Medicine composition for regulating blood fat

The invention relates to a medicine composition for regulating blood fat, belonging to the field of medicine. The medicine composition for regulating the blood fat comprises the following compounds byweight percent: 10-35 percent of 3,7-dihydroxy-2,4,6-trimethoxy phenanthrene, 10-35 percent of1-(2,7-dihydroxy-4,6-dimethoxy phenanthrene)-2,7-dihydroxy-4,6-dimethoxy phenanthrene, 10-35 percent of 7-hydroxyl group-2,6-dimethoxy-1,4-phenanthrenequinone, 10-35 percent of kaempferol-3-O-beta-D-glucopyranoside, 10-35 percent of kaempferol-3-O-beta-rutinoside and 10-35 percent of rutin. The inventionhas the advantages that the ingredients of the medicine composition are all obtained by being extracted and separated from the aboveground part of dioscorea nipponica makino; the medicine compositionbelongs to natural products and has high capability for regulating the biological activity of the blood fat; and an optimal proportion of ingredients of compositions for treating hyperlipoidemia.

20(R)-pseudoginsenoside F11 as well as extraction method and medical purpose thereof

The invention relates to a 20(R)-pseudoginsenoside F11 as well as an extraction method and a medical purpose thereof, belonging to the field of a new compound and a medical purpose thereof. The preparation method comprises the following steps of: crushing western red ginseng, adding 3-6 times of 70-95% ethanol, heating, refluxing and extracting 3-7 times for 2-4 h every time, mixing extracting solutions and recovering and drying the solvent; repeatedly reacting an ethanol extract with an eluting agent of chcl3-meoh(90-110:15-30) through silica gel column chromatography and with an eluting agent of MeOH-H2O(50-70:30-50) through C-18 reversed-phase column chromatography; recrystallizing ethyl acetate to obtain 20(R)-pseudoginsenoside F11. The invention also discloses application of the 20(R)-pseudoginsenoside F11 to preparing antiarrhythmic medicaments.

Goose gall extract, preparation method and medicine use thereof

The invention relates to a goose gall extract, a preparation method and medicine use thereof, which belong to the field of traditionally Chinese medicine. The preparation method comprises the following steps: taking goose galls; removing gall coats; carrying out filtration; collecting filter liquid; adding 50 to 90 percent edible alcohol to the concentration of 50 to 90 percent; carrying out precipitation for 5 to 48 hours at 2 to 24 DEG C; carrying out filtration; collecting filter liquid to obtain goose bile raw liquid; recovering alcohol; and carrying out concentration and drying to obtain the goose gall extract. The invention also provides the application of the goose gall extract of the invention to the preparation of medicine for clearing away heat and toxic materials, protecting the liver and improving the immunity. The goose bile prepared through the modern extraction technology by the invention has the obvious function of activating and enhancing the reticulo endothelial system ...

Ginseng functional health sports drink and preparation method thereof

The invention relates to a ginseng functional health sports drink and a preparation method thereof, and belongs to a drink and a preparation method of the drink. Every 1000ml of the drink contains 10 to 100g of total ginsenoside ginseng root, 80 to 320ml of ginseng juice, 0.15 to 0.5g of glutamine, 0.1 to 0.2g of stevioside, 0.1 to 0.25g of potassium citrate, 0.05 to 0.2g of refined salt, 0.05 to 0.1g of heme-L-lysinate, 0.12 to 0.25g of taurine, 0.15 to 0.25g of vitamin C, 0.05 to 0.5g of pectin, and balance of mineral water. The drink has the advantages of uniform texture, good stability, and easiness in absorbing by living organisms, and the functional sports drink capable of well restoring strength is provided for athletes, exercisers and fatigued people.

American ginseng ginsenoside F5ab and extraction method and medicinal application thereof

The invention relates to American Ginseng ginsenoside F5ab and extraction method and medicinal application thereof, and belongs to a novel compound and the medicinal application thereof. The American ginseng as a raw material, is subjected to water extraction, adsorption of macroporous adsorbent resin, silica column chromatography, and recrystalization to form a novel compound which has the chemical name of 3-O-beta-D-glucopyranosyl-(1-2)-beta-D-glucopyranosyl-20-O-beta-D-xylopyranosyl-dammar-25(26)-ene-3beta,12beta,20S,24zeta-tetraol, which is called as American Ginseng ginsenoside F5ab for short. The yield is over 0.01 percent. The American Ginseng ginsenoside F5ab has wide medicinal application to preparing medicaments for treating myocardial ischemia.

24(R)-pseudoginsenoside-GQ as well as semisynthesis method and medicinal application thereof

The invention relates to 24(R)-pseudoginsenoside-GQ as well as a semisynthesis method and medicinal application thereof, belonging to a new compound as well as a synthesis method and medicinal application thereof. In the invention, 20(S)-ginsenoside Rg3 or 20(R)-ginsenoside Rg3 is used as a raw material, and under an acid condition, a new compound is synthesized through the steps of oxidization, cyclization, and the like, wherein the chemical name of the new compound is 3-O-[beta-D-glucopyranose-(1-2)-beta-D-glucopyranose group]-damma-20S, 24R-epoxy-3beta, 12beta, 25-triol being short for 24(R)-pseudoginsenoside-GQ, the productivity of which reaches higher than 80 percent. The 24(R)-pseudoginsenoside-GQ has wide medicinal application in preparing medicaments for treating coronary heart diseases, myocardial ischemia, ischemic shocks, arrhythmia and reperfusion damages and resisting cancer.

American ginseng saponin F6 as well as extraction method and medical application thereof

The invention relates to American ginseng saponin F6 as well as an extraction method and medical application thereof, which belong to a new compound as well as an extraction method and medical application thereof. The extraction method comprises the following steps: taking American ginseng fruit as a raw material, obtaining the new compound through macroporous absorbent resin, normal and reversed-phase silica gel column chromatography and a recrystallization method of fruit juice, wherein the new compound has the chemical name of 6-O-beta-D-glucopyranesyl-20-O-[alpha-L-arabinofuranosyl-(1-6)-beta-D-glucopyranosyl]-dammar-24-ene-3beta, 6alpha,12beta, 20S-tetraol and is abbreviated as the American ginseng saponin F6, and the yield reaches more than 0.01%. The American ginseng saponin F6 has wide application in preparing antitumor medicaments.

Method for extracting pseudoginsenoside RT5 and medical application

The invention relates to a method for extracting pseudoginsenoside RT5 and medical application, which belong to the field of medicaments. The method comprises the following steps of: after total saponins of American ginseng are added into macroporous resin, eluting by using water and 25 to 45 percent ethanol in turn till saponins are not reacted; continuously eluting by using 35 to 55 percent ethanol; collecting eluent; recycling a solvent; drying by distillation; and recrystallizing to obtain the pseudoginsenoside RT5. The pseudoginsenoside RT5 is applied to the preparation of anti-myocardial ischemia medicaments.

Dimer (5-methylol-furfural), synthetic method thereof and medical application thereof

The invention relates to dimer (5-methylol-furfural), a synthetic method thereof and medical application thereof, and belongs to a new compound, a synthetic method thereof and medical application thereof. The synthetic method comprises the following steps: dissolving 5-HMF into dimethyl sulfoxide, adjusting the pH to 3.0 to 4.0 by using acid, raising the reaction temperature to between 115 and 125 DEG C under the condition of stirring and heating and refluxing the mixture for 3 hours, then heating and refluxing the mixture for 2 hours at a temperature of 140 DEG C, cooling the mixture, adjusting the pH to 7.0 by using 0.1M alkali liquor, filtering the mixture, and condensing and drying the filtrate to obtain the crude dimer (5-methylol-furfural). The yield reaches more than 70 percent. The dimer (5-methylol-furfural) has wide medical application in preparing immune enhancement medicaments.

Novel macamide compounds as well as synthetic method and medical application of novel macamide compounds

The invention relates to new macamide compounds as well as a synthetic method and medical application of the new macamide compounds, belonging to new compounds as well as a synthetic method and medical application of the new compounds. The compounds are 9Z-N-(4-chloro-benzyl)-octadecenamide and 9Z, 12Z-N-(4-chloro-benzyl)-octadecadienamide. The new macamide compounds can be used for preparing hearth care products capable of enhancing physical strength, allaying tiredness and enhancing the sexual function or for preparing drugs capable of enhancing physical strength, allaying tiredness, enhancing the sexual function and treating erectile dysfunction of the male, have the effects of promoting sexual desire, improving the mating ability, increasing the indexes of sexual organs and the amount of sperms, improving the activity of sperms, increasing the testosterone content in blood and improving the 5-hydroxytryptamine level in the brain and has the characteristic of remarkable curative effect ...

Method for extracting pseudoginsenoside RT5 and medical application

The invention relates to a method for extracting pseudoginsenoside RT5 and medical application, which belong to the field of medicaments. The method comprises the following steps of: after total saponins of American ginseng are added into macroporous resin, eluting by using water and 25 to 45 percent ethanol in turn till saponins are not reacted; continuously eluting by using 35 to 55 percent ethanol; collecting eluent; recycling a solvent; drying by distillation; and recrystallizing to obtain the pseudoginsenoside RT5. The pseudoginsenoside RT5 is applied to the preparation of anti-myocardial ischemia medicaments.

西洋参果总皂苷提取物及其提取、精制方法及其医药用途

The present invention belongs to the field of medicine, and is especially American ginseng fruit general saponin extractive and its refining process and medicinal use. American ginseng fruit generalsaponin is extracted with American ginseng fruit as material and through scientific extracting process, and then refined through macroporous resin absorption to obtain American ginseng fruit general saponin product with American ginseng fruit general saponin content of 55-65 %. The product is especially suitable for use in preparing medicine for coronary heart disease, myocardial ischemia, arrhythmia, type-II diabetes and other diseases.

American ginseng saponin F6 as well as extraction method and medical application thereof

The invention relates to American ginseng saponin F6 as well as an extraction method and medical application thereof, which belong to a new compound as well as an extraction method and medical application thereof. The extraction method comprises the following steps: taking American ginseng fruit as a raw material, obtaining the new compound through macroporous absorbent resin, normal and reversed-phase silica gel column chromatography and a recrystallization method of fruit juice, wherein the new compound has the chemical name of 6-O-beta-D-glucopyranesyl-20-O-[alpha-L-arabinofuranosyl-(1-6)-beta-D-glucopyranosyl]-dammar-24-ene-3beta, 6alpha,12beta, 20S-tetraol and is abbreviated as the American ginseng saponin F6, and the yield reaches more than 0.01%. The American ginseng saponin F6 haswide application in preparing antitumor medicaments.

Application of pseudo-ginsenoside GQ

The invention belongs to the field of medicines and relates to the application of pseudo-ginsenoside GQ, in particular to the application of the pseudo-ginsenoside GQ in the preparation of medicaments for preventing and treating brain tissue damage caused by local and global cerebral ischemia and the application of the pseudo-ginsenoside GQ in the preparation of medicaments for treating transientischemic attack, cerebral thrombosis and cerebral infarction. The medicaments prepared by the invention can prevent and treat brain tissue damage caused by local and global cerebral ischemia, reduce cerebral necrosis area, protect cerebral tissues, reduce the generation of malondialdehyde (MDA), retard energy metabolism, improve the hypoxia tolerance ability of the cerebral tissue, and treat transient ischemic attack, cerebral thrombosis and cerebral infarction.

Dama-20S, 25S-epoxy-3beta, 12beta, 26-triol as well as extracting method and pharmaceutical application thereof

The invention relates to dama-20S, 25S-epoxy-3beta, 12beta, 26-triol, as well as an extracting method and a pharmaceutical application thereof and belongs to the field of medicines. The extracting method comprises the following steps: getting proper amount of the American ginseng stem, adding 3-8 times of 60-95% ethanol, heating, performing reflux extraction, extracting 50L for 3-6 hours each time and for 5-7 times, combining the extracting solution, and recovering the solvent till the solvent does not exist; performing silica gel column chromatogram on the ethanol extractive with an eluent comprising CHCl3 and MeOH at a ratio of 90-120:10-30, performing C18 reversed-phase column chromatography with an eluent comprising MeOH and H2O at a ratio of 80-90:20-10, and recrystalizing with ethanol and water in the ratio of 2:4-6 to obtain the Dama-20S, 25S-epoxy-3beta, 12beta, 26-triol. The compound not only has an antitumor activity, but also has the pharmacological actions for treating the coronary ...

Pseudoginsenoside G1 and extraction method and medicinal applications thereof

The invention relates to a pseudoginsenoside G1 and an extraction method and medicinal applications thereof, belonging to a new compound and medicinal applications thereof. The method comprises the following steps: taking Red American ginseng to grind, adding 3-7 times of 70-95% ethanol to heat and reflux for extraction, wherein each extraction requires 2-4 hours and 3-6 times of extractions are needed; mixing the extracting solutions, recovering the solvent till dry; adopting the silica gel column chromatography to treat ethanol extract, wherein the eluent is CHCl3-MeOH and the weight ratio is 80-110:20-40; adopting the C-18 reversed phase column chromatography to treat, wherein the eluent is MeOH-H2O and the weight ratio is 50-70:30-50; and using the mixture of methanol and water in a weight ratio of 1:2-5 to perform crystallization and obtain the pseudoginsenoside G1. The chemical name of the product is 3-O-[beta-D-glucopyranosyl-(1-2)-beta-D-glucopyranosyl]-dammarane-12-one-20S,24R-epoxy ...

Pseudoginsenoside-Pdq and its semi-synthesis process and medicine use

Pseudo gensenoside-Pgq and its semi-synthesis and medicinal use

The present invention relates to a new compound, its chemical name is 3-o-beta-D-glucopyranosyl-(1-2)-beta-D-glucopyranosyl-damar-20(24)-epoxy-3beta, 12 beta, 25-triol, called in brief pseudo ginsengsaponin-pgq, its yield can be higher than 80%. This pseudo ginseng saponin-pgq can be used in the preparation of medicine for treating cardiomyopathy, arrhythmia etc.

Macamide compound, preparation method and medicine purpose thereof

The invention relates to a macamide compound, a preparation method and a medicine purpose thereof, which belong to the medicine field. The preparation method includes: adding 0.6mmol of oleic acid or erucic acid, 0.6mmol of4-chlorobenzylamine, 0.6mmol of triethylamine, 0.03-0.04mmol of catalyst 4-dimethylamino pyridine, and 0.6mmol of N,N'-dicyclohexylcarbodiimide in a CH2Cl2 solvent, stirring for 24 hours under room temperature, reacting to obtain a crude product, separating and purifying by silica gel column chromatography to obtain the macamide compound. The macamide compound or its pharmaceutical composition can be used for treating male sexual disfunction, and has the advantages of obvious curative effect, low cost, and less toxic and side effect.

Split-ring lupane derivative as well as preparation method and application thereof

The invention discloses a split-ring lupane derivative and a preparation method and application thereof.The structure of the derivative is shown as a formula II or a formula III, and the preparation method comprises the steps that 1, a DMF solution of a raw material compound I or an acid-alcohol reaction product of the raw material compound I, a dehydrating agent, a catalyst and reactants are stirred to react, and then an intermediate A is obtained; and (2) stirring and reacting the DMF solution of the intermediate A, a dehydrating agent, a catalyst and a reactant RbOH to obtain the derivative shown in the formula II or the formula III. Meanwhile, the invention discloses application of the derivative in preparation of a multi-target cell injury and death inhibitor. The invention also discloses an application of a pharmaceutical composition comprising the derivative. The invention verifies that the 3, 4-split-ring lupane derivative has a BIP/CHOP inhibitor and an FGF2/EGFR agonist effect ...

紫丁香总皂苷提取物及其制备方法及其药物组合物

... 本发明涉及一种紫丁香总皂苷提取物、制备方法及其药物组合物。属于医药领域。将紫丁香叶加水煮2～3次，每次1～3小时；将各次水煮所得的溶液合并，过滤，滤液备用；将上述滤液过大孔吸附树脂，然后用水洗涤，至接近无色，弃去洗液，以50％～88％乙醇洗脱，收集该次洗脱液；将该洗脱液回收乙醇后，浓缩，干燥，得紫丁香总皂苷提取物。其特征为淡黄色至深橙色，粉末状，味苦，含量为占紫丁香干叶总重的3％～7％。含有紫丁香提取物作为活性成分的药物组合物，用于治疗肝病或保肝。 ...

Hazel endothelin and extracting method and drug application thereof

The invention relates to a hazel endothelin and an extracting method thereof and a drug application thereof, belonging to new compound and drug application thereof and comprising the following steps: taking corylus heterophylla fisch leaf as raw material, extracting by ethanol, extracting by organic solvent, carrying out gel silica column chromatography, recrystallizing to obtain a new compound with the chemical name of 7, 8, 10-trimethoxy-4, 5-dihydrophenanthro [2,3] dioxolane which is hazel endothelin A for short and the yield is above 0.01%. The hazel endothelin A has wide drug applicationin preparing drugs for treating hyperlipaemia.

Pseudoginsenoside G1 and extraction method and medicinal applications thereof

The invention relates to a pseudoginsenoside G1 and an extraction method and medicinal applications thereof, belonging to a new compound and medicinal applications thereof. The method comprises the following steps: taking Red American ginseng to grind, adding 3-7 times of 70-95% ethanol to heat and reflux for extraction, wherein each extraction requires 2-4 hours and 3-6 times of extractions are needed; mixing the extracting solutions, recovering the solvent till dry; adopting the silica gel column chromatography to treat ethanol extract, wherein the eluent is CHCl3-MeOH and the weight ratio is 80-110:20-40; adopting the C-18 reversed phase column chromatography to treat, wherein the eluent is MeOH-H2O and the weight ratio is 50-70:30-50; and using the mixture of methanol and water in a weight ratio of 1:2-5 to perform crystallization and obtain the pseudoginsenoside G1. The chemical name of the product is 3-O-[beta-D-glucopyranosyl-(1-2)-beta-D-glucopyranosyl]-dammarane-12-one-20S,24R-epoxy ...

Medical composition

The invention relates to a medical composition which belongs to a medical preparation. The medical composition is prepared from 0.01 percent to 10 percent (w/v) of pseudo-ginsenoside GQ and medical-acceptable solution, and the pH value is from 3.0 to 7.0. The invention has the advantages that the whole-body active allergic reaction of the pseudo-ginsenoside GQ injection liquid is negative, and the passive skin allergic test reaction of the pseudo-ginsenoside GQ is negative. The injection liquid is stable and has good clarity. The lyopilization powder is stable.

Natural Scutellaria baicalensis phenolic acid food additive and preparation and application thereof

The invention relates to a natural Scutellaria baicalensis phenolic acid food additive and preparation and an application thereof. The natural food additive is prepared with the method as follows: Scutellaria baicalensis is dried and crushed, is heated and extracted by alkaline solution and is filtered; extract is added with acid, precipitated and rinsed to be neutral; and the obtained product is dried and crushed to obtain the food additive. The natural food additive can be used for antioxidation, anticorrosion and refreshment for various kinds of solid and liquid food. The natural food additive of the invention has no organic solvent residual, has the action of antioxidation, anticorrosion and refreshment and has simple method and low cost.

Dimer (5-methylol-furfural), synthetic method thereof and medical application thereof

The invention relates to dimer (5-methylol-furfural), a synthetic method thereof and medical application thereof, and belongs to a new compound, a synthetic method thereof and medical application thereof. The synthetic method comprises the following steps: dissolving 5-HMF into dimethyl sulfoxide, adjusting the pH to 3.0 to 4.0 by using acid, raising the reaction temperature to between 115 and 125 DEG C under the condition of stirring and heating and refluxing the mixture for 3 hours, then heating and refluxing the mixture for 2 hours at a temperature of 140 DEG C, cooling the mixture, adjusting the pH to 7.0 by using 0.1M alkali liquor, filtering the mixture, and condensing and drying the filtrate to obtain the crude dimer (5-methylol-furfural). The yield reaches more than 70 percent. The dimer (5-methylol-furfural) has wide medical application in preparing immune enhancement medicaments.

Use of total polygalin in preparing medicine for promoting gastrointestinal peristalsis

Ginsenoside R10, extraction method and pharmaceutical use thereof

The invention relates to ginsenoside R10, an extraction method and pharmaceutical use thereof, and belongs to a new compound and the pharmaceutical use thereof. The extraction method comprises the following steps: taking stems and leaves of American ginseng, adding 3-5-fold water, extracting for 2-5 times (3-6 hours each time), merging extracting solutions, decompressing and concentrating, addingCHC13, extracting for 2-5 times, taking a water layer, continuously adding n-BuOH, extracting for 2-5 times, merging a n-BuOH layer, decompressing and concentrating until being dried, dissolving the obtained concentrated solution in propylene glycol with 10-fold volume, hydrolyzing for 12 hours under an alkaline condition (15%) at 180 DEC G, diluting hydrolysate with isometric water, and neutralizing until pH is 7; and adding D101 macroporous adsorbing resin, washing with water, eluting with 70-95% of EtOH, collecting EtOH eluent, recovering a solvent until being dried, carrying out repeated silica ...

simulated moving bed chromatography separation of 20(S) and 20(R)-ginsenoside Rg3 enantiomer

The invention discloses a chromatographic fractionation method used for the simulated moving bed of ginseng saponin Rg3 antimer. In the invention, a simulated moving bed chromatographic system is adopted, fixed phase containing octadecylsilanized silica gel (C18) is adopted, mixture of methyl alcohol and water is adopted for the mobile phase, and high-purity 20(R)-ginseng saponin Rg3 and 20(S)-ginseng saponin Rg3 are separated from the mixture of 20(R)-ginseng saponin and 20(S) ginseng saponin Rg3. Because the chromatographic fractionation of the simulated moving bed is a continuous process, the automaticity of the production of the invention is high, the production efficiency is high, the solvent can be reutilized, and noxious solvent is not contacted during the entire fractionation process.

Medicine composition for regulating blood fat

The invention relates to a medicine composition for regulating blood fat, belonging to the field of medicine. The medicine composition for regulating the blood fat comprises the following compounds by weight percent: 10-35 percent of 3,7-dihydroxy-2,4,6-trimethoxy phenanthrene, 10-35 percent of1-(2,7-dihydroxy-4,6-dimethoxy phenanthrene)-2,7-dihydroxy-4,6-dimethoxy phenanthrene, 10-35 percent of 7-hydroxyl group-2,6-dimethoxy-1,4-phenanthrenequinone, 10-35 percent of kaempferol-3-O-beta-D-glucopyranoside, 10-35 percent of kaempferol-3-O-beta-rutinoside and 10-35 percent of rutin. The invention has the advantages that the ingredients of the medicine composition are all obtained by being extracted and separated from the aboveground part of dioscorea nipponica makino; the medicine composition belongs to natural products and has high capability for regulating the biological activity of the blood fat; and an optimal proportion of ingredients of compositions for treating hyperlipoidemia.

Syringic general saponin extractive and its prepn and medicinal composition

The present ivnention relates to medicine. Lilac leaf is decocted for 2-3 times of 1-3 hr each; the merged decoction is filtered; the filtrate is adsorbed in macro porous resin, water washed to become color-less, and 50-88% ethanol eluted to collect the eluted liquid while recovering ethanol; and the eluted liquid is concentrated and dried to obtain the syringic total saponin extractive. The syringic total saponin extractive is yellow or deep orange bitter powder and accounts for 3-7 wt% of dry lilac leaf. The medicine composition containing syringic total saponin extractive as active component is used in treating hepatosis and protecting liver.

5-methylol-furfural-5-furfural-methanol, preparation method thereof and medical application thereof

The invention relates to 5-methylol-furfural-5-furfural-methanol, a preparation method thereof and medical application thereof, and belongs to a new compound, a preparation method thereof and medical application thereof. 5-methylol-furfural as a raw material is synthesized into the new compound through intermolecular polymerization reaction under the acid condition, the chemical name of the new compound is the 5-methylol-furfural-5-furfural-methanol, and the yield reaches more than 60 percent. The 5-methylol-furfural-5-furfural-methanol has wide medical application in preparing anti-ageing medicaments.

20(R)-pseudoginsenoside F11 as well as extraction method and medical purpose thereof

The invention relates to a 20(R)-pseudoginsenoside F11 as well as an extraction method and a medical purpose thereof, belonging to the field of a new compound and a medical purpose thereof. The preparation method comprises the following steps of: crushing western red ginseng, adding 3-6 times of 70-95% ethanol, heating, refluxing and extracting 3-7 times for 2-4 h every time, mixing extracting solutions and recovering and drying the solvent; repeatedly reacting an ethanol extract with an eluting agent of chcl3-meoh(90-110:15-30) through silica gel column chromatography and with an eluting agent of MeOH-H2O(50-70:30-50) through C-18 reversed-phase column chromatography; recrystallizing ethyl acetate to obtain 20(R)-pseudoginsenoside F11. The invention also discloses application of the 20(R)-pseudoginsenoside F11 to preparing antiarrhythmic medicaments.

Process for extracting ginsenoside Re, and use of medicine thereof

Use of bilobalide B in preparing medicine for promoting nerve cell regenerate

The invention relates to the application of ginkgolide B in the preparation of drugs promoting the regeneration of nerve cell, wherein, the nerve cell is the nerve cell at the positions of brain tissue hippocampus, striaturn and lateral ventricle. The ginkgolide B can penetrate the blood-brain barrier to promote the neural stem cells at the positions of cerebral cortex, the hippocampus and the like to proliferate and be transformed into neuron, thus increasing the number of regenerative cells, so as to achieve the goal of rehabilitating neural damnification and preventing and remedying the disease of cerebral stroke.

Application of gartanin compound in preparing medicaments for treating hyperlipidemia

The invention relates to application of a gartanin compound in preparing medicaments for treating hyperlipidemia. An extracting and preparing method of the gartanin compound comprises the following steps of: pulverizing corylus heferopuylla peels and extracting by using 20-25 percent of 30-95 percent alcohol at the temperature of 30-80 DEG C; recovering the alcohol until no alcohol taste exists; extracting by using ethyl acetate; and obtaining the gartanin compound through methods of silica column chromatography, recrystallization, and the like. The compound is a raw material medicine for novel medicine research, mp is 171-172 DEG C, and the productivity reaches 0.4-0.5 percent. The gartanin compound can be applied to preparing medicaments for treating hyperlipidemia.

Pseudo-ginsenoside G2, extraction method and drug application thereof

The invention relates to a pseudo-ginsenoside G2, an extraction method and a drug application thereof, belonging to a new compound and a drug application thereof. The extraction method comprises the following steps: taking west red ginseng, crushing, adding 70-95% ethanol in an amount of 3-6 times the amount of the red ginseng, heating for backflow extraction, the extraction is carried out 2-4 hours each time and for three times to six times in total, combining the extract, and recovering solvent until no solvent exists; repeatedly leading the ethanol extract to be subjected to silica gel column chromatography with an eluent (CHCL3-MeOH90-110:20-40) as well as C-18 reversed-phase column chromatography with an eluent (MeOH-H2O 50-70:25-40) and performing recrystallization by a solution (methanol-water 2:1-4) to obtain the pseudo-ginsenoside G2. The pseudo-ginsenoside G2 can be applied to preparation of calcium ion antagonist drugs.

Application of acanthopanax fruit extractive in preparing medicament for treating hyperlipoidemia

The invention relates to the application of an acanthopanax fruit extractive in preparing medicament for treating hyperlipoidemia, belonging to the technical field of medicine. An experimentation shows that the acanthopanax fruit extractive has very good function of treating the hyperlipoidemia, therefore, the acanthopanax fruit extractive can be used for preparing medicament for regulating blood fat, health-care products, food additives or compound preparations, and the like, and is mainly used for preparing the medicament for treating the hyperlipoidemia or improving symptoms of the hyperlipoidemia, wherein the medicament or the health-care products include the prior dosage forms, such as a troche, a capsule, a dripping pill, a pilula, a granular formulation, a soft capsule, a syrup, a chewable tablet, a patch, and the like.

simulated moving bed chromatography separation of 20(S) and 20(R)-ginsenoside Rg3 enantiomer

The invention discloses a chromatographic fractionation method used for the simulated moving bed of ginseng saponin Rg3 antimer. In the invention, a simulated moving bed chromatographic system is adopted, fixed phase containing octadecylsilanized silica gel (C18) is adopted, mixture of methyl alcohol and water is adopted for the mobile phase, and high-purity 20(R)-ginseng saponin Rg3 and 20(S)-ginseng saponin Rg3 are separated from the mixture of 20(R)-ginseng saponin and 20(S) ginseng saponin Rg3. Because the chromatographic fractionation of the simulated moving bed is a continuous process, the automaticity of the production of the invention is high, the production efficiency is high, the solvent can be reutilized, and noxious solvent is not contacted during the entire fractionation process.

American ginseng ginsenoside F5ab and extraction method and medicinal application thereof

The invention relates to American Ginseng ginsenoside F5ab and extraction method and medicinal application thereof, and belongs to a novel compound and the medicinal application thereof. The American ginseng as a raw material, is subjected to water extraction, adsorption of macroporous adsorbent resin, silica column chromatography, and recrystalization to form a novel compound which has the chemical name of 3-O-beta-D-glucopyranosyl-(1-2)-beta-D-glucopyranosyl-20-O-beta-D-xylopyranosyl-dammar-25(26)-ene-3beta,12beta,20S,24zeta-tetraol, which is called as American Ginseng ginsenoside F5ab for short. The yield is over 0.01 percent. The American Ginseng ginsenoside F5ab has wide medicinal application to preparing medicaments for treating myocardial ischemia.

Hazelnut element B, extracting method and pharmaceutical use thereof

The present invention relates to a hazelnut element B, an extracting method and a pharmaceutical use thereof. The hazelnut element belongs to a novel compound and the pharmaceutical use. The Corylus heterophylla Fisch.ex Bess leaf is used as a raw material. Through alcohol extraction, organic solvent extraction, silica gel column chromatography and recrystallization process, a novel compound is obtained. The chemical name of the novel compound is 1,3-dihydroxy-5,8-dimethoxy-2,4-bis(3-methylbut-2-enyl)-xanthen-9-one. The novel compound is called as hazelnut element B in short. The production rate is more than 0.01%. The hazelnut element B has a broad pharmaceutical use in preparing the medicine for treating hyperlipemia.

Application of acanthopanax fruit extractive in preparing medicament for treating hyperlipoidemia

The invention relates to the application of an acanthopanax fruit extractive in preparing medicament for treating hyperlipoidemia, belonging to the technical field of medicine. An experimentation shows that the acanthopanax fruit extractive has very good function of treating the hyperlipoidemia, therefore, the acanthopanax fruit extractive can be used for preparing medicament for regulating bloodfat, health-care products, food additives or compound preparations, and the like, and is mainly used for preparing the medicament for treating the hyperlipoidemia or improving symptoms of the hyperlipoidemia, wherein the medicament or the health-care products include the prior dosage forms, such as a troche, a capsule, a dripping pill, a pilula, a granular formulation, a soft capsule, a syrup, a chewable tablet, a patch, and the like.

Medical application of psuedo-ginsenoside F11

The invention belongs to the technical field of medicaments, and in particular relates to novel medical application of psuedo-ginsenoside F11. Experimental study shows that the psuedo-ginsenoside F11 has good functions for treating myocardial ischemia, cerebral ischemia and stroke, so the active ingredient can be used to prepare medicaments for treating cardio-cerebral vascular diseases, health products, food additives or compound preparations and the like. The psuedo-ginsenoside F11 is mainly used to prepare medicaments for treating or improving symptoms of the myocardial ischemia, the cerebral ischemia and the stroke. The medicaments or health products have all the prior preparation formulations such as tablets, capsules, injections, freeze-dried powders, emulsions for injection, powders, dripping pills, pills, granules, soft capsules, syrups, masticatories and patches.

Semi-synthetic method of pseudo-ginsenoside F11

The invention relates to a semi-synthetic method of pseudo-ginsenoside F11. The method adopts ginsenoside Rg2 as raw material and synthesizes the pseudo-ginsenoside F11 compound by the steps of oxidatThe invention relates to a semi-synthetic method of pseudo-ginsenoside F11. The method adopts ginsenoside Rg2 as raw material and synthesizes the pseudo-ginsenoside F11 compound by the steps of oxidation and cyclization and the like under acid condition; and the chemical name thereof is 6-O-Alpha-L-rhamnopyranosyl(1-2)-Beta-D-glucopyranosyl-dammar-20S, 24S-epoxy-3Beta, 6Alpha, 12Beta, 25-tetrahydrion and cyclization and the like under acid condition; and the chemical name thereof is 6-O-Alpha-L-rhamnopyranosyl(1-2)-Beta-D-glucopyranosyl-dammar-20S, 24S-epoxy-3Beta, 6Alpha, 12Beta, 25-tetrahydric alcohol. The method has convenient source of materials, mild reaction condition, simple and convenient operation, high yield and short production period and is suitable for realizing industrial proic ...

5-methylol-furfural-5-furfural-methanol, preparation method thereof and medical application thereof

The invention relates to 5-methylol-furfural-5-furfural-methanol, a preparation method thereof and medical application thereof, and belongs to a new compound, a preparation method thereof and medical application thereof. 5-methylol-furfural as a raw material is synthesized into the new compound through intermolecular polymerization reaction under the acid condition, the chemical name of the new compound is the 5-methylol-furfural-5-furfural-methanol, and the yield reaches more than 60 percent. The 5-methylol-furfural-5-furfural-methanol has wide medical application in preparing anti-ageing medicaments.

Goose gall extract, preparation method and medicine use thereof

The invention relates to a goose gall extract, a preparation method and medicine use thereof, which belong to the field of traditionally Chinese medicine. The preparation method comprises the following steps: taking goose galls; removing gall coats; carrying out filtration; collecting filter liquid; adding 50 to 90 percent edible alcohol to the concentration of 50 to 90 percent; carrying out precipitation for 5 to 48 hours at 2 to 24 DEG C; carrying out filtration; collecting filter liquid to obtain goose bile raw liquid; recovering alcohol; and carrying out concentration and drying to obtain the goose gall extract. The invention also provides the application of the goose gall extract of the invention to the preparation of medicine for clearing away heat and toxic materials, protecting the liver and improving the immunity. The goose bile prepared through the modern extraction technology by the invention has the obvious function of activating and enhancing the reticulo endothelial system ...

Transplanted wild ginseng ginsenoside B as well as extraction method and medical application thereof

The invention relates to a transplanted wild ginseng ginsenoside B as well as an extraction method and medical application thereof, belonging to the medical field. The extraction method comprises the following steps of: crushing a dry transplanted wild ginseng root, heating with ethanol for backflow and extraction, concentrating under reduced pressure, extracting to obtain an n-butyl alcohol part, then separating, purifying to obtain the transplanted wild ginseng ginsenoside B. The transplanted wild ginseng ginsenoside B is applied to preparing medicaments for treating myocardial ischemia, hemorrhagic shock, arrhythmia and reperfusion injury.

(20S,25R)-dammar-20,25-epoxy-3beta,12beta,26,24beta-tetrol and extracting method and medical applications thereof

The invention relates to (20S,25R)-dammar-20,25-epoxy-3beta,12beta,26,24beta-tetrol and an extracting method and medical applications thereof and belongs to the field of medicines. The extracting method includes: smashing red ginseng, adding ethanol having a concentration of 80-90% the volume of which is 3-5 times of the volume of the red ginseng, heating, performing reflux extraction for 3-5 times with each time of the reflux extraction being performed for 2-4 h, combining extraction liquids, recovering the solvent until the extraction product is dry, adding the obtained extraction product to D101 macroporous adsorption resin, washing with water first, eluting with ethanol having a concentration of 85%, collecting ethanol eluate, recovering the solvent in the ethanol eluate until the ethanol eluate is dry, subjecting the obtained extraction product to three times of column chromatography on silica gel with the particle size of the silica gel being 200-400 meshes and an eluant being a mixture ...

Medical application of psuedo-ginsenoside F11

The invention belongs to the technical field of medicaments, and in particular relates to novel medical application of psuedo-ginsenoside F11. Experimental study shows that the psuedo-ginsenoside F11 has good functions for treating myocardial ischemia, cerebral ischemia and stroke, so the active ingredient can be used to prepare medicaments for treating cardio-cerebral vascular diseases, health products, food additives or compound preparations and the like. The psuedo-ginsenoside F11 is mainly used to prepare medicaments for treating or improving symptoms of the myocardial ischemia, the cerebral ischemia and the stroke. The medicaments or health products have all the prior preparation formulations such as tablets, capsules, injections, freeze-dried powders, emulsions for injection, powders, dripping pills, pills, granules, soft capsules, syrups, masticatories and patches.

Ginsenoside R10, extraction method and pharmaceutical use thereof

The invention relates to ginsenoside R10, an extraction method and pharmaceutical use thereof, and belongs to a new compound and the pharmaceutical use thereof. The extraction method comprises the following steps: taking stems and leaves of American ginseng, adding 3-5-fold water, extracting for 2-5 times (3-6 hours each time), merging extracting solutions, decompressing and concentrating, adding CHC13, extracting for 2-5 times, taking a water layer, continuously adding n-BuOH, extracting for 2-5 times, merging a n-BuOH layer, decompressing and concentrating until being dried, dissolving the obtained concentrated solution in propylene glycol with 10-fold volume, hydrolyzing for 12 hours under an alkaline condition (15%) at 180 DEC G, diluting hydrolysate with isometric water, and neutralizing until pH is 7; and adding D101 macroporous adsorbing resin, washing with water, eluting with 70-95% of EtOH, collecting EtOH eluent, recovering a solvent until being dried, carrying out repeated silica ...

Application of pseudo-ginsenoside GQ

The invention belongs to the field of medicines and relates to the application of pseudo-ginsenoside GQ, in particular to the application of the pseudo-ginsenoside GQ in the preparation of medicaments for preventing and treating brain tissue damage caused by local and global cerebral ischemia and the application of the pseudo-ginsenoside GQ in the preparation of medicaments for treating transient ischemic attack, cerebral thrombosis and cerebral infarction. The medicaments prepared by the invention can prevent and treat brain tissue damage caused by local and global cerebral ischemia, reduce cerebral necrosis area, protect cerebral tissues, reduce the generation of malondialdehyde (MDA), retard energy metabolism, improve the hypoxia tolerance ability of the cerebral tissue, and treat transient ischemic attack, cerebral thrombosis and cerebral infarction.

Hazelnut element B, extracting method and pharmaceutical use thereof

The present invention relates to a hazelnut element B, an extracting method and a pharmaceutical use thereof. The hazelnut element belongs to a novel compound and the pharmaceutical use. The Corylus heterophylla Fisch.ex Bess leaf is used as a raw material. Through alcohol extraction, organic solvent extraction, sililca gel column chromatography and recrystallization process, a novel compound is obtained. The chemical name of the novel compound is 1,3-dihydroxy-5,8-dimethoxy-2,4-bis(3-methylbut-2-enyl)-xanthen-9-one. The novel compound is called as hazelnut element B in short. The production rate is more than 0.01%. The hazelnut element B has a broad pharmaceutical use in preparing the medicine for treating hyperlipemia.

人参果三醇组皂苷提取物及其提取、精制方法及其医药用途

A herminium's triolhistisaponine is prepared from herminium herb through extracting its total saponin, and purifying by macroreticular adsorption resin. It can be used for preparing the medicines to treat diabetes B.

Semisynthesizing method for 20(S)-ginsenoside Rg3, and use in medicine

The present invention relates to a semi-synthesis method of 20(S)-ginsenoside Rg3 and its medicinal application. Said invention uses the ginsenoside panaxadiol group as raw mateerial for semi-synthesis, and adopts chemical method, through the processes of semi-synthesis and purification to obtain 20(S)-ginsenoside Rg3 pure product. Said product is special suitable for preparing the medicines for curing cancer of lung, melanoma, S180 sarcoma, carcinoma of colon and antivirotic.

Process for extracting ginsenoside Re, and use of medicine thereof

The present invention relates to an extraction process of ginsenoside Re and its new medicinal application. It is characterized by using a new macroporous polymeric adsorbent AB-8 type, its method issimple, has no need of repeated extraction, and its ginsenoside Re yield is high,can be up to 4.0%. Said invented ginsenoside Re can be extensively used for preparing medicines for curing arrhythmia,myocardial ischemia and injury due to reperfusion.

Pseudo gensenoside Pgq and its semi synthesis and medicinal use

Semisynthesizing method for 20(S)-ginsenoside Rg3, and use thereof in medicine

Semi-synthetic method of pseudo-ginsenoside F11

The invention relates to a semi-synthetic method of pseudo-ginsenoside F11. The method adopts ginsenoside Rg2 as raw material and synthesizes the pseudo-ginsenoside F11 compound by the steps of oxidation and cyclization and the like under acid condition; and the chemical name thereof is 6-O-Alpha-L-rhamnopyranosyl(1-2)-Beta-D-glucopyranosyl-dammar-20S, 24S-epoxy-3Beta, 6Alpha, 12Beta, 25-tetrahydric alcohol. The method has convenient source of materials, mild reaction condition, simple and convenient operation, high yield and short production period and is suitable for realizing industrial production.

Application of 20(S)-ginsenoside Rg3 in preparation of medicines for treating non-small cell lung cancer

The invention relates to medicine application of 20(S)-ginsenoside Rg3, in particular to application of 20(S)-ginsenoside Rg3 in preparation of medicines for treating a non-small cell lung cancer. In the invention, selecting a human non-small cell lung cancer cell strain (A549 lung adenocarcinoma, H460 large cell lung cancer and LTEP-78 lung squamous carcinoma) to be inoculated under the skin of a naked mouse, and observing the influence of the SPG-Rg3 on the non-small cell lung cancer; and carrying out CD34 immunohistochemistry staining and TUNEL immunofluorescence staining on tumor tissues,and observing the influence of the SPG-Rg3 on tumor angiogenesis and apoptosis. The inclusion proves that the 20(S)-ginsenoside Rg3 can remarkably inhibit the growth of the non-small cell lung cancer, has the action mechanism related with the promotion of the tumor apoptosis and the inhibition of the tumor angiogenesis and unobvious cooperation action when being combined with cyclophosphamide forapplication ...

Use of total polygalin in preparing medicine for promoting gastrointestinal peristalsis

The present invention relates to application of general polygalin in preparing medicine for promoting gastrointestinal peristalsis. Pharmacological experiment shows that general polygalin has the excellent function of promoting gastrointestinal peristalsis and may be used in treating diseases caused by bad gastrointestinal peristalsis and no toxic side effect. The present invention expands the application range of polygala root medicine material. The general polygalin is used as the active component and is mixed with medicine supplementary material including excipient, solvent, disintegratingagent, adhesive, solubilizing agent, preservative, etc to prepare proper clinical preparation.

Application of mangosteen rind extract in preparing medicament for treating myocardial ischemia

The invention discloses an application of a mangosteen pericarp extraction in preparing medicines for the anti-myocardial ischemia, the coronary heart disease treatment and the angina pectoris treatment. The mangosteen pericarp is smashed and then extracted by 30 to 95 percent of ethanol which is recovered to obtain a raw material medicine used in the new herbal-drug research. The mangosteen pericarp extraction extracted and purified by the invention has the effects on the anti-myocardial ischemia, the coronary heart disease treatment and angina pectoris treatment.

人参皂甙Re作为制备治疗记忆障碍的药物中的应用

An application of ginsenoside in preparing the medicines for treating the dysmnesia caused by chemical medicine, natural sanility and A beta is disclosed. Its advantage is high curative effect.

Girald daphne bark leaf extract and medicinal application thereof

The invention relates to a girald daphne bark leaf extract and medicinal application thereof, which belong to the field of medicaments. The girald daphne bark leaf extract is prepared by the following steps of: performing reflux and extraction on girald daphne bark leaves for three times by using 60 to 90 percent ethanol in an amount which is 5 to 20 times that of the girald daphne bark leaves, wherein the extraction time of each time is 2.0 hours; recovering the ethanol from extracting solution until relative density is 1.1 to 1.2; adding an appropriate amount of water for dispersion; performing standing and filtering; loading the extracting solution onto a macroporous absorption resin column for absorption; performing elution with the water until the solution is colorless; performing elution with 40 to 90 percent ethanol; concentrating the eluent; and drying the concentrated eluent. The girald daphne bark leaf extract is applied to the preparation of medicaments for treating arthritis ...

20（S）-人参皂苷Rg#-[2]的半合成方法

The present invention relates to a semisynthesis method of 20(s)-ginsenoside Rgz. It includes the following steps: dissolving the raw material ginsenoside Re in 20-30% ethyl alcohol aqueous solution with 0.01-0.05 MHCl, heating for 2-3 hr, in water bach with 70-80 deg.c, cooling, making said solution pass through anion exchange resin, removing acid and collecting effluent, recovering solvent to obtain ginsenoside Rgz crude product, then using methyl alcohol-ethyl acetate to make said crude product be repeatedly recrystallized to make purification or making said crude product undergo the process of silica-gel column chromatographic treatment and using chloroform-methyl alcohol-water as eluent, collecting ginsenoside Rg2 portion.

Use of bilobalide B in preparing medicine for promoting nerve cell regenerate

The invention relates to the application of ginkgolide B in the preparation of drugs promoting the regeneration of nerve cell, wherein, the nerve cell is the nerve cell at the positions of brain tissue hippocampus, striaturn and lateral ventricle. The ginkgolide B can penetrate the blood-brain barrier to promote the neural stem cells at the positions of cerebral cortex, the hippocampus and the like to proliferate and be transformed into neuron, thus increasing the number of regenerative cells, so as to achieve the goal of rehabilitating neural damnification and preventing and remedying the disease of cerebral stroke.

Preparation method of 24(R)-ocotillol DQ and pharmacal application thereof

The invention relates to a preparation method of 24(R)-ocotillol DQ and pharmacal application thereof, belonging to the field of medicines. The preparation method comprises the following steps of: taking 1.0kg of ginsenoside, and adding water for dissolving; adding the dissolved ginsenoside onto a processed macroporous adsorption resin column; eluting with 35-55 percent alcohol until no saponin reacts, and then eluting with 60-90 percent alcohol; after the eluent is evaporated to dryness, adding sodium hydroxide for hydrolyzing, and regulating the pH of a hydrolysate to neutrality; adding the hydrolysate onto a macroporous adsorption resin column AB-8, desalting, and then eluting with 60-90 percent alcohol; and after the eluent is evaporated to dryness, oxidizing and recrystallizing to obtain a product. The invention can be applied to preparing medicaments for preventing and treating brain tissue damages caused by local and global brain ischemia, treating transient ischemic attacks, cerebral ...

Rosa davurica total flavone extract, its extracting method and its medical use

The invention provides a rosa davurica total flavone extract, its extracting method and its medical use, and relates to a traditional Chinese medicine extract in effective medical parts, an extracting method thereof and the medical use thereof. The invention comprises the following steps: drying and crushing traditional Chinese medicine rosa davurica and performing a heat backflow extraction by 65% to 75% of ethanol, putting an extraction solution into 30 to 60 meshes of polyamide column, washing to colorless and eluting with ethanol of the concentration of 65 to 75 %, collecting an eluent and recovering ethanol to obtain raw material medicines used for the research of new medicines of traditional Chinese medicine. According to the invention, the total flavone content in the extract detected by using an UV spectrophotometry method is more than 50%. The rosa davurica total flavone extract which is extracted and purified by the invention has the functions of treating coronary heart diseases ...

Transplanted wild ginseng ginsenoside B as well as extraction method and medical application thereof

Application of 20(S)-ginsenoside Rg3 in preparation of medicines for treating non-small cell lung cancer

The invention relates to medicine application of 20(S)-ginsenoside Rg3, in particular to application of 20(S)-ginsenoside Rg3 in preparation of medicines for treating a non-small cell lung cancer. In the invention, selecting a human non-small cell lung cancer cell strain (A549 lung adenocarcinoma, H460 large cell lung cancer and LTEP-78 lung squamous carcinoma) to be inoculated under the skin of a naked mouse, and observing the influence of the SPG-Rg3 on the non-small cell lung cancer; and carrying out CD34 immunohistochemistry staining and TUNEL immunofluorescence staining on tumor tissues, and observing the influence of the SPG-Rg3 on tumor angiogenesis and apoptosis. The inclusion proves that the 20(S)-ginsenoside Rg3 can remarkably inhibit the growth of the non-small cell lung cancer, has the action mechanism related with the promotion of the tumor apoptosis and the inhibition of the tumor angiogenesis and unobvious cooperation action when being combined with cyclophosphamide for application ...