16-05-2019 дата публикации
Номер: US20190142834A1
Автор:
Biannic Berenger,
Han Xinping,
Hu Dennis X.,
KETCHAM John Michael,
Leger Paul Robert,
Maung Jack,
Okano Akinori,
Schwarz Jacob Bradley,
Shibuya Grant,
Wustrow David Juergen,
Young Kyle
Принадлежит:
Disclosed herein, inter alia, compounds and methods of use thereof for the modulation of USP7 activity. 4. The compound of claim 1 , wherein Lis an unsubstituted C-Calkylene or a bond.56.-. (canceled)10. The compound of claim 7 , wherein Lis a substituted C-Calkylene claim 7 , an unsubstituted C-Calkylene claim 7 , or a bond.1112.-. (canceled)14. The compound of claim 13 , wherein:{'sup': '2', 'Ris hydrogen;'}{'sup': '3', 'sub': 1', '8, 'Ris substituted or unsubstituted C-Calkyl, halogen, or CN;'}{'sup': '4', 'Ris hydrogen or halogen;'}{'sup': '5', 'sub': 1', '8', '3', '8, 'Ris substituted or unsubstituted C-Calkyl, unsubstituted C-Ccycloalkyl, halogen or CN; and'}{'sup': '6', 'sub': 1', '8', '3', '8', '6, 'Ris independently halogen, substituted or unsubstituted C-Calkyl, unsubstituted C-Ccycloalkyl, unsubstituted 3 to 7 membered heterocycloalkyl, unsubstituted Caryl, or unsubstituted 5 to 6 membered heteroaryl.'}1531.-. (canceled)32. The compound of claim 1 , wherein Ris hydroxyl-substituted methyl claim 1 , hydroxyl-substituted ethyl claim 1 , or hydroxyl-substituted propyl.33. The compound of claim 32 , wherein Ris methyl substituted with —NH—SOCHor ethyl substituted with —NH—SOCH.34. The compound of claim 32 , wherein Ris methyl substituted with —NH—C(O)CHor ethyl substituted with —NH—C(O)CH.35. The compound of claim 13 , wherein:{'sup': 7', '7, 'sub': 3', '8, 'claim-text': [{'sup': 7', '8', '8', '8', '8', '8', '8, 'sub': 3', '3', '3', '3', '2', '2', '2', '2', '2', '2', '2', '2', '3', '2', '2', '2', '3', '3', '4', '2', '2', '2', '2', '2', '2', '3', '3', '3', '3', '2', '2', '2', '2', '2', '2', '2', '2', '1', '8', '3', '8', '6, 'Ris independently halogen, —CF, —CCl, —CBr, —CI, —CHF, —CHCl, —CHBr, —CHI, —CHF, —CHCl, —CHBr, —CHI, —CN, —N, —OH, —NH, —COOH, —CONH, —NO, —N, —SH, —SOH, —SOH, —SONH, —NHNH, —ONH, —NHC(O)NHNH, —NHSOH, —NHC(O)H, —NHC(O)—OH, —NHOH, —OCF, —OCCl, —OCBr, OCI, —OCHF, —OCHCl, —OCHBr, —OCHI, —OCHF, —OCHCl, —OCHBr, —OCHI, R-substituted or ...
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