26-10-2011 дата публикации
Номер: CN102225935A
Принадлежит:
The invention discloses a manufacturing method of proPiconazole. The manufacturing method comprises that 2,4-dichloroacetophenone and 1,2-pentanediol undergo a cyclization reaction, and then bromine and the reaction products of the cyclization reaction undergo a bromination reaction to form 2-bromomethyl-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolane. The manufacturing method is characterized in that solid heteropolyacid catalysts are utilized in the cyclization reaction, and are filtered and recycled after the cyclization reaction is finished; then the bromination reaction is caused and the 2-bromomethyl-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolane, 1,2,4-triazole and potassium carbonate undergo a condensation reaction to form the proPiconazole after the bromination reaction is finished. Through the manufacturing method, new impurities which can be introduced because catalysts take part in a bromination reaction are reduced. In the invention, because a potassium triazole preparation process ...
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