08-12-2010 дата публикации
Номер: CN0101386676B
Автор:
YAN YONGGANG,
LU GUOYU,
LI HONG,
NAN JINGTIAN,
YANG JIE,
LUO XIAOMAN,
YANG AIPING,
YONGGANG YAN,
GUOYU LU,
HONG LI,
JINGTIAN NAN,
JIE YANG,
XIAOMAN LUO,
AIPING YANG
Принадлежит:
The invention relates to a polyacyl adenine compound and a preparation method thereof. The structure of the compound is shown in formula (I), wherein Ar represents 1,4- diphenyl, 1,3- diphenyl, biphenyl ether-4, 4'-diphenyl, and biphenyl sulfone-4, 4'-diphenyl. The method comprises the following steps: taking one of anhydrous calcium chloride and anhydrous lithium chloride as a catalyst and inertgas for protection, adding corresponding aroma diacid chloride to adenine solution dissolved in an amide polarity aprotic solvent under the condition of sufficient mixing and at a temperature of between 5 DEG C below and 5 DEG C, carrying out neutralization reaction with dried aprotic amines to generate chlorine hydride, and then obtaining the polyacyl adenine product after continuous reaction atthe temperature increased to between 60 and 80 DEG C. The polyacyl adenine compound has the properties of high temperature resistance, biosafety, innocuity, degradability under certain conditions, and the ...
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