Method and Devices for Sonographic Imaging

The present invention comprises methods and devices for generating and providing contrast medium for sonography of structures such as ducts and cavities. The invention provides for creation of a contrast medium comprising detectable acoustic variations between two phases, for example, a gas and a liquid. Sonography is the primary means of imaging but other conventional detection means may also be employed with the present invention. 1. A contrast medium generating and delivery device , comprising a container assembly comprising at least one container for containing a fluid , a component for moving a fluid from the container , and connections for fluid connection of at least one container to a contrast medium generating chamber.2. The device of claim 1 , comprising two containers claim 1 , each with a component for moving a fluid from a container.2. The device of claim 2 , wherein each container is a syringe and the component for moving a fluid from the container claim 2 , is a syringe plunger.3. The device of claim 2 , further comprising a component for actuating both syringe plungers simultaneously.4. The device of claim 1 , further comprising a contrast medium generating chamber comprising a static mixer.5. The device of claim 4 , further comprising a container in fluid connection with an air port to atmosphere or other gas source.6. The device of claim 5 , wherein at least one check valve is in fluid connection with the container in fluid connection with the air port.7. The device of claim 5 , wherein at least two check valves are in fluid connection with the container in fluid connection with the air port.8. The device of claim 1 , further comprising a pressure relief mechanism.9. The device of claim 8 , wherein the pressure relief mechanism comprises a pressure release valve.10. The device of claim 1 , wherein the contrast medium generating chamber comprises a mixing chamber and does not include a static mixer.11. The device of claim 1 , further comprising an ...

Methods and Devices for Conduit Occlusion

The present invention comprises systems, methods and devices for the delivery of compositions for occluding or of means for opening conduits. The implantable occlusive material may be delivered pre-formed or in situ cured and, may be a resorbable material that supports tissue ingrowth that eventually replaces the material leaving little or no original material in place. The delivery system is positioned to allow for placement of the occlusive material into the body conduit. Use of delivery systems, methods and devices for re-opening an occluded body conduit are also included. 128.-. (canceled)29. A method for occluding two fallopian tubes in a human or animal body , comprising ,a) providing a delivery system that delivers an effective amount of an occlusive material composition, wherein the delivery system comprises a delivery device comprising an introducer shaft comprising an atraumatic tip and defining two openings spaced from the atraumatic tip for providing two catheters; two catheters, wherein each catheter comprises an end structure on a delivery end; and means for providing an occlusive material composition into and through the two catheters;b) positioning the atraumatic tip of the introducer shaft at or near the fundus of a uterus;c) positioning the delivery end of each of the catheters at or near a uterine cornua such that each of the end structures is at or near a tubal ostium, wherein the end structure maintains the delivery end in the uterine cornua and aids in localized delivery of the occlusive material composition;d) delivering from each cathether an effective amount of an occlusive material composition at or near the ostia of the fallopian tubes; ande) occluding the fallopian tubes by forming an occlusion with the occlusive material composition within the lumen of each fallopian tube.30. The method of claim 29 , wherein the two fallopian tubes are occluded without removal and re-introduction claim 29 , or substantial repositioning claim 29 , of the ...

Methods and Devices for Conduit Occlusion

The present invention comprises systems, methods and devices for the delivery of compositions for occluding or of elements for opening conduits. The implantable occlusive material may be delivered pre-formed or in situ cured and, may be a resorbable or degradable material that supports tissue ingrowth or wound healing or a similar response that replaces the cured occlusive material leaving little or no original occlusive material in place. The delivery system is positioned to allow for placement of the occlusive material into the body conduit. Use of delivery systems, methods and devices for re-opening an occluded body conduit are also included.

Methods and Devices for Delivery of Compositions to Conduits

The present invention comprises systems, methods and devices for the delivery of visualizable or treatment compositions or therapeutic agents comprising device elements for diagnosis and/or treatment of conduits. A delivery system comprising an introducer shaft having at least one exit port and at least one delivery catheter for placement of compositions into the conduit, such as a fallopian tube. 119.-. (canceled)20. A method of treatment , comprising ,a) providing a treatment composition to at least a portion of at least one fallopian tube of a human or animal by a delivery system that delivers an effective amount of the treatment composition, wherein the delivery system comprises a delivery device comprising at least an introducer shaft comprising an atraumatic tip for positioning the tip at the uterine fundus and at least one exit port for providing at least one catheter; at least one catheter, wherein at least one catheter comprises an end structure on a delivery end that maintains the delivery end in at least one uterine cornua and aids in localized delivery of the treatment composition, and elements for providing the treatment composition into and through at least one catheter; andb) allowing the treatment composition to remain in at least one fallopian tubes for a predetermined time.21. The method of claim 20 , further comprising claim 20 , c) providing an effective amount of a treatment composition directly to the uterus.22. The method of claim 20 , wherein the treatment composition comprises therapeutic agents comprising methotrexate claim 20 , hormones claim 20 , fertility enhancing compounds claim 20 , fertility interfering compounds claim 20 , motility enhancing compounds claim 20 , motility interfering compounds claim 20 , compounds affecting the cilia/deciliation cycle claim 20 , cilia growth enhancing or interfering compounds claim 20 , ovarian follicle treatment compounds claim 20 , antibacterial claim 20 , antimicrobial claim 20 , antifungal claim ...

Methods and Devices for Managing Fluid Pressure

The present invention comprises methods, compositions, devices and systems for determining the status of, or treating, a body structure or conduit. An embodiment of the invention comprises a fluid pressure control device for pressure control of fluid introduced into a body structure or conduit.

METHODS AND DEVICES FOR CERVICAL CELL AND TISSUE SAMPLING

The present invention comprises methods and devices comprising a cutting element used to contact circumferentially and longitudinally the surface walls of the endocervical canal to provide for broad and complete contact of the intended surface with the device, resulting in attainment of a sufficient volume and comprehensive tissue sample for analysis as an endocervical curettage or screening pap smear. The device may provide for a reservoir for the obtained sample to be contained when removing from the cervical canal and vagina. The device may be comprised of a detachable means or be of a material that allows the user to cut the sampling head of the device for placement in collection means to maximize the amount of tissue or cells being sent to the laboratory for analysis. 1. A method of obtaining an endocervical sample , comprising: i. a handle having a distal end and a longitudinal axis;', 'ii. an elongate wand extending outwardly from the distal end of the handle substantially along the longitudinal axis, wherein the wand has an exterior surface, a front end and a back end, and wherein the back end is fixedly mounted to the distal end of the handle.;', 'iii. a selectively moveable actuator coupled to the handle and to a sheath;', 'iv. a sheath selectively encapsulating a portion of the wand and fixedly mounted to a portion of the wand proximate the front end of the wand and to a portion of an actuator, wherein the distal end portion of the sheath and a portion of the exterior surface of the wand underlying the distal end portion of the sheath define a sample collection cavity, wherein the sheath defines at least one slit on a distal end portion of the sheath, the slit being bordered by opposing edges, wherein the slit is selectively movable between a closed position, in which the opposing edges of the helical slit substantially adjoin to substantially seal the sample collection cavity, and an open position, in which the opposing edges of the slit are spaced from ...

Methods and Devices for Conduit Occlusion

The present invention comprises systems, methods and devices for the delivery of compositions for occluding or of means for opening conduits. The implantable occlusive material may be delivered pre-formed or in situ cured and, may be a resorbable material that supports tissue ingrowth that eventually replaces the material leaving little or no original material in place. The delivery system is positioned to allow for placement of the occlusive material into the body conduit. Use of delivery systems, methods and devices for re-opening an occluded body conduit are also included. 128-. (canceled)29. A contraceptive device , comprising ,an introducer shaft having a closed tip for contacting the fundus of a uterus and having at least one exit port spaced from the closed tip for providing at least one catheter; andat least one catheter, comprising at the delivery end, an end structure that aids in localized delivery of a composition to the tubal ostia of a fallopian tube, wherein the end structure is a cup, nozzle, or balloon.30. The contraceptive device of claim 29 , wherein the introducer shaft has one exit port and wherein the contraceptive device has one catheter.31. The contraceptive device of claim 29 , wherein the introducer shaft has two exit ports and wherein the contraceptive device has two catheters.32. The contraceptive device of claim 29 , further comprising means for providing the composition into and through the at least one catheter.33. The contraceptive device of claim 29 , further comprising a delivery device stabilizer for holding the contraceptive device in place once positioned therein a patient.34. The contraceptive device of claim 33 , wherein the delivery device stabilizer fits over or attaches to the cervix of the patient or fits into or expands within the cervix to hold the device in position.35. The contraceptive device of claim 29 , wherein the at least one catheter is a dual lumen balloon catheter.36. The contraceptive device of claim 29 , ...

Methods and Devices for Conduit Occlusion

The present invention comprises systems, methods and devices for the delivery of compositions for occluding or of elements for opening conduits. The implantable occlusive material may be delivered pre-formed or in situ cured and, may be a resorbable or degradable material that supports tissue ingrowth or wound healing or a similar response that replaces the cured occlusive material leaving little or no original occlusive material in place. The delivery system is positioned to allow for placement of the occlusive material into the body conduit. Use of delivery systems, methods and devices for re-opening an occluded body conduit are also included. 123.-. (canceled)24. A method for occluding one fallopian tube in a human or animal body , comprising ,(a) providing a delivery system that delivers an effective amount of an occlusive material composition, wherein the delivery system comprises a delivery device comprising an introducer shaft comprising an atraumatic tip and defining one opening spaced from the atraumatic tip for providing a catheter; one catheter, wherein the catheter comprises an end structure on a delivery end, and means for providing an occlusive material composition into and through the catheter; and an occlusive material composition;(b) positioning the atraumatic tip of the introducer shaft at or near the fundus of a uterus;(c) positioning the delivery end of the catheter at or near a uterine cornua such that the end structure is at or near a tubal ostium, wherein the end structure maintains the delivery end in the uterine cornua and aids in localized delivery of the occlusive material composition;(d) delivering from the catheter an effective amount of the occlusive material composition at or near the ostia of the fallopian tubes; and(e) occluding one fallopian tube by forming an occlusion with the occlusive material composition within the lumen of the fallopian tube.25. The method of claim 24 , wherein the fallopian tube is fallopian tube of a human. ...

Methods and Devices for Delivery of Compositions to Conduits

The present invention comprises systems, methods and devices for the delivery of visualizable or treatment compositions or therapeutic agents comprising device elements for diagnosis and/or treatment of conduits. A delivery system comprising an introducer shaft having at least one exit port sad at least one delivery catheter tor placement of compositions into the conduit, such as a fallopian tube. 119.-. (canceled)20. A method of treatment , comprising ,providing a treatment composition to at least a portion of one or two fallopian tubes of a human or animal by a delivery system that delivers an effective amount of the treatment composition, wherein the delivery system comprises a delivery device comprising at least an introducer shaft comprising an atraumatic tip for positioning the tip at the uterine fundus and one or two exit ports for providing one or two catheters; one or two catheters, wherein each of the one or two catheters comprises an end structure on a delivery end that maintains the delivery end in an uterine cornua and aids in localized delivery of the treatment composition; and elements for providing the treatment composition into and through the one or two catheters; and a treatment composition.21. The method of claim 20 , wherein a treatment composition is provided to at least a portion of one fallopian tube claim 20 , wherein the delivery device has one exit port and one catheter claim 20 , and wherein the treatment composition is provided into and through the one catheter.22. The method of claim 20 , wherein a treatment composition is provided to at least a portion of two fallopian tubes claim 20 , wherein the delivery device has two exit ports and two catheters claim 20 , and wherein the treatment composition is provided into and through the two catheters.23. The method of claim 20 , further comprising (c) providing an effective amount of a treatment composition directly to the uterus.24. The method of claim 21 , further comprising (c) providing ...

METHODS AND DEVICES FOR DELIVERING TO CONDUIT

The present invention comprises systems, methods and devices for the delivery of compositions for diagnosing or treating conduits. The delivery system is positioned to allow for placement of the composition into the body conduit. Use of delivery systems, methods and devices for delivering to a body conduit are also included. 1. A method for diagnosing and treating at least a portion of one or two conduits in a human or animal body , comprising ,(a) providing a delivery system that delivers an effective amount of one or more compositions, wherein the delivery system comprises a delivery device comprising an introducer shaft comprising one or two exit ports for providing one or two catheters, one or two catheters each comprising an end structure on a delivery end, one or more compositions, and a means for providing the one or more compositions into and through the one or two catheters;(b) delivering an effective amount of a composition comprising a diagnostic material such that the composition enters at least a portion of the one or two conduits; and(c) delivering an effective amount of a composition comprising a therapeutic material such that the composition enters at least a portion of the one or two conduits.2. The method of claim 1 , wherein the one or two conduits is a fallopian tube of a mammal.3. The method of claim 1 , wherein delivering an effective amount of a composition comprising a diagnostic material and delivering an effective amount of a composition comprising a therapeutic material occur without removal and re-introduction or substantial repositioning of the introducer shaft.4. The method of claim 1 , wherein delivering an effective amount of a composition comprising a diagnostic material and delivering an effective amount of a composition comprising a therapeutic material occur sequentially or simultaneously.5. The method of claim 1 , wherein the composition comprising a diagnostic material and the composition comprising a therapeutic material are ...

Methods and Devices for Conduit Occlusion

The present invention comprises systems, methods and devices for the delivery of compositions for occluding or of means for opening conduits. The implantable occlusive material may be delivered pre-formed or in situ cured and, may be a resorbable material that supports tissue ingrowth that eventually replaces the material leaving little or no original material in place. The delivery system is positioned to allow for placement of the occlusive material into the body conduit. Use of delivery systems, methods and devices for re-opening an occluded body conduit are also included. 128-. (canceled)29. A method for opening the lumen of at least one occluded fallopian tube , comprising ,a) providing a delivery system comprising a delivery device comprising at least an introducer shaft with at least one exit port for providing at least one catheter; at least one catheter comprising an end structure on a delivery end, and one or more elements for opening a conduit,b) providing the introducer shaft through the cervix,c) positioning the delivery end of at least one catheter at or near the uterine cornua so that the one or more elements for opening a conduit are at an occlusion in the lumen of at least one fallopian tube;d) activating the one or more elements for opening a conduit at the occlusion in the lumen of the at least one fallopian tube; ande) opening the lumen of the at least one fallopian tube.30. The method of claim 29 , wherein the one or more elements for opening the conduit comprise devices or members for providing shockwaves to shatter the occluding material claim 29 , chemical elements including solvents claim 29 , biological elements including enzymes claim 29 , or mechanical elements including stiff or cutting catheter ends to recanalize the lumen.31. The method of claim 29 , further comprisingf) maintaining the opening of the lumen of the at least one fallopian tube by providing a stent within the lumen of the at least one fallopian tube.32. A method for ...

METHODS AND COMPOSITIONS COMPRISING BIODEGRADABLE CYANOACRYLATES

Disclosed herein are methods of making and using cyanoacrylate compositions comprising one or more cyanoacrylates, a high level of at least one stabilizing agent and at least one free-radical polymerization inhibitor. Methods disclosed comprise making such compositions and using such compositions, for example, for occluding conduits such as fallopian tubes. 1. A biodegradable cyanoacrylate composition , comprising ,a) a cyanoacrylate component comprising at least one cyanoacrylate, wherein the cyanoacrylate component is 80 wt % or greater;b) a stabilizer component in a range from 500 ppm to 1500 ppm; andc) a polymerization inhibitor component in a range from 4000 to 7000 ppm.2. The biodegradable cyanoacrylate composition of claim 1 , wherein the cyanoacrylate component comprises at least two cyanoacrylate monomers.3. The biodegradable cyanoacrylate composition of claim 1 , wherein the cyanoacrylate monomer is methyl cyanoacrylate claim 1 , ethyl cyanoacrylate claim 1 , propyl cyanoacrylate claim 1 , butyl cyanoacrylate claim 1 , pentyl cyanoacrylate claim 1 , hexyl cyanoacrylate claim 1 , septyl cyanoacrylate claim 1 , octyl nonyl cyanoacrylate claim 1 , decyl 2-cyanoacrylate claim 1 , allyl cyanoacrylate claim 1 , methoxyethyl cyanoacrylate claim 1 , methoxyisopropyl cyanoacrylate claim 1 , methoxypropyl cyanoacrylate claim 1 , methoxybutyl cyanoacrylate claim 1 , methoxypentyl cyanoacrylate claim 1 , or combinations thereof.4. The biodegradable cyanoacrylate composition of claim 1 , wherein the stabilizer component comprises an alkyl sulfide claim 1 , alkyl sulfate claim 1 , alkyl sulfonyl claim 1 , alkyl sulfone claim 1 , alkyl sulfoxide claim 1 , alkyl sulfite claim 1 , sultone claim 1 , sulfur dioxide claim 1 , sulfur trioxide claim 1 , sulfonic acid claim 1 , lactone claim 1 , boron trifluoride claim 1 , acetic acid claim 1 , or 3-sulfolene claim 1 , mercaptan claim 1 , or combinations thereof.5. The biodegradable cyanoacrylate composition of claim 4 , wherein ...

Methods and devices for conduit occlusion

The present invention comprises systems, methods and devices for the delivery of compositions for occluding or of means for opening conduits. The implantable occlusive material may be delivered pre-formed or in situ cured and, may be a resorbable material that supports tissue ingrowth that eventually replaces the material leaving little or no original material in place. The delivery system is positioned to allow for placement of the occlusive material into the body conduit. Use of delivery systems, methods and devices for re-opening an occluded body conduit are also included.

METHODS AND DEVICES FOR CONDUIT OCCLUSION

The present invention comprises systems. Methods and devices for the delivery of compositions for occluding or of elements for opening conduits. The implantable occlusive material may be delivered preformed or in situ cured and, may be a resorbable or degradable material that supports tissue ingrowth or wound healing or a similar response that replaces the cured occlusive-material leaving little or no original occlusive material in place. The delivery system is positioned to allow for placement of the occlusive material into the body conduit. Use of delivery systems, methods and devices for re-opening an occluded body conduit are also included. 1. A method for occluding at least one conduit in a human or animal body , comprising ,a) providing a delivery system capable of delivering an effective amount of a composition comprising an occlusive material, wherein the delivery system comprises a delivery device comprising at least an introducer shaft with at least one exit port for providing at least one catheter; at least one catheter, a composition comprising an occlusive material, and elements for providing the composition comprising an occlusive material into and through at least one catheter;b) delivering an effective amount of the composition comprising an occlusive material at or near the target site; andc) occluding the conduit by forming an occlusion with the cured composition comprising an occlusive material within the lumen of the conduit.2. The method of claim 1 , wherein at least one conduit is occluded without removal and re-introduction or substantial repositioning of the introducer shaft.3. The method of claim 2 , wherein at least one conduit is a fallopian tube of a mammal.4. The method of claim 1 , wherein the composition comprising an occlusive material comprises a tissue adhesive.5. The method of where the composition comprising the occlusive material is ultrasound visible.6. The method of claim 5 , wherein the ultrasound visible material comprises ...

Methods and Devices for Cervical Cell and Tissue Sampling

The present invention comprises methods and devices comprising a cutting element used to contact circumferentially and longitudinally the surface walls of the endocervical canal to provide for broad and complete contact of the intended surface with the device, resulting in attainment of a sufficient volume and comprehensive tissue sample for analysis as an endocervical curettage or screening pap smear. The device may provide for a reservoir for the obtained sample to be contained when removing from the cervical canal and vagina. The device may be comprised of a detachable means or be of a material that allows the user to cut the sampling head of the device for placement in collection means to maximize the amount of tissue or cells being sent to the laboratory for analysis.

METHODS AND DEVICES FOR CONDUIT OCCLUSION

The present invention comprises systems, methods and devices for the delivery of compositions for occluding or of means for opening conduits. The implantable occlusive material may be delivered pre-formed or in situ cured and, may be a resorbable material that supports tissue ingrowth that eventually replaces the material leaving little or no original material in place. The delivery system is positioned to allow for placement of the occlusive material into the body conduit. Use of delivery systems, methods and devices for re-opening an occluded body conduit are also included. 128.-. (canceled)29. A method for occluding at least one fallopian tube in a mammal , comprising ,a) positioning at a uterine fundus of a mammal a closed tip of an introducer shaft of a delivery device of a delivery system that delivers an effective amount of an occlusive material composition, the delivery system comprising the delivery device comprising a handle; the introducer shaft having a proximal end operatively connected to the handle and the opposed closed tip, the introducer shaft defining a catheter channel along the interior length of the introducer shaft and defining at least one catheter channel opening spaced proximally from the closed tip of the introducer shaft, wherein the catheter channel is configured for providing at least one catheter; at least one catheter having a delivery end and an end structure, wherein the at least one catheter is configured to be received therein the catheter channel of the introducer shaft; and elements for providing an occlusive material composition into and through the catheter;wherein the closed tip of the introducer shaft is positioned at the uterine fundus by inserting the introducer shaft therethrough a cervix of the mammal until the closed tip contacts a uterine fundus of the mammal, and the at least one catheter channel opening is directed toward a uterine cornua of the mammal;b) moving the at least one catheter therethrough the catheter ...

CONTRAST AGENT GENERATION AND INJECTION SYSTEM FOR SONOGRAPHIC IMAGING

The present invention comprises methods and devices for generating and providing contrast medium for sonography of structures such as ducts or cavities. The invention provides for creation of a contrast medium comprising detectable acoustic variations between two phases, for example, a gas and a liquid. Sonography is the primary means of imaging but other conventional detection means may also be employed with the present invention. 1. A contrast medium generating and delivery device , comprising ,a container assembly comprising and first and second syringe, the first syringe configured for containing saline and the second syringe configured for containing air or gas; a contrast medium generating chamber; a first connection for fluid connection between the first syringe and the contrast medium generating chamber, and a second connection for fluid connection between the second syringe and the contrast medium generating chamber; an air port positioned between the second syringe and the contrast medium generating chamber in the connection for fluid connection between the second syringe and the contrast medium generating chamber, that is in fluid connection with the second syringe; and a third connection for fluid connection between the contrast medium generating chamber and an exit port distal to the contrast medium generating chamber;first and second syringe plungers, respectively disposed within the first and second syringes for simultaneously moving saline or air or gas into the respective syringe, and for simultaneously moving the contained saline or air from the respective syringe, through the respective first and second connection for fluid connection, to the contrast medium generating chamber to form a contrast medium comprising saline and air that exits through the exit port.2. The device of claim 1 , further comprising a component for actuating both syringe plunger simultaneously.3. The device of claim 1 , wherein at least one check valve is in fluid connection ...

Methods and Devices for Endometrial Cell and Tissue Sampling

The present invention comprises methods and devices comprising a scraping element used to contact circumferentially and longitudinally the surface walls of the uterine cavity to provide for broad contact of the intended surface with the device, resulting in attainment of a sufficient volume and comprehensive tissue sample for analysis as an endometrial biopsy or screening uterine cancer. The device may provide for a reservoir for the obtained sample to be contained when removing from the uterine cavity, cervical canal, and vagina. The device may be comprised of a detachable means or be of a material that allows the user to cut the sampling head of the device for placement in collection means to maximize the amount of tissue or cells being sent to the laboratory for analysis. 1. A method of obtaining an endometrial sample , comprising: i. a handle having a distal end and a longitudinal axis;', 'ii. an elongate wand extending outwardly from the distal end of the handle substantially along the longitudinal axis, wherein the wand has an exterior surface, a front end and a back end, and wherein the back end is fixedly mounted to a portion of the handle;', 'iii. a selectively moveable actuator coupled to a portion of the handle and to a sheath;', 'iv. a sheath member selectively encapsulating a portion of the wand and fixedly mounted to a portion of the wand proximate the front end of the wand and to a portion of an actuator member, wherein the distal end portion of the sheath member and a portion of the exterior surface of the wand underlying the distal end portion of the sheath member define a sample collection cavity, wherein the sheath member defines at least one slit on a distal end portion of the sheath member, the slit being bordered by opposing edges, wherein the slit is selectively movable between a closed position, in which the opposing edges of the helical slit substantially adjoin to substantially seal the sample collection cavity, and an open position, in ...

METHODS AND DEVICES FOR ENDOMETRIAL CELL AND TISSUE SAMPLING

The present invention comprises methods and devices comprising a scraping element used to contact circumferentially and longitudinally the surface walls of the uterine cavity to provide for broad contact of the intended surface with the device, resulting in attainment of a sufficient volume and comprehensive tissue sample for analysis as an endometrial biopsy or screening uterine cancer. The device may provide for a reservoir for the obtained sample to be contained when removing from the uterine cavity, cervical canal, and vagina. The device may be comprised of a detachable means or be of a material that allows the user to cut the sampling head of the device for placement in collection means to maximize the amount of tissue or cells being sent to the laboratory for analysis. 116-. (canceled)17. A method of diagnosing uterine cancer in a subject , comprising:a) examining an endometrial sample comprising tissue and/or cells for aplastic or abnormal cells obtained by an endometrial sampling apparatus, comprising,i. a handle having a distal end and a longitudinal axis;ii. an elongate wand extending outwardly from the distal end of the handle substantially along the longitudinal axis, wherein the wand has an exterior surface, a front end and a back end, and wherein the back end is fixedly mounted to the distal end of the handle;iii. a selectively moveable actuator coupled to the distal end of the handle and to a sheath;iv. a sheath member selectively encapsulating a portion of the wand and fixedly mounted to a portion of the wand proximate the front end of the wand and to a portion of an actuator member, wherein the distal end portion of the sheath member and a portion of the exterior surface of the wand underlying the distal end portion of the sheath member define a sample collection cavity, wherein the sheath member defines at least one slit on a distal end portion of the sheath member, the slit being bordered by opposing edges, wherein the slit is selectively movable ...

METHODS AND DEVICES FOR SONOGRAPHIC IMAGING

The present invention comprises methods and devices for providing contrast medium for sonography of structures such as ducts and cavities. The invention provides for creation of detectable acoustic variations between two generated phases of a gas and a liquid to make a contrast medium. Sonography is the primary means of imaging but other conventional detection means may also be employed with the present invention. 124.-. (canceled)25. A liquid and gas contrast medium-forming device , comprising a container assembly comprising two containers having the same volume , a first container for containing a gas and a second container for containing a liquid , two plungers , each disposed in a respective container , each for moving a liquid or gas from the respective container in a substantially 1:1 ratio of liquid to gas; a connection between the two plungers wherein the two plungers are connected so that the liquid and gas from the respective containers are moved simultaneously , components fluid connections for connecting each of the two containers to a contrast pattern generating chamber , wherein the gas and liquid form a gas-liquid composition having a multiply repeating pattern of discrete , alternating pattern of a gas phase and a liquid phase , andoptionally comprising a catheter assembly in fluid connection with the container assembly.26. The device of claim 25 , further comprising a pump drive attached to the connection between the two plungers or to each of the two plungers in a simultaneous fashion.27. The device of claim 25 , wherein the fluid further comprises one or more of a surfactant claim 25 , emulsifier claim 25 , stabilizing or dispersing agents.28. The device of claim 25 , wherein at least one container is prefilled.29. The device of claim 25 , wherein both containers are prefilled.30. The device of claim 25 , wherein the gas-liquid contrast medium composition further comprises a therapeutic agent.31. The device of claim 25 , wherein the gas comprises ...

METHODS AND DEVICES FOR CONDUIT OCCLUSION

The present invention comprises systems, methods and devices for the delivery of compositions for occluding or of means for opening conduits. The implantable occlusive material may be delivered pre-formed or in situ cured and, may be a resorbable material that supports tissue ingrowth that eventually replaces the material leaving little or no original material in place. The delivery system is positioned to allow for placement of the occlusive material into the body conduit. Use of delivery systems, methods and devices for re-opening an occluded body conduit are also included. 128.-. (canceled)29. A method for delivering a fluid composition to one fallopian tube in a mammal , comprising ,a) positioning at the cornua of one fallopian tube of a mammal, an end structure of a catheter so that a delivery end of the catheter is located within the uterine cornua and is at or near a tubal ostium, wherein the end structure maintains the delivery end in the uterine cornua and aids in localized delivery of the fluid composition;b) delivering an effective amount of the fluid composition through and out the delivery end of the catheter so that at least a portion of the fluid composition is delivered to the fallopian tube.30. The method of claim 29 , wherein the end structure comprises a nozzle claim 29 , balloon claim 29 , or a cup.31. The method of claim 29 , further comprising claim 29 ,c) withdrawing the catheter.32. The method of claim 29 , further comprising claim 29 , imaging with sonography the uterus claim 29 , the fallopian tube or both claim 29 , before the step a).33. The method of claim 31 , further comprising claim 31 , imaging with sonography the uterus claim 31 , the fallopian tube or both claim 31 , before step a) or after step c).34. The method of claim 31 , further comprising imaging with sonography the uterus claim 31 , the fallopian tube or both claim 31 , before step a) and after step c).35. A method for delivering a fluid composition to two fallopian tubes ...

CONTRAST AGENT INJECTION SYSTEM FOR SONOGRAPHIC IMAGING

The present invention comprises methods and devices for generating and providing contrast medium for sonography of structures such as ducts and cavities. The invention provides for creation of a contrast medium comprising detectable acoustic variations between two phases, for example, a gas and a liquid. Sonography is the primary means of imaging but other conventional detection means may also be employed with the present invention. 1. A contrast medium generating and delivery device , comprising a container assembly comprising a first and second syringe , the first syringe for containing saline and the second syringe , in fluid connection with an air port , for containing air or gas , first and second syringe plungers , respectively disposed within the first and second syringes for moving saline or air or gas into the syringe and for moving the contained saline or air or gas from the respective syringe , and connections for fluid connection of the first and second syringes to a contrast medium generating chamber comprising a static mixer , a pressure relief valve distal to and operably associated with the contrast medium generating chamber , and an exit port distal to the pressure relief valve.2. (canceled)3. (canceled)4. The device of claim 1 , further comprising a component for actuating both syringe plungers simultaneously.5. (canceled)6. (canceled)7. The device of claim 1 , wherein at least one check valve is in fluid connection with the container in fluid connection with the air port.8. The device of claim 1 , wherein at least two check valves are in fluid connection with the container in fluid connection with the air port.912.-. (canceled)13. The device of claim 1 , further comprising a catheter attached to the exit port.1421.-. (canceled) This application claims the priority U.S. patent application Ser. No. 12/245,265, filed Oct. 3, 2008, PCT Application No. PCT/US2009/059370, filed Oct. 2, 2009, and U.S. Provisional Patent Application Ser. No. 61/411,856, ...

Methods and Devices for Conduit Occlusion

The present invention comprises systems, methods and devices for the delivery of compositions for occluding or of means for opening conduits. The implantable occlusive material may be delivered pre-formed or in situ cured and, may be a resorbable material that supports tissue ingrowth that eventually replaces the material leaving little or no original material in place. The delivery system is positioned to allow for placement of the occlusive material into the body conduit. Use of delivery systems, methods and devices for re-opening an occluded body conduit are also included. 128-. (canceled)29. A method for occluding one fallopian tube in a mammal , comprising ,a) providing a delivery system that delivers an effective amount of an occlusive material composition, the delivery system comprising a delivery device comprising at least a handle; an introducer shaft having a proximal end operatively connected to the handle and an opposed closed tip, the introducer shaft defining a catheter channel along the interior length of the introducer shaft and defining a respective catheter channel opening spaced proximally from the closed tip of the introducer shaft, wherein the catheter channel is configured for providing a respective catheter; one catheter having a delivery end, wherein the catheter is configured to be received therein the catheter channel of the introducer shaft; and means for providing an occlusive material composition into and through the catheter;b) inserting the introducer shaft therethrough a cervix of the mammal until the closed tip contacts a uterine fundus of the mammal, and the catheter channel opening is directed toward a uterine cornua of the mammal;c) moving the catheter therethrough the catheter channel until the delivery end of the catheter exits the catheter channel opening and the delivery end of the catheter is located within the uterine cornua and the end structure is at or near a tubal ostium, wherein the end structure maintains the delivery ...

METHODS AND COMPOSITIONS FOR CONDUIT OCCLUSION

The present invention comprises systems, methods and devices for the delivery of compositions for occluding or of means for opening conduits. The implantable occlusive material may be delivered pre-formed or in situ cured and, may be a resorbable material that supports tissue ingrowth that eventually replaces the material leaving little or no original material in place. The delivery system is positioned to allow for placement of the occlusive material into the body conduit. Use of delivery systems, methods and devices for re-opening an occluded body conduit are also included. 128.-. (canceled)29. A method for occluding one fallopian tube in a mammal , comprising ,a) positioning at the cornua of one fallopian tube of a mammal, an end structure of a catheter so that a delivery end of the catheter is located within the uterine cornua and is at or near a tubal ostium, wherein the end structure maintains the delivery end in the uterine cornua and aids in localized delivery of the occlusive material composition;b) delivering an effective amount of an occlusive material composition through and out the delivery end of the catheter so that the fallopian tube is occluded, wherein the occlusive material composition comprises a material that polymerizes after delivery of the occlusive material composition.30. The method of claim 29 , wherein the end structure comprises a nozzle claim 29 , balloon claim 29 , or a cup.31. The method of claim 29 , further comprising claim 29 ,c) withdrawing the catheter.32. The method of claim 29 , further comprising claim 29 , imaging with sonography the uterus claim 29 , the fallopian tube or both claim 29 , before the step a).33. The method of claim 31 , further comprising claim 31 , imaging with sonography the uterus claim 31 , the fallopian tube or both claim 31 , before step a) or after step c).34. The method of claim 31 , further comprising imaging with sonography the uterus claim 31 , the fallopian tube or both claim 31 , before step a) ...

Methods and compositions for endometrial cell and tissue sampling

The present invention comprises methods and devices comprising a scraping element used to contact circumferentially and longitudinally the surface walls of the uterine cavity to provide for broad contact of the intended surface with the device, resulting in attainment of a sufficient volume and comprehensive tissue sample for analysis as an endometrial biopsy or screening uterine cancer. The device may provide for a reservoir for the obtained sample to be contained when removing from the uterine cavity, cervical canal, and vagina. The device may be comprised of a detachable means or be of a material that allows the user to cut the sampling head of the device for placement in collection means to maximize the amount of tissue or cells being sent to the laboratory for analysis.

METHODS AND DEVICES FOR SONOGRAPHIC IMAGING

The present invention comprises methods and devices for providing contrast medium for sonography of structures such as ducts and cavities. The invention provides for creation of detectable acoustic variations between two generated phases of a gas and a liquid to make a contrast medium. Sonography is the primary means of imaging but other conventional detection means may also be employed with the present invention. 124.-. (canceled)25. A contrast medium device , comprising a container assembly comprising two containers , each for containing a fluid , two components , each for moving a fluid from a container , wherein the two components are connected so that the fluids from the containers are moved simultaneously , components for connecting the two containers to a contrast pattern generating chamber , and optionally comprising a catheter assembly in fluid connection with the container assembly.261. The device of claim , wherein the containers are syringes and the components for moving a fluid from each container , are syringe plungers.272. The device of claim , wherein a syringe pump drive block advances the plungers in a simultaneous fashion.281. The device of claim , wherein one container contains a fluid that is liquid.294. The device of claim , wherein the liquid contains a surfactant , emulsifier , stabilizing or dispersing agents.301. The device of claim , wherein one container contains a gas and a second container contains a liquid.316. The device of claim , wherein the liquid contains a surfactant , emulsifier , stabilizing or dispersing agents.322. The device of claim , wherein the two syringes are differently sized or of similar size. The present invention relates to methods and devices for sonographic imaging of organs, ducts and cavities. In particular, methods and devices of the present invention use detectable acoustic variations of alternating patterns of a gas phase and a liquid phase traversing a passage.Non-surgical diagnostic procedures for ...

METHODS AND DEVICES FOR CONDUIT OCCLUSION

The present invention comprises systems, methods and devices for the delivery of compositions for occluding or of means for opening conduits. The implantable occlusive material may be delivered pre-formed or in situ cured and, may be a resorbable material that supports tissue ingrowth that eventually replaces the material leaving little or no original material in place. The delivery system is positioned to allow for placement of the occlusive material into the body conduit. Use of delivery systems, methods and devices for re-opening an occluded body conduit are also included. 128-. (canceled)29. A method for occluding one fallopian tube in a mammal , comprising ,a) providing a delivery system that delivers an effective amount of an occlusive material composition, the delivery system comprising a delivery device comprising at least a handle; an introducer shaft having a proximal end operatively connected to the handle and an opposed closed tip, the introducer shaft defining a catheter channel along the interior length of the introducer shaft and defining a respective catheter channel opening spaced proximally from the closed tip of the introducer shaft, wherein the catheter channel is configured for providing a respective catheter; one catheter having a delivery end, wherein the catheter is configured to be received therein the catheter channel of the introducer shaft; and means for providing an occlusive material composition into and through the catheter;b) inserting the introducer shaft therethrough a cervix of the mammal until the closed tip contacts a uterine fundus of the mammal, and the catheter channel opening is directed toward a uterine cornua of the mammal;c) moving the catheter therethrough the catheter channel until the delivery end of the catheter exits the catheter channel opening and the delivery end of the catheter is located within the uterine cornua and the end structure is at or near a tubal ostium, wherein the end structure maintains the delivery ...

Methods and devices for controlled delivery

Disclosed herein are exemplary medical devices for controlled delivery of material compositions, particularly occlusive, therapeutic, or diagnostic compositions.

Methods and Devices for Managing Fluid Pressure

The present invention comprises methods, compositions, devices and systems for determining the status of, or treating, a body structure or conduit. An embodiment of the invention comprises a fluid pressure control device for pressure control of fluid introduced into a body structure or conduit. 22. The method of claim 21 , wherein the catheter is a uterine access catheter having a balloon near the distal end of the catheter for maintaining an imaging fluid in the uterus.23. The method of claim 21 , further comprising the step of viewing the imaging fluid in at least the proximal portion of the at least one fallopian tube or uterus or both.24. The method of claim 23 , wherein the imaging fluid is viewed with sonography.25. The method of claim 21 , wherein the imaging fluid further comprises a treatment fluid.26. The method of claim 21 , wherein the uterus having an altered physical structure has undergone one or more of a surgical procedure claim 21 , a medical procedure claim 21 , or a trauma that has changed the physical structure of the uterus.27. The method of claim 21 , wherein the at least one fallopian tube having an altered physical structure has undergone one or more of a surgical procedure claim 21 , a medical procedure claim 21 , or a trauma that has changed the physical structure of the at least one fallopian tube.28. The method of claim 21 , wherein the uterus and the at least one fallopian tube having an altered physical structures have undergone one or more of a surgical procedure claim 21 , a medical procedure claim 21 , or a trauma that has changed the physical structure of the at least one fallopian tube.29. The method of claim 21 , wherein the imaging fluid is delivered at least to the uterus.30. The method of claim 29 , wherein delivering the imaging fluid to the uterus further comprises delivering the imaging fluid to the at least a portion of at least one fallopian tube.31. The method of claim 21 , wherein the pressure relief valve is configured ...

Methods and devices for delivery of compositions to conduits

The present invention comprises systems, methods and devices for the delivery of visualizable or treatment compositions or therapeutic agents comprising device elements for diagnosis and/or treatment of conduits. A delivery system comprising an introducer shaft having at least one exit port and at least one delivery catheter for placement of compositions into the conduit, such as a fallopian tube.

Contrast medium device for sonographic imaging

The present invention comprises methods and devices for providing contrast medium for sonography of structures such as ducts and cavities. The invention provides for creation of detectable acoustic variations between two generated phases of a gas and a liquid to make a contrast medium. Sonography is the primary means of imaging but other conventional detection means may also be employed with the present invention.

Methods and devices for conduit occlusion

The present invention comprises systems, methods and devices for the delivery of compositions for occluding or of means for opening conduits. The implantable occlusive material may be delivered pre-formed or in situ cured and, may be a resorbable material that supports tissue ingrowth that eventually replaces the material leaving little or no original material in place. The delivery system is positioned to allow for placement of the occlusive material into the body conduit. Use of delivery systems, methods and devices for re-opening an occluded body conduit are also included.

Methods and devices for conduit occlusion

The present invention comprises systems, methods and devices for the delivery of compositions for occluding or of means for opening conduits. The implantable occlusive material may be delivered pre-formed or in situ cured and, may be a resorbable material that supports tissue ingrowth that eventually replaces the material leaving little or no original material in place. The delivery system is positioned to allow for placement of the occlusive material into the body conduit. Use of delivery systems, methods and devices for re-opening an occluded body conduit are also included.

Methods and devices for managing fluid pressure

The present invention comprises methods, compositions, devices and systems for determining the status of, or treating, a body structure or conduit. An embodiment of the invention comprises a fluid pressure control device for pressure control of fluid introduced into a body structure or conduit.

Methods and devices for controlled delivery

Disclosed herein are exemplary medical devices for controlled delivery of material compositions, particularly occlusive, therapeutic, or diagnostic compositions.

Methods and devices for conduit occlusion

The present invention comprises systems, methods and devices for the delivery of compositions for occluding or of means for opening conduits. The implantable occlusive material may be delivered pre-formed or in situ cured and, may be a resorbable material that supports tissue ingrowth that eventually replaces the material leaving little or no original material in place. The delivery system is positioned to allow for placement of the occlusive material into the body conduit. Use of delivery systems, methods and devices for re-opening an occluded body conduit are also included.

Methods and compositions comprising biodegradable cyanoacrylates

Disclosed herein are methods of making and using cyanoacrylate compositions comprising one or more cyanoacrylates, a high level of at least one stabilizing agent and at least one free-radical polymerization inhibitor. Methods disclosed comprise making such compositions and using such compositions, for example, for occluding conduits such as fallopian tubes.

Contrast medium device for sonographic imaging

The present invention comprises methods and devices for providing contrast medium for sonography of structures such as ducts and cavities. The invention provides for creation of detectable acoustic variations between two generated phases of a gas and a liquid to make a contrast medium. Sonography is the primary means of imaging but other conventional detection means may also be employed with the present invention.

Methods and devices for controlled delivery

Disclosed herein are exemplary medical devices for controlled delivery of material compositions, particularly occlusive, therapeutic, or diagnostic compositions.

Methods and devices for endometrial cell and tissue sampling

The present invention comprises methods and devices comprising a scraping element used to contact circumferentially and longitudinally the surface walls of the uterine cavity to provide for broad contact of the intended surface with the device, resulting in attainment of a sufficient volume and comprehensive tissue sample for analysis as an endometrial biopsy or screening uterine cancer. The device may provide for a reservoir for the obtained sample to be contained when removing from the uterine cavity, cervical canal, and vagina. The device may be comprised of a detachable means or be of a material that allows the user to cut the sampling head of the device for placement in collection means to maximize the amount of tissue or cells being sent to the laboratory for analysis.

Contrast medium device for sonographic imaging

The present invention comprises methods and devices for providing contrast medium for sonography of structures such as ducts and cavities. The invention provides for creation of detectable acoustic variations between two generated phases of a gas and a liquid to make a contrast medium. Sonography is the primary means of imaging but other conventional detection means may also be employed with the present invention.

Methods and devices for endometrial cell and tissue sampling

The present invention comprises methods and devices comprising a scraping element used to contact circumferentially and longitudinally the surface walls of the uterine cavity to provide for broad contact of the intended surface with the device, resulting in attainment of a sufficient volume and comprehensive tissue sample for analysis as an endometrial biopsy or screening uterine cancer. The device may provide for a reservoir for the obtained sample to be contained when removing from the uterine cavity, cervical canal, and vagina. The device may be comprised of a detachable means or be of a material that allows the user to cut the sampling head of the device for placement in collection means to maximize the amount of tissue or cells being sent to the laboratory for analysis.

Methods and devices for sonographic imaging

The present invention comprises methods and devices for providing contrast medium for sonography of structures such as ducts and cavities. The invention provides for creation of detectable acoustic variations between two generated phases of a gas and a liquid to make a contrast medium. Sonography is the primary means of imaging but other conventional detection means may also be employed with the present invention.

Devices, methods and compositions for reproductive organs

Disclosed herein are exemplary medical devices for delivery of compositions to a target site. A disclosed medical device may comprise a delivery device comprising a delivery device comprising a handle, a composition delivery container and its plunger, an insertion tube, a dual lumen catheter comprising an exit port and optionally, an end structure, and fluid connections therefor, components for moving one or more catheters or for compressing one or more catheters. Methods of treatment and diagnosis using a disclosed delivery device, compositions for such methods and kits and systems are also disclosed.

Methods and devices for controlled delivery

Disclosed herein are exemplary medical devices for controlled delivery of material compositions, particularly occlusive, therapeutic, or diagnostic compositions.

Methods and devices for controlled delivery

Disclosed herein are exemplary medical devices for controlled delivery of material compositions, particularly occlusive, therapeutic, or diagnostic compositions.

Methods and compositions for endometrial cell and tissue sampling

The present invention comprises methods and devices comprising a scraping element used to contact circumferentially and longitudinally the surface walls of the uterine cavity to provide for broad contact of the intended surface with the device, resulting in attainment of a sufficient volume and comprehensive tissue sample for analysis as an endometrial biopsy or screening uterine cancer. The device may provide for a reservoir for the obtained sample to be contained when removing from the uterine cavity, cervical canal, and vagina. The device may be comprised of a detachable means or be of a material that allows the user to cut the sampling head of the device for placement in collection means to maximize the amount of tissue or cells being sent to the laboratory for analysis.

Methods and Devices for Conduit Occlusion

The present invention comprises systems, methods and devices for the delivery of compositions for occluding or of means for opening conduits. The implantable occlusive material may be delivered pre-formed or in situ cured and, may be a resorbable material that supports tissue ingrowth that eventually replaces the material leaving little or no original material in place. The delivery system is positioned to allow for placement of the occlusive material into the body conduit. Use of delivery systems, methods and devices for re-opening an occluded body conduit are also included.

Methods and devices for managing fluid pressure

The present invention comprises methods, compositions, devices and systems for determining the status of, or treating, a body structure or conduit. An embodiment of the invention comprises a fluid pressure control device for pressure control of fluid introduced into a body structure or conduit.

Methods and devices for managing fluid pressure

The present invention comprises methods, compositions, devices and systems for determining the status of, or treating, a body structure or conduit. An embodiment of the invention comprises a fluid pressure control device for pressure control of fluid introduced into a body structure or conduit.

生分解性シアノアクリレートを含む方法および組成物

【課題】例えば、卵管等の導管を閉塞させるために使用するシアノアクリレートを含む組成物、キット、および医療機器のコンポーネントを提供する。【解決手段】ａ）メトキシイソプロピルシアノアクリレート及びメトキシプロピルシアノアクリレートからなるシアノアクリレート成分であって、８０ｗｔ％以上であるシアノアクリレート成分であり、前記メトキシイソプロピルシアノアクリレート及びメトキシプロピルシアノアクリレートの重量比が、５０：５０、３０：７０又は７０：３０である、シアノアクリレート成分と、ｂ）５００ｐｐｍから１５００ｐｐｍまでの範囲内のアルキルスルフィド等の安定剤成分と、ｃ）４０００ｐｐｍから７０００ｐｐｍまでの範囲内のブチルヒドロキシアニソール等の重合禁止剤成分とを含む、生分解性シアノアクリレート組成物を提供する。【選択図】なし

Devices, methods and compositions for reproductive organs

Disclosed herein are exemplary medical devices for delivery of compositions to a target site. A disclosed medical device may comprise a delivery device comprising a delivery device comprising a handle, a composition delivery container and its plunger, an insertion tube, a dual lumen catheter comprising an exit port and optionally, an end structure, and fluid connections therefor, components for moving one or more catheters or for compressing one or more catheters. Methods of treatment and diagnosis using a disclosed delivery device, compositions for such methods and kits and systems are also disclosed.

Methods and devices for sonographic imaging

The present invention comprises methods and devices for providing contrast medium for sonography of structures such as ducts and cavities. The invention provides for creation of detectable acoustic variations between two generated phases of a gas and a liquid to make a contrast medium. Sonography is the primary means of imaging but other conventional detection means may also be employed with the present invention.

Methods and devices for conduit occlusion

The present invention comprises systems, methods and devices for the delivery of compositions for occluding or of means for opening conduits. The implantable occlusive material may be delivered pre-formed or in situ cured and, may be a resorbable material that supports tissue ingrowth that eventually replaces the material leaving little or no original material in place. The delivery system is positioned to allow for placement of the occlusive material into the body conduit. Use of delivery systems, methods and devices for re-opening an occluded body conduit are also included.

Devices for controlled delivery

Methods and devices for sonographic imaging

The present invention comprises methods and devices for generating and providing contrast medium for sonography of structures such as ducts or cavities. The invention provides for creation of a contrast medium comprising detectable acoustic variations between two phases, for example, a gas and a liquid. Sonography is the primary means of imaging but other conventional detection means may also be employed with the present invention.

Methods and devices for cervical cell and tissue sampling

Methods and devices for cervical cell and tissue sampling

The present invention comprises methods and devices comprising a cutting element used to contact circumferentially and longitudinally the surface walls of the endocervical canal to provide for broad and complete contact of the intended surface with the device, resulting in attainment of a sufficient volume and comprehensive tissue sample for analysis as an endocervical curettage or screening pap smear. The device may provide for a reservoir for the obtained sample to be contained when removing from the cervical canal and vagina. The device may be comprised of a detachable means or be of a material that allows the user to cut the sampling head of the device for placement in collection means to maximize the amount of tissue or cells being sent to the laboratory for analysis.

Methods and devices for cervical cell and tissue sampling

The present invention comprises methods and devices comprising a cutting element used to contact circumferentially and longitudinally the surface walls of the endocervical canal to provide for broad and complete contact of the intended surface with the device, resulting in attainment of a sufficient volume and comprehensive tissue sample for analysis as an endocervical curettage or screening pap smear. The device may provide for a reservoir for the obtained sample to be contained when removing from the cervical canal and vagina. The device may be comprised of a detachable means or be of a material that allows the user to cut the sampling head of the device for placement in collection means to maximize the amount of tissue or cells being sent to the laboratory for analysis.

Devices for cervical cell and tissue sampling

Devices for controlled delivery

Disclosed herein are exemplary medical devices for controlled delivery of material compositions, particularly occlusive, therapeutic, or diagnostic compositions.

Indretninger til kontrolleret levering

Methods and devices for controlled delivery

Disclosed herein are exemplary medical devices for controlled delivery of material compositions, particularly occlusive, therapeutic, or diagnostic compositions.

Devices and methods for a variably locking syringe assembly

The present invention disclosed exemplary variably lockable syringe assemblies, methods of making and using the same. Such syringe assemblies can be used in multiple medical, surgical, veterinary and research applications. A syringe assembly disclosed herein may dispense a dose of a composition one or more times by locking and unlocking the plunger.

Devices and methods for a variably locking syringe assembly

Disclosed herein are exemplary variably lockable syringe assemblies, methods of making and using the same. Such variably locking syringe assemblies are useful in many applications.

Devices for controlled delivery

Disclosed herein are exemplary medical devices for controlled delivery of material compositions, particularly occlusive, therapeutic, or diagnostic compositions.

Devices, methods and compositions for reproductive organs

Disclosed herein are exemplary medical devices for delivery of compositions to a target site. A disclosed medical device may comprise a delivery device comprising a delivery device comprising a handle, a composition delivery container and its plunger, an insertion tube, a dual lumen catheter comprising an exit port and optionally, an end structure, and fluid connections therefor, components for moving one or more catheters or for compressing one or more catheters. Methods of treatment and diagnosis using a disclosed delivery device, compositions for such methods and kits and systems are also disclosed.

Dispositivos para la administración controlada

Methods and devices for controlled delivery

Disclosed herein are exemplary medical devices for controlled delivery of material compositions, particularly occlusive, therapeutic, or diagnostic compositions.

Devices, Methods and Compositions for Reproductive Organs

Disclosed herein are exemplary medical devices for delivery of compositions to a target site. A disclosed medical device may comprise a delivery device comprising a delivery device comprising a handle, a composition delivery container and its plunger, an insertion tube, a dual lumen catheter comprising an exit port and optionally, an end structure, and fluid connections therefor, components for moving one or more catheters or for compressing one or more catheters. Methods of treatment and diagnosis using a disclosed delivery device, compositions for such methods and kits and systems are also disclosed.

Devices, methods and compositions for reproductive organs

Disclosed herein are exemplary medical devices for delivery of compositions. Medical devices disclosed herein comprise components for the intake of one or more compositions through one port so that little to none of the composition is lost within the device because the composition is then delivered out the same port throughwhich the composition was drawn into the device.

Methods and devices for cervical cell and tissue sampling

The present invention comprises methods and devices comprising a cutting element used to contact circumferentially and longitudinally the surface walls of the endocervical canal to provide for broad and complete contact of the intended surface with the device, resulting in attainment of a sufficient volume and comprehensive tissue sample for analysis as an endocervical curettage or screening pap smear. The device may provide for a reservoir for the obtained sample to be contained when removing from the cervical canal and vagina. The device may be comprised of a detachable means or be of a material that allows the user to cut the sampling head of the device for placement in collection means to maximize the amount of tissue or cells being sent to the laboratory for analysis.

Methods and devices for endometrial cell and tissue sampling

The present invention comprises methods and devices comprising a scraping element used to contact circumferentially and longitudinally the surface walls of the uterine cavity to provide for broad contact of the intended surface with the device, resulting in attainment of a sufficient volume and comprehensive tissue sample for analysis as an endometrial biopsy or screening uterine cancer. The device may provide for a reservoir for the obtained sample to be contained when removing from the uterine cavity, cervical canal, and vagina. The device may be comprised of a detachable means or be of a material that allows the user to cut the sampling head of the device for placement in collection means to maximize the amount of tissue or cells being sent to the laboratory for analysis.

Contrast agent injection system for sonographic imaging

The present invention comprises methods and devices for generating and providing contrast medium for sonography of structures such as ducts and cavities. The invention provides for creation of a contrast medium comprising detectable acoustic variations between two phases, for example, a gas and a liquid. Sonography is the primary imaging technique but other conventional detection techniques may also be employed with the present invention.