INTERACTIVE DOSE MANIPULATION USING PRIORITIZED CONSTRAINTS

In a method of interactive manipulation of the dose distribution of a radiation treatment plan, after an initial candidate treatment plan has been obtained, a set of clinical goals are transferred into a set of constraints. Each constraint may be expressed in terms of a threshold value for a respective quality index of the dose distribution. The dose distribution can then be modified interactively by modifying the threshold values for the set of constraints. Re-optimization may be performed based on the modified threshold values. A user may assign relative priorities among the set of constraints. When a certain constraint is modified, a re-optimized treatment plan may not violate those constraints that have priorities that are higher than that of the modified constraint, but may violate those constraints that have priorities that are lower than that of the modified constraint. 1. A computer product comprising a non-transitory computer readable medium storing a plurality of instructions that when executed control a computer system to allow interactive manipulation of dose distribution of a radiation treatment plan using an external-beam radiation treatment system , the instructions comprising:obtaining, by the computer system, an initial radiation treatment plan, the initial radiation treatment plan producing an initial dose distribution that satisfies a plurality of clinical goals, wherein the plurality of clinical goals are expressed in terms of a plurality of initial threshold values for a plurality of quality indexes, each respective quality index relating to a respective statistical quantity of the initial dose distribution;converting, by the computer system, the plurality of clinical goals into a plurality of constraints relating to the plurality of quality indexes, each constraint having a respective initial reference value corresponding to the initial threshold value of the respective quality index, each respective constraint having a corresponding priority ...

Systems, methods and devices for automated target volume generation

Systems and method for automatically generating structures, such as target volumes, in a treatment image using structure-guided deformation to propagate the structures from a planning image onto the subsequently acquired treatment image.

Systems, methods and devices for automated target volume generation

Systems and method for automatically generating structures, such as target volumes, in a treatment image using structure-guided deformation to propagate the structures from a planning image onto the subsequently acquired treatment image.

DEFORMABLE IMAGE REGISTRATION BASED ON AN IMAGE MASK

In accordance with at least some embodiments of the present disclosure, a process to improve computed tomography (CT) to cone beam computed tomography (CBCT) registration is disclosed. The process may include receiving a CT image generated by CT-scanning of an object, and receiving a CBCT image generated by CBCT-scanning of the object. The process may include generating an image mask based on Digital Imaging and Communications in Medicine (DICOM) information extracted from the CBCT image. For a specific pixel in the CBCT image, the image mask contains a corresponding data-field indicating whether the specific pixel contains image data generated based on the CBCT-scanning of the object. The process may further include generating a registered image by utilizing the image mask to perform a DIR between the CT image and the CBCT image. 1. A method , comprising:receiving a two-dimensional (2D) computed tomography (CT) image of an object;receiving a 2D cone beam computed tomography (CBCT) image of the object;generating an image mask based on the 2D CBCT image, wherein for a specific pixel in the 2D CBCT image, the image mask contains a corresponding data-field indicating whether the specific pixel contains valid image data that are generated based on CBCT-scanning of the object; andperforming a deformable image registration (DIR) operation to generate a registered image based on the image mask, the 2D CT image, and the 2D CBCT image.2. The method as recited in claim 1 , further comprising:performing a dose estimation or a contour propagation on the object based on the registered image.3. The method as recited in claim 1 , further comprising:extracting information associated with an illuminated region from the 2D CBCT image.4. The method as recited in claim 3 , wherein the generating of the image mask further comprises:generating a reconstruction area for the 2D CBCT image based on the information associated with the illuminated region; andassigning a data value to the ...

Streamlined, guided on-couch adaptive workflow

Systems and methods for implementing an adaptive therapy workflow that minimizes time needed to create a session patient model, select an appropriate plan for the treatment session, and treat the patient.

INTERACTIVE DOSE MANIPULATION USING PRIORITIZED CONSTRAINTS

In a method of interactive manipulation of the dose distribution of a radiation treatment plan, after an initial candidate treatment plan has been obtained, a set of clinical goals are transferred into a set of constraints. Each constraint may be expressed in terms of a threshold value for a respective quality index of the dose distribution. The dose distribution can then be modified interactively by modifying the threshold values for the set of constraints. Re-optimization may be performed based on the modified threshold values. A user may assign relative priorities among the set of constraints. When a certain constraint is modified, a re-optimized treatment plan may not violate those constraints that have priorities that are higher than that of the modified constraint, but may violate those constraints that have priorities that are lower than that of the modified constraint. 1. A method for interactively manipulating dose distribution of a radiation treatment plan using an external-beam radiation treatment system , the method comprising:obtaining, by a computer system, an initial radiation treatment plan, the initial radiation treatment plan producing an initial dose distribution that satisfies a plurality of clinical goals, wherein the plurality of clinical goals are expressed in terms of a plurality of initial threshold values for a plurality of quality indexes, each quality index relating to a respective statistical quantity of the initial dose distribution;converting, by the computer system, the plurality of clinical goals into a plurality of constraints relating to the plurality of quality indexes, each constraint having a respective initial reference value corresponding to the initial threshold value of the respective quality index, each respective constraint having a corresponding priority indicating relative importance of the respective constraint among the plurality of constraints;providing a user interface to a user, the user interface allowing the user ...

DEFORMABLE IMAGE REGISTRATION WITH AWARENESS OF COMPUTED TOMOGRAPHY (CT) RECONSTRUCTION AREA

In accordance with at least some embodiments of the present disclosure, a process to improve computed tomography (CT) to cone beam computed tomography (CBCT) registration is disclosed. The process may include receiving a CT image generated by CT-scanning of an object, and receiving a CBCT image generated by CBCT-scanning of the object. The process may include generating an image mask based on Digital Imaging and Communications in Medicine (DICOM) information extracted from the CBCT image. For a specific pixel in the CBCT image, the image mask contains a corresponding data-field indicating whether the specific pixel contains image data generated based on the CBCT-scanning of the object. The process may further include generating a registered image by utilizing the image mask to perform a DIR between the CT image and the CBCT image. 1. A method to improve computed tomography (CT) to cone beam computed tomography (CBCT) registration , comprising:receiving, by a deformable image registration (DIR) system, a CT image generated by CT-scanning of an object;receiving, by the DIR system, a CBCT image generated by CBCT-scanning of the object;generating, by the DIR system, an image mask based on Digital Imaging and Communications in Medicine (DICOM) information extracted from the CBCT image, wherein for a specific pixel in the CBCT image, the image mask contains a corresponding data-field indicating whether the specific pixel contains image data generated based on the CBCT-scanning of the object; andgenerating, by the DIR system, a registered image by utilizing the image mask to perform a DIR between the CT image and the CBCT image.2. The method as recited in claim 1 , further comprising:performing an automatic dose estimation or a contour propagation on the object based on the registered image.3. The method as recited in claim 1 , wherein the DICOM information further comprises DICOM Target Center and DICOM Reconstruction Diameter.4. The method as recited in claim 3 , wherein ...

Streamlined, guided on-couch adaptive workflow

Systems and methods for implementing an adaptive therapy workflow that minimizes time needed to create a session patient model, select an appropriate plan for the treatment session, and treat the patient.

Deformable image registration based on masked computed tomography (CT) image

In accordance with at least some embodiments of the present disclosure, a process to improve computed tomography (CT) to cone beam computed tomography (CBCT) registration is disclosed. The process may include receiving a CT image generated by CT-scanning of an object, and receiving a CBCT image generated by CBCT-scanning of the object. The process may include generating an image mask based on Digital Imaging and Communications in Medicine (DICOM) information extracted from the CBCT image. For a specific pixel in the CBCT image, the image mask contains a corresponding data-field indicating whether the specific pixel contains image data generated based on the CBCT-scanning of the object. The process may further include generating a registered image by utilizing the image mask to perform a DIR between the CT image and the CBCT image.

Determining a radiation treatment plan for delivering radiation to a patient using an external-beam radiation treatment system

Streamlined, guided on-couch adaptive workflow

Systems and methods for implementing an adaptive therapy workflow that minimizes time needed to create a session patient model, select an appropriate plan for the treatment session, and treat the patient.

Streamlined, guided on-couch adaptive workflow

Systems and methods for implementing an adaptive therapy workflow that minimizes time needed to create a session patient model, select an appropriate plan for the treatment session, and treat the patient.

Interactive dose manipulation using prioritized constraints

Systems, methods and devices for automated target volume generation

Systems and method for automatically generating structures, such as target volumes, in a treatment image using structure-guided deformation to propagate the structures from a planning image onto the subsequently acquired treatment image.

Streamlined, guided on-couch adaptive workflow

Systems and methods for implementing an adaptive therapy workflow that minimizes time needed to create a session patient model, select an appropriate plan for the treatment session, and treat the patient.

Determining a radiation treatment plan for delivering radiation to a patient using an external-beam radiation treatment system

A method of determining a radiation treatment plan for delivering radiation to a patient using an external-beam radiation treatment system is described. A first clinical goal and a second clinical goal are received, wherein the first clinical goal includes a first acceptable threshold value and a first desired threshold value for a first quality index relating to a first statistical quantity of a dose distribution, and the second clinical goal includes a second acceptable threshold value and a second desired threshold value for a second quality index relating to a second statistical quantity of the dose distribution. A cost function is obtained which includes a first term with a first weight and a second term with a second weight, wherein the first term is proportional to a value of the first quality index in excess of the first acceptable threshold value, and the second term is proportional to a value of the second quality index in excess of the second acceptable threshold value, and wherein the first weight is inversely proportional to a difference between the first desired threshold value and the first acceptable threshold value, and the second weight is inversely proportional to a difference between the second desired threshold value and the second acceptable threshold value. Optimization then uses the cost function to obtain an optimal radiation treatment plan having an optimal value for the cost function.

Interactive dose manipulation using prioritized constraints

In a method of interactive manipulation of the dose distribution of a radiation treatment plan, after an initial candidate treatment plan has been obtained, a set of clinical goals are transferred into a set of constraints. Each constraint may be expressed in terms of a threshold value for a respective quality index of the dose distribution. The dose distribution can then be modified interactively by modifying the threshold values for the set of constraints. Re-optimization may be performed based on the modified threshold values. A user may assign relative priorities among the set of constraints. When a certain constraint is modified, a re-optimized treatment plan may not violate those constraints that have priorities that are higher than that of the modified constraint, but may violate those constraints that have priorities that are lower than that of the modified constraint.

Systems, methods and devices for automated target volume generation

Systems and method for automatically generating structures, such as target volumes, in a treatment image using structure-guided deformation to propagate the structures from a planning image onto the subsequently acquired treatment image.

Streamlined, guided on-couch adaptive workflow

Systems and methods for implementing an adaptive therapy workflow that minimizes time needed to create a session patient model, select an appropriate plan for the treatment session, and treat the patient.

Systems, methods and devices for automated target volume generation

Systems and method for automatically generating structures, such as target volumes, in a treatment image using structure-guided deformation to propagate the structures from a planning image onto the subsequently acquired treatment image.