11-02-2016 дата публикации
Номер: US20160038502A1
Принадлежит:
Formulations of the HIV compounds atazanavir and cobicistat, and methods of treatment utilizing these formulations, are set forth. 1. A formulation of antiretroviral drugs useful against HIV , comprising:a) atazanavir; andb) cobicistat.2. The formulation of claim 1 , wherein said atazanavir is in the form of atazanavir sulfate.3. The formulation of claim 2 , wherein said formulation is in the form of a tablet claim 2 , wherein said tablet is not a monolithic tablet or a trilayer tablet claim 2 , said trilayer tablet having an inert excipient layer as the middle layer.4. The formulation of claim 3 , wherein said tablet is a bilayer tablet which does not show visible cracking.5. The formulation of claim 4 , wherein said bilayer tablet delivers about 300 mg as the free base of atazanavir sulfate claim 4 , and about 150 mg. of cobicistat.6. The formulation of claim 5 , further comprising at least one excipient.7. The formulation of claim 6 , further comprising at least two excipients.8. The formulation of claim 7 , comprising at least three excipients.9. The formulation of claim 8 , wherein said excipients are selected from the group of stearic acid claim 8 , magnesium stearate claim 8 , microcrystalline cellulose claim 8 , sodium starch glycolate claim 8 , crospovidone claim 8 , hydroxypropyl cellulose claim 8 , and croscarmellose sodium.10. The formulation of claim 6 , wherein said excipient is microcrystalline cellulose.11. The formulation of claim 1 , wherein said atazanavir comprises about 20-45% (w/w) of said formulation.12. The formulation of claim 1 , wherein said cobicistat comprises about 15-40% (w/w) of said formulation.13. The formulation of claim 1 , wherein said atazanavir and said cobicistat together comprise about 35-85% (w/w) of said formulation.14. A method of treating HIV infection in a patient claim 1 , which comprises administering to said patient the formulation as claimed in .15. A method of treating HIV infection in a patient claim 4 , which ...
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