09-07-2015 дата публикации
Номер: US20150191478A1
Автор:
Ahn Kyoung Kyu,
Gal Ji Yeong,
Hyun Kwan Hoon,
KIM Dong Hoon,
KIM Tae Kyun,
Kim Tae-Hoon,
LEE Ge Hyeong,
Lee Gyu Jin,
Lee Hyun Joo,
Lim Hee Jong,
NAM Su Youn,
PARK Jun Chul,
Park Kaapjoo,
SEO Hyoung Sig
The present invention provides a fused ring compound containing furan or a pharmaceutically acceptable salt thereof, a method for preparing same, a pharmaceutical composition comprising same, and a use thereof. The fused ring compound containing furan or a pharmaceutically acceptable salt thereof inhibits the activity of phosphatidylinositol 3-kinase (PI3K) and can therefore be used in a pharmaceutical composition for treating and preventing respiratory diseases, inflammatory diseases, proliferative diseases, cardiovascular diseases, or central nervous system diseases which occur due to the over-activation of PI3K. 6. The compound of claim 5 , whereinA is hydrogen,{'sub': 1', '2', 'm', '2', 'm', '2', 'm, 'B is —(C≡C)R; —(CH)Q; —(C≡C)(CH)Q; or —(CONH)(CH)Q,'}m is 0,{'sub': 6', '12, 'Q is C-Caryl; 5- to 12-membered heterocycloalkyl; or 5- to 12-membered heteroaryl,'}{'sub': 1', '6', '1', '6', '1', '6', '2', '6', '3', '7', '1', '4', '1', '4', '6', '12', '1', '4', '1', '3', '1', '6', '6', '12', '1', '6', '1', '3', '6', '12', '1', '6', '1', '6', '3', '7', '1', '6', '6', '12', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '3', '7', '1', '6', '1', '4', '1', '6, 'wherein Q is optionally substituted with one or more substituents selected from the group consisting of hydroxy; amino; halogen; cyano; C-Calkyl optionally substituted with one or more substituents selected from the group consisting of halogen, hydroxy, cyano, C-Calkoxy and C-Calkylcarbonyloxy; C-Calkenyl; 4-oxo-2-thioxothiazolidin-5-ylidenyl; C-Ccycloalkyl; 5- to 7-membered heterocycloalkyl-C-Calkyl (wherein, said heterocycloalkyl is optionally substituted with C-Calkyl); C-Caryl; 5- to 12-membered heteroaryl (wherein, said heteroaryl is optionally substituted with C-Calkyl); 3- to 12-membered heterocycloalkyl (wherein, said heterocycloalkyl is optionally substituted with C-Calkyl); C-Calkoxy optionally substituted with one or more of halogen and cyano; C-Caryl-C-Calkyloxy (wherein, said aryl is optionally ...
Подробнее
