05-11-2014 дата публикации
Номер: CN104127425A
Принадлежит:
The invention discloses an application of gastrodin for preventing and treating osteoporosis, gastrodin has nontoxic effect to osteoblast precursor cells, and has no influence on cell proliferation; gastrodin has protection effect on apoptosis of MC3T3-E1 caused by hydrogen peroxide; improves oxidative stress state induced by H2O2 in a differentiation process of the MC3T3-E1, and has protective function on MC3T3-E1 osteogenic differentiation inhibition caused by H2O2; besides, gastrodin can inhibit expression of a bone absorption factor. Therefore, gastrodin can play a role of protecting osteoporosis through improvement on osteoblast apoptosis and differentiation inhibition, and indirect inhibition of osteoclast activation. In an osteoporosis model of castrated mice, gastrodin can improve oxidative stress state in serum, improves a bone micro-structure of cancellous bone of distal femur and lumbar vertebra, and increases osteogenesis rate of distal femur, so that gastrodin can improve bone ...
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