30-07-2020 дата публикации
Номер: US20200239856A1
Принадлежит:
The present invention aims to provide a method for producing a cartilage tissue, which enables production of a cartilage tissue having an appropriate thickness, form, and mechanical strength, and a cartilage tissue produced by the method for producing a cartilage tissue. Provided is a method for producing a cartilage tissue including a step of seeding a collagenase-treated cartilage tissue piece in the form of a block 50 to 1,000 μm on a side onto a porous substrate composed of a bioabsorbable material. 1. A method for producing a cartilage tissue comprisinga step of seeding a collagenase-treated cartilage tissue piece in the form of a block 50 to 1,000 μm on a side onto a porous substrate composed of a bioabsorbable material.2. The method for producing a cartilage tissue according to claim 1 ,wherein the cartilage tissue piece is in the form of a block 100 to 800 μm on a side.3. The method for producing a cartilage tissue according to claim 1 ,wherein the porous substrate is a nonwoven fabric having an average pore size of 20 to 50 μm.4. The method for producing a cartilage tissue according to claim 1 ,wherein the bioabsorbable material constituting the porous substrate is polyglycolide.5. The method for producing a cartilage tissue according to claim 1 ,wherein the porous substrate is fixed to a mold composed of a bioabsorbable material to combine and integrate with the mold.6. The method for producing a cartilage tissue according to claim 5 ,wherein the bioabsorbable material constituting the mold is polycaprolactone.7. A cartilage tissue comprisinga porous substrate composed of a bioabsorbable material anda collagenase-treated cartilage tissue piece in the form of a block 50 to 1,000 μm on a side seeded on the porous substrate. The present invention relates to a method for producing a cartilage tissue, which enables production of a cartilage tissue having an appropriate thickness, form, and mechanical strength, and to a cartilage tissue produced by the method ...
Подробнее
