New method for inhibiting synthesis of liver fat and preventing and treating fatty liver

Zinc finger protein ZBTB20 in chondrocyte-specific knockout mouse model and application thereof

The invention relates to a ZBTB20 in a chondrocyte-specific knockout mouse model and application thereof, belonging to the technical field of genes, in particular to a function and an application of a zinc finger protein. The invention discloses the application of the zinc finger protein ZBTB20 in the preparation of a combination for promoting or inhibiting the proliferation of chondrocytes of mammals. The invention also discloses a method for screening the combination for promoting or inhibiting the proliferation of the chondrocytes of the mammals based on the zinc finger protein ZBTB20 used as a target point. The invention first points out the importance of the zinc finger protein ZBTB20 in the aspect of adjusting the proliferation of the chondrocytes, thereby providing an effective target point for the research on diseases related to cartilage growth.

New method for inhibiting synthesis of liver fat and preventing and treating fatty liver

The invention discloses the use of zinc finger protein ZBTB20 for preparing a compound capable of inhibiting the synthesis of fat in the liver of mammal. The invention further discloses a method for filtering an efficient substance that inhibits the synthesis of fat in the liver of mammal based by taking the zinc finger protein ZBTB20 as a target point. The new method for controlling synthesis of liver fat and preventing and treating fatty liver firstly reveals the important functions of the zinc finger protein ZBTB20 in regulating the synthesis of liver cell fat, and thus providing an efficient target point for the research on medicaments preventing fatty liver.