Настройки

Укажите год
-

Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

Подробнее
-

Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

Подробнее

Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Укажите год
Укажите год
Применить Всего найдено 25. Отображено 19.
13-09-2012 дата публикации

COMPOSITIONS AND METHODS FOR TREATMENT OF PAIN

Номер: US20120230957A1
Автор: Klumpp David J., Rudick Charles N., Schaeffer Anthony J.
Принадлежит: Northwestern University

The present invention provides compositions and methods for treatment or prevention of pain resulting from infection, infection related pain, and non-infectious pain as well as treatment or prevention of infections or adverse health consequences associated with infections. 1. A method for treatment or prevention of pain comprising administering a probiotic composition to a subject having pelvic pain.2. The method of claim 1 , wherein said pain is due to an active or inactive urinary tract infection.3. The method of claim 1 , wherein said subject has previously been diagnosed with a urinary tract infection.4. The method of claim 1 , wherein said probiotic compositions comprise probiotic bacteria.5. The method of claim 1 , wherein said probiotic compositions comprise compositions derived from probiotic bacteria.6. The method of claim 1 , wherein probiotic compositions comprise LPS.7E. coli. The method of claim 4 , wherein said probiotic composition an asymptomatic strain isolated from the human urinary tract.8E. coli. The method of claim 7 , wherein said probiotic composition comprises a strain of selected from the group consisting of NUA2 claim 7 , NUA1 claim 7 , 2-21 claim 7 , 2-37 claim 7 , 2-35 claim 7 , 2-32 claim 7 , 2-13 claim 7 , 2-29 claim 7 , 2-42 claim 7 , 2-44 claim 7 , 2-8 claim 7 , 2-43 claim 7 , NUA3 claim 7 , 83972 claim 7 , 2-33 and 2-12.9E. coli. The method of claim 8 , wherein said probiotic bacteria comprises strain 83972 or a bacteria or strain that produces a functionally equivalent reduction in pain.10E. coli. The method of claim 8 , wherein said probiotic bacteria comprises strain 2-12 or a bacteria or strain that produces a functionally equivalent reduction in pain.11. The method of claim 1 , wherein said probiotic composition treats or prevents infection and/or inflammation in addition to pain.12. The method of claim 1 , wherein said probiotic composition treats or prevents pain without treating or preventing infection and/or inflammation.13. ...

Подробнее
Номер записи: 1
14-11-2013 дата публикации

METHODS FOR TREATING CHRONIC PELVIC PAIN SYNDROME WITH ANTIBODIES THAT BINDS MCP-1 OR MIP-1A

Номер: US20130303530A1
Автор: Klumpp David, Schaeffer Anthony J., Thumbikat Praveen
Принадлежит: Northwestern University

The present invention provides methods and compositions for treating chronic pelvic pain syndrome. In particular, the present invention provides methods and compositions for treating chronic pelvic pain syndrome with an agent that targets MCP-1, MIP-1α, or the CCR-2 receptor. 1. A method of treating a subject having , or suspected of having , chronic pelvic pain syndrome comprising:treating a subject with an agent that targets MCP-1, MIP-1α, or the CCR-2 receptor,wherein said subject has one or more symptoms of chronic pelvic pain syndrome,wherein said agent is selected from the group consisting of: an indolopiperidine, a spiropiperidine, a 2-substituted indole, a pyrazolone derivative, a 2-substituted benzimidazole, an N,N-dialkylhomopiperazine, a bicyclic pyrrole, a 5-aryl pentadienamide, and a cyclic amine derivative; andwherein said treating is under conditions such that at least one of said symptoms is reduced or eliminated.2. A method of diagnosing and treating chronic pelvic pain syndrome comprising:a) detecting the expression of MCP-1 and/or MIP-1α in said sample from a subject, wherein said subject has one or more symptoms of chronic pelvic pain syndrome; andb) treating said subject with an agent that targets MCP-1, MIP-1α, the CCR-2 receptor, wherein said treating is under conditions such that at least one of said symptoms is reduced or eliminated, and wherein said agent is selected from the group consisting of: an indolopiperidine, a spiropiperidine, a 2-substituted indole, a pyrazolone derivative, a 2-substituted benzimidazole, an N,N-dialkylhomopiperazine, a bicyclic pyrrole, a 5-aryl pentadienamide, and a cyclic amine derivative.3. The method of claim 2 , wherein said chronic pelvic pain syndrome is non-inflammatory chronic pelvic pain syndrome.4. The method of claim 2 , wherein said subject is male claim 2 , and wherein said sample comprises an expressed prostatic secretion sample from said subject.5. The method of claim 4 , wherein said expressed ...

Подробнее
Номер записи: 2
20-03-2014 дата публикации

MAST CELL MARKERS AND PREVENTION, DIAGNOSIS, AND THERAPY FOR CHRONIC PELVIC PAIN SYNDROME

Номер: US20140079718A1
Автор: Done Joseph, Klumpp David J., Rudick Charles, Schaeffer Anthony J., Thumbikat Praveen
Принадлежит: Northwestern University

The present invention provides compositions and methods for detection, diagnosis, treatment and/or prevention of chronic pelvic pain syndrome. In particular, the present invention provides biomarkers of chronic pelvic pain syndrome (e.g., mast cell markers (e.g., tryptase)), and/or inhibition of mast cell function (e.g. inhibition of MCP-1 and/or MIP-1α) to treat or prevent chronic pelvic pain syndrome. 1. A method for treating and/or preventing chronic pelvic pain syndrome in a subject , comprising administering therapeutic composition comprising a therapeutically effective amount of an inhibitor of mast cell function to said subject.2. The method of claim 1 , wherein said inhibitor of mast cell function comprises a combination of a mast cell stabilizer and a histamine receptor antagonist.3. The method of claim 2 , wherein said therapeutic composition further comprising one or more inhibitors of MCP-1 and/or MIP-1α.4. The method of claim 2 , wherein said histamine receptor antagonist comprises a histamine receptor 1 antagonist and/or histamine receptor 2 antagonist.5. A method for treating and/or preventing chronic pelvic pain syndrome in a subject claim 2 , comprising co-administering a mast cell stabilizer and a histamine receptor antagonist.6. The method of claim 5 , further comprising administering one or more inhibitors of MCP-1 or MIP-1α.7. A composition for the treatment or prevention of CPPS claim 5 , comprising:a) a mast cell stabilizer; andb) a histamine receptor antagonist.8. The composition of claim 7 , further comprising an inhibitor of a CPPS biomarker.9. The composition for the treatment or prevention of CPPS of claim 7 , wherein said histamine receptor antagonist comprises a histamine receptor 1 antagonist and/or a a histamine receptor 2 antagonist.10. The composition for the treatment or prevention of CPPS of claim 7 , comprising inhibitors of MIP-1α and/or MCP-1.11. A method for detecting chronic pelvic pain syndrome in a subject claim 7 , ...

Подробнее
Номер записи: 3
03-03-2016 дата публикации

MAST CELL MARKERS AND PREVENTION, DIAGNOSIS, AND THERAPY FOR CHRONIC PELVIC PAIN SYNDROME

Номер: US20160058756A1
Автор: Done Joseph, Klumpp David J., Rudick Charles, Schaeffer Anthony J., Thumbikat Praveen
Принадлежит:

The present invention provides compositions and methods for detection, diagnosis, treatment and/or prevention of chronic pelvic pain syndrome. In particular, the present invention provides biomarkers of chronic pelvic pain syndrome (e.g., mast cell markers (e.g., tryptase)), and/or inhibition of mast cell function (e g inhibition of MCP-1 and/or MIP-1α) to treat or prevent chronic pelvic pain syndrome. 1. A method for treating and/or preventing chronic pelvic pain syndrome in a subject , comprising administering therapeutic composition comprising a therapeutically effective amount of an inhibitor of mast cell function to said subject.2. The method of claim 1 , wherein said inhibitor of mast cell function comprises a combination of a mast cell stabilizer and a histamine receptor antagonist.3. The method of claim 2 , wherein said therapeutic composition further comprising one or more inhibitors of MCP-1 and/or MIP-1α.4. The method of claim 2 , wherein said histamine receptor antagonist comprises a histamine receptor 1 antagonist and/or histamine receptor 2 antagonist.5. A method for treating and/or preventing chronic pelvic pain syndrome in a subject claim 2 , comprising co-administering a mast cell stabilizer and a histamine receptor antagonist.6. The method of claim 5 , further comprising administering one or more inhibitors of MCP-1 or MIP-1α.7. A composition for the treatment or prevention of CPPS claim 5 , comprising:a) a mast cell stabilizer; andb) a histamine receptor antagonist.8. The composition of claim 7 , further comprising an inhibitor of a CPPS biomarker.9. The composition for the treatment or prevention of CPPS of claim 7 , wherein said histamine receptor antagonist comprises a histamine receptor 1 antagonist and/or a a histamine receptor 2 antagonist.10. The composition for the treatment or prevention of CPPS of claim 7 , comprising inhibitors of MIP-1α and/or MCP-1.11. A method for detecting chronic pelvic pain syndrome in a subject claim 7 , ...

Подробнее
Номер записи: 4
29-03-2018 дата публикации

Altered microbiome of chronic pelvic pain

Номер: US20180087094A1
Автор: Anthony J. Schaeffer, Bryan A. White, David J. Klumpp
Принадлежит: Northwestern University, University of Illinois

Provided herein are kits, compositions, and methods for diagnosing and treating interstitial cystitis (IC) and/or interstitial cystitis/bladder pain syndrome (IC/BPS) based on finding lower levels of certain bacteria in a subject's stool sample (e.g., O. splanchnicus, F. prausnitzii, C. aerofaciens, E. sinensis, L. longoviformis , and R. intestinalis ). In certain embodiments, then present invention provides probiotic formulations containing live bacteria (e.g., from O. splanchnicus, F. prausnitzii, C. aerofaciens, E. sinensis, L. longoviformis , and R. intestinalis ).

Подробнее
Номер записи: 5
26-05-2016 дата публикации

Live-attenuated compositions for bacterial infections

Номер: US20160144012A1
Автор: Anthony Schaeffer, Benjamin Billips, David Klumpp
Принадлежит: Northwestern University

The present invention relates to compositions and methods for disease treatment and prevention through administration of a live attenuated composition. In particular, the present invention provides compositions and methods for the treatment and prevention of urinary tract infection by administration of a live attenuated compositions lacking O-antigen ligase activity.

Подробнее
Номер записи: 6
21-08-2014 дата публикации

Live-attenuated compositions for bacterial infections

Номер: US20140234369A1
Автор: Anthony Schaeffer, Benjamin Billips, David Klumpp
Принадлежит: Northwestern University

The present invention relates to compositions and methods for disease treatment and prevention through administration of a live attenuated composition. In particular, the present invention provides compositions and methods for the treatment and prevention of urinary tract infection by administration of a live attenuated compositions lacking O-antigen ligase activity.

Подробнее
Номер записи: 7
08-10-2015 дата публикации

ALTERED MICROBIOME OF CHRONIC PELVIC PAIN

Номер: US20150284781A1
Автор: Klumpp David J., Schaeffer Anthony J., White Bryan A.
Принадлежит:

Provided herein are kits, compositions, and methods for diagnosing and treating interstitial cystitis (IC) and/or interstitial cystitis/bladder pain syndrome (IC/BPS) based on finding lower levels of certain bacteria in a subject's stool sample (e.g., and ). In certain embodiments, then present invention provides probiotic formulations containing live bacteria (e.g., from and ). 1. A method comprising:testing, or having tested a stool sample from a subject suspected of suffering from interstitial cystitis (IC) and/or interstitial cystitis/bladder pain syndrome (IC/BPS), to determine the level of bacteria from at least one bacterial species from a bacterial genus,{'i': Odoribacter, Faecalibacterium, Colinsella, Eggerthella, Lactonifactor,', 'Roseburia., 'wherein said bacterial genus is selected from the group consisting of: and'}2Odoribacter splanchnicus, Faecalibacterium prausnitzii, Colinsella aerofaciens, Eggerthella sinensis, Lactonifactor longoviformis,Roseburia intestinalis.. The method of claim 1 , wherein said at least one species is selected from the group consisting of: and3Odoribacter splanchnicus, Faecalibacterium prausnitzii, Colinsella aerofaciens, Eggerthella sinensis, Lactonifactor longoviformis,Roseburia intestinalis.. The method of claim 1 , wherein said at least one species is at least two species selected from the group consisting of: and4Odoribacter splanchnicus, Faecalibacterium prausnitzii, Colinsella aerofaciens, Eggerthella sinensis, Lactonifactor longoviformis,Roseburia intestinalis.. The method of claim 1 , wherein said at least one species is at least five species selected from the group consisting of: and5. The method of claim 1 , wherein said stool sample is tested with a sequencing assay specific to ribosomal rRNA of said at least one species.6. The method of claim 1 , wherein said subject has symptoms of IDC and/or IC/BPS.78.-. (canceled)9Odoribacter, Faecalibacterium, Colinsella, Eggerthella, Lactonifactor,Roseburia.. A composition ...

Подробнее
Номер записи: 8
12-11-2015 дата публикации

Compositions and methods for treatment of pain

Номер: US20150320806A1
Автор: Anthony J. Schaeffer, Charles N. Rudick, David J. Klumpp
Принадлежит: Northwestern University

The present invention provides compositions and methods for treatment or prevention of pain resulting from infection, infection related pain, and non-infectious pain as well as treatment or prevention of infections or adverse health consequences associated with infections.

Подробнее
Номер записи: 9
15-11-2018 дата публикации

Compositions and methods for treatment of pain

Номер: US20180325965A1
Автор: Anthony J. Schaeffer, Charles N. Rudick, David J. Klumpp
Принадлежит: Northwestern University

The present invention provides compositions and methods for treatment or prevention of pain resulting from infection, infection related pain, and non-infectious pain as well as treatment or prevention of infections or adverse health consequences associated with infections.

Подробнее
Номер записи: 10
28-11-2019 дата публикации

Altered microbiome of chronic pelvic pain

Номер: US20190360024A1
Автор: Anthony J. Schaeffer, Bryan A. White, David J. Klumpp
Принадлежит: Northwestern University, University of Illinois

Provided herein are kits, compositions, and methods for diagnosing and treating interstitial cystitis (IC) and/or interstitial cystitis/bladder pain syndrome (IC/BPS) based on finding lower levels of certain bacteria in a subject's stool sample (e.g., O. splanchnicus, F. prausnitzii, C. aerofaciens, E. sinensis, L. longoviformis, and R. intestinalis). In certain embodiments, then present invention provides probiotic formulations containing live bacteria (e.g., from O. splanchnicus, F. prausnitzii, C. aerofaciens, E. sinensis, L. longoviformis, and R. intestinalis).

Подробнее
Номер записи: 11
24-12-2020 дата публикации

Methods of Treating Dog Urinary Tract Infections

Номер: US20200397835A1
Автор: Anthony J. Schaeffer, David J. Klumpp, JoEllen L. Westropp
Принадлежит: Individual

Provided are methods for treating acute and recurring urinary tract infections in dogs.

Подробнее
Номер записи: 12
01-12-2011 дата публикации

Mast cell markers and prevention, diagnosis, and therapy for chronic pelvic pain syndrome

Номер: US20110293631A1
Автор: Anthony J. Schaeffer, Charles Rudick, David J. Klumpp, Joseph Done, Praveen Thumbikat
Принадлежит: Northwestern University

The present invention provides compositions and methods for detection, diagnosis, treatment and/or prevention of chronic pelvic pain syndrome. In particular, the present invention provides biomarkers of chronic pelvic pain syndrome (e.g., mast cell markers (e.g., tryptase)), and/or inhibition of mast cell function (e g inhibition of MCP-1 and/or MIP-1α) to treat or prevent chronic pelvic pain syndrome.

Подробнее
Номер записи: 13
19-11-2013 дата публикации

Treatment of chronic pelvic pain syndrome

Номер: US8586044B2
Автор: Anthony J. Schaeffer, Charles Rudick, David J. Klumpp, Joseph Done, Praveen Thumbikat
Принадлежит: Northwestern University

The present invention provides compositions and methods for detection, diagnosis, treatment and/or prevention of chronic pelvic pain syndrome. In particular, the present invention provides biomarkers of chronic pelvic pain syndrome (e.g., mast cell markers (e.g., tryptase)), and/or inhibition of mast cell function (e.g. inhibition of MCP-1 and/or MIP-1α) to treat or prevent chronic pelvic pain syndrome.

Подробнее
Номер записи: 14
11-06-2019 дата публикации

Altered microbiome of chronic pelvic pain

Номер: US10316368B2
Автор: Anthony J. Schaeffer, Bryan A. White, David J. Klumpp
Принадлежит: Northwestern University, University of Illinois

Provided herein are kits, compositions, and methods for diagnosing and treating interstitial cystitis (IC) and/or interstitial cystitis/bladder pain syndrome (IC/BPS) based on finding lower levels of certain bacteria in a subject's stool sample (e.g., O. splanchnicus, F. prausnitzii, C. aerofaciens, E. sinensis, L. longoviformis , and R. intestinalis ). In certain embodiments, then present invention provides probiotic formulations containing live bacteria (e.g., from O. splanchnicus, F. prausnitzii, C. aerofaciens, E. sinensis, L. longoviformis , and R. intestinalis ).

Подробнее
Номер записи: 15
06-06-2023 дата публикации

Methods of treating dog urinary tract infections

Номер: US11666609B2
Автор: Anthony J. Schaeffer, David J. Klumpp, JoEllen L. Westropp
Принадлежит: Northwestern University, UNIVERSITY OF CALIFORNIA

Provided are methods for treating acute and recurring urinary tract infections in dogs.

Подробнее
Номер записи: 16
24-02-2011 дата публикации

Live-attenuated compositions for bacterial infections

Номер: WO2010132764A3
Автор: Anthony Schaeffer, Benjamin Billips, David Klumpp
Принадлежит: Northwestern University

The present invention relates to compositions and methods for disease treatment and prevention through administration of a live attenuated composition. In particular, the present invention provides compositions and methods for the treatment and prevention of urinary tract infection by administration of a live attenuated compositions lacking O-antigen ligase activity.

Подробнее
Номер записи: 17
15-05-2018 дата публикации

Compositions and methods for treatment of pain

Номер: US09968642B2
Автор: Anthony J. Schaeffer, Charles N. Rudick, David J. Klumpp
Принадлежит: Northwestern University

The present invention provides compositions and methods for treatment or prevention of pain resulting from infection, infection related pain, and non-infectious pain as well as treatment or prevention of infections or adverse health consequences associated with infections.

Подробнее
Номер записи: 18
10-10-2017 дата публикации

Altered microbiome of chronic pelvic pain

Номер: US09783858B2
Автор: Anthony J. Schaeffer, Bryan A. White, David J. Klumpp
Принадлежит: Northwestern University, University of Illinois

Provided herein are kits, compositions, and methods for diagnosing and treating interstitial cystitis (IC) and/or interstitial cystitis/bladder pain syndrome (IC/BPS) based on finding lower levels of certain bacteria in a subject's stool sample (e.g., O. splanchnicus, F. prausnitzii, C. aerofaciens, E. sinensis, L. longoviformis , and R. intestinalis ). In certain embodiments, then present invention provides probiotic formulations containing live bacteria (e.g., from O. splanchnicus, F. prausnitzii, C. aerofaciens, E. sinensis, L. longoviformis , and R. intestinalis ).

Подробнее
Номер записи: 19