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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 147. Отображено 147.
21-05-2014 дата публикации

Horizontal support device capable of automatically adapting to shapes

Номер: CN103801793A
Автор: LAN BO
Принадлежит:

The invention discloses a support device capable of automatically adapting to shapes. The support device comprises pressing plates, pillars, spring sleeves and mandrils, wherein top plates and bottom plates are fixed at the both ends of every pillar; positioning hole plates, the spring sleeves and the like are arranged below the top plates; multiple through holes are formed in the positioning hole plates; the number of the mandrils, the number of the spring sleeves and the number of the through holes are the same; the spring sleeves are fixed between an upper hole plate and a lower hole plate, the positions of the both ends of every spring sleeve are consistent with the positions of the through holes, the spring sleeves are arranged according to a multiple rows and multiple lines manner, and springs are arranged in the spring sleeves; the mandrils are arranged in the spring sleeves, the bottoms of the mandrils are pressed at the tops of the springs, the upper parts of the mandrils penetrate ...

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03-09-2014 дата публикации

Ventilation air methane adsorber

Номер: CN104014223A
Принадлежит:

The invention discloses a ventilation air methane adsorber. The ventilation air methane adsorber comprises a closed adsorber box body, wherein a plurality of adsorption filtering cores are arranged in the adsorber box body, a ventilation air inlet pipeline and an enriched gas outlet pipeline are arranged at the bottom of the adsorber box body respectively, a hot air inlet pipeline and an emptying pipeline are arranged at the top part of the adsorber box body respectively, an upper guiding partition plate and a lower guiding partition plate, which are provided with air holes, are arranged in the adsorber box body, the adsorption filtering core is arranged between the upper guiding partition plate and the lower guiding partition plate and comprises a filtering core framework and an adsorption material, the filtering core framework comprises a tubular inner framework and a tubular outer framework, a plurality of air holes are formed in the walls of the tubular inner framework and the tubular ...

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13-08-2003 дата публикации

Method for testing circuit board interconnction line based on boundary scanning device

Номер: CN0001435695A
Автор: LI YINGWU, LAN BO, YINGWU LI, BO LAN
Принадлежит:

A circuit board interconnection lines test method based on boundary scan device includes determining scan chain description file, net list file and boundary scan language description file (BDSL), compiling them, determining test scan chain, applying the test exciting data to the test exciting pins of device, capturing the response data from the response pins of device, and analyzing. Its advantages are high test efficiency and low cost.

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15-12-2010 дата публикации

Black bar detection method of PS (Presensitized Plate) substrate

Номер: CN0101915694A
Принадлежит:

The invention discloses a black bar detection method of a PS (Presensitized Plate) substrate. A PS substrate sample is washed with alkali, acid and water, electrolyzed and secondarily washed with alkali, acid and water sequentially, and the invisible black bar defect on the surface of the PS substrate can be showed. Therefore, the detection and the judgment of the black bar defect of the PS substrate are achieved. The detection judgment rate of the black bars of the substrate before leaving factory can be greatly improved, and the return of goods and the claim for damages caused by the black bar defect can be greatly decreased.

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12-05-2010 дата публикации

Compound extrusion unit for producing tubeless bicycles and mouth device thereof

Номер: CN0101704294A
Принадлежит:

The invention provides a compound extrusion unit for producing tubeless bicycles and a mouth device thereof. According to flow direction of a sizing material, the mouth device comprises a performed mouth board, a mouth board and a mouth box, which are sequentially connected; and the mouth board is embedded in the mouth box. The performed mouth board has an integral structure; the mouth board comprises an upper mouth board and a lower mouth board, which are matched with each other; the extrusion unit comprises an extrusion system and a temperature-control system, which are connected with each other; the extrusion system comprises three compound heads and three extrusion machines which are connected with the three compound heads respectively; and three extrusion machines are arranged pickaback, and the mouth device in the three compound heads is the mouth device. The mouth device can avoid streaming and burning of the sizing material in the process of inner compounding and guarantee stable ...

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04-08-2023 дата публикации

Composite medicament for efficiently preventing and treating asparagus stem blight and preparation method thereof

Номер: CN116530519A
Принадлежит:

The invention discloses a composite medicament for efficiently preventing and treating asparagus stem blight and a preparation method thereof, and belongs to the technical field of pesticides. The composite agent is prepared from the following raw materials in parts by mass: 2 to 4 parts of tuzet, 2 to 4 parts of metalaxyl manganese zinc, 1 to 4 parts of carbendazim, 1.2 to 1.8 parts of triadimefon wettable powder, 1.5 to 3 parts of difenoconazole and 0.5 to 2 parts of propiconazole. The composite agent is mixed with a surfactant, glycerol, a stabilizer and water to serve as a bactericide for preventing and treating asparagus stem blight. By compounding a plurality of raw materials, the use amount of a single raw material is greatly reduced, the use amount of pesticides is reduced, the control effect on asparagus stem blight is improved, and meanwhile, the pesticide residue amount is reduced.

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21-05-2014 дата публикации

Water-fire resistant ventilation air methane mixing device

Номер: CN103801205A
Принадлежит:

The invention discloses a water-fire resistant ventilation air methane mixing device, comprising a water storage barrel and a mixing barrel connected with the water storage barrel, wherein the water storage barrel is arranged at the bottom of the mixing barrel; a low-concentration gas intake pipe is arranged on the water storage barrel; a pipe orifice of the intake pipe is merged below the liquid level; at least two ventilation air intake pipes are arranged at the lower part of the mixing barrel; an escape pipe is arranged on the upper wall surface of the mixing barrel; ventilation air entering the mixing barrel forms a circumferential rotational flow by the at least two ventilation air intake pipes. The invention provides the mixing device which is good in mixing effect, high in safety performance and small in fluid pressure loss, and has dewatering and dust removing functions. The device is applicable to mixing of low-concentration gas with ventilation air or air as well as flammable ...

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06-01-2016 дата публикации

Stride floor normal water recycle system

Номер: CN0204940401U
Принадлежит:

The utility model discloses a stride floor normal water recycle system for water recovery in the public place of many floors comprises water tank, suspension control switch and water inlet and outlet pipes, its characterized in that has put a middle water storage box (3) of intermittent type formula retaining upset and a suspension section of thick bamboo (5) in water tank (4), overflow pipeline (6) is connected to one side of water tank, and the opposite side of water tank has outlet conduit (8) to connect to tee bend (11), the washing drainage pipe of next floor that tee bend (11) still are connected with the water tank downside of water supply line 12 and next floor communicates with each other, and tee bend (11) have spring valve (10), the one of which flexibility act as go -between (9) be between a suspension section of thick bamboo (5) and tee bend spring valve (10). The simple structure of this system, with low costs, the water conservation effect is but very showing.

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08-08-2023 дата публикации

Solar energy and geothermal energy coupling energy supply system and operation method

Номер: CN116557998A
Принадлежит:

The invention belongs to the technical field of comprehensive utilization of renewable energy sources, and particularly relates to a solar energy and geothermal energy coupling energy supply system and an operation method. A solar energy and geothermal energy coupling energy supply system comprises a cold well, a ground source heat pump unit, a plate heat exchanger, a solar heat collection field and a hot well, the cold well is communicated with the ground source heat pump unit and the plate heat exchanger through pipelines, and one end of the solar heat collection field is communicated with the hot well through a pipeline. The ground source heat pump unit is communicated with the plate heat exchanger through a pipeline, and the plate heat exchanger is communicated with the user terminal through a pipeline. Cold energy stored in the cold well is used for supplying cold energy, and heat stored in the hot well is used for supplying heat, so that the problems that the water taking temperature ...

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28-04-2023 дата публикации

High-sulfur-content flash steam pressurizing sledge

Номер: CN116020213A
Автор: CHEN YU, MA HAIYANG, LAN BO
Принадлежит:

The invention discloses a high-sulfur-content flash steam pressurizing sledge which comprises a rack, and a diaphragm compressor is arranged on one side of the middle of the rack. According to the sulfur-containing gas-liquid separation device, the first-stage gas-liquid separator and the second-stage gas-liquid separator are arranged, sulfur-containing flash steam enters the first-stage gas-liquid separator through a sixth connecting pipe after being subjected to primary cooling, then secondary gas-liquid separation is conducted through the first-stage gas-liquid separator, gas obtained after secondary gas-liquid separation enters the second membrane head through a fifth connecting pipe, and the sulfur-containing flash steam enters the second membrane head through a third connecting pipe; at the moment, the diaphragm compressor controls a second diaphragm head to compress gas, then the compressed gas enters a third connecting pipe, then the gas is guided into a second-stage cooling exchanger ...

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18-04-2023 дата публикации

Forming die and forging method for compressor disc forge piece of two-in-one structure

Номер: CN115971392A
Принадлежит:

The invention provides a forming die of a gas compressor disc forge piece of a two-in-one structure. The forming die comprises an upper die, a lower die, a middle ring die lining pattern die and a middle ring die annular outer sleeve. The upper die, the middle ring die, the lining pattern die and the lower die are respectively used for forming the upper, middle and lower contours of the forge piece, and the upper die, the middle ring die, the lining pattern die and the lower die can define a forging die cavity for forging the two-in-one structure gas compressor disc forge piece. The middle ring die annular outer sleeve is used for hooping the middle ring die lining pattern die. The invention further provides a forging method applying the forming die for the gas compressor disc forge piece of the two-in-one structure. The forging method comprises the steps that a double-parting-surface forge piece is designed; designing a middle ring mold; designing a bar billet and an upsetting intermediate ...

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11-03-2015 дата публикации

Unmanned aerial vehicle first-person perspective control system

Номер: CN104407607A
Автор: LAN BO
Принадлежит:

The invention relates to an unmanned aerial vehicle first-person perspective control system comprising a vehicle-mounted box and a control cabin. The vehicle-mounted box is internally provided with a first-person perspective video acquisition and back transmission system, a single-chip microcomputer, a temperature sensor set, an aerial vehicle power energy sensor set, a task work control steering engine, a vehicle-mounted box communication radio station, a vehicle-mounted box self-flying instrument and a vehicle-mounted box self-flying instrument radio station. The ground control cabin is internally provided with a computer host, a control cabin communication radio station, a control cabin self-flying instrument radio station, a self-flying rocking bar, a task rocking bar, a keyboard, a mouse, a task displayer, a self-flying display screen and a control cabin AV graph transmission radio station. The unmanned aerial vehicle first-person perspective control system has the first-person perspective ...

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30-09-2015 дата публикации

Cross-floor water recovery utilization system

Номер: CN104947740A
Принадлежит:

The invention discloses a cross-floor water recovery utilization system for public place water recovery in multi-floor; the cross-floor water recovery utilization system comprises a water box, a suspension control switch and in/out water pipes; the features are that an intermittent water storage overturn intermediate water storage box (3) and a suspension cylinder (5) are arranged in the water box (4); one side of the water box is connected with an overflow pipe (6), and the other side of the water box is connected with a tee joint (11) through a water outlet pipe (8); the tee joint (11) is also connected with a water supply line (12) and a cleaning drainpipe of a next+1 floor, wherein the cleaning drainpipe of the next+1 floor is connected with a lower side of a water box of a next floor; the tee joint (11) is provided with a spring valve (10); a flexible stay wire (9) is tied between the suspension cylinder (5) and the tee joint spring valve (10). The cross-floor water recovery utilization ...

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26-03-2014 дата публикации

Positioning device and positioning method

Номер: CN103687003A
Принадлежит:

The invention discloses a positioning device and a positioning method. The positioning device comprises an upper computer, an underground switch and positioning substations, wherein the upper computer, the underground switch and the positioning substations are connected in sequence. Each positioning substation comprises a substation gateway, a plurality of positioning base stations and a plurality of position marking cards. The positioning base stations are respectively in wireless connection with the substation gateways, and the position marking cards are connected with the substation gateways through the positioning base stations respectively. The positioning base stations are used for recognizing the position marking cards and positioning cards, carrying out gathering and processing to obtain position marking data of the position marking cards and positioning data of the positioning cards, and sending the position marking data of the position marking cards and the positioning data of ...

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13-02-2020 дата публикации

Fungicidal Composition and Fungicide for Controlling Asparagus Stem Blight

Номер: US20200045969A1

The present invention provides a fungicidal composition and a fungicide for controlling asparagus stem blight, and belongs to the technical field of controlling asparagus stem blight. The composition includes difenoconazole and propamidine; and the weight ratio of the difenoconazole to the propamidine is 20:1-1:20. The fungicide of the present invention includes difenoconazole, propamidine and an auxiliary material; and the difenoconazole and propamidine account for 3%-90% by mass of the total amount of the fungicide. The present invention uses difenoconazole and propamidine as active ingredients, where a combined use of them has a synergistic effect on the pathogenic fungi of asparagus stem blight, and especially has an obvious synergistic effect on the asparagus stem blight in a ratio range of 20:1-1:20. In the present invention, a fungicide can be prepared as having a commonly-used agricultural dosage through a certain technical means, and the fungicide can provide an effective management tool for controlling of the asparagus stem blight.

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27-03-2018 дата публикации

Metal gear is belt cleaning device for measurement

Номер: CN0207138377U

The utility model discloses a metal gear is belt cleaning device for measurement, including savings box, nozzle, solid fixed ring and the support frame that is equipped with the gear cleaner, the nozzle has a plurality of to all install on solid fixed ring, and the orientation of nozzle all directional be located on the solid fixed ring axis a bit, savings box sends the gear cleaner into the nozzle through hydraulic pump and pipeline, gu fixed ring passes through coupling assembling to be connected with the support frame, and motor drive coupling assembling rotates to it rotates around the axis of oneself to drive solid fixed ring. Primer fluid press pump and motor are on the engaging tooth of messenger's gear cleaner from jet to the gear, along with motor output shaft's rotation, gu fixedring rotates to engaging tooth and tooth's socket sanitization with the gear. Than traditional gear mode of rinsing, not only avoid damaging of gear engagement tooth, and than manual cleaning, reduced ...

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02-05-2023 дата публикации

Leg structure of dual-drive connecting rod robot

Номер: CN116039795A
Принадлежит:

The invention relates to the technical field of robots, in particular to a dual-drive connecting rod robot leg structure. The first driving device and the second driving device are connected to the two sides of the main support respectively, the first connecting rod device is connected to the first driving device, the second connecting rod device is connected to the second driving device, and the third driving device is connected to the first connecting rod device and the second connecting rod device. The main support comprises a connecting plate, a first connecting frame and a second connecting frame, the first connecting frame and the second connecting frame are connected to the two sides of the connecting plate respectively, the first driving device is provided with a first base, the first base is fixedly connected to the first connecting frame, the second driving device is provided with a second base, and the second base is fixedly connected to the second connecting frame. The connecting ...

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25-07-2023 дата публикации

Pressurizing precession hydraulic control system with multiple working modes

Номер: CN116480646A
Принадлежит:

The invention provides a pressurization precession hydraulic control system with multiple working modes. The pressurization precession hydraulic control system comprises a load sensitive pump, a pilot oil pump, a multi-way valve assembly, a hydraulic cylinder, a hydraulic motor, a proportional pressure reducing valve, an electromagnetic reversing valve, a hydraulic control reversing valve, a manual overflow valve and the like. The rotary rock breaking machine has three working modes of pressurized feeding, single-pump-driven rotary rock breaking and double-pump-driven rotary rock breaking; according to the pressurized feeding working mode, a hydraulic pump drives a hydraulic cylinder to stretch out and draw back, and the advantages of rapid feeding and pressurized propelling of a drilling tool to actively break rocks are achieved. The single-pump-driven rotary rock breaking working mode is that a single hydraulic pump drives double motors to rotate forwards and backwards, and the advantages ...

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13-04-2021 дата публикации

Soil disinfection device for preventing and treating asparagus stem blight

Номер: CN212936608U

The utility model relates to the technical field of asparagus stem blight prevention and treatment, in particular to a soil disinfection device for asparagus stem blight prevention and treatment, which comprises a vehicle body and a ploughing and spraying device arranged at the bottom of the vehicle body, and is characterized in that the vehicle body comprises a rack with a rectangular plane frame structure, and the bottom of the rack is rotatably connected with the ploughing and spraying device through a lug plate; wheels are installed on the two sides of the bottom of the rack. The ploughing and spraying device comprises a roller with a semi-open hole, a rotating shaft is fixed in the center of the roller in a penetrating mode, the two ends, extending out of the roller, of the rotating shaft are connected to the lug plates through bearings, the open end of the roller is rotatably connected with a sliding ring, and a plurality of rake nails are evenly distributed on the rolling outer surface ...

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26-11-2003 дата публикации

Device function automatic detection method based on boundary scanning structure

Номер: CN0001458592A
Принадлежит:

The present invention discloses automatic device function testing method based on boundary scanning structure. The logical relationship of the tested device function is first obtained, test vector input file and correct test responding file are then determined based on the logical relationship, and the test exciting input pins are then value assigned based on the test vector input file and the test values are applied to the chip kernel circuit of the tested device, and the test response output pins of the tested device are finally scanned to obtain the response data of the tested chip. The test response data are compared with the correct test responding file to obtain the test result. The said function test has low cost, high efficiency and simple operation.

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04-04-2023 дата публикации

Preparation method of multi-element doped cross-linked porous carbon loaded cobalt phosphide negative electrode material

Номер: CN115893367A
Принадлежит:

The invention discloses a preparation method of a multi-element doped cross-linked porous carbon loaded cobalt phosphide negative electrode material for a lithium ion battery, and the preparation method comprises the following steps: mixing maltose and thiourea to obtain first mixed powder; grinding a cobalt source and the first mixed powder to obtain second mixed powder; dropwise adding phytic acid into the second mixed powder to obtain first mixed slurry; and drying the first mixed slurry, and sintering under a preset temperature condition to obtain the multi-element doped cross-linked porous carbon loaded cobalt phosphide negative electrode material for the lithium ion battery. The preparation method is simple and easy to implement and good in repeatability, and the multi-element doped cross-linked porous carbon loaded cobalt phosphide negative electrode material prepared by the method has high capacity and excellent cycling stability.

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28-07-2023 дата публикации

Deeply-buried subway station hall and long entrance and exit channel combined smoke exhaust system and method

Номер: CN116499060A
Принадлежит:

The invention relates to a deep-buried subway station hall and long entrance and exit channel combined smoke exhaust system and method, and belongs to the technical field of subway station fire smoke exhaust. A closed suspended ceiling space above a long entrance and exit channel serves as a natural smoke exhaust air duct, and natural smoke exhaust is achieved through the chimney effect; compared with the prior art, direct contact and mutual mixing between ascending smoke and descending air are avoided, the smoke exhaust efficiency is greatly improved, the definition in the entrance and exit channel is improved, and the technical problem that a mechanical smoke exhaust system in the long entrance and exit channel of the deeply-buried subway station cannot effectively exhaust smoke under the fire working condition is solved.

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04-08-2020 дата публикации

Composition for effective control of asparagus stalks and application thereof

Номер: BE0001026953A1
Принадлежит:

La présente invention divulgue une composition pour lutter contre le dépérissement des tiges d'asperge, et appartient au domaine technique de la lutte biologique en agriculture. La composition comprend un oligosaccharide de chitosane, un oligosaccharide mixte d'origine algaire, un extrait actif d'herbe médicinale chinoise, un tensioactif, et de l'eau.

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07-12-2011 дата публикации

Black bar detection method of PS (Presensitized Plate) substrate

Номер: CN0101915694B
Принадлежит:

The invention discloses a black bar detection method of a PS (Presensitized Plate) substrate. A PS substrate sample is washed with alkali, acid and water, electrolyzed and secondarily washed with alkali, acid and water sequentially, and the invisible black bar defect on the surface of the PS substrate can be showed. Therefore, the detection and the judgment of the black bar defect of the PS substrate are achieved. The detection judgment rate of the black bars of the substrate before leaving factory can be greatly improved, and the return of goods and the claim for damages caused by the black bar defect can be greatly decreased.

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26-05-2023 дата публикации

Method for determining rendering kernel of multi-kernel browser

Номер: CN116166909A
Принадлежит:

The invention provides a method for determining a rendering kernel of a multi-kernel browser. The method comprises the following steps: S1, acquiring webpage features, client environment features, a user role value and user configuration information; s2, determining kernel index information of the current multi-kernel browser; s3, determining information entropies of the webpage features, the client environment features, the user role information and the user configuration information for the index information; s4, constructing a decision tree prediction model, and training the decision tree prediction model; and S5, inputting the information in the steps S1-S3 into the trained decision tree prediction model for processing, outputting the kernel corresponding to the current webpage, and rendering the webpage based on the kernel, so that different webpages can be browsed by adopting one multi-core browser, multiple browsers do not need to be repeatedly installed, the use is convenient, and ...

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04-02-2015 дата публикации

UAV airborne computer system

Номер: CN104333733A
Автор: LAN BO
Принадлежит:

The invention relates to a UAV airborne computer system which comprises a network switch which is respectively connected to a sensor group and an image transmission system to collect the collection signals of the sensor group and the image transmission system. The network switch is connected to a steering engine control system, and the mutual communication of steering engine control signals is realized. The network switch is connected to an industrial control computer, the pro processing of network switch collection data is realized by the industrial control computer. The network switch is connected to a communication radio station, the data sending of the UAV airborne computer system to a ground end is realized, and a power board supplies power to the whole system. The UAV airborne computer system is used as the core system of a flight remote device, has important functions of information collecting, processing and intelligent instruction issuing, and can perform multiple tasks simultaneously ...

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01-06-2011 дата публикации

Fire-retardant low concentration gas burner

Номер: CN0102080824A
Принадлежит:

The invention discloses a fire-retardant low concentration gas burner, which comprises a combustor. The combustor comprises a combustor body with a multi-layer structure, and an upper end cover and a lower end cover which are arranged on the upper end and lower end of the combustor body respectively and are closely connected with the combustor body. The combustor body has a supporting layer, a fire-retardant layer, a diversion plate layer and a burning layer from inside to outside in turn. The supporting layer is used for supporting the fire-retardant layer; the fire-retardant layer and the burning layer are made of multi-layer metal fabric or metal fiber sintered felt; the diversion plate layer is provided with a plurality of uniformly distributed diversion channels for communicating the fire-retardant layer and the burning layer, and the diversion plate layer also plays a role in supporting the whole combustor; the burner further comprises a gas inlet pipeline and an ignition device.

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04-06-2014 дата публикации

Multi-air-source dynamic diversion device

Номер: CN103836226A
Принадлежит:

The invention discloses a multi-air-source dynamic diversion device which comprises a cavity, a rotating shaft, an upper rotating blade, a lower rotating blade and a diversion structure. The diversion structure comprises the rotating blades arranged on the rotating shaft. The rotating blades divide the cavity into a plurality of isolation areas. Each isolation area corresponds to one diversion air outlet. Air enters the cavity from a first air source inlet. By rotating the upper rotating blade, the air enters the different isolation areas from the first air inlet, and then flows out through the different diversion air outlets. The rotating blades are adopted for dividing the cavity into the isolation areas, the air after diversion flows out from the different diversion outlets, then the rotating blades rotate by a certain angle to enable blade inlet holes to correspond to the isolation areas of the next station, and therefore reversing of air flow can be achieved, and dynamic diversion ...

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05-11-2003 дата публикации

Logic cluster fault testing method for non-boundary scanning device

Номер: CN0001453593A
Принадлежит:

The logic cluster fault testing method for non-boundary scan device features that test excitation is output to the logic cluster of non-boundary scan device via the boundary scanner adjacent to the non-boundary scan device to capture test response, and the test response is further compared and analyzed to complete the logic cluster fault test of the non-boundary scan device. The test method of the present invention has low cost and simple and convenient operation, and is one efficient but cheap chip fault testing method.

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28-07-2023 дата публикации

Pharmaceutical composition and application thereof in prevention and treatment of asparagus stem blight

Номер: CN116491513A
Принадлежит:

The invention discloses a pharmaceutical composition and application thereof in prevention and treatment of asparagus stem blight, and belongs to the technical field of agricultural biological prevention and treatment. The pharmaceutical composition disclosed by the invention is prepared from the following raw materials in parts by weight: 5 to 8 parts of magnesium sulfate, 6 to 10 parts of pentaerythritol, 2 to 12 parts of N, N-diethylphenazine-1-formamide, 4 to 8 parts of cnidium lactone, 40 to 55 parts of plant extracting solution, 8 to 16 parts of surfactant, 10 to 15 parts of glycerol and 60 to 78 parts of electrolyzed water. The N, N-diethylphenazine-1-formamide, the cnidium lactone and the plant extract are biological bactericides, are environment-friendly and have a synergistic effect, the prevention and treatment effect on the asparagus stem blight is improved, and magnesium sulfate and pentaerythritol can enhance the fungus resistance of asparagus plants. The prepared pharmaceutical ...

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05-05-2023 дата публикации

Seismic data classification method based on time attention mechanism

Номер: CN116068651A
Принадлежит:

The invention relates to a seismic data classification method based on a time attention mechanism, and the method comprises the steps: collecting seismic data, processing the seismic data, and generating a spectrogram, the seismic data being time series data; performing feature extraction on the spectrogram to obtain time period features with weights and global features; and obtaining a classification result of the seismic data according to the time period features with the weights and the global features. According to the method, the shallow layer features, the deep layer features, the time period features and the global features of the seismic data are extracted, fusion judgment is carried out, the attention of a deep learning model on the global attributes of the seismic data can be improved, the features of the original data are fully utilized, the processing capacity of the seismic data features can be optimized, and the classification precision of the seismic data is improved.

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07-07-2023 дата публикации

Linear drag chain device with bending path

Номер: CN116398586A
Принадлежит:

The invention provides a linear drag chain device with a bending path, a winding and unwinding surface of a drag chain is perpendicular to a moving surface of an implemented device, a roller way assembly is mounted on a support and used for supporting and guiding the drag chain, one end of the drag chain is fixedly connected to the upper end of the support, and the other end of the drag chain is fixedly connected to the implemented device. The device to be implemented is located on the outer side of the support and has a certain path according to operation requirements, the support is laid along the path, the device to be implemented can move along the outline of the outer side of the support, the drag chain can be retracted and released along with movement of the device to be implemented, and the drag chain is vertically installed on the support. According to the linear drag chain device with the bending path, the drag chain and the support are vertically arranged, then the inner side ...

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26-05-2023 дата публикации

Locomotive wireless reconnection method and system and storage medium

Номер: CN116161076A
Принадлежит:

The invention discloses a locomotive wireless reconnection method and system and a storage medium, and relates to the technical field of rail locomotives, and the technical scheme is characterized in that the locomotive wireless reconnection method comprises the following steps: establishing a locomotive list containing locomotive numbers; the locomotives in the locomotive list meet the condition of automatic connection; obtaining a target locomotive number; whether the number of the target locomotive is in a locomotive list or not is judged, and if yes, the target locomotive is wirelessly connected and grouped; locomotive marshalling information is updated; and sending the locomotive marshalling information to each locomotive, so that the network equipment of each locomotive updates the network configuration mode according to the current self network configuration and the locomotive marshalling information. Through the acquisition method provided by the invention, the target locomotives ...

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25-10-2019 дата публикации

Slurry dewatering device and slurry curing machine

Номер: CN0209537275U

The utility model provides a mud dewatering device and a mud curing machine, which belong to the field of mud purification equipment and comprise a plurality of mud dewatering devices arranged side byside, a water filtering layer and a solid conveying belt. The mud dewatering device comprises a spiral conveying shaft, a filter cartridge coaxially arranged outside the spiral conveying shaft in a sleeving manner, and a feeding cylinder and a discharging cylinder which are fixedly arranged; a plurality of filter holes are formed in the filter cartridge; the two ends of the filter cartridge are rotationally connected into the discharging cartridge and the discharging cartridge correspondingly, and the filter cartridge is driven by the motor to rotate to form a centrifugal structure. Wherein afeeding port with an upward opening is formed in the feeding cylinder, a discharging cylinder with a discharging port with a downward opening is arranged on the discharging cylinder, the two ends ofthe ...

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29-08-2023 дата публикации

Seismic signal processing method based on multi-feature fusion

Номер: CN116660992A
Принадлежит:

The invention discloses a seismic signal processing method based on multi-feature fusion, and the method comprises the steps: obtaining time series data through a seismograph, carrying out the segmentation, dimensionality reduction and convolution operation of a collected seismic signal, obtaining the shallow features of the seismic signal, carrying out the vector coding of the shallow features, obtaining a corresponding vector token, and carrying out the segmentation, dimensionality reduction and convolution of the vector token. Secondly, splicing the vector tokens, inputting the spliced vector tokens into a self-attention mechanism network to obtain vector tokens with weights, inputting the vector tokens with the weights into a multi-head attention mechanism network, and finally obtaining a classification result of the seismic signals through classification tokens in a module. According to the method, the fine-grained features and the coarse-grained features of the seismic signals are ...

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15-04-2015 дата публикации

Flow collecting equipment and radial flow collecting pipe automatic switching device

Номер: CN104515841A
Принадлежит:

The invention discloses a radial flow collecting pipe automatic switching device and flow collecting equipment using the radial flow collecting pipe automatic switching device, in the radial flow collecting pipe automatic switching device, a motor drives a gear through a transmission shaft, a sewage port control rod and a rain port control rod are perpendicular to each other and staggered up and down, one ends of the sewage port control rod and the rain port control rod are meshed on the upper and lower parts of the gear, the other ends of the sewage port control rod and the rain port control rod passes through, from inner side to outward, a conversion valve wall to align corresponding water outlets on a storage flow pool wall; in order to make one of the sewage port control rod and the rain port control rod outward stretched and one of the sewage port control rod and the rain port control rod inward drawn when the gear rotates in the same direction so as to enable the sewage port control ...

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26-03-2014 дата публикации

Self-adaptation calibration method based on field intensity positioning technology

Номер: CN103687002A
Принадлежит:

The invention discloses a self-adaptation calibration method based on the field intensity positioning technology. The method comprises the steps that a controller sets calibration parameters comprise a target positioning card ID, a calibration content value and a threshold value of an assigned positioning parameter; the controller sends a calibration order with the calibration content value information to a target positioning card; after receiving the calibration order, the target positioning card sets the calibration content value and sends data packets to a positioning substation periodically based on the setting; the controller obtains the value of the assigned positioning parameter of the target positioning card based on the current calibration content value, compares the value with the set threshold value, indicates the target positioning card to keep the current calibration content value setting according to the comparison result, or continues to send the calibration order to the ...

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28-04-2023 дата публикации

Robot with floatable rack

Номер: CN116022263A
Принадлежит:

The invention relates to the technical field of robots, in particular to a robot with a floatable rack, which comprises a rack and leg structures mounted on two sides of the rack, and the rack can rotatably move on the leg structures; the rack comprises side plates, a cross beam frame for connecting the side plates, and a power supply mounted on the cross beam frame and connected with the leg structure; the leg structure comprises a first driving device, a second driving device, a first connecting rod device, a second connecting rod device and a third driving device, wherein the first driving device and the second driving device are connected to the two sides of the side plate respectively, the first connecting rod device is connected to the first driving device, the second connecting rod device is connected to the second driving device, and the third driving device is connected to the first connecting rod device and the second connecting rod device. The first limiting block and the second ...

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26-03-2014 дата публикации

Video content comparing method based on digital signal processor

Номер: CN103686345A
Принадлежит:

The invention discloses a video content comparing method based on a digital signal processor. The method comprises the steps that single-channel video bitstream data and standard video bitstream data are forwarded to DSP modules according to the load balanced scheduling strategy, and the DSP modules obtain the key frame image sequence of the video data and the key frame image sequence of the standard video data; the DSP modules extract the characteristics of the key frame image sequence of the video data and the key frame image sequence of the standard video data according to the improved SIFT algorithm and the TOM algorithm to obtain the feature vector sequence of the video data and the feature vector sequence of the standard video data to determine the synchronous video data and standard video data, and if the similarity of the feature vector sequence of the video data and the feature vector sequence of the standard video data is larger than the preset similarity threshold value, the ...

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17-08-2020 дата публикации

Composition for effective control of asparagus stalks and application thereof

Номер: BE0001026953B1
Принадлежит:

La présente invention divulgue une composition pour lutter contre le dépérissement des tiges d'asperge, et appartient au domaine technique de la lutte biologique en agriculture. La composition comprend un oligosaccharide de chitosane, un oligosaccharide mixte d'origine algaire, un extrait actif d'herbe médicinale chinoise, un tensioactif, et de l'eau.

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19-05-2010 дата публикации

Compound gas mixing device for coal mine

Номер: CN0101708437A
Принадлежит:

The invention discloses a compound gas mixing device for a coal mine. The gas mixing device comprises an ejector, an air distribution system, a gas distribution system, a mixed gas conveying system and a main control unit; the air distribution system comprise an air parameter collecting system arranged on an air pipeline and an air parameter adjusting system; the gas distribution system comprises a gas parameter collecting system arranged on a gas pipeline and a gas parameter adjusting system; the mixed gas conveying system comprises a mixed gas parameter collecting system; and the main control unit is used for receiving data signals from the air parameter collecting system, the gas parameter collecting system and the mixed gas parameter collecting system and sending command signals to the air parameter adjusting system and the gas parameter adjusting system. The invention can continuously convey distribution gas in large quantity or variable quantity in real-time according to downstream ...

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31-12-2003 дата публикации

Process for circuit sampling logic analysis based on boundary scanning and apparatus therefor

Номер: CN0001464424A
Автор: LI YINGWU, LAN BO, YINGWU LI, BO LAN
Принадлежит:

The invention relates to a process for circuit sampling logic analysis based on boundary scanning comprising, Initializing the pins and sampling frequency for the devices to be sampled in the logicalmodule system. The system analyzing the tested circuit board scanning chain information according the set device pins and information of sampling frequency to obtain the least serial shift counter ofthe scanning chain. Loading the sampling instruction in the tested device to be sampled through the boundary scanning bus line controller. The boundary scanning bus line controller commanding the device to be sampled to enter sampling status, picking the value on the tested pins of the device and storing it into the register of the scanning element. controlling the tested device to perform shifting function, Transferring the sampled value to the computer for analysis and display through the boundary scanning bus line controller. The method in the invention is executed by the logical module and the ...

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04-08-2023 дата публикации

Novel multi-core structure composite agarose gel microsphere and preparation method thereof

Номер: CN116532092A
Принадлежит:

The invention discloses a novel multi-core structure composite agarose gel microsphere and a preparation method thereof. The core of the microsphere is small agarose microspheres with the particle size of not more than 60 microns, and the small agarose microspheres are uniformly dispersed in the microsphere; and the shell layer of the microsphere is a neutral polysaccharide composite material. The preparation method comprises the following steps: firstly preparing an inner-core agarose microsphere, then crosslinking and activating the inner-core agarose microsphere, and finally preparing the novel multi-core structure composite agarose gel microsphere by taking the activated and crosslinked agarose gel microsphere as an inner core and a pre-crosslinked polysaccharide gel microsphere as a shell layer. The core-shell type microsphere has a pore structure of an inner core and a macroporous structure of a shell layer, the high-resolution chromatography medium is prepared through crosslinking ...

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08-04-2015 дата публикации

Micro individual combat unmanned plane system

Номер: CN104503458A
Автор: LAN BO
Принадлежит:

The invention relates to a micro individual combat unmanned plane system. The micro individual combat unmanned plane system comprises an aircraft, a hand-held controller and an individual helmet, wherein the aircraft is equipped with airborne communication equipment, an airborne controller and airborne task equipment, the aircraft and the hand-held controller are in wireless connection through wireless communication equipment, and the aircraft and the individual helmet are in wireless connection through wireless communication equipment. The micro individual combat unmanned plane system has advantages of excellent pneumatic layout, excellent self stability, high security, strong outfield maintenance capability, convenient carrying, simple operation and short start preparation time.

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16-12-2015 дата публикации

Extensive applicability's shaw hardness tester test jig

Номер: CN0204882211U
Автор: LIU NING, ZHOU SHU, LI DEWEI, LAN BO
Принадлежит:

The utility model discloses an extensive applicability's shaw hardness tester test jig, the on -line screen storage device comprises a base, with base fixed connection's stand and with base fixed connection's outer plug -in components, set up a fixed orifices that has the fixture block on the lateral wall of base, outer plug -in components are including the base member that is equipped with the cavity, mounting and plug assemblies, protruding stretching there is the boss in the cavity, the mounting includes with base member sliding connection's cylinder and has the arc connecting block and the arc fixed block of arc movable block, the arc fixed block is used for fixed column work piece, plug assemblies includes the inserted bar, connecting rod and catch bar, connecting rod one end is articulated with the inserted bar, the other end is articulated with the catch bar, the inserted bar passes the boss, the one end that the connecting rod was kept away from to the inserted bar is equipped with ...

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25-07-2012 дата публикации

Compound gas mixing device for coal mine

Номер: CN0101708437B
Принадлежит:

The invention discloses a compound gas mixing device for a coal mine. The gas mixing device comprises an ejector, an air distribution system, a gas distribution system, a mixed gas conveying system and a main control unit; the air distribution system comprise an air parameter collecting system arranged on an air pipeline and an air parameter adjusting system; the gas distribution system comprisesa gas parameter collecting system arranged on a gas pipeline and a gas parameter adjusting system; the mixed gas conveying system comprises a mixed gas parameter collecting system; and the main control unit is used for receiving data signals from the air parameter collecting system, the gas parameter collecting system and the mixed gas parameter collecting system and sending command signals to the air parameter adjusting system and the gas parameter adjusting system. The invention can continuously convey distribution gas in large quantity or variable quantity in real-time according to downstream ...

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04-06-2008 дата публикации

Pipeline connection hydraulic clamping device

Номер: CN0101190510A
Принадлежит:

The invention provides a pipeline connecting hydraulic clamp machine which is used for clamping the pipeline connection in the mechanical field when a pipeline is connected. Corresponding positions between two plywoods are respectively provided with a plywood connecting part; the plywood connecting parts at two sides are mutually connected by plywood connecting part shafts; the internal end at one side of the upper part of the plywood is provided with a hydraulic cylinder which is internally provided with a hydraulic rod; the lower sides of the two plywoods are respectively provided with plywood mouths which are in semiround cut shape. Owning to the large driving force of the application of the hydraulic driving plywood and the lever function of the plywood, the plywood mouths are subject to enough clamping force thus clamping the connecting end of the pipeline and being convenient for the tightly screwing of the connecting nuts thus implementing the dense connection of the pipeline. The ...

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29-10-2014 дата публикации

Hydrodynamic performance measuring mechanism in stability testing device for ship model in waves

Номер: CN104118532A
Принадлежит:

The invention discloses a hydrodynamic performance measuring mechanism in a stability testing device for a ship model in waves. The hydrodynamic performance measuring mechanism comprises a base supported by a trailer measuring bridge in a sliding mode, a supporting frame penetrates through the base and is fixedly connected with the base, a pulley at the upper end of the supporting frame is provided with a steel wire rope in a winding mode, one end of the steel wire rope is connected with a balance weight, and the other end of the steel wire rope is connected with a heaving rod. The heaving rod penetrates through the base and can slide up and down, the heavy rod is fixedly connected with a middle bracing wire extending end in a bracing wire type sensor, the bottom end of the heavy rod is sequentially provided with a three-component force sensor and a supporting seat, the two side walls of the supporting seat are provided with pitching shaft, and the pitching shaft and a rolling shaft form ...

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07-11-2019 дата публикации

CONDUCTING OPTIMIZED CROSS-BLOCKCHAIN CURRENCY TRANSACTIONS USING MACHINE LEARNING

Номер: US2019340586A1
Принадлежит:

Methods and apparatuses are described for conducting cross-blockchain currency transactions. A server receives, from a client device, a request for a conversion of an amount of a first currency to an amount of a second currency. The amount of the first currency is stored in an electronic wallet associated with a user of the client device. The server determines one or more sequences of currency transactions executable that achieves the conversion from the amount of the first currency to the amount of the second currency, the one or more sequences of currency transactions comprising converting between cryptocurrencies operating on different blockchains. The server identifies one of the one or more sequences of currency transactions associated with an optimal value. The server executes the identified sequence of currency transactions associated with the optimal value.

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02-04-2014 дата публикации

Video real-time comparison method

Номер: CN103699886A
Принадлежит:

The invention discloses a video real-time comparison method, which comprises the following steps in the mode that firstly, the video image time sequence characteristics are utilized for carrying out frame synchronization, then, the image texture characteristics are utilized for carrying out video real-time comparison. The video real-time comparison method has the characteristics that the efficiency of the algorithm is high, the calculation speed is high, the hardware consumption is low, the real-time performance is high, and the large-scale multi-path video comparison processing can be favorably carried out. The method provided by the invention aims at the IPTV (Internet protocol television) supervision, and can also be applied to other services in aspects of video characteristic extraction, comparison, supervision and the like. In addition, the method provided by the invention can be realized through DSP (digital signal processor) hardware, and corresponding algorithms and solving methods ...

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14-04-2023 дата публикации

Energy storage leg structure and robot

Номер: CN115959219A
Принадлежит:

The invention relates to the technical field of robots, in particular to an energy storage leg structure and a robot. Comprising a first driving device, a first driving frame connected to the first driving device, a second driving device connected to the first driving frame, a second driving frame and a power storage device which are connected to the second driving device, a connecting rod device connected to the power storage device and the second driving frame, and a third driving device connected to the connecting rod device. The second driving device is provided with a second fixing base, and the force storage device comprises a force storage disc connected to the second fixing base and a force storage torsional spring arranged in the force storage disc and used for connecting the force storage disc with the second driving device in a driving mode. The force storage torsion springs are arranged on the second fixing base and the second driving device, under the action of the torsion ...

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09-02-2005 дата публикации

Method for automatic identifying circuit board type

Номер: CN0001576865A
Автор: LI YINGWU, LAN BO, YINGWU LI, BO LAN
Принадлежит:

The automatic circuit board type identifying method includes mainly making all devices in the scanning chain of the circuit boards into by-pass state; identifying circuit board type based on the number of digit '0's shifted out from the scanning chain; making all devices in the scanning chain of the circuit boards into instruction capturing state and identifying circuit board type based on the instruction capturing initial value shifted from the boundary scanning devices of the scanning chain; or identifying circuit board type via matching ID code of devices based on the data shifted out during the system on. The present invention makes it possible to identify the circuit board type automatically during boundary scanning test and to solve the problem of needing manually configuring circuit boards.

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01-05-2018 дата публикации

Knapsack type hand sprayer

Номер: CN0207284889U

The utility model discloses a knapsack type hand sprayer belongs to disease and pest control equipment field, the power distribution box comprises a box body, be equipped with pump barrel and cock stem in the box, inside the cock stem front end stretched into the pump barrel, the rear end was rotated and is connected the rocker, the handle is regarded to the one end of rocker, and the other end stretches into to the inside of box, and the part that this rocker stretched into in the box is equipped with a bevel gear, and a bevel gear meshes the 2nd bevel gear, is fixed with the pivot on the 2ndbevel gear, is equipped with the spiral shell in the pivot. This device drives the helical blade rotation through rocker drive pivot, pivot, and the rocker is the drive pivot in the drive cock stem,does not need other power supplies to provide the drive and does all can to ensure helical blade's stability, at the sprayed liquid medicine in -process, prevent liquid medicine layering, deposit, guarantee ...

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23-01-2008 дата публикации

Bursary long-range control management system based on wide area network

Номер: CN0101110729A
Автор: LAN BO, WU HAO, BO LAN, HAO WU
Принадлежит:

The present invention relates to a cash-deposit room remote controlling and management system based on the wide area network, which belongs to the controlling technology field. The system selects and adds network equipments on the base of the existing cash-deposit room alarming system, which are connected through the wide area network; the improvement part is that a remote controlled management software is installed in the centralized control host computer; a central router or exchanger (2) and a net point router or exchanger (4) are connected on the network line (3) between the centralized control host computer (1) and the alarming host computer (5); after the network module (6) is connected with the control interface of the alarming host computer (5), the network module is connected with the net point router or exchanger (4) through network interface of the network module (6) with a five-kind twisted pair line; an electric bolt lock (9) which is installed inside the cash-deposit room ...

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02-05-2013 дата публикации

METHOD, DEVICE AND SYSTEM FOR DISPLAYING THREE-DIMENSIONAL STEREO IMAGES

Номер: US20130106926A1
Принадлежит:

A 3D displaying device includes a first panel, a second panel and a backlight unit. The first panel includes a first liquid crystal layer for providing a left-eye image and a right-eye image. The second panel includes a first driving electrode substrate, a second driving electrode substrate and a second liquid crystal layer disposed between the first driving electrode substrate and the second driving electrode substrate, whereby light passing therethrough to generate polarization of a first angle or a second angle, wherein the second panel includes at least three sub-panel units. The backlight unit is disposed below the first panel and includes at least three light-emitting areas respectively corresponding to the at least three sub-panel units for providing a light source to the first panel and the second panel. 1. A device for displaying three-dimensional stereo images , the device comprising:a first panel comprising a first liquid crystal layer for providing a left-eye image and a right-eye image;a second panel comprising a first driving electrode substrate, a second driving electrode substrate, a second liquid crystal layer disposed between the first driving electrode substrate and the second driving electrode substrate, whereby light passing therethrough to generate a polarization of a first angle or a second angle, wherein the second panel comprises at least three sub-panel units; anda backlight unit disposed below the first panel and comprising at least three light-emitting areas respectively corresponding to the three sub-panel units for providing a light source to the first panel and the second panel.2. The device according to claim 1 , wherein one of the first driving electrode substrate and the second driving electrode substrate comprises at least three sheets of first driving electrodes claim 1 , and the first driving electrodes are electrically isolated from one another.3. The device according to claim 2 , wherein the other one of the first driving ...

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04-07-2013 дата публикации

TOUCH SYSTEM FOR INCREASING A REPORT RATE AND METHOD FOR INCREASING A REPORT RATE OF A TOUCH SYSTEM

Номер: US20130169586A1
Принадлежит:

A touch system for increasing a report rate includes a touch panel and a readout circuit. The touch panel is used for being touched by at least one object. A first axial direction of the touch panel has N first sensing lines and a second axial direction of the touch panel has M second sensing lines. The readout circuit is used for transmitting driving signals to each at least two first sensing lines of the N first sensing lines simultaneously, receiving sensing signals corresponding to the at least two first sensing lines through the M second sensing lines in turn, and calculating and outputting coordinates of at least one object touching the touch panel to a host according to the sensing signals corresponding to the at least two first sensing lines. The driving signals corresponding to the at least two first sensing lines partially overlap each other. 1. A touch system for increasing a report rate , the touch system comprising:a touch panel for being touched by at least one object, a first axial direction of the touch panel having N first sensing lines and a second axial direction of the touch panel having M second sensing lines, wherein each first sensing line corresponds to M sensing units, each second sensing line corresponds to N sensing units, and N and M are integers; anda readout circuit for transmitting driving signals to each at least two first sensing lines of the N first sensing lines simultaneously, receiving sensing signals corresponding to the at least two first sensing lines through the M second sensing lines in turn, and calculating and outputting coordinates of the at least one object touching the touch panel to a host according to the sensing signals corresponding to the at least two first sensing lines;wherein the driving signals corresponding to the at least two first sensing lines partially overlap each other.2. The touch system of claim 1 , wherein the touch panel is a projected capacitive touch panel.3. The touch system of claim 2 , wherein ...

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15-08-2013 дата публикации

Touch device and touch sensing method thereof

Номер: US20130207907A1
Принадлежит: Chunghwa Picture Tubes Ltd

A touch device and a touch sensing method thereof are provided. With driving lines and corresponding sensing lines are arranged alternately, the distance between the sensing lines is increased, so as to avoid touch quality being affected by the mutual interference caused by the sensing lines.

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22-08-2013 дата публикации

DISPLAY FOR DISPLAYING THREE-DIMENSIONAL IMAGES AND METHOD FOR DISPLAYING THREE-DIMENSIONAL IMAGES

Номер: US20130215104A1
Автор: LAN Bo-Wei, LI Hung-Chun
Принадлежит:

A display includes a gravity sensor, a timing controller, a backlight module, a first liquid crystal panel, a liquid crystal driver, and a second liquid crystal panel. The gravity sensor generates a direction signal. The timing controller receives a three-dimensional image, outputs a left eye image and a right eye image of the three-dimensional image in turn, outputs a control signal, and outputs a backlight control signal. The backlight module turns on a backlight. The first liquid crystal panel receives and displays the left eye image and the right eye image of the three-dimensional image. The liquid crystal driver receives the control signal and the direction signal, and outputs a voltage control signal. The second liquid crystal panel rotates liquid crystals within the second liquid crystal panel according to the voltage control signal. 1. A display for displaying three-dimensional images , the display comprising:a gravity sensor for generating a direction signal according to a direction of gravity;a timing controller for receiving a three-dimensional image, determining output sequence of a left eye image and a right eye image of the three-dimensional image according to the direction signal, outputting a control signal according to a timing of the three-dimensional image, and outputting a backlight control signal corresponding to a vertical blanking interval;a backlight module coupled to the timing controller for turning on a backlight according to the backlight control signal;a first liquid crystal panel coupled to the timing controller for receiving and displaying the left eye image and the right eye image of the three-dimensional image;a liquid crystal driver coupled to the timing controller for outputting a voltage control signal according to the control signal;a second liquid crystal panel coupled to the liquid crystal driver for rotating liquid crystals within the second liquid crystal panel to a first angle or a second angle according to the voltage ...

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01-02-2018 дата публикации

COMPOSITIONS AND METHODS FOR THERAPEUTIC ANTI-CANCER VACCINATION

Номер: US20180028630A1
Автор: Chen Lan Bo
Принадлежит:

An immunogenic composition that includes a glycoconjugate containing a fusion protein composed of an immunoglobulin gamma Fc domain fused to a tumor-associated antigen, the fusion protein being cross-linked to an azido-modified stage-specific embryonic antigen 4 conjugated to diphtheria toxoid cross-reactive material 197; and α-galactosylceramide C34 or α-glucosylceramide C34. Also provided are methods for treating cancer by administering the immunogenic composition to a patient. 2. The immunogenic composition of claim 1 , wherein the TAA is lymphocyte antigen 6 complex claim 1 , locus K (LY6K) claim 1 , cell division cycle associated 1 (CDCA1) claim 1 , insulin-like growth factor-II mRNA-binding protein 3 (IMP-3) claim 1 , kinesin family member 20A (KIF20A) claim 1 , glypican-3(GPC3) claim 1 , forkhead box M1 (FOXM1) claim 1 , cadherin 3 (CDH3) claim 1 , secreted protein acidic and rich in cysteine (SPARC) claim 1 , cell division cycle 45 ligand (CDC45L) claim 1 , DEP domain containing 1 (DEPDC1) claim 1 , M-phase phosphoprotein 1 (MPHOSPH1) claim 1 , prostate-specific antigen (PSA) claim 1 , prostate-specific membrane antigen (PSMA) claim 1 , human epidermal growth factor receptor 2/neuroblastoma (HER2/neu) claim 1 , carcinoembryonic antigen (CEA) claim 1 , mutated epidermal growth factor receptor (EGFR) claim 1 , melanoma antigen (MAGE) claim 1 , mucin-1 (MUC-1) claim 1 , or New York esophageal squamous cell carcinoma 1 (NY-ESO-1).3. The immunogenic composition of claim 2 , wherein the Fcγ forms the N-terminus of the fusion protein.4. The immunogenic composition of claim 3 , wherein the TAA is cross-linked to the DT.5. The immunogenic composition of claim 4 , wherein the azido modification is at the non-reducing end of the SSEA4 or the SSEA4 analog.6. The immunogenic composition of claim 2 , wherein the TAA forms the N-terminus of the fusion protein.7. The immunogenic composition of claim 6 , wherein the TAA is cross-linked to the DT.8. The immunogenic ...

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01-02-2018 дата публикации

ANTI-SSEA4 CHIMERIC ANTIGEN RECEPTORS AND THEIR USE FOR TREATING CANCER

Номер: US20180028631A1
Автор: Chen Lan Bo
Принадлежит:

A chimeric antigen receptor containing (i) a single chain Fv that specifically binds to stage-specific embryonic antigen 4 and (ii) an endodomain from CD3ζ or FcεRIγ. Also provided is a nucleic acid encoding the chimeric antigen receptor and an expression vector that contains the nucleic acid operably linked to a promoter that is active in T cells. Furthermore, two similar methods for treating a tumor are disclosed. The first method includes (i) obtaining T cells from a subject, (ii) transducing the T cells in vitro with an expression vector encoding a chimeric antigen receptor that contains an scFv specifically recognizing stage-specific embryonic antigen 4, (iii) expanding the transduced T cells in vitro, and (iv) infusing the expanded transduced T cells into the subject. The second method includes, in place of step (ii) above, transducing the T cells in vitro with an expression vector encoding a chimeric antigen receptor that is specific for a tumor antigen other than stage-specific embryonic antigen 4, and further requires a step of administering an antibody against stage-specific embryonic antigen 4. 1. A chimeric antigen receptor , comprising a single chain Fv (scFv) that specifically binds to stage-specific embryonic antigen 4 (SSEA4) , and a first endodomain from CD3ζ or FcεRIγ.2. The chimeric antigen receptor of claim 1 , further comprising a second endodomain from CD28 claim 1 , CD137 claim 1 , CD4 claim 1 , OX40 claim 1 , or ICOS claim 1 , wherein the scFv is fused to the second endodomain and the second endodomain is fused to the first endodomain.3. A nucleic acid encoding the chimeric antigen receptor of .4. An expression vector comprising the nucleic acid of operably linked to a promoter claim 3 , wherein the promoter is active in T cells.5. The chimeric antigen receptor of claim 2 , further comprising a third endodomain from CD28 claim 2 , CD137 claim 2 , CD4 claim 2 , OX40 claim 2 , or ICOS claim 2 , wherein the third endodomain is different from the ...

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01-02-2018 дата публикации

METHOD OF TREATING TUMORS WITH NK AND NKT CELLS EXPRESSING ANTI-SSEA4 CHIMERIC ANTIGEN RECEPTORS

Номер: US20180028632A1
Автор: Chen Lan Bo
Принадлежит:

Two methods for treating a tumor are disclosed. The first method includes (i) obtaining NK cells or NKT cells from a subject, (ii) transducing the NK cells or NKT cells in vitro with an expression vector encoding a chimeric antigen receptor that contains an scFv specifically recognizing stage-specific embryonic antigen 4, (iii) expanding the transduced NK cells or NKT cells in vitro, and (iv) infusing the expanded transduced NK cells or NKT cells into the subject. The second method includes, in place of step (ii) above, transducing the NK cells or NKT cells in vitro with an expression vector encoding a chimeric antigen receptor that is specific for a tumor antigen other than stage-specific embryonic antigen 4, and further requires a step of administering an antibody against stage-specific embryonic antigen 4. 1. A method for treating a subject having a tumor , the method comprising:obtaining NK cells or NKT cells from the subject;transducing the NK cells or NKT cells in vitro with an expression vector encoding a chimeric antigen receptor (CAR) containing an endodomain from CD3ζ or from FcεRIγ fused to a scFv that specifically recognizes stage-specific embryonic antigen 4 (SSEA4), whereby the transduced NK cells or NKT cells express the CAR;expanding the transduced NK cells or NKT cells in vitro; andinfusing the expanded transduced NK cells or NKT cells into the subject, whereby an anti-tumor immune response is raised.2. The method of claim 1 , wherein the CAR further contains a second endodomain from CD28 claim 1 , CD137 claim 1 , CD4 claim 1 , OX40 claim 1 , ICOS claim 1 , Ly49D claim 1 , Ly49H claim 1 , KIR2DL4 claim 1 , KIR2DS1 claim 1 , KIR2DS2 claim 1 , KIR2DS3 claim 1 , KIR2DS4 claim 1 , KIR2DS5 claim 1 , KIR3DS1 claim 1 , NKG2C claim 1 , NKG2E claim 1 , NKG2D claim 1 , NKp30 claim 1 , NKp44 claim 1 , NKp46 claim 1 , NKp80 claim 1 , DNAM-1 claim 1 , or PILR.3. The method of claim 2 , wherein the tumor is a breast claim 2 , colon claim 2 , gastrointestinal ...

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01-02-2018 дата публикации

Chimeric antigen receptor combination therapy for treating tumors

Номер: US20180028633A1
Автор: Lan Bo Chen
Принадлежит: Individual

A method for treating a tumor in a subject by administering at least three of the following treatment modalities: (i) an antibody, (ii) T cells bearing a first chimeric antigen receptor (CAR), (iii) NK cells bearing a second CAR, and (iv) NKT cells bearing a third CAR. The antibody binds specifically to stage-specific embryonic antigen 4 and each CAR contains a scFv that also binds specifically to SSEA4.

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01-02-2018 дата публикации

METHOD FOR PROLONGING AND ENHANCING ANTI-TUMOR VACCINE RESPONSE

Номер: US20180028634A1
Автор: Chen Lan Bo
Принадлежит:

A method for treating a tumor includes administering (i) a vaccine that contains stage-specific embryonic antigen 4 conjugated to a carrier, (ii) an antibody that binds specifically to SSEA-4, and (iii) immune cells expressing a chimeric antigen receptor that specifically binds to SSEA-4. The tumor, which expresses SSEA-4, can be a breast, colon, gastrointestinal, kidney, lung, liver, ovarian, pancreatic, rectal, stomach, testicular, thymic, cervical, prostate, bladder, skin, nasopharyngeal, esophageal, oral, head and neck, bone, cartilage, muscle, lymph node, bone marrow, or brain tumor. 1. A method for treating a tumor , the method comprising administering to a subject having a tumor a vaccine that contains stage-specific embryonic antigen 4 (SSEA4) conjugated to a carrier , an antibody that binds specifically to SSEA-4 (anti-SSEA4 Ab) , and immune cells expressing a chimeric antigen receptor (CAR) that specifically binds to SSEA-4 , wherein the tumor expresses SSEA-4.2. The method of claim 1 , wherein the vaccine further contains α-galactosylceramide C34 or α-glucosylceramide C34 as an adjuvant.3. The method of claim 2 , wherein the immune cells are T cells claim 2 , NK cells claim 2 , NKT cells claim 2 , or a mixture thereof and the CAR contains (i) a scFv that binds specifically to SSEA4 and (ii) a CD3ζ endodomain or an FcεRIγ endodomain.4. The method of claim 3 , wherein the CAR further contains a second endodomain from CD28 claim 3 , CD137 claim 3 , CD4 claim 3 , OX40 claim 3 , ICOS claim 3 , Ly49D claim 3 , Ly49H claim 3 , KIR2DL4 claim 3 , KIR2DS1 claim 3 , KIR2DS2 claim 3 , KIR2DS3 claim 3 , KIR2DS4 claim 3 , KIR2DS5 claim 3 , KIR3DS1 claim 3 , NKG2C claim 3 , NKG2E claim 3 , NKG2D claim 3 , NKp30 claim 3 , NKp44 claim 3 , NKp46 claim 3 , NKp80 claim 3 , DNAM-1 claim 3 , or PILR.5. The method of claim 4 , wherein the vaccine claim 4 , the anti-SSEA4 Ab claim 4 , and the immune cells are administered sequentially.6. The method of claim 5 , wherein the tumor ...

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01-02-2018 дата публикации

METHOD FOR TREATING A TUMOR WITH BIFUNCTIONAL AGENTS THAT BIND TO TUMOR CARBOHYDRATE ANTIGENS

Номер: US20180030123A1
Автор: Chen Lan Bo
Принадлежит:

A method for treating a tumor with at least two bifunctional agents. The bifunctional agents each include a binding domain that specifically binds to stage-specific embryonic antigen 4 (SSEA4) or an SSEA4 analog, and an effector domain selected from a cytokine, a cytotoxic agent, an immunoglobulin Fc domain, anti-CD3, and anti-CD16. 1. A method for treating a tumor in a subject , the method comprising administering to the subject having a tumor at least two different bifunctional agents each of which contains a binding domain linked to an effector molecule , wherein the binding domain specifically binds to stage-specific embryonic antigen 4 (SSEA4) or an SSEA4 analog , cells in the tumor express SSEA4 or the SSEA4 analog , and the effector molecule is a cytotoxic agent , a cytokine , an immunoglobulin Fc domain , anti-CD3 , or anti-CD16.2. The method of claim 1 , wherein one of the at least two different bifunctional agents contains an effector molecule selected from the group consisting of Diphtheria toxin claim 1 , Pseudomonas exotoxin A claim 1 , doxorubicin claim 1 , methotrexate claim 1 , an auristatin claim 1 , a maytansine claim 1 , a calicheamicin claim 1 , a duocarmycin claim 1 , a pyrrolobenzodiazepine dimer claim 1 , and SN-38.3. The method of claim 2 , wherein one of the at least two different bifunctional agents contains an effector molecule selected from the group consisting of G-CSF claim 2 , GM-CSF claim 2 , IFNγ claim 2 , IFNα claim 2 , IL-1β claim 2 , IL-2 claim 2 , IL-4 claim 2 , IL-6 claim 2 , IL-7 claim 2 , IL-9 claim 2 , IL-12 claim 2 , IL-13 claim 2 , IL-15 claim 2 , IL-17 claim 2 , IL-21 claim 2 , IL-23 claim 2 , and TNF.4. The method of claim 3 , wherein the tumor is a breast claim 3 , colon claim 3 , gastrointestinal claim 3 , kidney claim 3 , lung claim 3 , liver claim 3 , ovarian claim 3 , pancreatic claim 3 , rectal claim 3 , stomach claim 3 , testicular claim 3 , thymic claim 3 , cervical claim 3 , brain claim 3 , prostate claim 3 , ...

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01-02-2018 дата публикации

METHODS AND COMPOSITIONS FOR ENHANCING ANTI-SSEA4 IMMUNOTHERAPY

Номер: US20180030124A1
Автор: Chen Lan Bo
Принадлежит:

A method for treating a tumor by administering an antibody or antibody fragment that binds specifically to stage-specific embryonic antigen 4, and an agent that enhances T cell anti-tumor responses. Also provided is a pharmaceutical composition for treating a tumor. The pharmaceutical composition contains an anti-SSEA4 antibody or antibody fragment, an agent that enhances T cell responses, and a pharmaceutically acceptable excipient. 1. A method for treating a tumor , the method comprising administering to a subject having a tumor an antibody or antibody fragment that binds specifically to stage-specific embryonic antigen 4 (SSEA4) , and an agent that enhances T cell anti-tumor responses , wherein cells in the tumor express SSEA4.2. The method of claim 1 , wherein the agent that enhances T cell anti-tumor responses is an inhibitor of a target selected from the group consisting of cytotoxic T lymphocyte-associated protein 4 (CTLA-4) claim 1 , programmed cell death-1 (PD-1) claim 1 , programmed cell death ligand-1 (PD-L1) claim 1 , programmed cell death ligand-2 (PD-L2) claim 1 , lymphocyte activation gene-3 (LAG-3) claim 1 , T cell immunoglobulin and mucin domain 3 (TIM-3) claim 1 , indoleamine 2 claim 1 ,3-dioxigenase 1 (IDO1) claim 1 , T cell Ig and ITIM domain (TIGIT) claim 1 , B- and T-lymphocyte attenuator (BTLA) claim 1 , and a combination thereof.3. The method of claim 2 , wherein the antibody or antibody fragment is a humanized anti-SSEA4 monoclonal antibody (mAb).4. The method of claim 3 , wherein the tumor is a breast claim 3 , colon claim 3 , gastrointestinal claim 3 , kidney claim 3 , lung claim 3 , liver claim 3 , ovarian claim 3 , pancreatic claim 3 , rectal claim 3 , stomach claim 3 , testicular claim 3 , thymic claim 3 , cervical claim 3 , prostate claim 3 , bladder claim 3 , skin claim 3 , nasopharyngeal claim 3 , esophageal claim 3 , oral claim 3 , head and neck claim 3 , bone claim 3 , cartilage claim 3 , muscle claim 3 , lymph node claim 3 , bone ...

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07-02-2019 дата публикации

Backlight module and display device

Номер: US20190041567A1

A backlight module includes a light source, a light guide plate and a light-adjusting member. A light source chromaticity is measured from light generated by the light source. The light guide plate has a light-incident surface and a light-emitting surface. Light generated by the light source enters the light guide plate and emits out from the light-emitting surface. With the light-adjusting member, a first light guide plate chromaticity is measured from the light-emitting surface. There is a first difference value between the first light guide plate chromaticity and the light source chromaticity. Without the light-adjusting member, a second light guide plate chromaticity is measured from the light-emitting surface. There is a second difference value between the second light guide plate chromaticity and the light source chromaticity. The first difference value is different from the second difference value.

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07-05-2020 дата публикации

COMPOSITION AND METHOD FOR AIDING SLEEP

Номер: US20200138748A1
Автор: Chen Lan Bo
Принадлежит: Sequential Medicine Limited

Disclosed is a controlled-release formulation for treating disturbed sleep or insomnia in a subject. The formulation is formulated to release diphenhydramine HCl and a sleep aid in sequence at two stages. 1. A controlled-release formulation , comprising diphenhydramine HCl and a sleep aid which is zolpidem tartrate or lorazepam , wherein the formulation is formulated for a first stage release of the diphenhydramine HCl immediately after administering to a subject , and a second stage release of the sleep aid that starts 0.5-6 hours after initiation of the first stage.2. The formulation of claim 1 , comprising 40-60 mg of diphenhydramine HCl.3. The formulation of claim 1 , comprising 4-6 mg of zolpidem tartrate.4. The formulation of claim 1 , comprising 0.4-0.6 mg of lorazepam.5. The formulation of claim 2 , comprising 50 mg of diphenhydramine HCl.6. The formulation of claim 3 , comprising 5 mg of zolpidem tartrate.7. The formulation of claim 4 , comprising 0.5 mg of lorazepam.8. The formulation of claim 1 , wherein the formulation is a tablet or capsule for oral administration.9. The formulation of claim 8 , wherein the tablet or capsule contains a plurality of particles claim 8 , each particle including a drug core and a polymeric composition encapsulating the core claim 8 , wherein the drug core contains zolpidem tartrate or lorazepam.10. The formulation of claim 9 , wherein the polymeric composition encapsulating the drug core containing zolpidem tartrate dissolves at above pH 5.5 claim 9 , or the polymeric composition encapsulating the drug core containing lorazepam dissolves at above pH 6.5.11. The formulation of claim 9 , wherein the polymeric composition includes a polymethacrylate.12. The formulation of claim 1 , comprising one or more pharmaceutical excipients.13. A method of treating disturbed sleep or insomnia claim 1 , comprising administering the formulation of to a subject in need thereof. In patients suffering sleep disruptions, one can observe a ...

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08-06-2017 дата публикации

Backlight module and display device

Номер: US20170160460A1

A backlight module includes a light source, a light guide plate and a light-adjusting member. A light source chromaticity is measured from light generated by the light source. The light guide plate has a light-incident surface and a light-emitting surface. Light generated by the light source enters the light guide plate and emits out from the light-emitting surface. With the light-adjusting member, a first light guide plate chromaticity is measured from the light-emitting surface. There is a first difference value between the first light guide plate chromaticity and the light source chromaticity. Without the light-adjusting member, a second light guide plate chromaticity is measured from the light-emitting surface. There is a second difference value between the second light guide plate chromaticity and the light source chromaticity. The first difference value is different from the second difference value.

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06-08-2015 дата публикации

COMPOSITION AND METHOD FOR AIDING SLEEP

Номер: US20150216811A1
Автор: Chen Lan Bo
Принадлежит:

Described is a controlled-release formulation for treating disturbed sleep or insomnia in a subject. The formulation is formulated to release a compound or combination of compounds in sequence at multiple stages. 1. A controlled-release formulation , comprising one or more compounds for aiding sleep , wherein the formulation is formulated for releasing each compound at a specific time and a specific dose in a subject after the formulation is administered to the subject.2. The formulation of claim 1 , wherein the formulation is formulated for releasing different compounds or different combinations of compounds at different time points in a subject after the formulation is administered to the subject.3. The formulation of claim 1 , wherein the formulation is formulated for releasing the one or more compounds at two or more stages claim 1 , wherein claim 1 , at each stage claim 1 , release of a compound or a combination of compounds is initiated at a specific time in a subject after the formulation is administered to the subject.4. The formulation of claim 3 , wherein the formulation is formulated for two to twelve stages of release.5. The formulation of claim 4 , wherein the time interval between the initiation of each stage of release is 0.5 to 23 hours.6. The formulation of claim 5 , wherein the first stage is for immediate release of one or more compounds.7. The formulation of claim 3 , wherein the one or more compounds are selected from the group consisting of a barbiturate claim 3 , diazepam claim 3 , estazolam claim 3 , flunitrazepam claim 3 , lorazepam claim 3 , midazolam claim 3 , nitrazepam claim 3 , oxazepam claim 3 , triazolam claim 3 , temazepam claim 3 , chlordiazepoxide claim 3 , alprazolam claim 3 , eszopiclone claim 3 , zaleplon claim 3 , zolpidem claim 3 , zopiclone claim 3 , diphenhydramine claim 3 , dimenhydrinate claim 3 , doxylamine claim 3 , mirtazapine claim 3 , promethazine claim 3 , a plant component or extract claim 3 , Validol claim 3 , ...

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03-09-2020 дата публикации

MONOCLONAL ANTIBODIES THAT BIND TO SSEA4 AND USES THEREOF

Номер: US20200276308A1
Автор: Chen Lan Bo
Принадлежит:

A nucleic acid construct that encodes a monoclonal antibody or antigen-binding fragment that specifically binds to stage-specific embryonic antigen 4. The monoclonal antibody or antigen-binding fragment includes a heavy-chain CDR1 having the sequence of SEQ ID NO: 33 or SEQ ID NO: 40, a heavy-chain CDR2 having the sequence of SEQ ID NO: 34 or SEQ ID NO: 39, a heavy-chain CDR3 having the sequence of SEQ ID NO: 35 or SEQ ID NO: 41, a light-chain CDR1 having the sequence of SEQ ID NO: 36 or SEQ ID NO: 42, a light-chain CDR2 having the sequence of SEQ ID NO: 37 or SEQ ID NO: 43, and a light-chain CDR3 having the sequence of SEQ ID NO: 38 or SEQ ID NO: 44. Also disclosed are recombinant cells containing the nucleic acid construct. 1. A nucleic acid construct that encodes a monoclonal antibody or an antigen-binding fragment thereof , the construct encoding a heavy-chain CDR1 (H-CDR1) having the sequence of SEQ ID NO: 33 or SEQ ID NO: 40 , a heavy-chain CDR2 (H-CDR2) having the sequence of SEQ ID NO: 34 or SEQ ID NO: 39 , a heavy-chain CDR3 (H-CDR3) having the sequence of SEQ ID NO: 35 or SEQ ID NO: 41 , a light-chain CDR1 (L-CDR1) having the sequence of SEQ ID NO: 36 or SEQ ID NO: 42 , a light-chain CDR2 (L-CDR2) having the sequence of SEQ ID NO: 37 or SEQ ID NO: 43 , and a light-chain CDR3 (L-CDR3) having the sequence of SEQ ID NO: 38 or SEQ ID NO: 44 , wherein the monoclonal antibody or antigen-binding fragment specifically binds to stage-specific embryonic antigen 4.2. The nucleic acid construct of claim 1 , wherein the H-CDR1 has the sequence of SEQ ID NO: 33 claim 1 , the H-CDR2 has the sequence of SEQ ID NO: 34 claim 1 , the H-CDR3 has the sequence of SEQ ID NO: 35 claim 1 , the L-CDR1 has the sequence of SEQ ID NO: 42 claim 1 , the L-CDR2 has the sequence of SEQ ID NO: 43 claim 1 , and the L-CDR3 has the sequence of SEQ ID NO: 44.3. A nucleic acid construct that encodes a monoclonal antibody having a heavy-chain sequence selected from the group consisting of SEQ ID ...

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26-09-2019 дата публикации

CHIMERIC ANTIGEN RECEPTORS THAT BIND TO SSEA4 AND USES THEREOF

Номер: US20190290744A1
Автор: Chen Lan Bo
Принадлежит:

An isolated nucleic acid that contains a nucleotide sequence that encodes the polypeptide of SEQ ID NO: 3. The polypeptide of SEQ ID NO: 3 specifically binds to stage-specific embryonic antigen 4 (SSEA4). Also disclosed is a recombinant cell comprising the isolated nucleic acid described above, a viral vector containing the above isolated nucleic acid, and an isolated polypeptide including the sequence of SEQ ID NO: 3. Provided as well is a chimeric antigen receptor (CAR) that includes a single chain Fv having the sequence of SEQ ID NO: 3 and specifically binding to SSEA4. Moreover, a method is disclosed for treating a tumor by transducing in vitro the T cells of a subject having a tumor expressing SSEA4 with a vector that encodes the CAR, expanding the transduced T cells, and infusing the expanded transduced T cells into the subject, whereby an anti-tumor T cell response is raised. 1. An isolated nucleic acid , comprising a nucleotide sequence that encodes the polypeptide of SEQ ID NO: 3.2. The isolated nucleic acid of claim 1 , wherein the nucleotide sequence is SEQ ID NO: 1.3. A recombinant cell comprising the isolated nucleic acid of claim 2 , wherein the recombinant cell expresses the polypeptide of SEQ ID NO: 2.4. The recombinant cell of claim 3 , wherein the cell is a T cell.5. A viral vector comprising the isolated nucleic acid of claim 1 , wherein the viral vector is a lentiviral vector claim 1 , a gamma-retroviral vector claim 1 , or an adeno-associated viral vector.6. The viral vector of claim 5 , wherein the nucleotide sequence is SEQ ID NO: 1.7. An isolated polypeptide comprising the sequence of SEQ ID NO: 3 claim 5 , wherein the isolated polypeptide specifically binds to stage-specific embryonic antigen 4.8. A chimeric antigen receptor claim 5 , comprising a single chain Fv (scFv) that specifically binds to stage-specific embryonic antigen 4 claim 5 , and a first endodomain from CD3ζ or FcεRγ claim 5 , wherein the scFv has the sequence of SEQ ID NO: 3. ...

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03-10-2019 дата публикации

MONOCLONAL ANTIBODIES THAT BIND TO SSEA4 AND USES THEREOF

Номер: US20190298828A1
Автор: Chen Lan Bo
Принадлежит:

An isolated monoclonal antibody or antigen-binding fragment that specifically binds to stage-specific embryonic antigen 4. The monoclonal antibody or antigen-binding fragment includes a heavy-chain CDR1 having the sequence of SEQ ID NO: 33 or SEQ ID NO: 40, a heavy-chain CDR2 having the sequence of SEQ ID NO: 34 or SEQ ID NO: 39, a heavy-chain CDR3 having the sequence of SEQ ID NO: 35 or SEQ ID NO: 41, a light-chain CDR1 having the sequence of SEQ ID NO: 36 or SEQ ID NO: 42, a light-chain CDR2 having the sequence of SEQ ID NO: 37 or SEQ ID NO: 43, and a light-chain CDR3 having the sequence of SEQ ID NO: 38 or SEQ ID NO: 44. Also disclosed is an anti-tumor method carried out by administering the above monoclonal antibody or antigen-binding fragment to a subject having a tumor that expresses stage-specific embryonic antigen 4. Further provided are nucleic acids encoding the above sequences and recombinant cells containing the nucleic acids. 1. An isolated monoclonal antibody or antigen-binding fragment thereof comprising a heavy-chain CDR1 (H-CDR1) having the sequence of SEQ ID NO: 33 or SEQ ID NO: 40 , a heavy-chain CDR2 (H-CDR2) having the sequence of SEQ ID NO: 34 or SEQ ID NO: 39 , a heavy-chain CDR3 (H-CDR3) having the sequence of SEQ ID NO: 35 or SEQ ID NO: 41 , a light-chain CDR1 (L-CDR1) having the sequence of SEQ ID NO: 36 or SEQ ID NO: 42 , a light-chain CDR2 (L-CDR2) having the sequence of SEQ ID NO: 37 or SEQ ID NO: 43 , and a light-chain CDR3 (L-CDR3) having the sequence of SEQ ID NO: 38 or SEQ ID NO: 44 ,wherein the monoclonal antibody or antigen-binding fragment specifically binds to stage-specific embryonic antigen 4.2. The isolated monoclonal antibody or antigen-binding fragment of claim 1 , wherein the H-CDR1 has the sequence of SEQ ID NO: 33 claim 1 , the H-CDR2 has the sequence of SEQ ID NO: 34 claim 1 , the H-CDR3 has the sequence of SEQ ID NO: 35 claim 1 , the L-CDR1 has the sequence of SEQ ID NO: 42 claim 1 , the L-CDR2 has the sequence of SEQ ...

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01-12-2016 дата публикации

COMPOSITION AND METHOD FOR AIDING SLEEP

Номер: US20160346216A1
Автор: Chen Lan Bo
Принадлежит:

Described is a controlled-release formulation for treating disturbed sleep or insomnia in a subject. The formulation is formulated to release a compound or combination of compounds in sequence at multiple stages. 1. A controlled-release formulation , comprising one or more compounds for aiding sleep , wherein the formulation is formulated for releasing each compound at a specific time and a specific dose in a subject after the formulation is administered to the subject.2. The formulation of claim 1 , wherein the formulation is formulated for releasing different compounds or different combinations of compounds at different time points in a subject after the formulation is administered to the subject.3. The formulation of claim 1 , wherein the formulation is formulated for releasing the one or more compounds at two or more stages claim 1 , wherein claim 1 , at each stage claim 1 , release of a compound or a combination of compounds is initiated at a specific time in a subject after the formulation is administered to the subject.4. The formulation of claim 3 , wherein the formulation is formulated for two to twelve stages of release.5. The formulation of claim 4 , wherein the time interval between the initiation of each stage of release is 0.5 to 23 hours.6. The formulation of claim 5 , wherein the first stage is for immediate release of one or more compounds.7. The formulation of claim 3 , wherein the one or more compounds are selected from the group consisting of a barbiturate claim 3 , diazepam claim 3 , estazolam claim 3 , flunitrazepam claim 3 , lorazepam claim 3 , midazolam claim 3 , nitrazepam claim 3 , oxazepam claim 3 , triazolam claim 3 , temazepam claim 3 , chlordiazepoxide claim 3 , alprazolam claim 3 , eszopiclone claim 3 , zaleplon claim 3 , zolpidem claim 3 , zopiclone claim 3 , diphenhydramine claim 3 , dimenhydrinate claim 3 , doxylamine claim 3 , mirtazapine claim 3 , promethazine claim 3 , a plant component or extract claim 3 , Validol claim 3 , ...

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29-10-2020 дата публикации

CHIMERIC ANTIGEN RECEPTORS THAT BIND TO SSEA4 AND USES THEREOF

Номер: US20200338177A1
Автор: Chen Lan Bo
Принадлежит:

An isolated nucleic acid that contains a nucleotide sequence that encodes the polypeptide of SEQ ID NO: 3. The polypeptide of SEQ ID NO: 3 specifically binds to stage-specific embryonic antigen 4 (SSEA4). Also disclosed is a recombinant cell comprising the isolated nucleic acid described above, a viral vector containing the above isolated nucleic acid, and an isolated polypeptide including the sequence of SEQ ID NO: 3. Provided as well is a chimeric antigen receptor (CAR) that includes a single chain Fv having the sequence of SEQ ID NO: 3 and specifically binding to SSEA4. Moreover, a method is disclosed for treating a tumor by transducing in vitro the T cells of a subject having a tumor expressing SSEA4 with a vector that encodes the CAR, expanding the transduced T cells, and infusing the expanded transduced T cells into the subject, whereby an anti-tumor T cell response is raised. 1. An isolated polypeptide comprising the sequence of SEQ ID NO: 3 , wherein the isolated polypeptide specifically binds to stage-specific embryonic antigen 4.2. A chimeric antigen receptor , comprising a single chain Fv (scFv) that specifically binds to stage-specific embryonic antigen 4 , and a first endodomain from CD3ζ or FccRIγ , wherein the scFv has the sequence of SEQ ID NO: 3.3. The chimeric antigen receptor of claim 2 , further comprising a second endodomain from CD28 claim 2 , CD137 claim 2 , CD4 claim 2 , OX40 claim 2 , or ICOS claim 2 , wherein the scFv is fused to the second endodomain and the second endodomain is fused to the first endodomain.4. The chimeric antigen receptor of claim 3 , wherein the chimeric antigen receptor has the sequence of SEQ ID NO: 4.5. The chimeric antigen receptor of claim 3 , further comprising an epidermal growth factor receptor t domain III-IV at its C-terminus.6. The chimeric antigen receptor of claim 5 , wherein the chimeric antigen receptor has the sequence of SEQ ID NO: 2. The present application is a divisional of copending U.S. patent ...

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07-11-2019 дата публикации

CONDUCTING OPTIMIZED CROSS-BLOCKCHAIN CURRENCY TRANSACTIONS USING MACHINE LEARNING

Номер: US20190340586A1
Автор: Lan Bo, Sheng Xinxin, Witt Alex
Принадлежит:

Methods and apparatuses are described for conducting cross-blockchain currency transactions. A server receives, from a client device, a request for a conversion of an amount of a first currency to an amount of a second currency. The amount of the first currency is stored in an electronic wallet associated with a user of the client device. The server determines one or more sequences of currency transactions executable that achieves the conversion from the amount of the first currency to the amount of the second currency, the one or more sequences of currency transactions comprising converting between cryptocurrencies operating on different blockchains. The server identifies one of the one or more sequences of currency transactions associated with an optimal value. The server executes the identified sequence of currency transactions associated with the optimal value. 1. A system for conducting cross-blockchain currency transactions , the system comprising:a server computing device including a memory for storing programmatic instructions and a processor for executing the programmatic instructions, anda database coupled to the server computing device, receive, from a first client computing device, a request for a conversion of an amount of a first currency listed for trading on at least one of a plurality of cryptocurrency exchanges to an amount of a second currency listed for trading on at least one of the plurality of cryptocurrency exchanges, the amount of at least one of the first currency or the second currency stored in an electronic wallet associated with a user of the first client computing device;', 'determine one or more sequences of currency transactions executable between two or more of the plurality of cryptocurrency exchanges that achieves the conversion from the amount of the first currency to the amount of the second currency, at least one of the one or more sequences of currency transactions comprising converting between cryptocurrencies operating on ...

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27-02-2007 дата публикации

Water-soluble bean-based extracts

Номер: US7182972B2
Принадлежит: Quercegen Pharma LLC

This invention relates to a water-soluble bean-based extract including one or more isoflavone glycosides. Also INCLUDED is a method of preparing such a water-soluble bean-based extract.

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01-04-2003 дата публикации

Water-soluble soybean extracts

Номер: US6541062B2

This invention relates to a water-soluble soybean-based extract including one or more isoflavone glycosides. Also described is a method of preparing such a water-soluble soybean-based extract.

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15-08-2002 дата публикации

Rare event detection system

Номер: CA2436448A1
Принадлежит: Individual

Disclosed is a method of detecting a target body in a specimen field of multiple candidate bodies by differential fluorescence labeling of different portions of the target body. The flexibility provided by the user of fluorophores allows for rapid detection of any rare target body with high efficiency and accuracy.

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11-08-1992 дата публикации

PREPARATION AND METHOD OF CANCER TREATMENT

Номер: NO923126D0
Принадлежит: Fuji Photo Film Co Ltd

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28-05-2004 дата публикации

Water-soluble bean-based extracts

Номер: NZ520237A

A water-soluble bean based extract comprising one or more isoflavone derivatives of the formula as shown, where: R1 is hydrogen or hydroxy, R2 is hydrogen or methoxy, R3 is hydrogen or CO-R4, R4 is methyl or carboxymethyl. The water soluble bean based extract, in the dried form, includes from about 5 to about 50 parts by weight of isoflavone derivatives and has a solubility from about 10mg/ml to about 1,000mg/ml in water at about 25oC.

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29-10-2009 дата публикации

Patent DE60042980D1

Номер: DE60042980D1

Подробнее
14-02-1993 дата публикации

Composition and method for treating cancer

Номер: CA2075750A1
Принадлежит: Individual

A pharmaceutical composition for treatment of cancer comprises: (A) a therapeutically effective amount of at least one compound selected from the group consisting of compounds represented by the General Formula (I) (see fig.I) wherein X1 and X2, which may be the same or different, each represents O, S, Se, -CH=CH-, (see fig.II), or (see fig.III); Y1 represents O, S, Se, or (see fig.IV); R1 and R3, which may be the same or different, each represents an alkyl group; R2 represents an alkyl group, an aryl group or a heterocyclic group; Z1 and Z2, which may be the same or different, each represents an atomic group necessary to form a 5- or 6-membered ring; L1 represents a methine group or L1 and R3 may combine and form a 5- or 6-membered ring; R4 and R5, which may be the same or different, each represents a alkyl group; R6 and R7, which may be the same or different, each represents an alkyl group or an aryl group; Q represents a pharmaceutically acceptable anion; 1 represents 1 or 2; m and n, which may be the same or different, each represents 0 or 1; and (B) a pharmaceutically acceptable carrier or diluent.

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12-06-2003 дата публикации

Methods and compositions for modulating the immune system and uses thereof

Номер: WO2003047524A2
Принадлежит: DANA-FARBER CANCER INSTITUTE

The present invention provides methods of preventing, treating or ameliorating one or more symptoms of disorders in which modulation of a subject's immune system is beneficial utilizing a lymphoid tissue inducing agent and an immunomodulatory agent. In particular, the present invention provides methods of preventing, treating or ameliorating a proliferative disorder, an infectious disease, a cardiovascular disease, an autoimmune disorder, or an inflammatory disorder or one or more symptoms thereof comprising administering to a subject in need thereof one or more lymphoid tissue inducing agents and one or immunomodulatory agents. The present invention also provides compositions and articles of manufacture for use in preventing, treating or ameliorating one or more symptoms associated with disorders in which modulation of a subject's immune system is beneficial, including, but not limited to proliferative disorders, infectious diseases, cardiovascular diseases, autoimmune disorders and inflammatory disorders. The present invention further provides methods for screening and identifying lymphoid tissue inducing agents and/or immunomodulatory agents.

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19-06-2018 дата публикации

Sparc encoding polynucleotide as a cancer therapy sensitizer

Номер: CA2802143C
Принадлежит: Dana Farber Cancer Institute Inc

The present invention relates to compositions and methods for sensitizing cancer therapy. The invention provides such compositions comprising a SPARC family polypeptide or polynucleotide, as well as recombinant cells containing a SPARC family polypeptide or polynucleotide. The compositions and methods of the invention are useful in in vitro study of cancer therapy resistance, as well as ex vivo and in vivo therapy of cancer.

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13-08-2015 дата публикации

Composition and method for aiding sleep

Номер: CA2934595A1
Автор: Lan Bo Chen
Принадлежит: Sequential Medicine Ltd

Described is a controlled-release formulation for treating disturbed sleep or insomnia. The formulation is formulated to release a compound or combination of compounds in sequence at multiple stages.

Подробнее
30-03-2022 дата публикации

Monoclonal antibodies that bind to ssea4 and uses thereof

Номер: EP3773716A4
Автор: Lan Bo Chen
Принадлежит: Cho Pharma Usa Inc

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08-08-2006 дата публикации

Periostin-based diagnostic assays

Номер: US7087727B2
Принадлежит: Dana Farber Cancer Institute Inc

The invention includes novel human periostin polypeptides and DNAs encoding them. Also embraced by the invention are human periostin specific antibodies, diagnostic assays for metastasis of breast cancer to bone, and preeclempsia.

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13-01-2016 дата публикации

Cancer therapy sensitizer

Номер: EP2561887B1
Принадлежит: Dana Farber Cancer Institute Inc

Подробнее
15-02-2006 дата публикации

Dentritic cell nodes

Номер: EP1490088A4
Принадлежит: Sciperio Inc

Подробнее
16-02-1999 дата публикации

Nucleic acids encoding tumor marker

Номер: US5872235A
Принадлежит: Dana Farber Cancer Institute Inc

The invention encompasses a novel tumor marker which is present on tumor cells and absent on corresponding normal cells, nucleic acid encoding the tumor marker, and a novel method of isolating DNA encoding the tumor marker or a gene which is differentially expressed in tissues.

Подробнее
01-04-2022 дата публикации

Chimeric antigen receptors that bind to ssea4 and uses thereof

Номер: IL274258B
Автор: Lan Bo Chen
Принадлежит: Cho Pharma Usa Inc, Lan Bo Chen

Подробнее
30-03-2006 дата публикации

Bis (thio-hydrazide amides) for treament of hyperplasia

Номер: WO2006033913A2
Принадлежит: Synta Pharmaceuticals Corp.

Methods and medical devices for treating a proliferative disorder in a subject, e.g., restenosis in a blood vessel that has been implanted with a stent, employ a bis(thio-hydrazide amide) represented by Structural Formula I or a pharmaceutically acceptable salt or solvate thereof. Y is a covalent bond or an optionally substituted straight chained hydrocarbyl group, or, Y, taken together with both >C=Z groups to which it is bonded, is an optionally substituted aromatic group. R1-R4 are independently -H, an optionally substituted aliphatic group, an optionally substituted aryl group, or R1 and R3 taken together with the carbon and nitrogen atoms to which they are bonded, and/or R2 and R4 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. R7-R8 are independently -H, an optionally substituted aliphatic group, or an optionally substituted aryl group. Z is O or S.

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04-12-2003 дата публикации

Dentritic cell nodes

Номер: CA2480011A1
Принадлежит: Individual

The present invention features dentritic cell nodes that can be used to vaccinate subjects against pathogens and to modulate a subject~s immune system to treat or prevent various diseases and conditions.

Подробнее
24-12-2021 дата публикации

Composition and method for aiding sleep

Номер: NZ720813A
Автор: Lan Bo Chen
Принадлежит: Lan Bo Chen, Sequential Medicine Ltd

Described is a controlled-release formulation for treating disturbed sleep or insomnia. The formulation is formulated to release a compound or combination of compounds in sequence at multiple stages. In a preferred embodiment, the formulation is formulated for a first stage immediate release of diphenhydramine HCl, a second stage release of zolpidem tartrate that starts 2-3 hours after initiation of the first stage, and a third stage release of lorazepam that starts 2-3 hours after initiation of the second stage.

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24-02-1998 дата публикации

Composition and method for treating cancer

Номер: CA2075750C

A pharmaceutical composition for treatment of cancer comprises: (A) a therapeutically effective amount of at least one compound selected from the group consisting of compounds represented by the General Formula (I) (see fig.I) wherein X1 and X2, which may be the same or different, each represents O, S, Se, -CH=CH-, (see fig.II), or (see fig.III); Y1 represents O, S, Se, or (see fig.IV); R1 and R3, which may be the same or different, each represents an alkyl group; R2 represents an alkyl group, an aryl group or a heterocyclic group; Z1 and Z2, which may be the same or different, each represents an atomic group necessary to form a 5- or 6-membered ring; L1 represents a methine group or L1 and R3 may combine and form a 5- or 6-membered ring; R4 and R5, which may be the same or different, each represents a alkyl group; R6 and R7, which may be the same or different, each represents an alkyl group or an aryl group; Q represents a pharmaceutically acceptable anion; 1 represents 1 or 2; m and n, which may be the same or different, each represents 0 or 1; and (B) a pharmaceutically acceptable carrier or diluent.

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23-04-2020 дата публикации

Chimeric antigen receptors that bind to SSEA4 and uses thereof

Номер: AU2019239730A1
Автор: Lan Bo Chen
Принадлежит: Cho Pharma Usa Inc

An isolated nucleic acid that contains a nucleotide sequence that encodes the polypeptide of SEQ ID NO: 3. The polypeptide of SEQ ID NO: 3 specifically binds to stage-specific embryonic antigen 4 (SSEA4). Also disclosed is a recombinant cell comprising the isolated nucleic acid described above, a viral vector containing the above isolated nucleic acid, and an isolated polypeptide including the sequence of SEQ ID NO: 3. Provided as well is a chimeric antigen receptor (CAR) that includes a single chain Fv having the sequence of SEQ ID NO: 3 and specifically binding to SSEA4. Moreover, a method is disclosed for treating a tumor by transducing

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13-12-1990 дата публикации

Methods of measuring membrane potential using j-aggregate forming dyes

Номер: WO1990015317A1

Disclosed is a method of detecting a localized biochemical event in a cell, wherein said event results in a change in the membrane potential of that cell. The method includes treating the cell with a composition containing a lipophilic, cationic dye having a delocalized positive charge and the ability to undergo multiple changes in fluorescence spectra upon aggregation. The cell is treated with the dye for a time sufficient to enable the dye to associate with the cell. Dye which has not associated with the cell is then removed. Fluorescence is observed when the cell is exposed to light having a wavelength suitable for exciting the dye. The spectrum obtained is indicative of the relative membrane potential of said cell, and a change in that membrane potential being indicative of the occurrence of a biochemical event.

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18-09-2002 дата публикации

Water-soluble bean-based extracts

Номер: EP1239743A1
Принадлежит: Individual

This invention relates to a water-soluble bean-based extract including one or more isoflavone glycosides. Also disclosed is a method of preparing such a water-soluble bean-based extract.

Подробнее
12-06-2003 дата публикации

Methods and compositions for modulating the immune system and uses thereof

Номер: CA2468698A1
Принадлежит: Individual

The present invention provides methods of preventing, treating or ameliorating one or more symptoms of disorders in which modulation of a subject's immune system is beneficial utilizing a lymphoid tissue inducing agent and an immunomodulatory agent. In particular, the present invention provides methods of preventing, treating or ameliorating a proliferative disorder, an infectious disease, a cardiovascular disease, an autoimmune disorder, or an inflammatory disorder or one or more symptoms thereof comprising administering to a subject in need thereof one or more lymphoid tissue inducing agents and one or immunomodulatory agents. The present invention also provides compositions and articles of manufacture for use in preventing, treating or ameliorating one or more symptoms associated with disorders in which modulation of a subject's immune system is beneficial, including, but not limited to proliferative disorders, infectious diseases, cardiovascular diseases, autoimmune disorders and inflammatory disorders. The present invention further provides methods for screening and identifying lymphoid tissue inducing agents and/or immunomodulatory agents.

Подробнее
06-12-2011 дата публикации

Cancer therapy sensitizer

Номер: US8071294B2
Принадлежит: Dana Farber Cancer Institute Inc

The present invention relates to compositions and methods for sensitizing cancer therapy. The invention provides such compositions comprising a SPARC family polypeptide or polynucleotide, as well as recombinant cells containing a SPARC family polypeptide or polynucleotide. The compositions and methods of the invention are useful in in vitro study of cancer therapy resistance, as well as ex vivo and in vivo therapy of cancer.

Подробнее
04-12-2003 дата публикации

Dentritic cell nodes

Номер: WO2003100034A2
Принадлежит: SCIPERIO, INC.

The present invention features dentritic cell nodes that can be used to vaccinate subjects against pathogens and to modulate a subject’s immune system to treat or prevent various diseases and conditions.

Подробнее
15-09-1988 дата публикации

A pharmaceutical composition comprising cyanine dye

Номер: AU1144688A
Принадлежит: Dana Farber Cancer Institute Inc

Подробнее
10-03-1992 дата публикации

Treatment of differentiated carcinoma or melanoma using dequalinium

Номер: CA1297022C
Принадлежит: Dana Farber Cancer Institute Inc

TREATMENT OF DIFFERENTIATED CARCINOMA OR MELANOMA USING DEQUALINIUM Abstract There IS described the treatment in mammals of differentiated carcinomas and melanomas using dequalinium. The effectiveness of the treatment was demonstrated by in vitro tests as well as in vivo tests in nude mice.

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05-08-2004 дата публикации

Cancer therapy sensitizer

Номер: WO2004064785A2
Принадлежит: Dana Farber Cancer Institute

The present invention relates to compositions and methods for sensitizing cancer therapy. The invention provides such compositions comprising a SPARC family polypeptide or polynucleotide, as well as recombinant cells containing a SPARC family polypeptide or polynucleotide. The compositions and methods of the invention are useful in in vitro study of cancer therapy resistance, as well as ex vivo and in vivo therapy of cancer. Figure 1 is a modular structure of human SPARC and the location and functions of synthetic peptides.

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21-12-2021 дата публикации

Favi̇pi̇ravi̇r i̇çeren farmasöti̇k bi̇r ürün

Номер: TR202008581A2

Buluş, favipiravir veya favipiravirin farmasötik olarak kabul edilebilir bir tuzunu içeren bir likit dozaj form ile ilgilidir.

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11-01-2024 дата публикации

Bactericide composition for preventing and treating asparagus officinalis stem blight

Номер: LU504700B1

The invention discloses a bactericide composition containing difenoconazole as an effective component, comprising common auxiliaries, difenoconazole and propamidine, wherein the mass ratio of difenoconazole to propamidine is 20:1-1:20. The difenoconazole and propamidine have obvious synergistic effect, which is suitable for controlling asparagus officinalis stem blight caused by Phomophilus asparagi.

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15-08-2008 дата публикации

Diagnostische tests auf periostinbasis

Номер: ATE403149T1
Принадлежит: Dana Farber Cancer Inst Inc

Подробнее
02-04-2024 дата публикации

Trunk side storage box

Номер: USD1020606S1
Автор: Bo Lan
Принадлежит: Individual

Подробнее
15-06-2023 дата публикации

Apparatus and method of measuring blood flow in the foot

Номер: WO2023107483A1
Принадлежит: PODIMETRICS, INC.

An apparatus for measuring foot blood flow has a platform with a platform contact surface configured to receive a foot force from a user placing their foot on the contact surface. The apparatus also has a plurality of PPG sets (having at least one light source and at least one detector) extending through the platform contact surface, and a plurality of springs. Each PPG set is coupled with one or more of the springs to movably couple with the platform. In addition, each spring is biased to produce a biasing force via its coupled PPG set when the contact surface of the platform receives the foot. To maintain consistent pressure against the skin and good signal to noise ratio, each PPG set and its corresponding one or more springs are configured so that the biasing force has a magnitude that is substantially independent of the foot force magnitude.

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02-01-2024 дата публикации

Apparatus and method of measuring blood flow in the foot

Номер: US11857303B2
Принадлежит: PODIMETRICS Inc

An apparatus for measuring foot blood flow has a platform with a platform contact surface configured to receive a foot force from a user placing their foot on the contact surface. The apparatus also has a plurality of PPG sets (having at least one light source and at least one detector) extending through the platform contact surface, and a plurality of springs. Each PPG set is coupled with one or more of the springs to movably couple with the platform. In addition, each spring is biased to produce a biasing force via its coupled PPG set when the contact surface of the platform receives the foot. To maintain consistent pressure against the skin and good signal to noise ratio, each PPG set and its corresponding one or more springs are configured so that the biasing force has a magnitude that is substantially independent of the foot force magnitude.

Подробнее
03-06-2021 дата публикации

Composition and method for aiding sleep

Номер: AU2018448857A1
Автор: Lan Bo Chen
Принадлежит: Sequential Medicine Ltd

Disclosed is a controlled-release formulation for treating disturbed sleep or insomnia in a subject. The formulation is formulated to release diphenhydramine HCl and a sleep aid in sequence at two stages.

Подробнее
21-09-2023 дата публикации

Monoclonal antibodies that bind to SSEA4 and uses thereof

Номер: AU2019242559B2
Автор: Lan Bo Chen
Принадлежит: Cho Pharma Usa Inc

An isolated monoclonal antibody or antigen-binding fragment that specifically binds to stage-specific embryonic antigen 4. The monoclonal antibody or antigen-binding fragment includes a heavy-chain CDR1 having the sequence of SEQ ID NO: 33 or SEQ ID NO: 40, a heavy-chain CDR2 having the sequence of SEQ ID NO: 34 or SEQ ID NO: 39, a heavy-chain CDR3 having the sequence of SEQ ID 5 NO: 35 or SEQ ID NO: 41, a light-chain CDR1 having the sequence of SEQ ID NO: 36 or SEQ ID NO: 42, a light-chain CDR2 having the sequence of SEQ ID NO: 37 or SEQ ID NO: 43, and a light-chain CDR3 having the sequence of SEQ ID NO: 38 or SEQ ID NO: 44. Also disclosed is an anti-tumor method carried out by administering the above monoclonal 10 antibody or antigen-binding fragment to a subject having a tumor that expresses stage-specific embryonic antigen 4. Further provided are nucleic acids encoding the above sequences and recombinant cells containing the nucleic acids.

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29-06-2021 дата публикации

Composition and method for aiding sleep

Номер: SG11202104661WA
Автор: Lan Bo Chen
Принадлежит: Lan Bo Chen, Sequential Medicine Ltd

Подробнее
11-04-2024 дата публикации

Preconnectorized optical distribution cable assemblies and corresponding methods of deployment

Номер: US20240118498A1
Принадлежит: Corning Research and Development Corp

The present disclosure relates to a distribution cable assembly that has various features to enable flexible configurations to accommodate various data center configurations.

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11-01-2024 дата публикации

Composition for preventing and treating asparagus stem blight and preparation method thereof

Номер: LU504686B1

The invention provides a composition for preventing and treating asparagus stem blight and a preparation method thereof, and belongs to the technical field of agricultural biological control. The composition of the invention consists of 30-60 parts of plant extract and 0.5-2 parts of surfactant; the plant extract is obtained by mixing Merremia boisiana (Gagn.) v. Ooststr. extract, Artemisiacapillaris Thunb. extract and Houttuynia cordata Thunb. extract according to the volume ratio of 4-8: 2-5: 2-5. The invention also provides a preparation method of the composition and an application method in preventing and treating asparagus stem blight. The composition provided by the invention has the advantages of simple and cheap raw materials, environmental protection, no secondary pollution to the agricultural growth environment, effective prevention and treatment of asparagus stem blight, and remarkable improvement of asparagus yield and quality.

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11-01-2024 дата публикации

Bio-organic fertilizer for preventing asparagus stem blight and preparation method thereof

Номер: LU504699B1

The invention discloses a bio-organic fertilizer for preventing asparagus stem blight and a preparation method thereof, which integrates the selection of modern antibacterial active substances and the fermentation technology of mixed bacteria microorganisms, and develops an efficient, green fermented bio-organic fertilizer by fermenting livestock manure, straws, Chinese herbal medicine raw materials, chitosan under the synergistic effect of microorganisms. The bio-organic fertilizer can effectively inhibit the occurrence of asparagus stem blight under different planting process conditions, change the disadvantages of using chemical agents to prevent asparagus stem blight or changing the growth conditions of bitter bamboo shoots in the prior art, reduce the pesticide residue in the asparagus planting process, have a wide application range, have obvious yield-increasing effect, can significantly improve the food safety and planting benefits of asparagus. The experimental results show that the prevention effect of the bio-organic fertilizer on asparagus stem blight can reach more than 80%.

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07-11-2019 дата публикации

Conducting optimized cross-blockchain currency transactions using machine learning

Номер: WO2019213311A1
Автор: Alex WITT, Bo Lan, Xinxin Sheng
Принадлежит: Smart Worldwide Financial Technology

Methods and apparatuses are described for conducting cross-blockchain currency transactions. A server receives, from a client device, a request for a conversion of an amount of a first currency to an amount of a second currency. The amount of the first currency is stored in an electronic wallet associated with a user of the client device. The server determines one or more sequences of currency transactions executable that achieves the conversion from the amount of the first currency to the amount of the second currency, the one or more sequences of currency transactions comprising converting between cryptocurrencies operating on different blockchains. The server identifies one of the one or more sequences of currency transactions associated with an optimal value. The server executes the identified sequence of currency transactions associated with the optimal value.

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08-03-1990 дата публикации

A FULL LENGTH cDNA ENCODING A HUMAN LAMININ BINDING PROTEIN

Номер: WO1990002180A1
Принадлежит: DANA-FARBER CANCER INSTITUTE

This invention is directed to a full length human laminin binding protein cDNA sequence derived from human colon carcinoma cells comprising substantially the sequence as set forth in Figure 3. It also concerns a subsequence corresponding substantially to the sequence starting with nucleotide number 162 and ending with nucleotide number 829 as set forth in Figure 3. In another aspect, this invention also relates to recombinant clones encoding a human laminin binding protein. In another embodiment, this invention relates to a laminin binding protein encoded by either sequence and to substantially isolated DNA encoding the laminin binding protein of the above-described cDNAs. Also of concern is a method for detecting the presence of carcinoma in a patient and a reagent for detecting the presence of carcinoma in a patient.

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11-01-2024 дата публикации

Biological pesticide for preventing and controlling asparagus stem blight

Номер: LU504685B1

The invention discloses a green biological pesticide that can effectively prevent and cure asparagus stem blight, belonging to the technical field of agricultural biological pest control. The Biological pesticide consists of the following parts by weight of raw materials: 10–20 parts of chitosan oligosaccharide, 20–40 parts of active extracts of Chinese herbal medicine, 10–40 parts of carbendazim, 8–15 parts of surfactant and 100–200 parts of water. The invention can significantly prevent and cure asparagus stem blight disease and improve asparagus production capacity through the synergistic effect of chitosan oligosaccharide, Carbendazim and active extracts of Chinese herbal medicine; the Biological pesticide is safe, green and pollution-free, which is conducive to the sustainable development of asparagus planting.

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15-06-2023 дата публикации

Apparatus and method of measuring blood flow in the foot

Номер: CA3238042A1
Принадлежит: PODIMETRICS Inc

An apparatus for measuring foot blood flow has a platform with a platform contact surface configured to receive a foot force from a user placing their foot on the contact surface. The apparatus also has a plurality of PPG sets (having at least one light source and at least one detector) extending through the platform contact surface, and a plurality of springs. Each PPG set is coupled with one or more of the springs to movably couple with the platform. In addition, each spring is biased to produce a biasing force via its coupled PPG set when the contact surface of the platform receives the foot. To maintain consistent pressure against the skin and good signal to noise ratio, each PPG set and its corresponding one or more springs are configured so that the biasing force has a magnitude that is substantially independent of the foot force magnitude.

Подробнее
04-06-2024 дата публикации

Solar panel

Номер: USD1029743S1
Автор: Bo Lan
Принадлежит: Shenzhen Veryeah Tech Co Ltd

Подробнее
04-01-2024 дата публикации

Power supply parallel control circuit, method and device

Номер: US20240006910A1
Автор: Bo Lan, Xinyan Liu
Принадлежит: Shenzhen Waye Technology Co Ltd

Disclosed are a power supply parallel control circuit, a method and a device. The circuit includes a power switching module, a first switch module, a second switch module, a third switch module and a fourth switch module all connected to the power switching module. The power switching module outputs a first switching signal according to a received switching control signal and control the second switch module to conduct unidirectionally. The first power supply continuously supplies power to a load and the third switch module is controlled to be on. The fourth switch module maintains unidirectional conduction and the second power supply starts to supply power to the load. The power switching module further outputs a second switching signal after a preset time to turn off the first switch module, the first power supply stops powering the load, and the fourth switch module is turned on.

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12-12-2023 дата публикации

Shade net

Номер: USD1007387S1
Автор: Bo Lan
Принадлежит: Individual

Подробнее
31-03-2020 дата публикации

一种垃圾桶的散热风道结构

Номер: CN210213594U
Автор: Bo Lan, 蓝波
Принадлежит: Chongqing Bioxin Technology Co Ltd

本实用新型公开了一种垃圾桶的散热风道结构,包括外筒和内筒;所述外筒和内筒之间形成有散热风道,所述散热风道内可拆卸设置有活性炭过滤盒;所述内筒敞口端设置有向外延伸的筒沿,所述外筒顶端设置有环形凸块,所述内筒通过筒沿可拆卸设置在环形凸块上;所述环形凸块上设置有多个导风结构,所述导风结构包括将气流引入风道内的进风口,所述进风口的横截面积沿气流流动方向逐渐减小;所述内筒下方设置有出风引流结构,所述出风引流结构的出风口端设置有引风机;所述外筒位于出风引流结构出风口下侧的壁上设置有排气格栅。本实用新型所述的垃圾桶的散热风道结构具有气流流通效果好、散热效果好等优点。

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05-05-2023 дата публикации

Composition for preventing and treating peanut root rot, preparation method and application thereof

Номер: LU503004B1

The invention provides a composition for preventing and treating peanut root rot, a preparation method and application thereof, and belongs to the technical field of crop disease control. The composition for preventing and treating peanut root rot provided by the invention comprises clove, licorice, turmeric, scutellaria baicalensis, Paris polyphylla, Phyllanthus emblica and Salvia miltiorrhiza, and the traditional Chinese medicines have synergistic effect, which can obviously enhance the disease resistance of peanut seeds to root rot, reduce the incidence of peanut root rot, improve the control effect and increase the emergence rate and yield of peanuts. At the same time, the composition of the invention uses all Chinese medicinal ingredients, and has no pollution and no influence on human health.

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06-06-2024 дата публикации

Fluid-dividing lid having one port distributing fluid to a plurality of outlets

Номер: WO2024118323A1
Автор: Lan Bo, Lien-Yu Hung
Принадлежит: CORNING INCORPORATED

Embodiments of the disclosure relate to a fluid dividing lid. The fluid dividing lid includes a first outer surface having an inlet port, a second outer surface opposite to the first outer surface and including a plurality of outlet ports. Further, the fluid dividing lid includes an intermediate region between the first outer surface and the second outer surface. The intermediate region includes a plurality of passages configured to divide a flow of fluid entering the inlet port among the plurality of outlet ports.

Подробнее
04-05-2023 дата публикации

Method for identifying blast resistance of wild rice

Номер: LU502999B1

The invention provides a method for identifying rice blast resistance of wild rice, which comprises the following steps: 1) sampling leaves; 2) placing the sheared leaves on a culture device, and placing 4 leaves in each Petri dish; culture in a light incubator at 24-26℃, relative humidity 100%, dark for 24 hours, then light for 24 hours a day, light intensity of 3,400 Lux for 12 hours, and light intensity of 1,310 Lux for 12 hours, and investigate the incidence after 6-10 days of culture; 3) investigation and standard of the disease: investigate the size of the disease spots, and determine the resistance according to the contrast varieties. The disease grades are divided into 5 grades, 0-2 grades are resistant, and 3-4 grades are susceptible; according to the invention, the method for inoculating Magnaporthe grisea is optimized, and the problems that the ratoon roots which can be transplanted are limited and can only meet the requirement of inoculating several physiological races of Magnaporthe grisea, the operation is complicated, and only one group of blades can be identified once, are solved. By adopting the culture device, the invention greatly simplifies the operation steps.

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16-04-1999 дата публикации

Inhibicion de las infecciones retrovirales mediante administracion de compuestos del acido naftalenosulfonico.

Номер: ES2127530T3
Принадлежит: Fuji Photo Film Co Ltd

METODO PARA INHIBIR LA INFECCION RETROVIRAL EN UN SUJETO QUE SUPONE LA ADMINISTRACION A DICHO SUJETO DE UNA CANTIDAD EFECTIVA TERAPEUTICAMENTE DE UN COMPUESTO DE ACIDO NAFTALENESULFONICO O UN COMPUESTO SALINO ACEPTABLE FARMACEUTICAMENTE DEL MISMO, TAL COMO SE DEFINE AQUI.

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06-06-2024 дата публикации

Multilayer channel plate having one port in communication with a plurality of outlets

Номер: WO2024118321A1
Автор: Ke Jiang, Lan Bo, Lien-Yu Hung
Принадлежит: CORNING INCORPORATED

Embodiments of the disclosure relate to a channel plate. The channel plate includes a first layer with a port in fluid communication with a first fluid dividing channel. The channel plate also includes a second layer having a second fluid dividing channel that complements the first fluid dividing channel to form a first fluid dividing passage. The second layer also has a plurality of third fluid dividing channels in fluid communication with the second fluid dividing channel. The channel plate further includes a third layer having a plurality of fourth fluid dividing channels that complements the plurality of third fluid channels to form a plurality of second fluid dividing passages. The third layer also has a plurality of outlets in fluid communication with the plurality of fourth fluid dividing channels. Fluid entering the port passes through the first and second fluid dividing passages to the plurality of outlets.

Подробнее
17-05-2024 дата публикации

Identification method of physiological race types of asparagus stem blight pathogen

Номер: NL2036497B1

The invention discloses an identification method of physiological race types of asparagus stem blight pathogen, which belongs to the technical field of crop pathogen physiological races identification. The construction method includes the following steps: collecting representative 5 pathogenic strains of asparagus stem blight, making spore suspension, and spraying it on different varieties of host plants by a spraying method to judge the virulence difference between pathogenic strains of asparagus stem blight; according to the virulence difference, distribution area and extensive planting and utilization of different varieties of hosts, the pathogenic identification host of asparagus stem blight is screened out. According to the construction method 10 of the invention, six identification hosts are screened out, and then systematic field experiments are carried out, so that 48 representative strains from different regions and taking asparagus varieties growing in different fields as hosts are identified in physiological race types, and 11 race types can be distinguished; therefore, the host system constructed by the invention has strong identification ability, can easily divide different physiological races, and has application value.

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11-12-2001 дата публикации

Extracts of kava-kava

Номер: AU2000248608A1
Автор: Lan Bo Chen, Mitsunori Ono
Принадлежит: Individual

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27-06-2024 дата публикации

Method for detecting the resistance of phomopsis asparagi-strain to carbendazim

Номер: NL2036613B1

The invention relates to the technical field of crop disease control, in particular to a method 5 for detecting the resistance of Rhizopus asparagi—strain to carbendazim, comprising: putting Rhizopus asparagi—strain in drug-based culture medium to obtain the growth inhibition rate of Rhizopus asparagi—strain; obtaining the inhibitory concentration EC50 of carbendazim on Rhizopus asparagi—strain according to the data of growth inhibition rate; obtaining the sensitivity baseline of Rhizopus asparagi—strain to carbendazim according to EC50 value; detecting the 10 resistance level of Rhizopus asparagi—strain to carbendazim according to the sensitivity baseline; among them, the drug-based culture medium consists of carbendazim and tryptone soybean culture medium. The pot experiment prove that that resistance level of asparagus stem blight obtained by the method for detect the resistance of asparagus stem blight to carbendazim is positively correlated with the resistance of strains verify by the pot experiment, which proves that 15 the method can accurately detect the resistance of asparagus stem blight to carbendazim, and provides a scientific basis for planting asparagus crops in the field and controlling diseases and pests.

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12-07-2024 дата публикации

Composition, preparation method and application thereof in preventing and treating peanut root rot

Номер: NL2036425B1

The invention provides a composition, a preparation method and an application thereof in controlling peanut root rot, and belongs to the technical field of crop disease control. The composition provided by the invention comprises Folium An‘emisiae Argyi, Glycyrrhiza uralensis Fisch., Lonicera japonica Thunb., Scute/[aria baicalensis Georgi, Cinnamomum cassia Presl, Phy/Ianz‘hus emb/ica Linn. and Salvia miltiorrhiza Bunge, which have synergistic effect, and can significantly enhance the disease resistance of peanut seeds to root rot, reduce the incidence of peanut root rot, improve the control effect, and improve the emergence rate and yield of peanuts. At the same time, the composition of the invention uses all traditional Chinese medicine components, which is pollution - free and will not affect human health.

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11-05-2023 дата публикации

Composition for preventing and controlling sesame wilt and application thereof

Номер: LU503008B1

The invention provides a composition for preventing and controlling sesame wilt and application thereof, and belongs to the technical field of crop disease prevention and control. The composition for preventing and controlling sesame wilt, contains zhongshengmycin and osthole as effective ingredients, and the mass ratio of zhongshengmycin to osthole is 4:1-1:4. The combination of zhongshengmycin and osthole has synergistic effect; the two active ingredients are biogenic pesticides, which are harmless to people, animals and the environment; the bacteriostatic mechanism of zhongshengmycin and osthole is different, and the pathogen of sesame wilt is not easy to produce drug resistance when they are combined, which is convenient for application and popularization and long-term application.

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16-07-2024 дата публикации

Method for detecting resistance of phomopsis asparagi-strain to mancozeb

Номер: NL2036615B1

Disclosed is a method for detecting the resistance of a Phomopsis asparagi—strain to mancozeb, and belongs to the technical field of crop disease prevention and control. The method 5 includes following steps: culturing a Phomopsis asparagi—strain in drug-based culture medium to obtain a growth inhibition rate of the Phomopsis asparagi—strain; obtaining the median effective concentration EC50 of mancozeb on the Phomopsis asparagi—strain according to the growth inhibition rate data; obtaining the sensitivity baseline of the Phomopsis asparagi—strain to mancozeb according to EC50 value; detecting the resistance level of the Phomopsis asparagi- 10 strain to mancozeb according to the sensitivity baseline; where the drug-based culture medium consists of mancozeb and Modified Martin Broth, and the concentration of mancozeb is 0.1-9 ug/ml. In the invention, the pot experiment proves that the resistance level of the Phomopsis asparagi—strain obtained by the method for detect the resistance of the asparagus stem blight to mancozeb is positively correlated with the resistance of the strain to mancozeb verified by the pot 15 experiment, this demonstrates that the method can accurately detect the resistance of the Phomopsis asparagi—strain to mancozeb, and provide scientific basis for planting asparagus crops in the field and controlling diseases and pests.

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06-12-2001 дата публикации

Extracts of kava-kava

Номер: WO2001091557A1
Автор: Lan Bo Chen, Mitsunori Ono
Принадлежит: Lan Bo Chen, Mitsunori Ono

This invention relates to a kava-kava lactone-containing product. Also disclosed is a method of preparing such a kava-kava lactone-containing product by extracting kava-kava lactones from crude kava-kava extracts with a solubilizing agent.

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30-07-2024 дата публикации

Bacteriostat for controlling rice blast and control method thereof

Номер: NL2036426B1

The invention provides a bacteriostat for controlling rice blast and a control method, and belongs to the technical field of pesticides. The bacteriostat contains kasugamycin, procymidone and prochloraz in the weight ratio of 1 - 20 : 5 - 1 : 3 - 1. Under this ratio, the three drugs can produce synergistic effect, effectively improve the killing effect of kasugamycin on drug-resistant rice blast fungus, and the combined use can produce stronger control effect on rice blast.

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05-12-2023 дата публикации

Passenger armrest storage box

Номер: USD1006514S1
Автор: Bo Lan
Принадлежит: Individual

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27-06-2024 дата публикации

Organic inorganic compound fertilizer for preventing and controlling rice seedling blight and its preparation method

Номер: NL2036408B1

The present invention discloses an organic inorganic compound fertilizer for preventing and 5 controlling rice seedling blight and its preparation method, belonging to the field of fertilizer technology. The raw materials of the fertilizer include the following components in mass parts: 20—25 parts of ammonium chloride, 20—25 parts of potassium chloride, 15—20 parts of calcium superphosphate, 5—10 parts of ammonium sulphate, 3—5 parts of ammonium molybdate, 50—60 parts of earthworm manure organic fertilizer, 15—20 parts of humic acid, 10—15 parts of attapulgite 10 clay powder, 5—8 parts of chitosan oligosaccharide, 3—5 parts of dandelion extract, 1—3 parts of Jiang gardenia extract, and 3—5 parts of complex microbial community. The synergistic cooperation of each component in the compound fertilizer can not only make the acidic effect of the compound fertilizer last for a long time, resist washing, suppress the return of salt and alkali underground, adjust the soil structure, inhibit the propagation of Fusarium oxysporum, create a 15 suitable growth environment for the growth of roots and stems, but also improve the disease resistance of rice seedlings and effectively reduce the incidence rate of rice seedling blight.

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30-08-2016 дата публикации

Composition and method for aiding sleep

Номер: US09427409B2
Автор: Lan Bo Chen
Принадлежит: Sequential Medicine Ltd

Described is a controlled-release formulation for treating disturbed sleep or insomnia in a subject. The formulation is formulated to release a compound or combination of compounds in sequence at multiple stages.

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