23-04-2020 дата публикации
Номер: US20200123158A1
Принадлежит:
The present invention relates to novel compounds and pharmaceutically acceptable salts or solvates thereof which have activity as inhibitors of growth. The invention also relates to pharmaceutical compositions comprising such compounds, salts or solvates and to the use of such compounds as medicaments, in particular in the treatment or prevention of schistosomiasis, also known as bilharzia. 2. A compound according to claim 1 , wherein Ris methyl claim 1 , ethyl claim 1 , n-propyl claim 1 , isopropyl claim 1 , cyclopropyl optionally substituted with one methyl group claim 1 , cyclobutyl claim 1 , cyclopropylmethyl claim 1 , CHF claim 1 , CFor CHCF.3. A compound according to claim 2 , wherein Ris ethyl claim 2 , isopropyl claim 2 , cyclopropyl claim 2 , cyclobutyl claim 2 , CFor CHCF.4. A compound according to wherein Ris H claim 1 , F or Cl.5. A compound according to claim 4 , wherein Ris F or Cl.6. A compound according to wherein Ris H claim 1 , OH claim 1 , OMe or OPO(OH)OH.7. A compound according to claim 6 , wherein Ris H.8. A compound according to wherein Ris H claim 1 , OH claim 1 , OMe or OPO(OH)OH.9. A compound according to claim 8 , wherein Ris OH.11. A compound according to wherein Ris H or OMe.12. A compound according to claim 11 , wherein Ris H.13. A compound according to wherein Ris H or F.14. A compound according to wherein X is C—Rwherein Ris H or F.15. A compound according to wherein Ris CF claim 1 , CFCF claim 1 , CHCF claim 1 , CH(CH) claim 1 , OCF claim 1 , OCH(CH) claim 1 , cyclopropyl claim 1 , cyclobutyl or SF.1820-. (canceled)21. A method for treating schistosomiasis comprising administering a therapeutically effective amount of a compound according to to a patient in need thereof.22. A pharmaceutical composition comprising (i) a therapeutically effective amount of a compound according to ; and (ii) a pharmaceutically acceptable excipient. This invention relates to compounds of formula (1a), (1b), (1c) and (1d) and pharmaceutically acceptable ...
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