08-07-1970 дата публикации
Номер: GB0001198005A
1,198,005. Foetal extracts; cosmetic compositions. L'OREAL. 25 March, 1968 [24 March, 1967], No. 14305/68. Heading A5B. Cutaneous teguments and/or tissues of the umbilical cord are removed from bovine or ovine foetuses and an active product is extracted therefrom with an aqueous ion-containing solution at a temperature not exceeding 4‹C., the resultant solution optionally being digested with a proteolytic enzyme e.g. pronase, papain, pepsin or trypsin, without delipidation, and the active product being recovered from the solution. The ion-containing solution may be an aqueous solution of neutral salts such as NaCl, KCl, LiCl, CaCl 2 and MgCl 2 ; acid salts such as K or Na phosphates or citrates; acids such as HCl, H 2 SO 4 and acetic acid; bases such as K, Na, NH 4 , Ca or Ba hydroxides; or of ionisable organic compounds such as urea or phenol. Preferably the foetal tissues are frozen and ground in the ion-containing solution which is then centrifuged, and the supernatant liquid containing the active product is separated by dialysis with distilled water, or by precipitation by the addition of absolute alcohol, then a mixture of alcohol and ether and then ether, the alcohol preferably containing K, Na, Ca, Ba or Zn acetate. Any mucosaccharides present in the supernatant liquid after centrifuging may be precipitated by addition of phosphotungstic acid. Cosmetic compositions for combatting falling out of hair comprise the active product and a cosmetic carrier or excipient and may be in the form of aqueous solutions, emulsions, creams or gels. The compositions may also comprise a dye, perfume, penetrating agent, emulsifying agent, anti-seborrhoeic agent, a known substance for combatting the falling out of hair and/or a preservative e.g. sodium merthiolate, hexachlorophene or an oxidised derivative of a benzoate. Methionine, vitamin E, inositol, salicyclic acid, lactic acid, allantoin and/or choline or its citrate may be present in the compositions.
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