Preparation method of moxifloxacin hydrochloride preparation

The invention discloses a preparation method of a moxifloxacin hydrochloride preparation, which comprises the following steps: adding moxifloxacin hydrochloride into water for injection, stirring until the moxifloxacin hydrochloride is dissolved, adding a sodium hydroxide solution to adjust the pH value, heating and stirring until the moxifloxacin hydrochloride is dissolved; and adding sodium chloride, fixing the volume, and sequentially cooling, filling, plugging and sterilizing to obtain the moxifloxacin hydrochloride preparation. The preparation volume can be reduced, the administration time is shortened, direct intravenous injection can be realized, and the cost is reduced.

Tartaric acid rogridone dispersing tablet and preparation method thereof

The invention discloses a tartaric acid rogridone dispersing tablet for curing II type diabetes mellitus and a preparation method thereof. The water-solubility of the tartaric acid rogridone is inferior, the absorption thereof is slow after taking orally, the bioavailability is low and no tartaric acid rogridone dispersing tablet is marketed at home and abroad. The tartaric acid rogridone dispersing tablet of the invention is prepared by using 0.5 to 15% of tartaric acid rogridone, 10 to 90% of filler, 1 to 10% of disintegrating agent, 0.1 to 30% of adhesive and 0.5 to 6% of lubricating agent. The invention not only widens the dosage form scope of the tartaric acid rogridone but also can rapidly disintegrate the dispersing tablet, quickly absorb and promote the bioavailability and blood concentration so as to promote the curative effect of the drug and conveniently take.

Clopidogrel hydrogen sulfate tablet and preparation method thereof

The invention relates to a clopidogrel hydrogen sulfate tablet and a preparation method thereof. Clopidogrel is more easily converted into clopidogrel acid and a clopidogrel dextroisomer is more easily converted into a levoisomer in the prior clopidogrel hydrogen sulfate tablet. The clopidogrel hydrogen sulfate tablet takes clopidogrel hydrogen sulfate as a main medicine and is matched with filling agent, disintegrant, flow agent and lubricant, and a mixture with the weight percent of 0.05-5 of one or two of vitamin C and butylated hydroxyanisole are added into the clopidogrel hydrogen sulfate tablet. The vitamin C and/or the butylated hydroxyanisole can well inhibit the clopidogrel from being converted into the clopidogrel acid and inhibit the clopidogrel dextroisomer from being converted into the levoisomer, thereby improving the stability of the clopidogrel hydrogen sulfate tablet and the safety and the effectiveness of clinical medicines.

Clopidogrel hydrogen sulfate tablet and preparation method thereof

Preparation method of praklutamide intermediate 2-(3-(5-nitropyridine-2-yl) propyl) oxazole

The invention discloses a preparation method of a proklutamide intermediate 2-(3-(5-nitropyridine-2-yl) propyl) oxazole, which comprises the following steps: by taking 4-(5-nitropyridine-2-yl) butyramide as a raw material, forming an oxazole ring with vinylene carbonate under the action of an Eaton reagent, adding water for quenching after the reaction is finished, filtering, washing, and drying to obtain the proklutamide intermediate 2-(3-(5-nitropyridine-2-yl) propyl) oxazole. And extracting by using an organic solvent to obtain the praklutamide intermediate 2-(3-(5-nitropyridine-2-yl) propyl) oxazole. The Eaton reagent is adopted to replace PPA (polyphosphoric acid), the problem that a reaction system is thick and is not beneficial to stirring is solved, the amount of acid wastewater generated by quenching reaction is reduced, and pollution to the environment is reduced.

Preparation method and application of gentiana macrophylla extract

The invention discloses a preparation method and application of a gentiana macrophylla extract, and the preparation method of the gentiana macrophylla extract comprises the following steps: cutting gentiana macrophylla, adding into an extraction tank, adding purified water, boiling, extracting for three times, collecting an extracting solution, passing the extracting solution through a macroporous resin column, collecting a target product, concentrating the obtained target product into thick paste, adding silica gel, mixing, and drying to obtain the gentiana macrophylla extract. And filtering by using a 80-mesh sieve, filtering by using a silica gel column, eluting by using an eluent, collecting the extract, concentrating to obtain a concentrated solution, finely washing, standing for crystallization, and finally drying to obtain the single extract. The preparation method is simple, and the obtained extract is a single component, can be used for preparing solid medicines and can also be ...