the housing, and a condensation chamber configured to remove moisture in the exhaust gas flowing from the exhaust duct into the catalytic filter part of the filter device.

Food disposal unit

The food disposal unit may comprise: a housing; a container disposed in the housing so as to accommodate food material; an exhaust duct which communicates with the container, and through which exhaust gas generated in the container flows; a filter device including a catalyst filter part, which filters the exhaust gas having passed through the exhaust duct, and a deodorizing filter part, which filters the exhaust gas having passed through the catalyst filter part and communicates with the outside of the housing; and a condensation chamber for removing the moisture of the exhaust gas flowing into the catalyst filter part of the filter device from the exhaust duct.

Hood system and control method therefor

A hood system according to one embodiment comprises: a main body having an exhaust duct, a fan configured to generate airflow in the exhaust duct, an arm including an intake port and configured to allow air to be sucked into the intake port so as to pass through the arm and thereafter in the exhaust duct, a driving unit configured to be driven to move the arm, a sensor module configured to sense an environmental state of the hood system, and at least one processor configured to control driving of the driving unit based on the sensed environmental state to move the arm and thereby position the intake port based on the sensed state.

Inhibidores de histona desmetilasas

Compuestos de la forma: (Consta fórmula) en la cual Q se selecciona entre –CH=NR12, –W, –CH2NHR13 , –CH=O y –CH(OR17)2 capaces de modular la actividad de histona desmetilasas (HDMEs), los cuales son útiles para la prevención y/o el tratamiento de enfermedades en donde la desregulación genómica está involucrada en la patogénesis, tal como por ej. cáncer y formulaciones y métodos de uso de dichos compuestos.

Pyridoxal-5-phosphate (p5p) analogs

Disclosed are compound, its stereoisomer, salt, hydrate, solvate, isotope or crystalline form thereof, represented by Formula (I), with X, R

Pyridoxal-5-phosphate (p5p) analogs

Disclosed are compound, its stereoisomer, salt, hydrate, solvate, isotope or crystalline form thereof, represented by Formula (I), with X, R 1 , R 2 , R 3 , R 4 and R 5 as disclosed herein. Also, disclosed is a process for their preparation, compositions containing such compounds, methods of medical treatment or prophylaxis of a disease by such compounds and uses thereof. The compounds of Formula (I) are pyridoxal-5-phosphate (P5P) analogs, and can act as prodrugs.

Gas burner

Pyridoxal-5-phosphate (p5p) analogs

Disclosed are compound, its stereoisomer, salt, hydrate, solvate, isotope or crystalline form thereof, represented by Formula (I), with X, R1, R2, R3, R4 and R5 as disclosed herein. Also, disclosed is a process for their preparation, compositions containing such compounds, methods of medical treatment or prophylaxis of a disease by such compounds and uses thereof. The compounds of Formula (I) are pyridoxal-5-phosphate (P5P) analogs, and can act as prodrugs.

Ice making apparatus and refrigerator having the same

Disclosed is an ice making apparatus and a refrigerator having the same. The refrigerator includes an ice making tray in which ice cubes are made, an ejector to discharge the ice cubes from the ice making tray, an ice bin to store the ice cubes discharged by the ejector, an auger to move the ice cubes in the ice bin, a first drive unit to provide the ejector with rotational force, a second drive unit to provide the auger with rotational force, an emitter to output optical signals so as to sense whether or not the ice cubes in the ice bin are at a full ice level, and a receiver to receive the optical signals output from the emitter, wherein any one of the emitter and the receiver is installed at the first drive unit, and the other one is installed at the second drive unit.