17-12-2014 дата публикации
Номер: CN104208072A
Принадлежит:
A provided megestrol acetate hot-melt extrusion preparation is composed of the following compositions in percent by mass: 5%-80% of megestrol acetate, 0.5%-16% of a surfactant, 5%-80% of a dispersing carrier, and 0.5%-24% of a plasticizer. The invention also provides a preparation method. The preparation method comprises performing mixing, fusion, mixing, extruding and crushing to obtain medicine particles, and finally preparing a capsule or a tablet. The solubility of megestrol acetate in water is increased, the bioavailability of megestrol acetate is improved, and thus relatively great clinical application value is provided. The method comprises the following advantages that 1, the method does not need solvents and water, is less in steps and avoids a drying step; 2, the method does not have pressable requirement on the main medicine, is simple, coherent and efficient in technological process; and 3, mixing and stirring in the processing process enable raw materials to be dispersed in ...
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